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62 results about "Ungulate" patented technology
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Ungulata (pronounced [ʊnɡʊˈlata]) is a diverse group of primarily large mammals with hoofs. These include odd-toed ungulates such as horses and rhinoceroses, and even-toed ungulates such as cattle, pigs, giraffes, camels, deer, and hippopotamuses, as well as sub-ungulates such as elephants. Most terrestrial ungulates use the tips of their toes, usually hoofed, to sustain their whole body weight while moving.
Bovine Pregnancy Test
InactiveUS20070184558A1Ensure high efficiency and accuracyBioreactor/fermenter combinationsAnimal reproductionPregnancy testsAntigen
This invention provides bovine pregnancy test methods and devices. The test is also suitable for other ruminant and / or ungulate animals. Antigens from Group A (early pregnancy antigens), and / or Group B (mid-pregnancy antigens), and Group C (early, mid- and late pregnancy antigens) are detected in a fluid from the animal, and pregnancy is reliably determined. The pregnancy assays of this invention are preferably carried out using immunoassay devices which provide immediate results in the field.
Owner:ASPENBIO PHARMA
Transgenic animals and uses thereof
InactiveUS20060041945A1Increase opportunitiesDecreasing expression of endogenousTissue cultureImmunoglobulinsMammalUngulate
In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and / or prion protein.
Owner:KYOWA HAKKO KIRIN CO LTD
Transgenic Ungulates Expressing CTLA4-IG and Uses Thereof
The present invention provides ungulates, including pigs, expressing CTLA4-Ig, as well as tissue, organs, cells and cell lines derived from such animals. Such animals, tissues, organs and cells can be used in research and medical therapy, including xenotransplanation. In addition, methods are provided to prepare organs, tissues and cells expressing the CTLA4-Ig for use in xenotransplantation, and nucleic acid constructs and vectors useful therein.
Owner:AYARES DAVID LEE
Antibodies specific for ungulate PrP
InactiveUS6537548B1Fast and efficient cost-effective assayFast and efficientImmunoglobulins against animals/humansAntibody ingredientsProteinaceous infectious particleUngulate
The present invention provides antibodies that specifically bind with a high degree of binding affinity to a native ungulate PrPC and / or a denatured ungulate PrPSc, but not to a native ungulate PrPSc. Preferred antibodies find native bovine PrPC and treated PrPSc but not native bovine PrPSc and can be used in an assay to determine if a sample is infected with infectious prions, i.e. PrPSc.
Owner:THE SCRIPPS RES INST
Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates
The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of non-bovine antibodies, preferably human antibodies.
Owner:KYOWA HAKKO KIRIN CO LTD
Compositions and methods for treating hoof diseases
ActiveUS20100137451A1Simple methodMore efficientBiocideHydroxy compound active ingredientsCross-linkDisease
The present invention is generally directed to compositions and methods for the treatment of an infectious disease of the foot of an animal. One aspect of the invention is directed to a method for preventing and / or treating one or more infectious diseases of the hoof in animals, comprising: preparing a copper-free and zinc-free composition comprising at least one cross-linking agent, wherein the cross-linking agent is not formaldehyde; and administering the composition to a lower leg and hoof area of said animal to prevent and / or treat said one or more infectious diseases. Another aspect of the invention is directed to a copper-free and zinc-free composition for the treatment and / or prevention of one or more infectious diseases of the hoof in animals, comprising at least one cross-linking agent, wherein said cross-linking agent is not formaldehyde. The present invention is also directed to a method for treating and / or preventing papillomatous digital dermatitis in an ungulate, comprising: preparing a copper-free and zinc-free composition comprising at least one cross-linking agent and at least one quaternary ammonium compound; and spraying or applying in a foam a therapeutically effective amount of said composition to a lower leg and hoof area of said ungulate in order to treat and / or prevent said papillomatous digitial dermatitis.
Owner:AGROCHEM USA LLC
Ungulates with genetically modified immune systems
The present invention provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which lack expression of functional endogenous immunoglobulin loci. The present invention also provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which express xenogenous, such as human, immunoglobulin loci. The present invention further provides ungulate, such as porcine genomic DNA sequence of porcine heavy and light chain immunogobulins. Such animals, tissues, organs and cells can be used in research and medical therapy. In addition, methods are provided to prepare such animals, organs, tissues, and cells.
Owner:REVIVICOR INC
Immunodynamic complexes and methods for using and preparing such complexes
InactiveUS20050249699A1Function increaseSimple structureBiocidePeptide/protein ingredientsStructure and functionSecretion
The present invention is directed to immunodynamic complexes that, in embodiments of the invention, are surprisingly antimicrobial and immunoactive. By “immunoactive,” it is meant that such compositions are capable of modulating, stimulating and repairing the immune system. Moreover, in embodiments of the invention, an immunodynamic complex is capable of supporting, maintaining and / or enhancing the structure and function of the immune system. In addition, this invention is directed to a method for preparing and using such compositions. Embodiments of the immunodynamic complexes of this invention are prepared from lacteal secretions derived from ungulates, such as cows.
Owner:SIXTY EIGHT
Reducing ungulate pressure on post-burn areas in mosaic burns
InactiveUS7143721B2Reducing ungulate pressureIncrease the lengthOther apparatusTaming and training devicesSelf limitingBiology
The present invention, in one embodiment, is a method of reducing ungulate pressure on burned sub-areas within a mosaic burn area. The method comprises identifying an unburned sub-area within the mosaic burn area and providing at least one highly palatable, portable, self-limiting, animal feed supplement in the first unburned sub-area. The highly palatable, portable, self-limiting, animal feed supplement attracts the ungulates to the first unburned sub-area and increases the length of the ungulates' stay in the first unburned sub-area. The ungulates are attracted to the first unburned sub-area by the supplement in preference to the burned sub-area with new growth.
Owner:RIDLEY USA
Bovine pregnancy test
InactiveUS7393696B2Ensure high efficiency and accuracyAnimal reproductionBioreactor/fermenter combinationsAntigenPregnancy tests
This invention provides bovine pregnancy test methods and devices. The test is also suitable for other ruminant and / or ungulate animals. Antigens from Group A (early pregnancy antigens), and / or Group B (mid-pregnancy antigens), and Group C (early, mid- and late pregnancy antigens) are detected in a fluid from the animal, and pregnancy is reliably determined. The pregnancy assays of this invention are preferably carried out using immunoassay devices which provide immediate results in the field.
Owner:ASPENBIO PHARMA
Compositions and Methods for Treatment of Diseases of the Foot of an Animal
InactiveUS20090110751A1Improve antibacterial propertiesLower Level RequirementsAntibacterial agentsBiocideDiseaseSulfate
The present invention is directed to an activator composition comprising copper sulfate, zinc sulfate, sodium chloride, and ammonium sulfate, for the activation of an anti-microbial composition. The resulting activated anti-microbial composition is used for the treatment of an infectious disease of a foot of an animal, particularly for the use of ungulates. Benefits of using the activator composition, either alone or in conjunction with other anti-microbial compositions, include the reduction of copper deposited into the environment from anti-microbial treatments, extended use of an anti-microbial composition, and maintenance of low levels of infectious diseases of the feet of animals.
Owner:DYNAMIC SUPPLY
Production of ungulates, preferably bovines that produce human immunoglobulins
The present invention relates to a method of producing an ungulate having both copies of the IgM heavy chain (mu) rag-1 and / or rag-2 gene eliminated from its genome. Animals which have IgM, rag-1 and / or rag-2 eliminated from their genome are unable to conduct the gene rearrangements that are necessary to generate the antigen receptors of B or T lymphocytes, and therefore will not develop native B or T cells. Because they are unable to produce B and T lymphocytes, these IgM, rag-1 or rag-2 ungulates cannot reject human hematopoietic stem cell preparations, and B and T lymphocytes which develop therefrom. Therefore, the present invention also involves injecting into IgM, rag-1 and / or rag-2 deficient ungulates, in utero or shortly after birth, human B and T lymphocytes whose immune systems produce human immunoglobulin that can be processed for therapeutic uses in humans.
Owner:KYOWA HAKKO KIRIN CO LTD
Ungulates with genetically modified immune systems
The present invention provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which lack expression of functional endogenous immunoglobulin loci. The present invention also provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which express xenogenous, such as human, immunoglobulin loci. The present invention further provides ungulate, such as porcine genomic DNA sequence of porcine heavy and light chain immunogobulins. Such animals, tissues, organs and cells can be used in research and medical therapy. In addition, methods are provided to prepare such animals, organs, tissues, and cells.
Owner:REVIVICOR INC
Immunocompromised Ungulates
InactiveUS20120090039A1Efficient modelingAntibody mimetics/scaffoldsMicrobiological testing/measurementModel systemB cell
Porcine animals, tissue and organs as well as cells and cell lines derived from such animals are provided that lack functional endogenous immunoglobulin loci and are deficient in immunoglobulin expression and B-cells. These animals are useful as model systems for research and for development of new pharmaceutical and biological agents. In addition, methods are provided to prepare such animals.
Owner:AYARES DAVID L +3
Method of reducing herbaceous fuels in areas susceptible to wildfires
InactiveUS8146539B2Increase attractivenessHighly palatableAvicultureOther apparatusSelf limitingEnvironment of Albania
A method of reducing herbaceous fuels may include identifying a region to reduce herbaceous fuels, dividing the region into susceptible areas, placing the susceptible areas in an order, and introducing an ingestible into a first susceptible area in the order. The method may also include selecting an ungulate group and the ingestible may be highly palatable, portable, and self-limiting. Placing the susceptible areas in an order may include analyzing the susceptible areas for a level of susceptibility, prioritizing the susceptible areas based on each area's conditions and surroundings, and / or considering practical aspects of treating all of the susceptible areas of the region. The ingestible may be moved throughout the region to reduce herbaceous fuels.
Owner:RIDLEY USA
Reducing ungulate pressure on post-burn areas in mosaic burns
InactiveUS20050193955A1Reducing ungulate pressureIncrease the lengthOther apparatusTaming and training devicesSelf limitingBiology
The present invention, in one embodiment, is a method of reducing ungulate pressure on burned sub-areas within a mosaic burn area. The method comprises identifying an unburned sub-area within the mosaic burn area and providing at least one highly palatable, portable, self-limiting, animal feed supplement in the first unburned sub-area. The highly palatable, portable, self-limiting, animal feed supplement attracts the ungulates to the first unburned sub-area and increases the length of the ungulates' stay in the first unburned sub-area. The ungulates are attracted to the first unburned sub-area by the supplement in preference to the burned sub-area with new growth.
Owner:RIDLEY USA
Methods and compositions for treating a hoof of an ungulate animal
ActiveUS20150096503A1Polyureas/polyurethane adhesivesPharmaceutical delivery mechanismDiphenylmethaneTriol
A method of treating a hoof of an ungulate animal. The method comprises coating one or both of (i) at least a portion of a bottom surface of the hoof or (ii) at least a portion of a block surface with a curable polymer and allowing the polymer to cure for a period of time. The polymer is cured within 60 seconds or less of the coating and the cured polymer has a Shore D hardness of about 10 to about 50. The curable polymer is provided as a two component system. The first component is a reaction product of (a) comprises 4-4′-diphenylmethane-diisocyanate, castor oil, isocyanatopropyltriethoxysilane, and glycidoxypropyltrimethoxysilane, and wherein (b) comprises dicyclohexylmethane-4,4-diisocyanate, polyether polyol, 4,4′-diphenylmethane-diisocyanate (MDI), and triethoxy(3-isocyanatopropyle)silane. The second component comprises polyoxypropylene oxide ether polyol, diol (2000 MW), polyxoypropylene oxide ether polyol, triol (450 MW), tetrahydroxypropylethylendiamine, metaxylenediamine, and organobismuth catalyst.
Owner:KERCKHAERT HOEFIJZERFAB BV
Compositions and methods including expression and bioactivity of bovine follicle stimulating hormone
ActiveUS20080312151A1Improve reproductive activityImproving superovulationPeptide/protein ingredientsImmunoglobulinsMammalEmbryo
The present invention provides methods of producing biologically active recombinant bFSH and methods of increasing reproduction in mammals, particularly bovine, using recombinant bFSH. Also provided are methods of producing single chain recombinant bFSH. The recombinant bFSH of the present invention increases superovulation, embryo development, and reproductive efficiency in cattle and other ungulates.
Owner:ASPENBIO PHARMA
Immunocompromised Ungulates
ActiveUS20160278349A1Antibody mimetics/scaffoldsVector-based foreign material introductionModel systemBiological agent
Porcine animals, tissue and organs as well as cells and cell lines derived from such animals are provided that lack functional endogenous immunoglobulin loci and are deficient in immunoglobulin expression and B-cells. These animals are useful as model systems for research and for development of new pharmaceutical and biological agents. In addition, methods are provided to prepare such animals.
Owner:REVIVICOR INC
Transgenic animals and uses thereof
InactiveUS7420099B2Reduces and eliminates expression of endogenousIncrease and decrease levelTissue cultureImmunoglobulinsMammalCell biology
In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and / or prion protein.
Owner:KYOWA HAKKO KIRIN CO LTD
Activity of recombinant equine follicle stimulating hormone
ActiveUS20100120677A1Improve reproductive efficiencyPromote reproductionPeptide/protein ingredientsImmunoglobulinsMammalEmbryo
The present invention provides methods of producing biologically active recombinant eFSH analogs and methods of increasing reproduction in mammals, particularly equine, using recombinant eFSH analogs. Also provided are methods of producing biologically active single chain recombinant eFSH. The recombinant eFSH analogs of the present invention increase superovulation, follicular development, embryo development, and reproductive efficiency in horses, cattle and other ungulates.
Owner:RGT UNIV OF CALIFORNIA +2
Grazing method for controlling and/or eradicating noxious plants including invasive plant species
InactiveUS20060112889A1Increase attractivenessHighly palatableAnimal feeding devicesAnimal housingSelf limitingBiology
The present invention is a method of controlling noxious plant species. The method comprises identifying a target area in a foraging area, selecting a treatment period, selecting an ungulate specie, providing an animal feed supplement at a first deployment location in the target area, and introducing the selected ungulate specie to the animal feed supplement in the target area during the treatment period. The target is considered such because it includes a noxious plant specie. During the treatment period, the selected ungulate specie will interact with the noxious plant specie in the target area. For example, the ungulates interact with the noxious plant specie by eating the noxious plant specie and / or by trampling the noxious plant specie. The animal feed supplement is highly-palatable, portable, self-limiting, attracts the ungulate specie to the target area, and increases the length of stay of the ungulate specie in the target area.
Owner:RIDLEY USA
Compositions and methods for treating hoof diseases
ActiveUS8389581B2More efficientSimple methodBiocideHydroxy compound active ingredientsCross-linkDisease
The present invention is generally directed to compositions and methods for the treatment of an infectious disease of the foot of an animal. One aspect of the invention is directed to a method for preventing and / or treating one or more infectious diseases of the hoof in animals, comprising: preparing a copper-free and zinc-free composition comprising at least one cross-linking agent, wherein the cross-linking agent is not formaldehyde; and administering the composition to a lower leg and hoof area of said animal to prevent and / or treat said one or more infectious diseases. Another aspect of the invention is directed to a copper-free and zinc-free composition for the treatment and / or prevention of one or more infectious diseases of the hoof in animals, comprising at least one cross-linking agent, wherein said cross-linking agent is not formaldehyde. The present invention is also directed to a method for treating and / or preventing papillomatous digital dermatitis in an ungulate, comprising: preparing a copper-free and zinc-free composition comprising at least one cross-linking agent and at least one quaternary ammonium compound; and spraying or applying in a foam a therapeutically effective amount of said composition to a lower leg and hoof area of said ungulate in order to treat and / or prevent said papillomatous digitial dermatitis.
Owner:AGROCHEM USA LLC
Production of chimeric bovine or porcine animals using cultured inner cell mass
Novel cultured inner cell mass (CICM) cells, and cell lines, derived from ungulates, in particular, pigs and cows, and methods for their preparation are provided. The subject CICMs possess similar morphology and express cell markers identically or substantially similarly to ICMs of undifferentiated developing embryos for prolonged culturing periods. Heterologous DNA is inserted into the subject CICM cells and cell lines so as produce transgenic CICM cell which are introduced into non-human fertilized embryos to produce transgenic chimeric embryos. The transgenic chimeric embryos are transferred into recipient females where they are permitted to develop into transgenic chimeric fetuses. Recipient females give birth to transgenic chimeric animals which are capable of transmitting the heterologous DNA to their progeny. Transgenic CICM cells are also used to produce cloned transgenic embryos, fetuses and offspring.
Owner:UNIV OF MASSACHUSETTS
Compositions and methods for treating hoof diseases
ActiveUS20130172425A1More efficientSimple methodBiocideHydroxy compound active ingredientsDiseaseCross-link
Owner:AGROCHEM USA LLC
Transgenic ungulate compositions and methods
InactiveUS7071373B1Quality improvementHepatocytesGenetically modified cellsPlant Germ CellsIndividual animal
Transgenic ungulates and compositions and methods for making and using same, are provided. Central to the invention are porcine, bovine, ovine and caprine embryonic stem cell lines and methods for establishing them. Cells of such lines are transformed with exogenous genetic material of interest and then used to provide chimeric ungulates confirmed by genetic markers which have germ cells comprising the exogenous genetic material. The chimeric ungulates are bred to provide transgenic ungulates. The transgenic animals of the invention may show improved qualities and can be used to provide human proteins or peptide hormones or can be used as xenograft donors.
Owner:THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS
Reinforced polymer cuff horseshoe
A reinforced polymer cuff horseshoe is formed in a substantially u-shape from a resilient, flexile, moldable material and includes a pliable, metal rod-like reinforcer shaped to include an anterior segment from which opposing side segments continuously extend to caudal ends separated as an open heel. The reinforcer is embedded in the material between ungulate and ground contact surfaces. A cuff member attached to the material between the ungulate and ground contact surfaces and configured to extend up from the ungulate surface for a predetermined extent while an inner, hoof-contacting surface of the cuff surrounds and snugly fits to an outer surface contour of a hoof. A plurality of grooves or open channels is arranged in the ungulate surface for receiving an adhesive or glue for bonding the horseshoe to a hoof.
Owner:NO ANVIL
Production of ungulates, preferably bovines that produce human immunoglobulins
InactiveUS7820878B2Eliminating expressionEnzymesGenetic engineeringLymphocyte antigen receptorIn utero
The present invention relates to a method of producing an ungulate having both copies of the IgM heavy chain (mu) rag-1 and / or rag-2 gene eliminated from its genome. Animals which have IgM, rag-1 and / or rag-2 eliminated from their genome are unable to conduct the gene rearrangements that are necessary to generate the antigen receptors of B- or T-lymphocytes, and therefore will not develop native B- or T-cells. Because they are unable to produce B- and T-lymphocytes, these IgM, rag-1, or rag-2 ungulates cannot reject human hematopoietic stem cell preparations, and B- and T-lymphocytes which develop therefrom. Therefore, the present invention also involves injecting into IgM, rag-1, and / or rag-2 deficient ungulates, in utero or shortly after birth, human B- and T-lymphocytes whose immune systems produce human immunoglobulin that can be processed for therapeutic uses in humans.
Owner:SAB LLC
Immunodynamic complexes and methods for using and preparing such complexes
InactiveUS20050265963A1Function increaseSimple structureCosmetic preparationsVirusesStructure and functionSecretion
The present invention is directed to immunodynamic complexes that, in embodiments of the invention, are surprisingly antimicrobial and immunoactive. By “immunoactive,” it is meant that such compositions are capable of modulating, stimulating and repairing the immune system. Moreover, in embodiments of the invention, an immunodynamic complex is capable of supporting, maintaining and / or enhancing the structure and function of the immune system. In addition, this invention is directed to a method for preparing and using such compositions. Embodiments of the immunodynamic complexes of this invention are prepared from lacteal secretions derived from ungulates, such as cows.
Owner:SIXTY EIGHT
Single dose recombinant bovine fsh after follicular synchronisation
InactiveUS20150335713A1Improve reproductive performancePromote reproductionElcosanoid active ingredientsPeptide/protein ingredientsMammalian reproductionPregnancy
The present invention relates to methods and compositions for increasing reproduction performance in non-human mammals using a biologically active recombinant Follicle Stimulating Hormone (rFSH). The invention also relates to methods for increasing ovulation or embryo production or pregnancies in non-human mammal using rFSH. The invention may be used in particular in ungulates such as bovine or equine.
Owner:CEVA SANTE ANIMALE
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