888 results about "Binding properties" patented technology

A unique method is disclosed for identifying and replacing immunoglobulin surface amino acid residues which converts the antigenicity of a first mammalian species to that of a second mammalian species. The method will simultaneously change immunogenicity and strictly preserve ligind binding properties. The judicious replacement of exterior amino acid residues has no effect on the ligind binding properties but greatly alters immunogenicity.

Single-molecule selection methods are provided for identifying target-binding molecules from diverse sequence and shape libraries. Complexes and imprints of selected target-binding molecules are also provided. The subject selection methods are used to identify oligonucleotide and nonnucleotide molecules with desirable properties for use in pharmaceuticals, drug discovery, drug delivery, diagnostics, medical devices, cosmetics, agriculture, environmental remediation, smart materials, packaging, microelectronics and nanofabrication. Single oligonucleotide molecules with desirable binding properties are selected from diverse sequence libraries and identified by amplification and sequencing. Alternatively, selected oligonucleotide molecules are identified by sequencing without amplification. Nonnucleotide molecules with desirable properties are identified by single-molecule selection from libraries of conjugated molecules or nucleotide-encoded nonnucleotide molecules. Alternatively, target-specific nonnucleotide molecules are prepared by imprinting selected oligonucleotide molecules into nonnucleotide molecular media. Complexes and imprints of molecules identified by single-molecule selection are shown to have broad utility as drugs, prodrugs, drug delivery systems, willfully reversible cosmetics, diagnostic reagents, sensors, transducers, actuators, adhesives, adherents and novel multimolecular devices.

The present invention relates to Fc variants with optimized Fc receptor binding properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized Fc receptor binding properties, and methods for using Fc variants with optimized Fc receptor binding properties.

Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.

Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.

The present invention provides a nonmetallic twist tie in which the function inherent to the twist tie is of course available and the twist tie is easily made into a shape of being wound in a bundle with no slipping down of the tie into gap, no torsion of the tie itself, no curl, no twining and tangling of ties and no loosening or disjoining from a reel whereby its drawing-out from the wound shape is able to be carried out smoothly. The nonmetallic twist tie having a core part and a wing part constituted from a non-halogenous material is characterized in that (1) a shape having a total width is 1.5 to 20.0 mm, the average thickness of the wing part is 0.02 to 0.20 mm and the maximum thickness of the core part is 0.04- to 0.30-fold of the total width, (2) a binding property where a torsion strength is 5.0 to 15 N, (3) a rigidity where a tensile elasticity is 5,000 to 30,000 Mpa, (4) a property of forming a fixed shape where the property is 90% or more and a property of retaining a fixed shape where the rate of retaining the fixed shape is 70 to 95%, and (5) a drawing-out property where a degree of curving to the drawing-out direction is 10° or less and a curl radius to the winding direction retains the range of 50 to 200 mm.

A polymer assisted deposition process for deposition of metal oxide films is presented. The process includes solutions of one or more metal precursor and soluble polymers having binding properties for the one or more metal precursor. After a coating operation, the resultant coating is heated at high temperatures to yield metal oxide films. Such films can be epitaxial in structure and can be of optical quality. The process can be organic solvent-free.

Disclosed is an air purification filter with novel active media that attracts, migrates, binds, and destroys pathogens, including sub-micron pathogens, that are suspended in the air passing through the filter. These properties are incorporated in the micro-fibers comprising the active filter media by several novel methods. One embodiment uses polymers or solgel bound monomers of quaternary ammonium compounds as a biocide with both chemotactic and pathogen membrane lysing properties. Another embodiment uses biocide chemicals blended into the melt before filter fibers are extruded and electret dipole charged. The attracting-binding properties of the embodiments may be enhanced by including electropositive Boehmite nano-fiber strands in the active media, by coating a reversible voltage charged electro-conductive polymer, by the use of supplemental fusing and lysing chemicals, and by optional ion field charging of incoming pathogens.