593results about How to "Reduce rejection" patented technology

The invention provides methods to diagnose and follow the progression of disease through use of protein profile analysis.

The present invention concerns compounds comprising, within short sequences from a specific region of the kinase, that can modulate kinase-associated signal transduction.

Verification of Caller identification, used independently of caller ID or as an adjunct to caller ID for caller verification by matching caller voice samples to voice samples previously stored. Verification algorithms can be implemented as a stand alone device connected to the telephone line or the interne, in software which can be a resident on a PSTN phone, mobile phone or an IP phone or resident on a computer. Voice samples of the current caller are recorded and compared a database of previously recorded voice samples. When a call is received for the first time, the caller records the caller's name which is stored into a database and correlated with the received caller ID information of the present caller, if such information was received. If no caller ID information is received, the voice sample is stored in the database with an indication of a lack of caller ID information. The collection and storage of voice samples allows the use of such samples for voice authentication if the caller calls again. When a caller calls again, the caller records the caller's name as the current caller's voice sample which is compared to the stored database. The enhanced accuracy will aid in acceptance and rejection decisions as well as decisions regarding the handling of incoming telephone calls and will aid in the retrieval of additional information regarding the caller if available.

The invention belongs to the field of immunotherapy and relates to a universal CAR-T cell and a preparation method and application thereof. In the universal CAR-T cell, the functions of a T cell antigen receptor (TCR) and major histocompatibility complexes (MHC I and MHC II) in the T cell are inhibited while multi-gene knockout is performed; a gene encoding the TCR includes TRAC and / or TRBC; genesencoding the major histocompatibility complexes include HLA-A, B2MH and CIITA. The universal CAR-T cell can target relevant markers of specific tumors and inactivate the functions of the TCR and theMHC on the cell surface, can reduce immunological rejection caused by allogeneic cell therapy and safely and effectively remove tumor cells in the diseased human body, is not affected by the disease or a treatment mode of a patient in use and can be prepared at any time, treatment can be provided at the optimum time, and treatment effectiveness is ensured.

A system for obtaining a signature from a scan area on the surface of an article comprises: a signature generator that generates the signature from scattered coherent radiation detected from a plurality of points on the surface and includes a scan head comprising a coherent radiation source and photodetectors; a camera for capturing an image of the surface; a comparator that compares the captured image with a reference image to determine the location and orientation of the scan area; and a drive assembly that positions the scan head appropriately for generating a signature from the scan area in response to the determination of the location and orientation of the scan area.

An object of the present invention is to efficiently establish cells, tissues, and organs capable of serving as donors for treating diseases, without eliciting immune rejection reactions, without starting with an egg cell. This object was achieved by providing a pluripotent stem cell having a desired genome. The cell was produced by treating with a reprogramming agent, producing a fusion cell of an MHC deficient stem cell with a somatic cell, or after producing a fusion cell of a stem cell with a somatic cell, removing a gene derived from the stem cell by performing genetic manipulation with a retrovirus.

An EGR mixer comprises an upstream conduit section having a contracting flow area in a direction of air flow through the mixer, a downstream conduit section having an expanding flow area in the direction of air flow through the mixer, a slot formed in the downstream conduit section for admitting exhaust to the air flow, and an abrupt flow-expanding ridge disposed between the upstream and downstream conduit sections. With the EGR mixer configured in this manner, recirculated exhaust may be effectively homogenized into an intake air flow with reduced drag.

The invention discloses biological ink material for 3D printing and a preparation method and application thereof. The biological ink material is prepared by, by mass concentration percentage, 5-18% of biological macromolecules, 76-93.5% of water or 76-93.5% of pre-crosslinking agent, and 1.5-6% of coagulant, wherein the sum of the mass concentration percentage of the above raw materials is 100%. The biological ink material is characterized in that water washing and crosslinking are performing for shaping after printing. The biological ink material has the advantages that the biological ink material can be easily squeezed out during printing, does not block printing needles and can be easily shaped after being squeezed out; the biological ink material is low in antigenicity in the bodies of organisms, low in caused rejection reaction, biodegradable, nontoxic to the organisms and high in safety.

The present invention provides a liquid repellent membrane whose liquid repellency can be controlled by a varying physical stimulation; a novel fluorine compound which can be formed into the liquid repellent membrane; an electrical board, display device and color filter for display devices which are formed using the liquid repellent membrane by a method involving irradiation of visible light, which may be combined with a heating step, but needing no vacuum or ultraviolet ray irradiation process; methods for producing an electrical board, display device and color filter for display devices; and a pH sensor and ion sensor working on measurement of changed liquid repellency. The fluorine compound having liquid repellency is provided with a site at which it can be bound to a functional group, e.g., compound having a pigment unit.

Compounds and methods for sorbing organosulfur compounds from fluids are provided. Generally, compounds according to the present invention comprise mesoporous, nanocrystalline metal oxides. Preferred metal oxide compounds either exhibit soft Lewis acid properties or are impregnated with a material exhibiting soft Lewis acid properties. Methods according to the invention comprise contacting a fluid containing organosulfur contaminants with a mesoporous, nanocrystalline metal oxide. In a preferred embodiment, nanocrystalline metal oxide particles are formed into pellets (14) and placed inside a fuel filter housing (12) for removing organosulfur contaminants from a hydrocarbon fuel stream.

The inventions describes a method for increasing effector T cell accumulation in cancer cell-containing sites of a tumor, comprising administering to a subject in need thereof a pharmaceutically effective amount of an inhibitor of CXCR4 signaling.

The present invention provides certain donor animals, tissues and cells that are particularly useful for xenotransplantation therapies. In particular, the invention includes porcine animals, as well as tissue and cells derived from these, which lack any expression of functional alpha 1,3 galactosyltransferase (aGT) and express one or more additional transgenes which make these animals suitable donors for xenotransplantation of vascularized xenografts and derivatives thereof. Methods of treatment and using organs, tissues and cells derived from such animals are also provided.