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3141results about How to "Increase the gap" patented technology

Method and device for determining the position of a knee-joint endoprosthesis

InactiveUS20050251148A1Changed kinematic behavior of the knee jointIncrease the gapImage enhancementImage analysisProsthesisDistraction
To be able to determine the insertion position of the parts of an artificial knee joint without changing the original knee joint, a method is proposed for determining the position of the tibial part and/or the femoral part of a knee-joint endoprosthesis in relation to the proximal tibial head or to the distal femur in which the position of the femur and of the tibia are monitored by means of a navigation system, in which the distal femur and the proximal tibial head are laterally and medially displaced with a defined force into a spread position by means of a distraction appliance when the knee is straightened and bent, and the relative positions of the femur and the tibia, and consequently the size of the gap between the femur and the tibia, are thereby respectively determined, in which various virtual relative positions of the femur and the tibia are calculated according to geometrical data of the knee-joint endoprosthesis and to different assumed positions of the tibial part on the tibia and/or of the femoral part on the femur when the knee is straightened and bent, and in which an assumed position in which the virtual relative position of the femur and the tibia when the knee is straightened and bent differs from the spread position in a specified manner is determined as a selected position.
Owner:AESCULAP AG

Binding proteins specific for insulin-like growth factors and uses thereof

InactiveUS20070196376A1Reduce tumor growthIncrease clearanceAnimal cellsSugar derivativesFramework regionCross-reactivity
Binding proteins, such as antibodies directed to IGF-II with cross-reactivity to IGF-I and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the IGF-II with cross-reactivity to IGF-I are disclosed. Also discussed are nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and / or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3.
Owner:MEDIMMUNE LTD

Methods for treating an inflammatory disease of the bowel

The invention relates to an assay to select a candidate drug for the treatment of inflammatory disease due to cytokine production. The assay comprises: a) exposing said candidate drug to intestinal cells; and b) analysing the effect of the said candidate drug selected from the group consisting of the variation of nuclear export or import of transcription factors from the NF-κB family the disruption of transcriptional activity of transcription factors from the NF-κB family, the differential histone acetylation of p65 (RelA); the variation of the amount of PPARγ / RelA complexes in the cytosol of the cells; and a combination thereof. The invention further relates to methods for the treatment of inflammatory cytokine production associated diseases and to the use of a therapeutically effective dose of Bacteroides thetaiotaomicron or a component thereof.
Owner:4D PHARMA RES LTD +1

Process for preparing liquid seaweed fertilizer through enzymolysis and fermentation

ActiveCN104262008AEnlarged vascular cellsPromotes plant cell divisionOrganic fertilisersFertilizer mixturesMacromolecular SubstancesSeaweed food
The invention discloses a process for preparing a liquid seaweed fertilizer through enzymolysis and fermentation. The process disclosed by the invention can be used for generating a large quantity of soil beneficial bacteria and multiple special-effect metabolites by degrading macromolecular substances which are contained in seaweeds and difficult to utilize into micromolecular polysaccharide, monosaccharide and a nitrogen-containing compound in compound enzymolysis and multi-strain co-fermentation modes, thereby enhancing the biological activity of a seaweed fertilizer, preventing the destruction of strong base, high temperature and high pressure in the production process of the seaweed fertilizer and completely retaining abundant nutrient substances contained in the seaweeds. According to the process, the content of a product, namely alginic acid, is 40-60 g/L and is increased by more than 30% compared with that prepared from an enzymolysis method, an alkaline hydrolysis method, an acid hydrolysis method and a simple microbe fermentation method, and the effective viable count is more than or equal to 2 billion/mL; the product integrates natural nutrient components, antibiotic substances and plant hormones, combines the efficacy of three fertilizers, namely an organic fertilizer, a microbe fertilizer and a trace element fertilizer and has a wide application prospect.
Owner:JIANGMEN ZHIHU IND CO LTD
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