126 results about "Animal Organs" patented technology

The present invention provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which lack expression of functional endogenous immunoglobulin loci. The present invention also provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which express xenogenous, such as human, immunoglobulin loci. The present invention further provides ungulate, such as porcine genomic DNA sequence of porcine heavy and light chain immunogobulins. Such animals, tissues, organs and cells can be used in research and medical therapy. In addition, methods are provided to prepare such animals, organs, tissues, and cells.

A device is provided that allows for treatment or pre-treatment of an area of a human or animal organ intended to be penetrated to connect the vascular system of said human or animal with a sampling, infusion, or withdrawal container. The device comprises nitric oxide (NO) for obtaining a vaso-dilating effect at said area during said treatment or pre-treatment.

A surgical simulation assembly is provided for simulating realistic surgery on animal organs or human cadavers. The surgical simulation assembly comprises a generally flat tray having a central indentation for receiving an organ, at least one drainage aperture and at least one indented trough extending from the central indentation for receiving at least one tube. The tray is assembled with a simulator heart and lungs prepped for connection to a variable speed double action air pump assembly that creates both positive pressure and a vacuum on the heart to simulate a beating heart. The tray is supported on a basket having a lower containment portion for containing fluid waste collected during the simulated surgery. The basket is elevated by risers over a base designed to support the assembly.

The invention relates to an in-vitro animal organ perfusion device which comprises a liquid storage component, a temperature control component, an oxygenation component and a perfusion component, wherein the liquid storage component is used for storing a perfusion solution; the temperature control component is used for maintaining the temperature of the perfusion solution in transportation; the oxygenation component is used for introducing oxygen into the perfusion solution in transportation to generate an oxygenation effect; the perfusion component comprises an outer-layer heat insulation subsystem and an inner-layer perfusion subsystem, the inner-layer perfusion subsystem comprises a perfusion chamber with a cover, a perfusion tube and a bile drainage tube are arranged on the cover, theperfusion chamber is divided into an upper layer and a lower layer by a perforated partition for holding a to-be-perfused animal liver, and the lower layer is connected to the liquid storage componentthrough a recovery pipeline. The in-vitro animal organ perfusion device provided by the invention has the benefits that a controllable temperature environment and a perfusion solution oxygen concentration environment are provided on the basis of realizing an animal perfusion technique; more changeable and perfect experimental conditions can be provided for a related in-vitro animal organ tissue experiment; in the experiment process, a temperature probe, an oxygen concentration probe and a pH probe of the device can provide more experiment data.

The invention discloses a method for detecting human DNA by specifically detecting the human SRGAP2 gene, a primer and probe for specifically detecting the human SRGAP2 gene, and a TaqMan qPCR methodcapable of being used for detecting the human DNA in animal organs, tissue, cells, body fluid and blood. The method is suitable for detecting the human DNA in any animal sample and includes but not limited to biochores, metabolism and residues of cell and gene treatment products in the body of an animal receiving treatment.

Modified animal tissues, organs, and organ systems for use in simulated surgical procedures are disclosed. The tissues, organs, and / or organ systems can be modified by enhancing their electrical conductivity, by including simulated contents mimicking what would normally be present in live animals, and by having fake blood perfusing through them. Portions of different tissues, organs, or organ systems, which can be from the same or different animals, can be adhered to provide hybrid / chimeric tissues, organs, or organ systems, and also used for simulated surgical procedures. These modifications can provide surgeons with a more realistic experience during a simulated surgical procedure.

After a primary ischemic injury, which predominantly results in necrosis, there is a secondary injury in the neighbouring tissue, due at least to some extent to apoptosis. This secondary damage is usually not evident until several days after the initial ischemic event. The present invention provides methods of preventing, treating and / or alleviating secondary ischemic damage in a mammalian organ or tissue, comprising a step of administering an effective amount of an NF-κB inhibitor to said organ or tissue. Compositions for this purpose are also disclosed.