127 results about "Animal Organs" patented technology

A device for measuring elasticity of a human or animal organ or viscoelastic media having an ultrasonic signal after ultrasonic illumination including at least one sensor including an ultrasonic transducer, at least one position sensor, an actuator to trigger the device connected by wire link to an electric power source, and a controlled electrodynamic actuator attached to the ultrasonic transducer that generates a transitory low-frequency impulse having a frequency range between about 1 Hz and about 5000 Hz.

The present invention provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which lack expression of functional endogenous immunoglobulin loci. The present invention also provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which express xenogenous, such as human, immunoglobulin loci. The present invention further provides ungulate, such as porcine genomic DNA sequence of porcine heavy and light chain immunogobulins. Such animals, tissues, organs and cells can be used in research and medical therapy. In addition, methods are provided to prepare such animals, organs, tissues, and cells.

The invention relates to a preservation solution for organs, tissues or cells of human bodies or animals. The organ preservation solution comprises sodium citrate, potassium citrate, magnesium sulfate, sodium dihydrogen phosphate, sodium hydroxide, adenosine, arginine, tryptophan, mannitol, tetramethylpyrazine hydrochloride and other components. The organ preservation solution can be used for cooling, lavaging and preserving the organs of the human bodies or the animals, can effectively preserve human in vitro kidneys for 48 hours and animal in vitro kidneys for 72 hours, can prevent ischemia-reperfusion injury, and has great value for clinical application.

The invention discloses a formaldehyde-free animal specimen fixed liquid and a preparation method thereof, the formaldehyde-free animal specimen fixed liquid includes the following components: a biocide mildewcide, a protein denaturant, a polyol moisturizing agent and balance of water, and if the biocide mildewcide is in solid state, the mass concentration of the biocide mildewcide is 5-20 g / L, if the biocide mildewcide is liquid, the volume concentration of the biocide mildewcide is 1-2%; the volume concentration of the protein denaturant is 5%-40%; and the volume concentration of the polyol moisturizing agent is 2% to 10%. The formaldehyde-free animal specimen fixed liquid does not contain formaldehyde, and is non-volatile, and harmless to the human body; a fresh animal organ is washed with normal saline, and stored in the fixed liquid, a year later, the organ is not corrupted, free of mildew spot, and free of obvious color and shape change, the fixed liquid color has no obvious change, and the storage effect is good.

The invention discloses a medical image Graph Cut segmentation method based on a statistical shape model. The medical image Graph Cut segmentation method mainly solves the problem that low-contrast organs cannot be effectively segmented in a medical image in the prior art, and is implemented by the steps of: (1) establishing the statistical shape model of the low-contrast organs, and acquiring grey scale information; (2) pre-segmenting the low-contrast organs; (3) initialization Graph; (4) and segmenting the low-contrast organs. The medical image Graph Cut segmentation method based on the statistical shape model adds priori knowledge of shapes of organs on the basis of rapid segmentation by adopting a Graph Cut algorithm, reduces the possibilities of over-segmentation and under-segmentation, determines initial positions of the low-contrast organs according to relative relationship between animal organs and animal in-vitro contours, improves the segmentation efficiency, and is a rapid and effective organ segmentation method.

A device is provided that allows for treatment or pre-treatment of an area of a human or animal organ intended to be penetrated to connect the vascular system of said human or animal with a sampling, infusion, or withdrawal container. The device comprises nitric oxide (NO) for obtaining a vaso-dilating effect at said area during said treatment or pre-treatment.

A device for measuring elasticity of a human or animal organ, or viscoelastic environments presenting an ultrasonic signal after ultrasonic illumination and consecutively establishing a representation in two or three dimensions of the elasticity, including at least one ultrasonic bar including a plurality of transducers, an excitor that generates and delivers a low-frequency, direct or indirect applied force, a receiver that acquires ultrasonic signals, a controller that commands and processes data, and a scanner that carries out scanning with the bar in one dimension (1D) or in two dimensions (2D) in two perpendicular directions, respectively, to obtain a representation of the measure of the elasticity in two (2D) or three dimensions (3D).

A surgical simulation assembly is provided for simulating realistic surgery on animal organs or human cadavers. The surgical simulation assembly comprises a generally flat tray having a central indentation for receiving an organ, at least one drainage aperture and at least one indented trough extending from the central indentation for receiving at least one tube. The tray is assembled with a simulator heart and lungs prepped for connection to a variable speed double action air pump assembly that creates both positive pressure and a vacuum on the heart to simulate a beating heart. The tray is supported on a basket having a lower containment portion for containing fluid waste collected during the simulated surgery. The basket is elevated by risers over a base designed to support the assembly.

The invention relates to a biological tissue opto-acoustic confocal micro-imaging device and method, and belongs to the field of medical imaging. The biological tissue opto-acoustic confocal micro-imaging device is mainly composed of an imaging device, a signal collecting device and a control device. The imaging device and the signal collecting device are connected with the control device, and the imaging device is connected with the signal collecting device. The biological tissue opto-acoustic confocal micro-imaging device is simple and reasonable in structure, a clear three-dimensional image is obtained by improving the detection sensitivity and the image signal to noise ratio, the problems that an opto-acoustic micro-image of the biological tissue such as the subcutaneous blood vessels, tumors and animal organs is low in resolution ratio and contrast ratio under the out-of-focus situation are solved, and the biological tissue opto-acoustic confocal micro-imaging device and method are suitable for popularization and application.

In a human or animal organ or other region of interest, specific objects, such as liver metastases and brain lesions, serve as indicators, or biomarkers, of disease. In a three-dimensional image of the organ, the biomarkers are identified and quantified both before and after a surgical implant is implanted, and their reaction to the surgical implant is observed. Statistical segmentation techniques are used to identify the biomarker in a first image and to carry the identification over to the remaining images.

A composition comprising a water-soluble and stable complex formed by an alkyl ether derivative of gamma-cyclodextrin and curcumin and optionally comprising non-complexed cyclodextrin, the molar ratio of curcumin to cyclodextrin being between 1:1 and 1:6, and a method of manufacturing such a composition. The water-soluble and stable complex of curcumin is useful in therapy, e.g. for treatment of cancer, leukemia, myocardial infarction, stroke, sepsis, acute lung injury, acute liver failure, acute tubular necrosis, acute pancreatitis, radiation injury and other life-threatening conditions in a human or animal subject, as well as for preserving human or animal organs, tissues or cells at a hypothermic temperature.

The invention provides a kidney preservative fluid which comprises potassium citrate, sodium citrate, magnesium sulfate, disodium hydrogen phosphate, sodium dihydrogen phosphate, adenosine, L-arginine, ligustrazine and mannidex, which has the advantages of high penetrability, acidity stability, thus can prevent ischemia re-impregnating damage and conserve kidney as long as 72 hours.

The present invention relates to a non-invasive method for assessing the presence and / or severity of a lesion in an organ of an animal, including a human, said method comprising carrying out at least one non-invasive test resulting in a value, preferably a score result, and positioning the at least one value or score result in a class of a detailed classification, such as, for example, a detailed classification based on population percentiles, or on a reliable diagnostic interval (RDI), to be crossed with another RDI. The present invention also relates to a device, preferably a meter, carrying out the non-invasive method of the invention.

A device is provided that allows for treatment or pre-treatment of an area of a human or animal organ intended to be penetrated to connect the vascular system of said human or animal with a sampling, infusion, or withdrawal container. The device comprises nitric oxide (NO) for obtaining a vaso-dilating effect at said area during said treatment or pre-treatment.

The invention relates to an in-vitro animal organ perfusion device which comprises a liquid storage component, a temperature control component, an oxygenation component and a perfusion component, wherein the liquid storage component is used for storing a perfusion solution; the temperature control component is used for maintaining the temperature of the perfusion solution in transportation; the oxygenation component is used for introducing oxygen into the perfusion solution in transportation to generate an oxygenation effect; the perfusion component comprises an outer-layer heat insulation subsystem and an inner-layer perfusion subsystem, the inner-layer perfusion subsystem comprises a perfusion chamber with a cover, a perfusion tube and a bile drainage tube are arranged on the cover, theperfusion chamber is divided into an upper layer and a lower layer by a perforated partition for holding a to-be-perfused animal liver, and the lower layer is connected to the liquid storage componentthrough a recovery pipeline. The in-vitro animal organ perfusion device provided by the invention has the benefits that a controllable temperature environment and a perfusion solution oxygen concentration environment are provided on the basis of realizing an animal perfusion technique; more changeable and perfect experimental conditions can be provided for a related in-vitro animal organ tissue experiment; in the experiment process, a temperature probe, an oxygen concentration probe and a pH probe of the device can provide more experiment data.

The present invention provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which lack expression of functional endogenous immunoglobulin loci. The present invention also provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which express xenogenous, such as human, immunoglobulin loci. The present invention further provides ungulate, such as porcine genomic DNA sequence of porcine heavy and light chain immunogobulins. Such animals, tissues, organs and cells can be used in research and medical therapy. In addition, methods are provided to prepare such animals, organs, tissues, and cells.

The invention relates to the technical field of wound dressings, in particular to a tissue-specific wound dressing as well as a preparation method and application thereof. The tissue-specific wound dressing comprises an extracellular matrix extracted from tissue and a gelling material, wherein the tissue is an organ or an animal organ or tissue corresponding to the organ or tissue to which the dressing is applied, and the gelling material can crosslink and cure the extracellular matrix, so that the extracellular matrix has high adhesion to wet tissue and can be quickly adhered to a wound to stop bleeding. According to the tissue-specific wound dressing, the extracellular matrix and the gelling material are matched, so that compared with a common wound dressing, the tissue-specific wound dressing can shorten wound healing and tissue repairing time remarkably, has good hemostatic and wound healing effects, and can be used for massive hemorrhage or visceral hemorrhage. The tissue-specificwound dressing fills the blank that the extracellular matrix is used as a wound dressing.

The invention relates to a catheter for introducing into a hollow human or animal organ. Said catheter comprises a catheter tip that protrudes forwards and a region that is encased by an expandable tubular hollow body and that is situated behind the catheter tip. Said catheter is characterised in that a wire spiral is located in the encased region. It can also be advantageous to provide a radiopaque ring, in particular a platinum, gold or tungsten ring, on a hollow shaft of the catheter, together with several rib-type projections running around the hollow shaft and projecting from the latter, in a region in front of and / or behind the radiopaque ring.

The invention concerns a device for measuring elasticity of a human or animal organ, particularly the liver, or more generally all viscoelastic media delivering an ultrasonic signal after ultrasonic illumination, comprising at least a probe including an ultrasonic transducer (2), at least one position sensor, an actuator for triggering said device, wire-connected to an electric power supply. The invention is characterized in that it comprises an automatically controlled electrodynamic actuator, fixed to the ultrasonic transducer (2), capable of generating a transient low frequency mechanical stress having a frequency range between 1 Hz and 5000 Hz. The invention also concerns a method for calculating elasticity using said device.

The invention provides a multifunctional imaging probe. The multifunctional imaging probe is a radionuclide labelled peptide complex and takes a peptide compound which has the structure as shown in the formula (I) defined in the description and has the tumor targeting fluorescence imaging function, wherein X is a NOTA radical group or-CH2-, R is targeting peptide BBN with the structure as shown in the formula (II) defined in the description or targeting peptide RM26 with the structure as shown in the formula (III). The multifunctional imaging probe can be used for positron emission computer tomography (PET) and optical imaging simultaneously. The invention further provides a preparation method of the functional probe and application in preparation of a human or animal organ or tissue imaging agent, precise positioning on the tumor boundary can be achieved through application, and the advantages of real-time performance, high precision, high specificity, high sensitivity and high resolution are brought to preoperative and intraoperative imaging navigation.

The present invention relates to cell and tissue culture. In particular, the present invention provides a method for preparing an organotypic culture using dissociated cells or microexplants obtained from an animal organ. The method for preparing an organotypic culture comprises culturing cells from an organ on a surface characterised in that the cells are compacted. The invention further relates to a high-throughput method for the preparation of a collection of organotypic cultures. The invention further relates to a device for carrying out a method of organotypic culture according to the invention.

The invention discloses a method for detecting human DNA by specifically detecting the human SRGAP2 gene, a primer and probe for specifically detecting the human SRGAP2 gene, and a TaqMan qPCR methodcapable of being used for detecting the human DNA in animal organs, tissue, cells, body fluid and blood. The method is suitable for detecting the human DNA in any animal sample and includes but not limited to biochores, metabolism and residues of cell and gene treatment products in the body of an animal receiving treatment.

Modified animal tissues, organs, and organ systems for use in simulated surgical procedures are disclosed. The tissues, organs, and / or organ systems can be modified by enhancing their electrical conductivity, by including simulated contents mimicking what would normally be present in live animals, and by having fake blood perfusing through them. Portions of different tissues, organs, or organ systems, which can be from the same or different animals, can be adhered to provide hybrid / chimeric tissues, organs, or organ systems, and also used for simulated surgical procedures. These modifications can provide surgeons with a more realistic experience during a simulated surgical procedure.

The invention discloses a new process for purifying cytochrome C, which comprises the following steps: (1) extracting cytochrome C coarse extract from animal organs or yeasts; (2) adding an inorganic salt into the coarse extract to perform salting, standing, centrifuging and removing settled proteins, and collecting supernate; (3) adding buffer solution to regulate the inorganic salt concentration in the supernate to 20 to 35 percent, and purifying the supernate by using front-end hydrophobic chromatography, namely continuously loading the obtained solution onto a hydrophobic chromatographic column which is balanced by inorganic salt solution at a concentration of 20 to 35 percent in advance and collecting penetration solution; and (4) washing the chromatographic column by using the inorganic salt solution at a concentration of 20 to 35 percent till a stable light absorbance, collecting the efflux of the chromatographic column, mixing the efflux of the chromatographic column with penetration solution, and purifying to obtain cytochrome C. In the invention, the operation is simple and convenient, the separation and purification effect is good, the yield is high and cost is low.

The invention discloses a nitro imidazole xanthogenate complex marked by TcO with the formula of TcO (NMXT)2; in the formula, NMXT represents a compound containing nitro imidazole xanthogenate. The complex adopts Tc(V)O as a central nucleus and has a geometric configuration with the shape of an irregular square pyramid, wherein O atom in Tc=O bond is positioned at the top point and four sulphur atoms provided by two xanthogenate ligand molecules are positioned at the four points of the bottom surface. By the technical steps of synthesis of ligand NMXT and preparation of TcO (NMXT)2 complex, the TcO (NMXT)2 complex is obtained. The nitro imidazole xanthogenate complex has high radiochemical purity and good stability, has higher uptake value and good detention through in tumor and higher ratio of tumor / muscle, is widely applied to tumor imaging of human body and animal organs and is a novel tumor hypoxia imaging agent which is conveniently promoted and applied.

After a primary ischemic injury, which predominantly results in necrosis, there is a secondary injury in the neighbouring tissue, due at least to some extent to apoptosis. This secondary damage is usually not evident until several days after the initial ischemic event. The present invention provides methods of preventing, treating and / or alleviating secondary ischemic damage in a mammalian organ or tissue, comprising a step of administering an effective amount of an NF-κB inhibitor to said organ or tissue. Compositions for this purpose are also disclosed.

The invention relates to an instrument (1) for measuring the elasticity of a human or animal organ located behind the ribs (2). The inventive instrument is of the type that consists of a casing (3) comprising an actuator, the end of which is equipped with a transducer (4) that is actuated in order to measure the elasticity of the organ. The invention is characterised in that the measuring instrument (1) also comprises a means (7) for centring the transducer (4) between the ribs (2).