3162results about How to "Increase the gap" patented technology

End effectors with redundant closing mechanisms, and related tools and methods are disclosed. The disclosed end effectors may be particularly beneficial when used for minimally invasive surgery. An example surgical tool comprises an elongate shaft having a proximal end and a distal end, a tool body disposed at the distal end of the shaft, a jaw movable relative to the tool body between a clamped configuration and an open configuration, a first actuation mechanism coupled with the jaw and operable to vary the position of the jaw relative to the tool body between the clamped configuration and the open configuration, and a second actuation mechanism coupled with the jaw. The second actuation mechanism has a first configuration where the jaw is held in the clamped configuration and a second configuration where the position of the jaw relative to the tool body is unconstrained by the second actuation mechanism.

The present invention is a portable device that a computer can boot from, containing a prefabricated independent operating system environment which is engineered from the ground up to prioritize security while maximizing usability, in order to provide a safe, reliable and easy to use practical platform for high risk applications. An embodiment of the present invention may temporarily transform an ordinary computer into a naturally inexpensive logical appliance which encapsulates a turn-key functional solution within the digital equivalent of a military grade security fortress. This allows existing hardware to be conveniently leveraged to provide a self contained system which does not depend on the on-site labor of rare and expensive system integration and security experts.

A lumbar disc prosthesis is provided including a pair of disc members. The first member of the disc pair has a vertebral disc contact surface and a recessed portion on an opposing surface thereof. The second member of the disc pair has a vertebral disc contact surface and a protruding portion on an opposing surface thereof. The protruding portion of the second member engages with the recessed portion of the first member in use. Each of the first and second disc members are provided with at least three sections; a middle section and two end sections. The recessed and protruding portions are provided in the middle section of the respective disc members and each of the two end sections have a narrowing taper towards the ends of the disc members. The facet joint prosthesis includes a first member for attachment to a first posterior lumbar disc in use and a second member for attachment to a second posterior lumbar disc in use. At least a part of the first member is telescopically mounted in at least a part of the second member in use.

A micro-electro-mechanical transducer (such as a cMUT) having two electrodes separated by an insulator with an insulation extension is disclosed. The two electrodes define a transducing gap therebetween. The insulator has an insulating support disposed generally between the two electrodes and an insulation extension extending into at least one of two electrodes to increase the effective insulation without having to increase the transducing gap. Methods for fabricating the micro-electro-mechanical transducer are also disclosed. The methods may be used in both conventional membrane-based cMUTs and cMUTs having embedded springs transporting a rigid top plate.

The present invention is a method and apparatus for forming a bump for semiconductor interconnect applications, such as reverse wire bonding or stud bumping for flip chip interconnections. The bump is formed by (1) ball bonding at the bump site, (2) raising the capillary a predetermined height after forming the ball bond with the wire paying out of the capillary tip, (3) moving the capillary laterally a predetermined distance, preferably in a direction toward the site of other end of the wire loop, if the bump is to be used as the platform for a stitch bond of a wire loop, (4) raising the capillary further, and (5) moving the capillary diagonally downwardly and in the opposite direction of the first lateral motion. The wire is then severed by raising the capillary, closing the clamps and raising the capillary again to snap the wire pigtail off at the bump.

An endoscopic electrosurgical instrument is presented for encapsulating and resecting biologic tissue, such as a polyp, from an anatomical structure, such as a lumen. The instrument includes an encapsulation assembly which includes a snare coupled to an electrically non-conductive, shrinkable pouch in a drawstring-like configuration. The encapsulation assembly may be folded within the elongated cylindrical housing of the endoscopic instrument, positioned within the patient at the surgical site, and deployed for use. Once positioned over the polyp, the snare is tightened around the peduncle thereof, and the pouch is activated, thereby shrinking and encapsulating the polyp. The polyp may then be resected using conventional or electrosurgical techniques. The disclosed instrument may include surgical tools and / or electrosurgical electrodes for performing surgical procedures. The disclosed system may reduce the occurrence of undesirable arcing and may aid retrieval of resected tissue.

A protective headgear compression member includes a hollow compression cell having a top wall, a bowed side wall and a bottom wall and a liner element secured to that bottom wall coaxially to said cell. The liner element is composed of a flexible envelope substantially filled with resilient material and the envelope is secured to the bottom wall via an axially flexible connection to prevent the bottoming out of the liner element against the bottom wall of the cell.

To be able to determine the insertion position of the parts of an artificial knee joint without changing the original knee joint, a method is proposed for determining the position of the tibial part and / or the femoral part of a knee-joint endoprosthesis in relation to the proximal tibial head or to the distal femur in which the position of the femur and of the tibia are monitored by means of a navigation system, in which the distal femur and the proximal tibial head are laterally and medially displaced with a defined force into a spread position by means of a distraction appliance when the knee is straightened and bent, and the relative positions of the femur and the tibia, and consequently the size of the gap between the femur and the tibia, are thereby respectively determined, in which various virtual relative positions of the femur and the tibia are calculated according to geometrical data of the knee-joint endoprosthesis and to different assumed positions of the tibial part on the tibia and / or of the femoral part on the femur when the knee is straightened and bent, and in which an assumed position in which the virtual relative position of the femur and the tibia when the knee is straightened and bent differs from the spread position in a specified manner is determined as a selected position.

Provided are a nitride semiconductor light emitting element having a nitride semiconductor layered on an AlN buffer layer with improved qualities such as crystal quality and with improved light emission output, and a method of manufacturing a nitride semiconductor. An AlN buffer layer (2) is formed on a sapphire substrate (1), and nitride semiconductors of an n-type AlGaN layer (3), an InGaN / GaN active layer (4) and a p-type GaN layer (5) are layered in sequence on the buffer layer (2). An n-electrode (7) is formed on a surface of the n-type AlGaN layer (3), and a p-electrode (6) is formed on the p-type GaN layer (5). The n-type AlGaN layer (3) serves as a cladding layer for confining light and carriers. The AlN buffer layer (2) is manufactured by alternately supplying an Al material and an N material at a growing temperature of 900° C. or higher.

An infusion device with a disposable administration set which is inexpensive to manufacture. In the preferred embodiment of the present invention the disposable administration set has a plurality of elongated cam followers connected to a plate assembly, wherein the cam followers are displaced in a predetermined sequence and forced against a delivery tube by cam means driven by rotary drive means. The disposable administration set is injection molded as a single integral piece. The disposable administration set includes adjustment spacers disposed between the plate assembly and the cam followers which adjust the distance between them to keep the device accurate. In the preferred embodiment of the present invention the cam assembly is configured to provide fluid delivery at a consistent and uniform rate. The device may also incude a pressure sensing pin positioned on the cam assembly which contacts the tubing during the pumping cycle. The drive current is sampled and processed at predetermined phases during the cam rotation cycle to detect the presence of an occlusion in the tubing.

Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc.

In a blood dialysis system including a source of substitution fluid (10) and a blood dialysis machine, a hemodiafiltration system having a first dialyzer (1) including a first blood compartment (4) having a first blood inlet which receives blood to be cleaned and a first blood outlet which discharges partially diafiltered blood and a first dialysate compartment (5) having a first dialysate inlet and a first dialysate outlet, means (8) for mixing the partially diafiltered blood with substitution fluid from the source to obtain a blood / substitution fluid mixture, and a second hemofilter (2) including a second blood compartment (11) having a second blood inlet which receives the blood / substitution fluid mixture and a second blood outlet which discharges filtered blood and a second permeate compartment (12) having a second permeate outlet.

The present invention relates to a method of separating antibodies from other compound(s) in a liquid sample, wherein a mobile phase comprising said sample is contacted with a multi-modal separation matrix to adsorb undesired compounds while the antibodies remain free in the liquid, wherein the multi-modal separation matrix comprises first groups, which are capable of interacting with negatively charged sites of the target compounds, and second groups, which are capable of at least one interaction other than charge-charge interaction with said target compounds. The invention also relates to a chromatography column packed with the above-described multi-modal separation matrix and a filter having such multi-modal groups adsorbed to its surface.

A semiconductor material which has a high carbon dopant concentration and is composed of gallium, indium, arsenic and nitrogen is disclosed. The material is useful in forming the base layer of gallium arsenide based heterojunction bipolar transistors because it can be lattice matched to gallium arsenide by controlling the concentration of indium and nitrogen. The disclosed semiconductor materials have a low sheet resistivity because of the high carbon dopant concentration obtained.

Binding proteins, such as antibodies directed to IGF-II with cross-reactivity to IGF-I and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the IGF-II with cross-reactivity to IGF-I are disclosed. Also discussed are nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and / or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3.

The invention relates to an assay to select a candidate drug for the treatment of inflammatory disease due to cytokine production. The assay comprises: a) exposing said candidate drug to intestinal cells; and b) analysing the effect of the said candidate drug selected from the group consisting of the variation of nuclear export or import of transcription factors from the NF-κB family the disruption of transcriptional activity of transcription factors from the NF-κB family, the differential histone acetylation of p65 (RelA); the variation of the amount of PPARγ / RelA complexes in the cytosol of the cells; and a combination thereof. The invention further relates to methods for the treatment of inflammatory cytokine production associated diseases and to the use of a therapeutically effective dose of Bacteroides thetaiotaomicron or a component thereof.

A method of managing a patient having an accumulation of mucoid, mucopurulent or purulent material containing glycosaminoglycans, the method comprising the step of administering at least one glycosaminoglycans degrading enzyme to the patient in an amount therapeutically effective to reduce at least one of the following: the visco-elasticity of the material, pathogens infectivity and inflammation. An article of manufacture comprising an inhaler including, as an active ingredient, at least one glycosaminoglycans degrading enzyme for generating aerosols including the enzyme for management a patient having an accumulation of mucoid, mucopurulent or purulent material containing glycosaminoglycans.

A fiber resin plastic (FRP) based bicycle rim includes an FRP body and a metal tire receiving ring. The FRP body has first and second side surfaces, an annular outer edge surface, and an annular inner edge surface. The annular inner edge surface includes at least two spoke receiving ports for receiving and supportively coupling at least two spokes to the FRP body. The metal tire receiving ring is coupled to the FRP body and is disposed radially outwardly of the FRP body. The tire receiving ring includes first and second, generally parallel continuous braking surfaces.

The present invention relates to a machine for forming packaging on the basis of film that includes complementary closure strips, the machine comprising: feeder means for feeding onto the film a closure means comprising two support webs provided with at least a first longitudinal assembly constituted by two complementary strips and with a second longitudinal assembly disposed at a distance from the first, urging means for urging the support webs towards each other between the two longitudinal assemblies, and two rectilinear guides suitable for penetrating respectively into the gaps between each pair of lateral edges of the support webs. The present invention also provides a method, the resulting packages, and closure means for this purpose.

A bilayer seed layer structure is employed between a first read gap layer and a spin valve sensor for increasing the magnetoresistive coefficient (dr / R). In a bottom spin valve sensor the bilayer seed layer structure is located between the first read gap layer and a pinning layer and in a top spin valve sensor the bilayer seed layer structure is located between the first read gap layer and the free layer. The pinning layer is preferably iridium manganese (IrMn). The bilayer seed layer structure includes a first seed layer which is a metallic oxide and a second seed layer that is a nonmagnetic metal. A preferred embodiment is a first seed layer of nickel manganese oxide (NiMnO) and a second seed layer of copper (Cu).

A semiconductor chip (102) assembled on a substrate (101). The substrate has a first surface (101a) including conductive traces (110), which have a first length (111) and a first width (112), the first width being uniform along the first length, and further a pitch (114) to respective adjacent traces. The semiconductor chip has a second surface (102a) including contact pads (121); the second surface faces the first surface spaced apart by a gap (130). A conductive pillar (140) contacts each contact pad; the pillar includes a metal core (141) and a solder body (142), which connects the core to the respective trace across the gap. The pillar core (141) has an oblong cross section of a second width (151) and a second length (152) greater than the second width. Trace pitch (141) is equal to or smaller than twice the second width (151). The trace pitch is equal to or smaller than the second length (152).

The invention discloses a process for preparing a liquid seaweed fertilizer through enzymolysis and fermentation. The process disclosed by the invention can be used for generating a large quantity of soil beneficial bacteria and multiple special-effect metabolites by degrading macromolecular substances which are contained in seaweeds and difficult to utilize into micromolecular polysaccharide, monosaccharide and a nitrogen-containing compound in compound enzymolysis and multi-strain co-fermentation modes, thereby enhancing the biological activity of a seaweed fertilizer, preventing the destruction of strong base, high temperature and high pressure in the production process of the seaweed fertilizer and completely retaining abundant nutrient substances contained in the seaweeds. According to the process, the content of a product, namely alginic acid, is 40-60 g / L and is increased by more than 30% compared with that prepared from an enzymolysis method, an alkaline hydrolysis method, an acid hydrolysis method and a simple microbe fermentation method, and the effective viable count is more than or equal to 2 billion / mL; the product integrates natural nutrient components, antibiotic substances and plant hormones, combines the efficacy of three fertilizers, namely an organic fertilizer, a microbe fertilizer and a trace element fertilizer and has a wide application prospect.

The present invention relates to certain novel dinucleotides and formulations thereof which are highly selective agonists of the P2Y2 and / or P2Y4 purinergic receptor. They are useful in the treatment of chronic obstructive pulmonary diseases such as chronic bronchitis, PCD, cystic fibrosis, as well as prevention of pneumonia due to immobility. Furthermore, because of their general ability to clear retained mucus secretions and stimulate ciliary beat frequency, the compounds of the present invention are also useful in the treatment of sinusitis, otitis media and nasolacrimal duct obstruction. They are also useful for treatment of dry eye disease and retinal detachment as well as facilitating sputum induction and expectoration.

An objective of the invention is to provide anti-C5 antibodies and methods of using the same. The invention provides anti-C5 antibodies and methods of using the same. In some embodiments, an isolated anti-C5 antibody of the present invention binds to an epitope within the β chain of C5 with a higher affinity at neutral pH than at acidic pH. The invention also provides isolated nucleic acids encoding an anti-C5 antibody of the present invention. The invention also provides host cells comprising a nucleic acid of the present invention. The invention also provides a method of producing an antibody comprising culturing a host cell of the present invention so that the antibody is produced. The invention further provides a method of producing an anti-C5 antibody comprising immunizing an animal against a polypeptide which comprises the MG1-MG2 domain of the β chain of C5. Anti-C5 antibodies of the present invention may be for use as a medicament. Anti-C5 antibodies of the present invention may be for use in treating a complement-mediated disease or condition which involves excessive or uncontrolled activation of C5. Anti-C5 antibodies of the present invention may be for use in enhancing the clearance of C5 from plasma.

Methods and apparatus for forming a housing, such as for an electronic device, from multi-layer materials are disclosed. The multi-layer materials include at least two layers. Typically, one or more of the layers are metal. However, different layers of the multi-layer materials can be different metals. In one embodiment, an inner layer of the multi-layer materials can be provided with or form internal features that can be for attaching parts or components to the multi-layer materials. In another embodiment, processing of an inner layer of the multi-layer materials can facilitate part formation with increased curvature and / or internal part clearance. In another embodiment, the multi-layer materials can include an intermediate layer that facilitates creation of internal features that can be for attaching parts or components to the multi-layer materials. In still another embodiment, the multi-layer materials can provide a protective layer that serves to protect an outer surface of the housing during manufacturing and / or assembly.

The subject invention pertains to electrochromic polymers and polymer electrochromic devices. In a specific embodiment, two complementary polymers can be matched and incorporated into dual polymer electrochromic devices. The anodically coloring polymers in accordance with the subject invention can allow control over the color, brightness, and environmental stability of an electrochromic window. In addition, high device contrast ratios, high transmittance changes, and high luminance changes can be achieved, along with half-second switching times for full color change. Also provided are electrochromic devices such as advertising signage, video monitors, stadium scoreboards, computers, announcement boards, warning systems for cell phones, warning / information systems for automobiles, greeting cards, electrochromic windows, billboards, electronic books, and electrical wiring. The subject invention also provides for the use of complementary electrochromic polymers in the manufacture of electrochromic devices. In some embodiments, the devices of the invention can be prepared using metal vapor deposition or line patterning.