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The present invention features PD-1 binding proteins, a subset of which inhibits binding of PD-L1 to the PD-1 receptor. These binding proteins can be employed to modulate the immune system through the manipulation of the PD-1 signaling pathway, enhancing host immunity to treat infections and cancer.

An information distribution and processing system contains a sender and a plurality of processing units. The sender delivers a set of digital data, without receiving a request signal, to the plurality of processor units. The set of digital data contains a first set of displayable data, a second set of displayable data, at least one non-displayable symbol, and at least one linking reference associated with the second set of displayable data. If desired, a user can select the second set of displayable data. The associated linking reference is sent to a database. The database contains additional information. The associated linking reference is used by the database to search for the additional information, and returns the requested information to the user.

An information distribution and processing system contains a remote site, a sender and a receiving apparatus. The remote site contains a first set of digital data. The sender delivers a second set of digital data to the receiving device. In one embodiment of the present invention, the receiving device contain a timing device for automatically receiving the second set of digital data at predetermined times. The second set of digital data contains a first set of displayable data, a second set of displayable data, at least one non-displayable symbol, and at least one linking reference associated with the second set of displayable data. If desired, a user can select the second set of displayable data. The associated linking reference is sent to the remote site. The associated linking reference is used by the remote site to search for the additional information, and returns the requested information to the user.

Systems and methods related to ultrasonic microtube dental instruments designed to cut around a broken instrument by allowing the broken instrument to be placed within a lumen of the microtube instrument while simultaneously boring with the broken instrument and being guided by the broken instrument.

The present invention is directed to conjugates such as polymeric prodrugs of aromatic, hydroxyl-containing compounds and methods of making and using the same. These polymeric prodrugs are preferably esters of hydroxyl-containing aromatic compounds and are formed by reacting a desired aromatic, hydroxyl-containing compound with a substantially non-antigenic polymer so as to produce a transport form having an ester linkage between the aromatic compound and the polymer. Preferred aromatic hydroxyl-containing compositions include 10- and 11-hydroxycamptothecin derivatives. Methods of treatment are also disclosed.

An electrosurgical energy delivery apparatus includes an energy delivery circuit, a control circuit and an energy-harvesting system with a plurality of energy-harvesting circuits and a voltage regulator that provides a regulated DC voltage to the energy delivery circuit and / or the control circuit. The energy delivery circuit receives an electrosurgical energy signal having a primary frequency and selectively provides the electrosurgical energy signal to an energy delivery element. The control circuit connects to the energy delivery circuit and selectively enables the flow of electrosurgical energy to the energy delivery element. The plurality of energy-harvesting circuits each include an energy-harvesting antenna tuned to a particular frequency, a matched circuit configured to receive an RF signal from the energy-harvesting antenna, rectify the RF signal and generate a DC signal, and an energy storage device that connects to the voltage regulator to receive and store the DC signal.

Methods of treatment of tissue with electromagnetic radiation (EMR) to produce lattices of EMR-treated islets in the tissue are disclosed. Also disclosed are devices and systems for producing lattices of EMR-treated islets in tissue, and cosmetic and medical applications of such devices and systems.

Methods for making artificially sweetened calcium fortified beverages and beverage concentrates, and the stable beverage and beverage concentrates formed thereby; calcium-supplemented beverages and beverage concentrates comprising a unique blend of calcium salts.

Illumination systems, devices, and methods for cultivating biomasses. A bioreactor system is operable for growing photosynthetic organisms. The bioreactor system includes a bioreactor and an illumination system. The illumination system includes one more optical waveguides configured to light at least some of a plurality of photosynthetic organisms retained in the bioreactor. In some embodiments, the one or more optical waveguides include a plurality of structures configured to direct light energy from a solar energy collector, and a plurality of artificial light sources, along the interior of the waveguide. In some embodiments, the one more optical waveguides include a plurality of light-diffusing structures configured to guide at least a portion of the light from the solar energy collector and a plurality of artificial light sources directed along the interior of the waveguide, to the exterior of the waveguide.

The present invention is directed to a 3DP(TM) material system ad method, and an article made therefrom. The method of the present invention includes building cross-sectional portions of a three-dimensional article, and assembling the individual cross-sectional areas in a layer-wise fashion to form a final article. The individual cross-sectional areas are built by using an ink-jet printhead to deliver an aqueous fluid to a particulate material that includes plaster.

The invention relates to methods and devices for analyzing single molecules, i.e. nucleic acids. Such single molecules may be derived from natural samples, such as cells, tissues, soil, air and water without separating or enriching individual components. In certain aspects of the invention, the methods and devices are useful in performing nucleic acid sequence analysis by probe hybridization.

Medical implants formed of hydrophobic derivatives of natural biodegradable polysaccharides and that include bioactive agent are described. The implants demonstrate desirable bioactive agent release profiles and can be prepared to have high drug loading. The implants can be used to treat medical conditions, such as those requiring prolonged administration of the bioactive agent at a target location in the body.

The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.