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Device and method for inhibiting release of pro-inflammatory mediator

Stimulation of one or more neurons of the sympathetic nervous system, including the splenic nerve, to attenuate an immune response, including an inflammatory immune response, is discussed. Devices and systems to stimulate the sympathetic nervous system to attenuate an immune response are also discussed. Devices discussed include pulse generators and drug pumps. Systems are described as optionally having one or more sensors and operator instructions. In specific examples, stimulation of the splenic nerve of pigs with a pulse generator is shown to be safe and effective in attenuating a lipopolysaccharide-induced immune response.
Owner:MEDTRONIC INC

Apparatus, system, and method for unibody skate boot

Skate boot apparatuses, a skate, and a method are provided. A base including an upper face configured to receive a wearer's foot and a lower face configured to structurally support a skate mechanism is provided. An integral upper support is provided, the integral upper support extending upwardly from the base to a point above an ankle of the wearer, the integral support having a varying rigidity decreasing from a high rigidity near the base to a low rigidity near the point above the ankle of the wearer.
Owner:KOR HOCKEY
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