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Deactivation method of biochemistry substance, preparing method of cardiomyopeptidin and use of cardiomyopeptidin

A technique for cardiopeptide and biochemical substances, applied in the field of biochemistry, can solve the problems of lack of a standard, insufficient product activity, and difficulty in developing practically valuable medicines or health care products, so as to achieve the effect of ensuring biological activity.

Active Publication Date: 2007-08-08
大连珍奥药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] 1. The purity of the product and the activity of each part are not determined enough and there is no standard;
[0012] 2. The product is an animal extract and has not been inactivated. As a drug or health product, it has potential effects on the human body
[0013] The existence of the above-mentioned problems makes it difficult to develop into pharmaceuticals or health care products with practical value
[0014] In addition, the above-mentioned problems are also common and unresolved for a long time in biochemical products or biochemical products used to protect cardiovascular and cerebrovascular

Method used

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  • Deactivation method of biochemistry substance, preparing method of cardiomyopeptidin and use of cardiomyopeptidin
  • Deactivation method of biochemistry substance, preparing method of cardiomyopeptidin and use of cardiomyopeptidin
  • Deactivation method of biochemistry substance, preparing method of cardiomyopeptidin and use of cardiomyopeptidin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0129] Preparation of myocardin solution: Myocardin solution is an active small molecule polypeptide solution extracted from healthy young pig ventricular myocardium.

[0130] 1. Raw material (pig heart) quality control

[0131] Select hybrid pigs from Guangdong, Guangxi, Hunan, etc., 30 days ± 6 days after birth, body weight < 10 kg, heart weight 35 g ± 5 g, unified breeding site, unified feed, unified feeding time, unified purchase. Should provide: "Certificate of Quarantine of Animal Origin" or "Certificate of Quarantine of Animals Exiting the County", "Certificate of Disinfection of Carriers of Animals and Animal Products" and "Certificate of Non-infested Areas".

[0132] Before and after the slaughter of live pigs, according to the "Quarantine Operation Procedures for Pig Slaughtering Plants (Farms)", the national formal epidemic prevention and quarantine station conducts the quarantine before and after the slaughter of live pigs.

[0133] The heart of the live pig is ta...

Embodiment 2

[0149] Preparation of myocardin solution: Myocardin solution is an active small molecule polypeptide solution extracted from healthy young pig ventricular myocardium.

[0150] One, raw material (pig heart) quality control is the same as embodiment 1

[0151] Two, preparation: the method with reference to embodiment 1, wherein:

[0152] 1. Preliminary processing of the raw material (pig heart): remove the capsule, blood vessels, heart valves, tendon and atrium from the pig heart, clean the ventricular muscle with distilled water and chop it into about 1cm 3 small pieces, and then washed once with cold water for injection.

[0153] 2, the preparation of homogenate: feed intake according to the ratio of ventricular muscle: water for injection=1:1 (mass ratio), repeat homogenization three times in colloid mill (5000rpm / min centrifugal, each 5 minutes, interval 5 minutes), obtain homogenate. The homogenate is stored in stainless steel barrels, the volume of each barrel is not mor...

Embodiment 3

[0161] Preparation of myocardin solution: Myocardin solution is an active small molecule polypeptide solution extracted from healthy young pig ventricular myocardium.

[0162] One, raw material (pig heart) quality control is the same as embodiment 1

[0163] Two, preparation: the method with reference to embodiment 1, wherein:

[0164] 1. Preliminary processing of the raw material (pig heart): remove the capsule, blood vessels, heart valves, tendon and atrium from the pig heart, clean the ventricular muscle with distilled water and chop it into about 1cm 3 small pieces, and then washed once with cold water for injection.

[0165] 2, the preparation of homogenate: feed intake according to the ratio of ventricular muscle: water for injection=1:2 (mass ratio), repeat homogenization three times in colloid mill (4000rpm / min centrifugal, each 5 minutes, interval 5 minutes), obtain homogenate. The homogenate is stored in stainless steel barrels, the volume of each barrel is not mor...

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Abstract

The invention discloses an inactivating method of biological extract and making method and usage of myocardial peptide, which is characterized by the following: extracting active component from mammal heart; heating the active component under 60-85 deg.c; inactivating virus for 10-120min with temperature at 75-85 deg.c for 20-80 min at best; fitting for preparing cardiovascular and cerebrovascular drug.

Description

technical field [0001] The present invention relates to a kind of inactivation method of biochemical substance, especially the inactivation method of biochemical extract, and a kind of preparation method of cardiopeptin and its application, specifically, the present invention relates to the healthy mammals except human The invention discloses a preparation method and application of cardiopeptin extracted from the heart of the invention, which belong to the field of biochemical technology. Background technique [0002] The organs of healthy mammals contain a variety of biologically active substances. Extracting such active substances for the treatment of various diseases can break through the shackles of traditional drugs and provide a milestone in terms of inducing the anti-injury potential of cells in the body. Drugs for the treatment of certain diseases have received more and more attention from scientists in the past two decades. [0003] The bioactive substances extract...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N7/04C12N5/06C07K14/435A61K38/17A61P9/00
Inventor 李恕王日升梁强阮忠生
Owner 大连珍奥药业股份有限公司
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