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68 results about "Brain lesions" patented technology

Methods and devices for increasing learning and effects of training in healthy individuals and patients after brain lesions using DC stimulation and apparatuses and systems related thereto

Featured is a method and device for increasing learning and effects of training. Such methods include locating a pair of electrodes on a head of a person in relation to a specific area of the brain, applying a desired DC current to the electrodes at a level sufficient to stimulate the brain tissue; and controlling the DC current application so the current is applied to the specific brain area at least one of before, during or after such a learning or training event. In this way, application of the DC current to the brain area improves a subject's ability to acquire one of motor skills or knowledge of the learning or training event or the ability to retain the motor skills or knowledge of the learning or training event. The person to which the electrodes are attached can be healthy or a patient after brain lesions.
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE

Consistent sequential ultrasound acquisitions for intra-cranial monitoring

ActiveUS20160000411A1Quickly ascertain presenceQuickly ascertain presence and monitoringDiagnostic probe attachmentOrgan movement/changes detectionSonificationBrain lesions
A medical imaging probe (102) for contact with an imaging subject includes an indicium placement apparatus for, while the probe is in contact, selectively performing an instance of marking the subject so as to record a position of the probe. The device may further include a feed-back module for determining whether an orientation, with respect to a the mark, that currently exists for a medical imaging probe of the device meets a criterion of proximity to a predetermined orientation. Responsive to the determination that the criterion is met, a quantitative evaluation may be made automatically and without need for user intervention, vis live imaging via the probe, of a lesion that was, prior to the determination, specifically identified for the evaluation. Change, such as growth (116), in the lesion, like a brain lesion, may thereby be tracked over consistent sequential imaging acquisitions, such as through ultrasound.
Owner:KONINKLJIJKE PHILIPS NV

Cascade brain-targeting drug delivery system as well as preparation method and application thereof

The invention belongs to the field of pharmaceuticals and relates to a cascade brain-targeting drug delivery system and the application thereof. The cascade brain-targeting drug delivery system comprises a first-stage target functional molecule, a second-stage target functional molecule and a drug carrier. The cascade target drug delivery system can identify the blood-brain barrier through the first-stage target functional molecule and identify a brain lesion through the second-stage target functional molecule, so as to achieve the accurate targeting purpose, and can also accurately transfer imaging molecules or drugs to the brain lesion, so as to achieve good imaging and therapeutic effects. The cascade brain-targeting drug delivery system can be applied to prepare formulations for treatment or diagnosis of brain diseases (such as brain tumors) and nervous system diseases.
Owner:FUDAN UNIV

Marking catheter for placement using frameless stereotaxy and use thereof

A marking catheter made out of a flexible material and having a closed distal end and an open proximal end is provided. The marking catheter is sized and shaped to fit over the probe of a frameless stereotaxy system. One or more marking catheters may be positioned using the frameless stereotaxy system to define accurately an area identified in pre-operative imaging. For example, a plurality of marking catheters may be used to define physically the margins of a brain lesion. The brain lesion may then be removed to expose the positioned catheters, thereby assuring complete and effective lesion removal. The flexible catheters will move with any brain-shift occurring during lesion removal, thereby to maintain an accurate indication of the lesion margin.
Owner:WASCHER THOMAS M

Method and system for assessment of biomarkers by measurement of response to surgical implant

In a human or animal organ or other region of interest, specific objects, such as liver metastases and brain lesions, serve as indicators, or biomarkers, of disease. In a three-dimensional image of the organ, the biomarkers are identified and quantified both before and after a surgical implant is implanted, and their reaction to the surgical implant is observed. Statistical segmentation techniques are used to identify the biomarker in a first image and to carry the identification over to the remaining images.
Owner:VIRTUALSCOPICS

hNT-neuron human neuronal cells to replace ganglion cells

Disclosed herein is the treatment of vision loss in a mammal by transplanting an effective amount of hNT-Neuron cells. The treatment can be accomplished by injecting the cells into the retinal area of the eye. Additionally, the cells can be injected into the visual cortex of the brain. Conditions to be treated are vision loss due to optic nerve damage, including glaucoma, optic nerve sheath meningioma and glioma, Graves' ophthalmopathy, benign or malignant orbital tumors, metastatic lesions, tumors arising from the adjacent paranasal sinuses or middle cranial fossa, giant pituitary adenomas, brain tumors or abscesses, cerebral trauma or hemorrhage, meningitis, arachnoidal adhesions, pseudotumor cerebri, cavernous sinus thrombosis, dural sinus thrombosis, encephalitis, space-occupying brain lesions, severe hypertensive disease or pulmonary emphysema.
Owner:LAYTON BIOSCI

Brain-like disease treatment tissue model based on cell three-dimensional printing technology and preparation method and application thereof

The invention discloses a brain-like disease treatment tissue model based on a cell three-dimensional printing technology and a preparation method and application thereof. The preparation method comprises the steps of mixing primary nerve cells extracted from the affected part of the brain lesion with a hydrogel material and a cross-linking agent to obtain a printing biological ink; performing printing molding on the priting biological ink based on the mechanical characteristics of the layer structure and elastic modulus of the natural cerebral cortex by adopting the biological three-dimensional printing technology and then performing tissue culture to obtain the brain-like disease treatment tissue model based on the cell three-dimensional printing technology. Based on the morphological and mechanical properties of the natural brain, the in vitro brain-like model is constructed by the biological three-dimensional printing technology. An extracellular matrix suitable for nerve cell growth and survival can be constructed by controlling the elastic modulus of the extracellular matrix, and the primary cells that are not prone to survive can be adopted for printing. The model has the function of screening drugs in different biological and chemical properties and is a drug screening model with the blood-brain-barrier similar effects.
Owner:TSINGHUA UNIV

Nano-drug carrier crossing blood cerebral barrier

The invention discloses a nano-drug carrier crossing the blood cerebral barrier. The carrier can target brain lesions (brain tumors or other neurodegenerative diseases). The targeting drug carrier crossing the blood cerebral barrier contains all-heavy-chain human ferritin or a reconstruct or mutant of a functional fragment thereof. The carrier crosses the blood brain barrier via receptor-mediatedtranscytosis. The nano-drug carrier of the invention is expected to be an effective nano-drug carrier for the treatment of brain tumors or neurodegenerative diseases.
Owner:KUNSHAN XINYUNDA BIOTECH CO LTD

System for positioning brain lesion area

The invention relates to the field of positioning brain lesion areas, and specifically provides a system for positioning a brain lesion area. The system comprises a flexible conduit for intervening in brain tissues, and the flexible conduit is provided with an ultrasonic probe and / or an optical detector. The ultrasonic probe emits supersonic signals to brain tissues and receives supersonic signals reflected by the brain tissues, and the optical detector emits optical signals to the brain tissues and receives optical signals reflected by the brain tissues. The system further comprises a processor which identifies structure and blood volume change of the brain tissues according to the supersonic signals reflected by the brain tissues and received by the ultrasonic probe, and / or identifies structure and blood volume change of the brain tissues according to the optical signals reflected and / or scattered by the brain tissues and received by the optical detector to position the brain lesion area. Only minimally invasive drilling in the brain of a patient is required to accurately position the brain lesion area through supersonic signals, thereby substantially reducing clinic risk and damage to the body of the patient.
Owner:SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI

Brain lesion area volume obtaining method and device based on deep learning, computer equipment and storage medium

The invention relates to a brain lesion area volume obtaining method and device based on deep learning, computer equipment and a storage medium. The method comprises the following steps: acquiring CTperfusion imaging data related to the brain, wherein the CT perfusion imaging data are a plurality of CT perfusion images arranged according to a scanning time sequence; calculating according to the CT perfusion imaging data to obtain corresponding multi-channel image data; inputting multi-channel image data into the trained deep learning network, and obtaining a plurality of corresponding segmented images, wherein each segmented image comprises an infarction core region and an ischemia semi-dark region; and constructing a brain model in a three-dimensional form based on the plurality of segmented images, and performing calculation according to the brain model to obtain volumes of the infarction core region and the ischemia semi-dark region. By adopting the method, the accuracy and the calculation speed can be improved.
Owner:HANGZHOU ARTERYFLOW TECH CO LTD

Ultrasonic-based craniotomy robot system

The invention provides an ultrasonic-based craniotomy robot system. The system comprises a remote control center, a craniotomy control module, an ultrasonic signal secondary processing three-dimensional imaging module, a surgical execution module and an instrument working module. The remote control center is used for receiving image data, determining the location of a brain lesion, and initially planning a surgical path. The craniotomy control module is used for planning a secondary surgical path. The ultrasonic signal secondary processing three-dimensional imaging module is used for utilizingultrasonic waves to carry out three-dimensional imaging, and performing an ultrasonic surgical operation according to the secondary surgical path. The surgical execution module is used for performingsurgical operation according to a real-time image. The ultrasonic-based craniotomy robot system solves the problem of low surgical success rate or even inability to perform an operation due to lack of a professional neurosurgeon in a remote area, the surgical success rate is improved, guidance of the lesion position is automatically carried out, the recovery period of a patient is greatly shortened, and risk of a surgery failure is reduced.
Owner:刘伟民

Brain lesion image spatial distribution characteristic classification and identification method based on magnetic resonance imaging

The invention belongs to the technical field of image processing and application, and particularly relates to a brain lesion image spatial distribution feature classification and identification methodbased on magnetic resonance imaging. The method mainly comprises the steps of focus segmentation, individual image registration, space standardization, standard space template individualization, focus space distribution feature extraction, feature screening, modeling and the like. The core is in that an analysis method of a brain lesion image spatial distribution feature set is constructed by analyzing various features of lesions in an individual space and a standard space, and feature screening and modeling are carried out by using machine learning on the basis of the analysis method. The method can be used for classifying and identifying brain lesion images of different brain diseases or brain states caused by different antibodies, different genes and the like by using brain magnetic resonance images, and effective guidance is provided for clinic and scientific research.
Owner:AFFILIATED HUSN HOSPITAL OF FUDAN UNIV

Brain disease diagnosis service apparatus and brain disease diagnosis service method

The present disclosure relates to a brain disease diagnosis service apparatus including at least: a receiving unit for receiving an image of a subject to be diagnosed; a preprocessing unit for estimating a transformation matrix in order to align a predetermined standard image with the image received by the receiving unit, and for applying the estimated transformation matrix to a predetermined standard brain region map, thereby generating an individual brain region map for the subject to be diagnosed; a feature point extracting unit for calculating a ratio occupied by brain lesions for each brain region in the individual brain region map, generated by the preprocessing unit, of the subject to be diagnosed, thereby extracting feature points; and a disability type determining unit for determining a disability type on the basis of the ratio of the brain lesions, calculated by the feature point extracting unit, for each brain region.
Owner:THE ASAN FOUND

MRI (Magnetic Resonance Imaging) segmentation method for integrating attention mechanism aiming at brain lesion

The invention provides an MRI (Magnetic Resonance Imaging) segmentation method for integrating an attention mechanism aiming at brain lesions. The method comprises the following steps: S1, collecting a brain MRI image with a segmentation image result, and establishing a training set; s2, preprocessing the original brain MRI image to be segmented in the training set; s3, establishing a convolutional neural network with an attention mechanism, and training a model of the convolutional neural network by using the training set; s4, after model training is completed, using trained model parameters to predict the verification set image, and generating a brain MRI tissue and lesion segmentation map; s5, establishing an evaluation file, and evaluating a segmentation result; according to the method, more critical and important information can be extracted, and meanwhile, the training effect of training on a small data set is improved by means of transfer learning.
Owner:FUZHOU UNIV

Methods, apparatuses, and systems for creating 3-dimensional representations exhibiting geometric and surface characteristics of brain lesions

Methods, apparatuses, systems, and implementations for creating 3-dimensional (3D) representations exhibiting geometric and surface characteristics of brain lesions are disclosed. 2D and / or 3D MRI images of the brain may be acquired. Brain lesions and other abnormalities may be identified and isolated with each lesion serving as a region of interest (ROI). Saved ROI may be converted into stereolithography format, maximum intensity projection (MIP) images, and / or orthographic projection images. Data corresponding to these resulting 3D brain lesion images may be used to create 3D printed models of the isolated brain lesions using 3D printing technology. Analysis of the 3D brain lesion images and the 3D printed brain lesion models may enable a more efficient and accurate way of determining brain lesion etiologies.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST

Method for locating brain lesion

A surgeon utilizes a brain scan image to locate a brain lesion and to plan the operation to treat it. Distance measurements representing the location of the lesion are derived from various views of a brain scan image. In the operating room, he transfers these distance measurements onto the patient's cranium in a “warped” or curvilinear Cartesian coordinate system defined by intersecting orthogonal lines extending along the surface of the patient's cranium. As a result, the lesion is localized and the surgeon may establish the appropriate location and orientation of a bone flap to be used to access the lesion.
Owner:ST BARNABAS HEALTH CARE SYST

Monoclonal antibody against human neurofilament light polypeptide (NEFL) and application thereof

The invention relates to the field of biotechnology, and discloses a monoclonal antibody against a neurofilament light polypeptide (NEFL). The antibody is secreted by a hybridoma cell line OTI11F6 with a preservation number of CGMCC No.18189. The immunogen of the antibody is a NEFL 1-360aa polypeptide expressed by prokaryotic cells. An amino acid sequence of a light polypeptide (VL) of the antibody is as shown in SEQ ID No.1, and an amino acid sequence of a heavy polypeptide (VH) of the antibody is as shown in SEQ ID No.2. The VL of the antibody comprises three antigenic determinants: CDR1, CDR2, and CDR3, amino acid sequences of the three antigenic determinants are respectively as shown in SEQ ID No.3-5, the VH region of the antibody comprises three antigenic determinants: CDR1, CDR2, andCDR3, and amino acid sequences of the three antigenic determinants are respectively as shown in SEQ ID No.6-8. The antibody OTI11F6 can be applied to preparation of various immunoassay kits of NEFL,such as preparation of double-antibody sandwich enzyme-linked immunosorbent assay kits or chemiluminescence assay kits, and assistant diagnoses for brain injury and chronic brain lesions are provided.
Owner:无锡傲锐东源生物科技有限公司

Peptide homing to brain tumors

The present invention relates to a peptide, which specifically homes to the intracranial, early stage astrocytoma model that grows as islets and harbors co-opted tumor vessels in the brain. The peptide finds its use in targeted delivery of therapeutic substances to invasive brain cancer or metastatic brain lesions as such and in combination with conventional therapies, such as surgery and radiation, and anti-angiogenic therapies, and as a tool in diagnosis of, e.g., invasive brain cancer or metastatic brain lesions.
Owner:BURNHAM INST FOR MEDICAL RES +1

Medical instrument for analysis of white matter brain lesions

InactiveUS20180344161A1Increase fiber tracking accuracyImage enhancementMedical imagingFiberBrain lesions
The present invention relates to a medical instrument for automatically detecting affected regions in an examination area of a subject comprising: a memory containing machine executable instructions; and a processor for controlling the medical instrument, wherein execution of the machine executable instructions causes the processor to control the instrument to: obtain a first anatomical image of the examination area and a first image of fibers of the examination area, wherein a first parameter and a second parameter describe characteristics of the first anatomical image and the first image of fibers respectively; segment the first anatomical image into a plurality of segments indicating respective tissues and / or structures in the examination area; identify first lesions in the segmented first anatomical image; use values of the first and / or second parameters for determining seed points in the identified first lesions for a tracking algorithm for tracking first fibers in the first image of fibers.
Owner:KONINKLJIJKE PHILIPS NV

Methods, apparatuses, and systems for creating 3-dimensional representations exhibiting geometric and surface characteristics of brain lesions

Methods, apparatuses, systems, and implementations for creating 3-dimensional (3D) representations exhibiting geometric and surface characteristics of brain lesions are disclosed. 2D and / or 3D MRI images of the brain may be acquired. Brain lesions and other abnormalities may be identified and isolated with each lesion serving as a region of interest (ROI). Saved ROI may be converted into stereolithography format, maximum intensity projection (MIP) images, and / or orthographic projection images. Data corresponding to these resulting 3D brain lesion images may be used to create 3D printed models of the isolated brain lesions using 3D printing technology. Analysis of the 3D brain lesion images and the 3D printed brain lesion models may enable a more efficient and accurate way of determining brain lesion etiologies.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST

Consistent sequential ultrasound acquisitions for intra-cranial monitoring

ActiveUS10034658B2Quickly ascertain presence and monitoringDiagnostic probe attachmentOrgan movement/changes detectionSonificationBrain lesions
A medical imaging probe (102) for contact with an imaging subject includes an indicium placement apparatus for, while the probe is in contact, selectively performing an instance of marking the subject so as to record a position of the probe. The device may further include a feedback module for determining whether an orientation, with respect to a the mark, that currently exists for a medical imaging probe of the device meets a criterion of proximity to a predetermined orientation. Responsive to the determination that the criterion is met, a quantitative evaluation may be made automatically and without need for user intervention, via live imaging via the probe, of a lesion that was, prior to the determination, specifically identified for the evaluation. Change, such as growth (116), in the lesion, like a brain lesion, may thereby be tracked over consistent sequential imaging acquisitions, such as through ultrasound.
Owner:KONINKLJIJKE PHILIPS NV

Depression and bipolar disorder brain network analysis method based on dual-channel phase synchronization feature fusion

The invention discloses a depression and bipolar disorder brain network analysis method based on dual-channel phase synchronization feature fusion. The method comprises the following steps: constructing phase synchronization matrixes by using resting scalp electroencephalogram signals and respectively adopting a phase delay index, a weighted phase delay index and a phase lock value synchronization index, and fusing the phase synchronization matrixes, so that brain lesion areas of patients with depression and bipolar disorder can be effectively distinguished. Compared with the prior art, the method provided by the invention has the following advantages that more effective information can be obtained by fusing the three synchronous features to detect a weak interaction relationship among the signals, and whether the electrode signals of the brain region are in a synchronous state or not can be found favorably, and thus the lesion brain region can be identified effectively. Experiments show that compared with a healthy control group, the method has the advantage that the difference between the frontal lobe and the parietal lobe of a patient with depression and bipolar disorder is relatively large.
Owner:BEIJING UNIV OF TECH

A method of dti image analysis based on multivariate

InactiveCN103996196BOvercome the disadvantage of requiring prior knowledgeOvercome the disadvantage of not being able to observe subregions in the atlasImage analysisCharacter and pattern recognitionDiseasePatient group
The invention discloses a DTI image analytical method based on multiple variables. The DTI image analytical method based on the multiple variables is used for determining and extracting diseased areas of the brain white matter in the disease brain mechanism research, thereby providing an imaging basis for clinical treatment. The method includes the specific steps that data are preprocessed, wherein the preprocessing procedures include eddy current removal, head motion correction, cranium removal, dispersing and fitting and white matter skeleton building; characteristic extraction is conducted on the preprocessed data, the significant difference areas of a patient group and a healthy people group are obtained through replacement inspection and with the ages serving as the concomitant variables, the average value of the certain variables in the significant difference areas is worked out respectively, and the characteristic value is obtained; cross validation is conducted through a leave-one-out method, whether the stop criterion is met or not is judged, and if not, the average weight value of each characteristic is worked out, and the characteristic with the minimum average weight value is removed until the stop criterion is met; the finally obtained brain area is the brain lesion area. According to the method, the DTI imaging mode is adopted, the imaging basis is provided for finding the lesion area in the clinical treatment through the multivariable research method.
Owner:XIDIAN UNIV

Use of 3-methoxy-pregnenolone for the preparation of a drug for treating depressive disorders and long-term neurological diseases

ActiveUS20130244991A1Faster and more long-lasting crossingCrosses the blood-brain barrier betterOrganic active ingredientsDiseaseNervous system
A method for the treatment of a traumatic brain lesion comprises administering to the patient an effective quantity of 3∃-methoxy-pregna-5-ene-20-one (3∃-methoxy-PREG).
Owner:MAPREG

Imaging method and device thereof and nuclear magnetic system

The invention provides an imaging method and a device thereof and a nuclear magnetic system. The imaging method is applied to the nuclear magnetic system with an ADC image acquisition function. The method comprises the following steps of: obtaining a multi-layer apparent dispersion coefficient ADC image of a scanned brain, determining at least one first connected region from an infarct core candidate region of each layer of ADC image, determining an area in the ADC image, which is symmetrical to the first connected area in structure, as a second connected area, according to the first relativeADCs of the pixel points in the first connected area and the second relative ADCs of the pixel points in the second connected area, determining a target infarcted core region and a target ischemic penumbra from the first connected region and the second connected region, and marking the target infarcted core region and the target ischemic penumbra are ed in the ADC image. The method provided by theinvention has the advantage of high accuracy of a lesion region detection result, and can accurately mark a brain lesion region on the ADC image.
Owner:NEUSOFT MEDICAL SYST CO LTD

Infantile cerebral palsy acupuncture point heat treatment plaster

The invention relates to an infantile cerebral palsy acupuncture point heat treatment plaster, which is a plaster for external use for treating infantile cerebral palsy. The infantile cerebral palsy acupuncture point heat treatment plaster consists of folium artemisiae argyi, lumbricus, Chinese angelica, kudzu root, nux vomica, storax, borneol, cinnamon, Kanlisha and magnetic treatment sheets, has the function of improving the brain tissue blood circulation and the brain tissue function, recovering brain lesion blood and oxygen supply, activating the damaged dormant brain tissue cells and vibrating and treating the palsy, has good treatment effect and quick return during the treatment of the infantile cerebral palsy, can achieve the effect of addressing both symptoms and root causes and the goal of not easily relapsing after recovery.
Owner:张思鹰

Composition for treating brain lesions

InactiveCN107864626AFunctional recovery after premature ischemiaFunctional recovery after prolonged ischemiaOrganic active ingredientsNervous disorderBrain lesionsVeterinary dentistry
The present invention relates to a pharmaceutical composition which includes a biocompatible polymer and a eukaryotic cell to be used as a drug for the prevention and / or treatment of tissue lesions ofthe central nervous system caused by cerebral vascular ischaemia. The present invention also relates to a pharmaceutical kit which includes a biocompatible polymer and a eukaryotic cell for the prevention and / or treatment of tissue lesions of the central nervous system caused by cerebral vascular ischaemia. The present invention can be used in particular in the human and veterinary pharmaceuticalfields.
Owner:生物组织再生和修复公司 +3
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