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590 results about "Neutral ph" patented technology
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A pH of 7 is neutral. A pH less than 7 is acidic. A pH greater than 7 is basic. The pH scale is logarithmic and as a result, each whole pH value below 7 is ten times more acidic than the next higher value.
Hydrogel arthroplasty device
InactiveUS20090088846A1Stimulate bone cell growthEasy adhesionFinger jointsPowder deliveryCross-linkNeutral ph
An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.
Owner:THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPT OF VETERANS AFFAIRS +1
Enteric coated stable oral pharmaceutical composition of acid unstable drug and process for preparing the same
InactiveUS20040028737A1Long storage periodImprove solubilityBiocideGranular deliveryNeutral phMedicine
Enteric coated stable oral pharmaceutical composition of acid unstable drug. The enteric coating is a bilayer with a pH gradient across its thickness comprising an inner layer of neutral or near neutral pH 7-7.5 and an outer layer of acidic pH 2-6. Also process for preparng the enteric coated stable oral pharmaceutical composition of acid unstable drug. The enteric coating is first carried out at neutral or near neutral pH of 7-7.5 to form an inner layer of neutral or near neutral pH and then at acidic pH of 2-6 to form an outer layer of acidic pH.
Owner:KOPRAN RES LAB LTD
Dihydro and hexahydro isoalpha acids having a high ratio of trans to cis isomers, production thereof, and products containing the same
InactiveUS6583322B1Improve solubilityReduce solubilityOrganic compound preparationCarbonyl compound preparationHigh concentrationNeutral ph
Owner:KALAMAZOO HLDG INC
Preformed material for post-tensioned prestressing pipeline vacuum grouting or mudjacking and preparation method thereof
ActiveCN101602589AWide variety of sourcesSimple preparation processSolid waste managementMixing operation control apparatusNeutral phPre stress
The invention discloses a preformed material for post-tensioned prestressing pipeline vacuum grouting or mudjacking and a preparation method thereof. The preformed material includes the following components by weight percent: 65 to 95 percent of silicate cement, 0.01 to 3 percent of high-range water-reducing agent, 0 to 1 percent of stabilizing agent, 0.05 to 5 percent of retarding agent, 1 to 20 percent of expanding agent, 0.2 to 2 percent of corrosion inhibitor, 0.01 to 1 percent of air entraining agent and 0 to 30 percent of mineral materials, wherein by uniformly and proportionally mixing the silicate cement, the high-range water-reducing agent, the stabilizing agent, the retarding agent, the expanding agent, the corrosion inhibitor, the air entraining agent and the mineral materials, the post-tensioned prestressing pipeline vacuum grouting or mudjacking preformed material can be obtained. After being uniformly mixed and stirred with water with neutral pH value according to the water cement ratio ranging from 0.24 to 0.32, the preformed material can be used, the obtained grouting material has the advantages of low water cement ratio, favorable flowability, no water bleeding and delamination, and favorable pumpability; meanwhile, the preparation method of the preformed material is simple and the raw material sources of the preformed material are wide.
Owner:HUBEI CHIDGE TECH
Stabilized pharmaceutical peptide compositions
ActiveUS20060178304A1Improve stabilityExtended shelf lifePeptide/protein ingredientsMetabolism disorderNeutral phMedicine
Method for increasing the shelf-life of a pharmaceutical composition for parenteral administration comprising a glucagon-like peptide which is prepared from a peptide product that has been subjected to treatment at a pH above neutral pH.
Owner:NOVO NORDISK AS
ANTI-PCSK9 ANTIBODIES WITH pH-DEPENDENT BINDING CHARACTERISTICS
ActiveUS20140044730A1High affinityReduced binding affinityMetabolism disorderAntibody ingredientsDiseaseKexin
The present invention provides antibodies and antigen-binding fragments thereof that specifically bind proprotein convertase subtilisin / kexin-9 (PCSK9) with greater affinity at neutral pH than at acidic pH. The antibodies of the invention may possess one or more amino acid changes as compared to antibodies that do not exhibit pH-dependent binding properties. For example, the present invention includes anti-PCSK9 antibodies which possess one or more histidine substitutions in one or more complementarity determining regions. The antibodies of the invention, with pH-dependent binding properties, remain in circulation and exhibit cholesterol lowering activity for prolonged periods of time in animal subjects as compared to anti-PCSK9 antibodies that do not exhibit pH-dependent binding properties. The antibodies of the invention are therefore useful for treating diseases and disorders related to elevated HDL cholesterol, wherein the antibodies of the invention can be administered to a patient at a lower dose and / or with less frequent dosing as compared to antibodies that do not exhibit pH-dependent binding properties.
Owner:REGENERON PHARM INC
Hydrogen generation from water split reaction
A composite material comprising a mechanical mixture of aluminum oxide(s) and / or aluminum hydroxide(s) and aluminum (Al) metal, which when submerged in water, produces hydrogen gas at or near to neutral pH. The phenomenon has been demonstrated reproducibly. The evolution of hydrogen gas is dependent on several factors, namely, temperature, pH, proportion and particle size of ingredients and mixing conditions. The water split reaction proceeds for the mass ratio of Al to the oxide or hydroxide varying in the entire range up to the 99% of additive(s). The reaction proceeds in a pH range of water, 9>pH>4, and water temperature, from about 10° C. to 90° C.
Owner:THE UNIV OF BRITISH COLUMBIA
THERAPEUTIC ANTIGEN-BINDING MOLECULE WITH A FcRn-BINDING DOMAIN THAT PROMOTES ANTIGEN CLEARANCE
ActiveUS20140363428A1Low immunogenicityImprove stabilityAntipyreticAnalgesicsFc(alpha) receptorNeutral ph
The present invention provides: a modified FcRn-binding domain having an enhanced affinity for the Fc Receptor neonatal (FcRn) at neutral pH; an antigen-binding molecule comprising said FcRn-binding domain, which has low immunogenicity, high stability and form only a few aggregates; a modified antigen-binding molecule having an increased FcRn-binding activity at neutral or acidic pH without an increased binding activity at neutral pH for a pre-existing anti-drug antibody; use of the antigen-binding molecules for improving antigen-binding molecule-mediated antigen uptake into cells; use of the antigen-binding molecules for reducing the plasma concentration of a specific antigen; use of the modified FcRn-binding domain for increasing the total number of antigens to which a single antigen-binding molecule can bind before its degradation; use of the modified FcRn-binding domain for improving pharmacokinetics of an antigen-binding molecule; methods for decreasing the binding activity for a pre-existing anti-drug antibody; and methods for producing said antigen-binding molecules.
Owner:CHUGAI PHARMA CO LTD
Luminescent indicator dye and optical sensor
ActiveUS20060121623A1Analysis using chemical indicatorsChemical analysis using titrationNeutral phChemical compound
The present invention relates to a chemical compound that has applications as a luminescent indicator dye, and to an optical sensor, typically employed for determination of near-neutral pH values of aqueous samples. The optical sensor has particular application in the pH determination of body liquids such as, for example, blood, plasma and serum.
Owner:ROCHE DIAGNOSTICS OPERATIONS INC
Methods and compositions for administration of iron
ActiveUS20070161600A1Safe and efficientBiocideOrganic active ingredientsNeutral phIron carbohydrate complex
The present invention generally relates to treatment of iron-related conditions with iron carbohydrate complexes. One aspect of the invention is a method of treatment of iron-related conditions with a single unit dosage of at least about 0.6 grams of elemental iron via an iron carbohydrate complex. The method generally employs iron carbohydrate complexes with nearly neutral pH, physiological osmolarity, and stable and non-immunogenic carbohydrate components so as to rapidly administer high single unit doses of iron intravenously to patients in need thereof.
Owner:AMERICAN REGENT INC
Electron-conducting crosslinked polyaniline-based redox hydrogel, and method of making
ActiveUS20090321277A1Bioreactor/fermenter combinationsBiological substance pretreatmentsRedox enzymesPolymer science
A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme. The polymer matrix may be hydrated, and the absorbed water may make it permeable to, for example, glucose. The polyaniline may be polyaniline itself or a substituted polyaniline; the water-soluble crosslinker may be poly(ethylene glycol) diglycidyl ether, and the redox enzyme may be glucose oxidase. The polymer matrix may be produced by co-crosslinking (1) an adduct of an electrically conductive polymer and a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme in a single step at an about neutral pH, curing by drying. After hydration, the crosslinked polymer matrix may form a 3-dimensional glucose-permeable bioelectrocatalyst, catalyzing the electrooxidation of glucose.
Owner:ABBOTT DIABETES CARE INC
Systems and methods for dextrose containing peritoneal dialysis (PD) solutions with neutral pH and reduced glucose degradation product
The invention provides container systems, kits and methods for peritoneal dialysis (PD) solutions. Such a system, for example, includes a first compartment that contains a Pt) osmotic agent and a second compartment that contains a PD buffer agent. The compartments maintain their respective contents separately from one another for purposes of transport, storage and / or sterilization. However, the compartments are fluidly couplable, so that their respective contents can be combined with one another, e.g., following sterilization of the agents and prior to their introduction into the patient's abdomen.
Owner:FRESENIUS MEDICAL CARE HLDG INC +1
Composition and method for recovering hydrocarbon fluids from a subterranean reservoir
A composition comprising crosslinked expandable polymeric microparticles capable of hydrolysis at or below neutral pH and a method of modifying the permeability to water of a subterranean formation by introducing such compositions into the subterranean formation is disclosed and claimed. This invention further relates to compositions and methods for the recovery of hydrocarbon fluids from a subterranean reservoir or formation subjected to CO2 or CO2 Water Alternating Gas flooding at low pH and increases the mobilization and / or recovery rate of hydrocarbon fluids present in the subterranean formations.
Owner:CHAMPIONX USA INC
Methods for enhanced protein production
ActiveUS20130017577A1Increase cell densityA large amountAnimal cellsMicroorganism separationHigh cellLiquid layer
The present invention provides a method of increasing protein production in a cell culture by growing cells that produce the protein (e.g., the growth phase) in a perfusion cell culture to a high cell density (i.e., at least above about 40×106 cells / N mL) and then switching to a protein production phase, wherein the cells are cultured in a fed-batch cell culture. The present invention further provides a method for clarifying a protein from a cell culture by adjusting the pH of the cell culture to below neutral pH (i.e., below a pH of 7) and settling the cell culture, such that the cell culture separates to form a supernatant layer and a cell-bed layer, wherein the protein is in the supernatant layer.
Owner:ER SQUIBB & SONS INC
Insulin Derivatives
The present invention relates to insulin derivatives having a side chain attached either to the -amino group of the N-terminal amino acid residue of the B chain or to the amino group of a Lys residue present in the B chain of the parent insulin via an amide bond which side chain comprises at least one aromatic group; at least one free carboxylic acid group or a group which is negatively charged at neutral pH, a fatty acid moiety with 4 to 22 carbon atoms in the carbon chain; and possible linkers which link the individual components in the side chain together via amide bonds.
Owner:NOVO NORDISK AS
Methods for producing yeast-based vaccines
The invention provides methods for culturing yeast at a neutral pH level. Yeast cultured under neutral pH conditions exhibit desirable characteristics useful for biological purposes, such as the development of vaccines, prophylactics and therapeutics. The invention also provides for compositions and kits comprising yeast grown using the methodologies disclosed herein.
Owner:GLOBE IMMUNE INC
High fluidity grouting material and production method thereof
ActiveCN101798208AImprove mobilityEasy to pump over long distancesSolid waste managementNeutral phPortland cement
The invention discloses a high fluidity grouting material and a production method thereof. The high fluidity grouting material comprises the following components in percentage by weight: on the basis of 100 percent of total amount, 60 to 96 percent of conventional portland cement, 1 to 20 percent of calcite powder, 1 to 20 percent of a mineral modifying component, and 2 to 18 percent of swelling agent, wherein measuring on the basis of using the total amount of four substances as base number, 0.01 to 4 weight percent of high efficiency slushing agent and 0.0005 to 1 weight percent of plasticity swelling agent are added in the mixture of the four substances. The high fluidity grouting material can be made of raw materials mixed by adopting a dual-shaft paddle non-gravity high-efficiency mixer. The material has simple industrialized production process and stable product quality, adopts the water-cement ratio of between 0.24 and 0.28, is evenly blended by water with neutral pH value, and has the advantages of high fluidity, no bleeding, no segregation or layering, slight swelling, easy pump delivery, good durability and the like after the material is uniformly mixed by water.
Owner:HUBEI CHIDGE TECH
Stabilized Pharmaceutical Peptide Compositions
ActiveUS20080318865A1Improve stabilityPeptide/protein ingredientsMetabolism disorderNeutral phPeptide
Method for increasing the shelf-life of a pharmaceutical composition comprising a glucagon-like peptide which is prepared from a peptide product that has been dried at a pH above neutral pH.
Owner:NOVO NORDISK AS
Hydrophobic starch having near-neutral dry product pH
ActiveUS7375214B2Little and no corrosivityLow production costBiocideOrganic active ingredientsCombustionNeutral ph
A free-flowing, hydrophobic starch composition has a near-neutral dry product pH. Methods for making the hydrophobic starch composition by preparing an aqueous mixture comprising a starch, a siliconate, and an acid, where the aqueous mixture has a near-neutral pH, and drying the starch solids to obtain a hydrophobic starch. Novel fuel compositions comprise hydrophobic starch which can be used in internal combustion engines, such as diesel engines. Hydrophobic starch compositions may be used as fuels or fuel components. Novel methods of fueling and operating internal combustion engines use hydrophobic starch as fuel or fuel components.
Owner:CORN PROD DEV INC
Ozone disinfecting, decontaminating and deodorizing of animal manure
InactiveUS6056885AEfficiently and effectively disinfectingEfficiently and effectively and decontaminatingSolid waste disposalExcrement fertilisersNeutral phFeces
This invention relates to a method and apparatus for using ozone to disinfect, decontaminate and deodorize animal manure. The invention contemplates injecting ozone gas into manure, while the manure is rotated on an auger in a sealed chamber. As a result of the invention, the manure is disinfected, decontaminated, and deodorized, while nutrients in the manure and a neutral pH are maintained.
Owner:WASINGER ERIC
Methods and Apparatus for Generating Oxidizing Agents
InactiveUS20090152123A1Eliminate oxidative damageReduce and destroy contaminantElectrolysis componentsWater contaminantsNeutral phCarbon felt
Contemplated devices and methods include an electrolytic cell having a cathode and a carbon felt anode, wherein the carbon felt anode is configured as a flow-through anode for an aqueous solution in which a contaminant is dissolved or dispersed. The cell is operated at a current density that promotes formation of oxidizing species in neutral pH to thus destroy the contaminant and at a flow rate sufficient to prevent oxidative damage of the carbon felt.
Owner:APPLIED INTELLECTUAL CAPITAL
Methods and compositions for administration of iron
Owner:AMERICAN REGENT INC
Porous crystalline frameworks, process for the preparation therof and their mechanical delamination to covalent organic nanosheets (CONS)
ActiveUS20150266885A1Simple and safe and environmentally-friendly mechanical grindingStable exposureProductsGas treatmentNeutral phCrystallization
The invention disclosed herein provides, Porous Crystalline Frameworks (PCFs) also known as Covalent Organic Frameworks (COFs) that exhibit stability towards acidic, basic and neutral pH conditions. Further the invention discloses economical, environmentally-friendly process for the synthesis thereof.
Owner:COUNCIL OF SCI & IND RES
Method for preparing flower-shaped molybdenum disulfide micro-balloon
InactiveCN101113021ASimple processEasy to operateMolybdenum sulfidesNeutral phHigh volume manufacturing
The invention discloses a method which adopts hydrothermal compound method for preparing flower-shaped microsphere of molybdenum disulfide. The invention comprises the steps: Na2MoO4, CS (NH2)2 and inorganic additives are added to a reactor and deionized water of 60 percent of the reactor column is also added and then the reactor is sealed and kept in a constant temperature case with a temperature ranging from 150 DEG C to 250 DEG C at least for 12 hours to be cooled in ambient temperature; obtained objects are washed by deionized water eccentrically to a neutral pH value; the flower-shaped microsphere of molybdenum disulfide is obtained after the objects are dried. The method of the invention has simple technique, easy operation, low cost and the products prepared has high purity and is promising for large-scaled production.
Owner:ZHEJIANG UNIV
Method for preparing silver/graphene antimicrobial composite material
The invention provides a method for preparing a silver / graphene antimicrobial composite material, and the method provided by the invention comprises the following steps: a) providing a reductive graphene oxide-sodium polystyrene sulfate composite solution; b) heating the composite solution obtained in the step a) to 50-70 DEG C; and c) adding a silver nitrate solution into the heated composited solution obtained in the step b) for reaction, thus obtaining the silver / graphene antimicrobial composite material. The invention provides the method for preparing the silver / graphene antimicrobial composite material; and in the method, a reductive graphene oxide tablet is taken as a reducing agent for carrying out reduction on silver ions under a neutral pH condition so as to generate silver nano particles. In the method provided by the invention, no sodium borohydride is taken as a reducing agent, and in the whole preparation process, no potassium hydroxide is adopted, therefore, when the composite material prepared by the method is subjected to later application, no large biological irritant is caused. In addition, antibacterial experiments show that the silver / graphene antimicrobial composite material provided by the invention has a better antibacterial effect.
Owner:UNIV OF SCI & TECH OF CHINA
Reduction of the loss of zinc by its reaction with oxygen in galvanized steel and batteries
InactiveUS20070125644A1Improve Coulombic efficiencyMinimal porosityMachining electrodesFuel and primary cellsElectrochemical responseChemical reaction
A non-porous Zn2+ conducting inorganic lamellar layer is formed on the zinc coating of galvanized steel or on a zinc anode of an electrochemical cell. The layer reduces the rate of the unwanted chemical reaction of zinc and oxygen but allows desired electrochemical reactions underlying the cathodic protection of the steel and the efficient utilization of zinc anodes in electrochemical cells, e.g., a physiological buffer solution or serum as their electrolytes. The ion conducting non-porous lamellar layer having a hopeite phase Zn3(PO4)2.4H2O may be formed spontaneously on, e.g., NAFION® coated zinc anodes discharged in neutral pH saline phosphate solutions.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST
Transparent conductive film and preparation method thereof
InactiveCN104240798AReduce oxidationGood conductivity uniformityConductive layers on insulating-supportsCable/conductor manufactureNanowireNeutral ph
The invention discloses a transparent conductive film and a preparation method thereof. The transparent conductive film covers a transparent substrate and is a blend system of metal nano-wires and conducting polymer or is a combination layer of a metal nano-wire layer and a conducting polymer layer from bottom to top sequentially. The metal nano-wires include gold, silver, copper and nickel nano-wires; the conducting polymer refers to poly (3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) with neutral pH value. Conducting uniformity of the metal nano-wire film is improved, and the transparent conductive film has high stability when being stored, heated and applied with current in a water-oxygen environment.
Owner:SHANGHAI JIAO TONG UNIV
Anti-bacterial cleaning composition
ActiveUS20110311600A1Safe and effective cleaningSafe and effective and disinfectingBiocideCationic surface-active compoundsNeutral phSurface cleaning
The present invention is directed to a multi-surface cleaning composition having an anti-bacterial ingredient for cleaning furniture surfaces. The anti-bacterial cleaning component includes a quaternary ammonium chloride compound or combinations thereof. The composition further includes a pH adjuster to provide for a generally neutral pH in the range of about 6 to about 9 including a combination of components, preferably white distilled vinegar and an amine compound. The cleaning composition provides for good cleaning and disinfecting of wood surfaces and other furniture surfaces without leaving streaks.
Owner:SC JOHNSON & SON INC
Hydrogel arthroplasty device
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV +1
Anti-C5 antibodies
Owner:CHUGAI PHARMA CO LTD
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