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10231 results about "Transgene" patented technology
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A transgene is a gene or genetic material that has been transferred naturally, or by any of a number of genetic engineering techniques from one organism to another. The introduction of a transgene (called "transgenesis") has the potential to change the phenotype of an organism.
Inbred corn line LH283BtMON810
InactiveUS6852915B2Other foreign material introduction processesFermentationBiotechnologyGenetic Materials
An inbred corn line, designated LH283BtMON810, is disclosed. The invention relates to the seeds of inbred corn line LH283BtMON810, to the plants of inbred corn line LH283BtMON810 and to methods for producing a corn plant, either inbred or hybrid, by crossing the inbred line LH283BtMON810 with itself or another corn line. The invention further relates to methods for producing a corn plant containing in its genetic material one or more transgenes and to the transgenic plants produced by that method and to methods for producing other inbred corn lines derived from the inbred LH283BtMON810.
Owner:HOLDENS FOUND SEEDS
Full-length plant cDNA and uses thereof
Owner:NAT INST OF AGROBIOLOGICAL SCI +1
Maize chloroplast aldolase promoter compositions and methods for use thereof
ActiveUS7151204B2Simple compositionQuality improvementSugar derivativesOther foreign material introduction processesFructoseTransgene
The current invention provides the promoter of the Zea mays nuclear gene encoding chloroplast-localized fructose-1,6-bisphosphate (F16BP) aldolase. Compositions comprising this sequence are described, as are plants transformed with such compositions. Further provided are methods for the expression of transgenes in plants comprising the use of these sequences. The methods of the invention include the direct creation of transgenic plants with the chloroplastic F16BP aldolase promoter by genetic transformation, as well as by plant breeding methods. The sequences of the invention represent a valuable new tool for the creation of transgenic plants, preferably having one or more added beneficial characteristics.
Owner:MONSANTO TECH LLC
Corn Plant and Seed Corresponding to Transgenic Event MON89034 and Methods For Detection and Use Thereof
ActiveUS20080260932A1Microbiological testing/measurementClimate change adaptationNucleotideNucleotide sequencing
The present invention provides a transgenic corn event MON89034, and cells, seeds, and plants comprising DNA diagnostic for the corn event. The invention also provides compositions comprising nucleotide sequences that are diagnostic for said corn event in a sample, methods for detecting the presence of said corn event nucleotide sequences in a sample, probes and primers for use in detecting nucleotide sequences that are diagnostic for the presence of said corn event in a sample, growing the seeds of such corn event into corn plants, and breeding to produce corn plants comprising DNA diagnostic for the corn event.
Owner:MONSANTO TECH LLC
Fertile transgenic maize plants containing a gene encoding the pat protein
InactiveUS6395966B1Other foreign material introduction processesFermentationPhosphinothricin acetyltransferaseBotany
The present invention provides methods for increasing yield in plants by introducing a gene encoding phosphinothricin acetyltransferase. The invention further involves a method of transferring said increased yield phenotype to other lines of plants by crossing. A maize transformant is identified in which the phosphinothricin acetyltransferase gene integration event is correlated with increased yield.
Owner:MONSANTO TECH LLC
T227-1 flanking sequence
Owner:SES EURO N V
Soybean plant and seed corresponding to transgenic event mon87769 and methods for detection thereof
The present invention provides transgenic soybean event MON87769, and cells, seeds, and plants comprising DNA diagnostic for the soybean event. The invention also provides compositions comprising nucleotide sequences that are diagnostic for said soybean event in a sample, methods for detecting the presence of said soybean event nucleotide sequences in a sample, probes and primers for use in detecting nucleotide sequences that are diagnostic for the presence of said soybean event in a sample, growing the seeds of such soybean event into soybean plants, and breeding to produce soybean plants comprising DNA diagnostic for the soybean event.
Owner:MONSANTO TECH LLC
Transgenic non-human animals for producing chimeric antibodies
InactiveUS20060015957A1Inhibit expressionEasy to switchImmunoglobulinsGenetic engineeringAntigenHuman animal
The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity.
Owner:GENPHARM INT INC
Polypeptide compositions toxic to coleopteran insects
InactiveUS6063597AHigh expressionStably occupyBiocideSugar derivativesBiotechnologyNucleic acid sequencing
Disclosed are Coleopteran-toxic B. thuringiensis delta -endotoxins, nucleic acid sequences, and transgenic plants expressing these genes. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and transformation of suitable host cells.
Owner:MONSANTO TECH LLC
Bollworm insect resistance management in transgenic plants
InactiveUS20090313717A1Prevent and delay resistance developmentPreventing and delaying insect resistance developmentClimate change adaptationGenetic engineeringHelicoverpaHelicoverpa zea
This invention relates to the use of a combination of different proteins insecticidal to Helicoverpa zea or Helicoverpa armigerain an insect resistance management process, wherein such proteins are: a) a Cry2A protein such as Cry2Aa, Cry2Ab, or Cry2Ae and b) a Cry1A, Cry1F or VIP3A protein, particularly wherein such proteins binds saturably to the insect midgut membrane of Helicoverpa zea or Helicoverpa armigera, as well as plants and seeds expressing such combination of proteins, which are used to delay or prevent the development of resistance in populations of such insect species.
Owner:BAYER BIOSCIENCE N V
Rice actin 2 promoter and intron and methods for use thereof
The current invention provides regulatory regions from the rice actin 2 gene. In particular, the current invention provides the rice actin 2 promoter and actin 2 intron. Compositions comprising these sequences are described, as well as transformation constructs derived therefrom. Further provided are methods for the expression of transgenes in plants comprising the use of these sequences. The methods of the invention include the direct creation of transgenic plants with the rice actin 2 intron and / or promoter directly by genetic transformation, as well as by plant breeding methods. The actin 2 sequences of the invention represent a valuable new tool for the creation of transgenic plants, preferably having one or more added beneficial characteristics.
Owner:CORNELL RES FOUNDATION INC +1
Nucleotide sequences and corresponding polypeptides conferring modulated plant characteristics
ActiveUS20090094717A1Modulation characteristicLibrary member identificationVector-based foreign material introductionBiotechnologyNucleotide
The present invention relates to isolated nucleic acid molecules and their corresponding encoded polypeptides able confer the trait of modulated plant size, vegetative growth, organ number, plant architecture, sterility or seedling lethality in plants. The present invention further relates to the use of these nucleic acid molecules and polypeptides in making transgenic plants, plant cells, plant materials or seeds of a plant having such modulated growth or phenotype characteristics that are altered with respect to wild type plants grown under similar conditions.
Owner:CERES INC
Methods for generating high titer helper-free preparations of released recombinant AAV vectors
InactiveUS6989264B2Genetic therapy composition manufactureGroup 5/15 element organic compoundsGene deliveryHeterologous
This invention provides methods and compositions for producing high titer, substantially purified preparations of recombinant adeno-associated virus (AAV) that can be used as vectors for gene delivery. At the onset of vector production, AAV producer cells of this invention typically comprise one or more AAV packaging genes, an AAV vector comprising a heterologous (i.e. non-AAV) transgene of interest, and a helper virus such as an adenovirus. The AAV vector preparations produced are generally replication incompetent but are capable of mediating delivery of a transgene of interest (such as a therapeutic gene) to any of a wide variety of tissues and cells. The AAV vector preparations produced according to this invention are also substantially free of helper virus as well as helper viral and cellular proteins and other contaminants. The invention described herein provides methods of producing rAAV particles by culturing producer cells under conditions, such as temperature and pH, that promote release of virus. Also provided is a quantitative, high-throughput assay useful in the assessment of viral infectivity and replication, as well as in the screening of agent that affect viral infectivity and / or replication.
Owner:TARGETED GENETICS CORPORTION
Coleopteran-resistant transgenic plants and methods of their production using modified Bacillus thuringiensis Cry3Bb nucleic acids
Disclosed are nucleic acid segments comprising synthetically-modified genes encoding modified Coleopteran-toxic B. thuringiensis Cry 3Bb* delta-endotoxins. Also disclosed are methods of using these genes for preparing a Coleopteran-resistant transgenic plant and reducing insect in restations, and plants thereby produced.
Owner:MONSANTO TECH LLC
Transgenic plant event detection
ActiveUS8700336B2Reduce in quantityExtension of timeMicrobiological testing/measurementClimate change adaptationGenetic MaterialsTransgene
The present invention relates to detection of materials derived from transgenic plant events. In particular, the invention provides methods, reagents, kits and reference materials for detecting the presence or absence in a sample of genetic material derived from and attributable to select transgenic plant events.
Owner:SCIENSANO
Rodent HER2 tumor model
The invention concerns HER<HIL><PDAT>2< / BOLD><PDAT>-transgenic non-human mammals, animal models for screening drug candidates for the treatment of diseases and disorders associated with the overexpression of HER<HIL><PDAT>2< / BOLD><PDAT>. In particular, the invention concerns animal models designed to test drug candidates for the treatment of HER<HIL><PDAT>2< / BOLD><PDAT>-overexpressing cancers, including breast cancer, that are not responding or poorly responding to current treatments.< / PTEXT>
Owner:SAN VALLEY SYST +1
Transgenic mouse allergy models and methods for their use
InactiveUS6118044AImprove import efficiencySufficient amountMicrobiological testing/measurementTissue cultureAntibody typesAllergy
Transgenic mice which constitutively express an antibody-type molecule encoded by the transgene and which has an IgE heavy chain constant region and is specific for a pre-defined antigen, provide an allergic reaction to that antigen without prior sensitization and are useful as allergy models.
Owner:SANKYO CO LTD +1
Methods for genetic control of insect infestations in plants and compositions thereof
ActiveUS20070124836A1Inhibit expressionReduced expression levelSugar derivativesClimate change adaptationBiotechnologyDouble strand
The present invention relates to control of pest infestation by inhibiting one or more biological functions. The invention provides methods and compositions for such control. By feeding one or more recombinant double stranded RNA molecules provided by the invention to the pest, a reduction in pest infestation is obtained through suppression of gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and to particular combinations of transgenic pesticidal agents for use in protecting plants from pest infestation.
Owner:MONSANTO TECH LLC
Lepidopteran-active Bacillus thuringiensis delta-endotoxin compositions and methods of use
InactiveUS6593293B1Low steady state levelGreat and less stabilityBiocideBacteriaDelta endotoxinAureobasidium sp.
Disclosed are Bacillus thuringiensis strains comprising novel crystal proteins which exhibit insecticidal activity against lepidopteran insects. Also disclosed are novel B. thuringiensis genes and their encoded crystal proteins, as well as methods of making and using transgenic cells comprising the novel nucleic acid sequences of the invention.
Owner:MONSANTO TECH LLC
Compositions and methods for helper-free production of recombinant adeno-associated viruses
InactiveUS6953690B1Efficient productionIncrease the number ofBiocideGenetic therapy composition manufactureMammalWild type
A method for producing recombinant adeno-associated virus in the absence of contaminating helper virus or wild-type virus involves culturing a mammalian host cell containing a transgene flanked by adeno-associated virus (AAV) inverse terminal repeats and under the control of regulatory sequences directing expression thereof, an AAV rep sequence and an AAV cap sequence under the control of regulatory sequences directing expression thereof, and the minimum adenovirus DNA required to express an E1a gene product, an E1b gene product and an E2a gene product, and isolating therefrom a recombinant AAV which expresses the transgene in the absence of contaminating helper virus or wildtype AAV. This method obviates a subsequent purification step to purify rAAV from contaminating virus. Also provided are various embodiments of the host cell.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
Regulated expression of genes in plant seeds
InactiveUS6992237B1Improve the level ofIncrease in sizeSugar derivativesClimate change adaptationPlanting seedTransgene
Owner:PIONEER HI BRED INT INC
Methods and materials for making and using transgenic dicamba-degrading organisms
Owner:BOARD OF RGT UNIV OF NEBRASKA
Ecdysone receptor-based inducible gene expression system
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel inducible gene expression system and methods of modulating gene expression in a host cell for applications such as gene therapy, large-scale production of proteins and antibodies, cell-based high throughput screetng assays, functional genomics and regulation of traits in transgenic plants and animals.
Owner:PRECIGEN INC
Genomic plant sequences and uses thereof
The present invention discloses rice genomic promoter sequences. The promoters are particularly suited for use in rice and other cereal crops. Methods of modifying, producing, and using the promoters are also disclosed. The invention further discloses compositions, transformed host cells, transgenic plants, and seeds containing the rice genomic promoter sequences, and methods for preparing and using the same.
Owner:MONSANTO TECH LLC
Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
InactiveUS7049426B2Immunoglobulins against cytokines/lymphokines/interferonsImmunoglobulins against cell receptors/antigens/surface-determinantsAntigenExon
The present invention provides fully human antibodies in a transgenic animal of a desired isotype in response to immunization with any virtually any desired antigen. The human immunoglobulin heavy chain transgene in the foregoing animals comprises a human constant region gene segment comprising exons encoding the desired heavy chain isotype, operably linked to switch segments from a constant region of a different heavy chain isotype, i.e., a non-cognate switch region. Said additional constant region segment comprises a switch region and human constant region coding segment, wherein the constant region coding segment is operably linked to a switch region that it is not normally associated with, i.e., a non-cognate switch region. In the transgenes of the invention, the non-cognate switch region may be a switch region from a different species than the constant region coding segment. The switch region and membrane exons of the invention may comprise a human gamma-2 constant region and the secreted constant region exons are from a human gamma-1 or a human gamma-4 constant region.
Owner:ABQENIX INC
Synthetic 5'UTRs, Expression Vectors, and Methods for Increasing Transgene Expression
ActiveUS20100293625A1Increase transgene expressionImprove stabilityVectorsSugar derivativesReticulum cellIntein
The present invention provides synthetic 5′UTRs comprising a first polynucleotide fragment and a second polynucleotide fragment, wherein the first polynucleotide fragment comprises at least one splice site of a first eukaryotic gene, the second polynucleotide fragment comprises at least a portion of 5′ untranslated region of a second eukaryotic gene, and the first polynucleotide fragment is located 5′ of the second polynucleotide fragment. In one embodiment, the first polynucleotide fragment comprises the second intron of a sarcoplasmic / endoplasmic reticulum calcium ATPase gene and the second polynucleotide fragment comprises at least a portion of the 5′ untranslated region (5′UTR) of a eukaryotic casein gene. The synthetic 5′UTRs are useful for increasing the expression of a transgene when positioned between a promoter and a transgene within an expression vector. The present invention also provides vectors comprising synthetic 5′UTRs and methods for increasing the expression of a transgene using synthetic 5′UTRs.
Owner:PRECIGEN INC
ACC synthase genes from pineapple
InactiveUS6194639B1Uniform maturityAvoid less flexibilitySugar derivativesOther foreign material introduction processesACC SYNTHASEGMO Plants
New ACC synthase genes from pineapple are disclosed which have utility as targets for the generation of transgenic plants in which the expression of ACC synthase is substantially controlled to effect the regulation of plant development, and, in particular, initiation of natural flowering.
Owner:THE UNIV OF QUEENSLAND +2
Bacillus thuringiensis CryET29 compositions toxic to coleopteran insects and Ctenocephalides SPP
InactiveUS6537756B1Remarkable insecticidal activityGood reproducibilityBiocideBacteriaDelta endotoxinCtenocephalides felis felis
Disclosed is a novel delta-endotoxin, designated CryET29, that exhibits insecticidal activity against siphonapteran insects, including larvae of the cat flea (Ctenocephalides felis), as well as against coleopteran insects, including the southern corn rootworm (Diabrotica undecimpunctata), western corn rootworm (D. virgifera), Colorado potato beetle (Leptinotarsa decemlineata), Japanese beetle (Popillia japonica), and red flour beetle (Tribolium castaneum). Also disclosed are nucleic acid segments encoding CryET29, recombinant vectors, host cells, and transgenic plants comprising a cryET29 DNA segment. Methods for making and using the disclosed protein and nucleic acid segments are disclosed as well as assays and diagnostic kits for detecting cryET29 and CryET29 sequences in vivo and in vitro.
Owner:MONSANTO TECH LLC
CNS targeting aav vectors and methods of use thereof
ActiveUS20130195801A1Widely distributedStable and nontoxic gene transferOrganic active ingredientsBiocideAdeno associate virusTransgene
Owner:UNIV OF MASSACHUSETTS
Methods and compositions for improved enzyme activity in transgenic plants
InactiveUS20070289031A1Increase enzyme activityConfer resistanceClimate change adaptationOther foreign material introduction processesBiotechnologyPlant cell
Compositions and methods for increasing enzyme activity across a broad physiological spectrum in plants, plant cells, tissues and seeds are provided. Compositions include plants or plant parts comprising two or more polynucleotides encoding polypeptides that are active across a broader physiological spectrum than when either polynucleotide is expressed alone. Vectors comprising these polynucleotide molecules as well as host cells comprising the vectors are further provided. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In addition, methods are provided for producing the plants, plant cells, tissues and seeds of the invention. Methods for increasing plant yield and methods for conferring resistance to an herbicide in a plant are further provided.
Owner:ATHENIX
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