41174results about How to "Increase speed" patented technology

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

A biopsy system for retrieving biopsy tissue samples from different regions of the body is disclosed. The biopsy system includes a single use loading unit having a trocar assembly and a knife assembly. A trocar driver is operably connected to the trocar assembly and is actuable to move a trocar between retracted and advanced positions. The trocar driver is disengaged from the trocar assembly prior to firing the trocar into a target tissue mass to reduce drag on the trocar during firing. A knife driver is operably connected to the knife assembly such that when actuated, a knife is both rotatably and axially advanced about the trocar.

In a semiconductor device, and a method of manufacturing thereof, the device includes a substrate of single-crystal semiconductor material extending in a horizontal direction and a plurality of interlayer dielectric layers on the substrate. A plurality of gate patterns are provided, each gate pattern being between a neighboring lower interlayer dielectric layer and a neighboring upper interlayer dielectric layer. A vertical channel of single-crystal semiconductor material extends in a vertical direction through the plurality of interlayer dielectric layers and the plurality of gate patterns, a gate insulating layer being between each gate pattern and the vertical channel that insulates the gate pattern from the vertical channel.

Methods and apparatuses for compressing and holding a bulging or herniated intervertebral disc. A number of fastener embodiments are disclosed, including a resiliently curved fastener, suture, screw, staple, tack and others. The curved fastener is resiliently straightened and loaded into a needle for delivery and deployment. In the intervertebral disc, the deployed fastener resumes the curvature to grip and hold the bulge. Alternatively, the suture is anchored and used to tie down the bulging tissue. The screw, staple or tack can also be used to securely fasten, compress and hold the bulge from impinging upon adjacent nerves or tissues.

Suturing systems may comprise a cartridge and a drive unit which are detachable from each other. The cartridge often has a cartridge body, a plurality of jaws, and a cartridge interface. The drive unit has a drive unit body, a linkage, and a drive unit interface which will typically include a latch. A latch input is coupled to the latch so that a movement of the input moves the latch to the released position. The cartridge interface or the drive unit interface includes a channel while the other includes a shaft which is fittingly receivable in the channel. Opposed motions of the input and cartridge during cartridge removal avoid inadvertent detachment during use.

Medical devices, methods and systems for treating tissue are provided. An exemplary system comprises a fluid from a fluid from a fluid source at a fluid flow rate, a surgical device which provides power and the fluid to the tissue and a control mechanism which changes a fluid flow rate provided from the surgical device and changes a power level provided from the surgical device. The fluid flow rate changes between at least two-zero flow rates and the power level changes between at least two non-zero levels. An exemplary method comprises providing a fluid from a fluid source at a fluid flow rate, providing a surgical device which provides power and the fluid to the tissue, and changing the fluid flow rate of fluid provided from the surgical device with a change in power level provided from the surgical device.

A general programmatic interface-to-network messaging adapter exposes a suitable object integration interface or application programming interface to applications on a controller device and sends network data messages to invoke services or query status of a controlled device. The adapter maps application calls to the interface into network data messages according to service protocols of the controlled device. The general adapter provides the interface suitable to any specific service of a controlled device based on a data description of the interface, and converts the application calls to network data messages based on a data description of a protocol and format for network data messages to interact with the specific service. Once the interface / messaging description is obtained, applications on the controller device can programmatically interact with the adapter, and the adapter then handles appropriate message exchanges with the service of the controlled device. The general adapter allows controller device applications to be written using object-oriented programming, while avoiding code download.

A fastener (13) and fastener delivery device (73) for guiding, delivering and deploying the fastener (13) into tissue to provide sustained gripping forces and methods of use. The fastener (13) is curved with a spring-like or shape memory material (15) and gripping elements (14). The fastener (13) is resiliently straightened and loaded into a cartridge (7) within a needle (1). The needle (1) and cartridge (7) both contain a slit (2, 8), and the slits (2, 8) extend to the distal openings (16, 17) of the needle (1) and cartridge (7). When the slits (2, 8) are not aligned, out-of-phase with each other, the fastener (13) remains resiliently straightened in the needle (1). When the slits (2, 8) overlap, in-phase with each other, the fastener (13) resiliently curves and deploys from the slits (2, 8), elastically gripping adjacent tissue. The device (73) is free to be withdrawn, allowing the fastener (13) to slide out from the distal openings (16, 17) of both cartridge (7) and needle (1).

A gas-feeding apparatus configured to be connected to an evacuatable reaction chamber includes a gas-distribution head for introducing gases into the chamber through a head surface. The gas-feeding head includes a first section for discharging a gas through the head surface toward a susceptor and a second section for discharging a gas through the head surface toward the susceptor. The first and the second sections are isolated from each other in the gas-distribution head, at least one of which section is coupled to an exhaust system for purging therefrom a gas present in the corresponding section without passing through the head surface.

A runtime adaptable search processor is disclosed. The search processor provides high speed content search capability to meet the performance need of network line rates growing to 1 Gbps, 10 Gbps and higher. he search processor provides a unique combination of NFA and DFA based search engines that can process incoming data in parallel to perform the search against the specific rules programmed in the search engines. The processor architecture also provides capabilities to transport and process Internet Protocol (IP) packets from Layer 2 through transport protocol layer and may also provide packet inspection through Layer 7. Further, a runtime adaptable processor is coupled to the protocol processing hardware and may be dynamically adapted to perform hardware tasks as per the needs of the network traffic being sent or received and / or the policies programmed or services or applications being supported. A set of engines may perform pass-through packet classification, policy processing and / or security processing enabling packet streaming through the architecture at nearly the full line rate. A high performance content search and rules processing security processor is disclosed which may be used for application layer and network layer security. scheduler schedules packets to packet processors for processing. An internal memory or local session database cache stores a session information database for a certain number of active sessions. The session information that is not in the internal memory is stored and retrieved to / from an additional memory. An application running on an initiator or target can in certain instantiations register a region of memory, which is made available to its peer(s) for access directly without substantial host intervention through RDMA data transfer. A security system is also disclosed that enables a new way of implementing security capabilities inside enterprise networks in a distributed manner using a protocol processing hardware with appropriate security features.

The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen / antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen / antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.

A method for associating related electronic messages in computer storage. A first transportable application is created and stored. User input requesting creation of a link from the first transportable application to another transportable application is received. User input that selects a second transportable application from among a plurality of previously created transportable applications is received. A link from the first transportable application to the second transportable application is created and stored. As a result, transportable application may be inter-related in complex message webs. The message webs may also be inter-related in message web rings. Links may be generated manually or automatically, based on context, workflow processes, or other known relationships among applications. Recipient lists and data may propagate among fields of linked transportable applications, directly or according to abstract business rules. Further, multiple-part electronic messages are disclosed. A graphical user interface of an electronic messaging system displays a message in the form of one or more header portions and one or more body portions. Each of the body portions has a selection region. While one body portion is visible at a given time, all the selection regions are continuously visible in the user interface to facilitate selection of any of the body portions at a particular time. Selecting a selection region of a non-displayed body portion causes a server to generate a refreshed user interface that includes the entirety of the selected body portion, and that hides the previously viewed body portion. As a result, a large amount of associated information may be combined in a single message in a way that is clearly organized and easily accessible.

A device control model provides an integrated set of addressing, naming, discovery and description processes that enables automatic, dynamic and ad-hoc self-setup by devices to interoperate with other devices on a network. This permits a computing device when introduced into a network to automatically configure so as to connect and interact with other computing devices available on the network, without a user installation experience and without downloading driver software or persisting a configuration setup for connecting and interacting with such other computing devices. Upon completing interaction with such other devices, the computing device automatically releases the setup for such other devices so as to avoid persistent device configurations that might create a configuration maintenance and management burden.

A system and method for decoding an image of decodable indicia, the computer system that includes receiving a request to decode an image, disabling the automatic focus on a camera in a client, setting the focus to a predetermined focus point that is close to the camera lens, capturing the image, locating the decodable indicia in the image and decoding the image of decodable indicia.

A wireless power system having at least one of a remote device with multiple wireless power inputs capable of receiving power from a different wireless power source, a remote device including a hybrid secondary that can be selectively configured for multiple uses, a remote device including a hybrid secondary, a far field wireless power source having a low power mode, a remote device having the capability of communicating with multiple different wireless power sources to indicate that a wireless power hot spot is nearby, a wireless power supply including multiple wireless power transmitters.

A method and system of inputting alphabetic text having a virtual keyboard on a touch sensitive screen. The virtual keyboard includes a set of keys where an each letter of alphabet is associated with at least one key. The present invention allows someone to use the virtual keyboard with continuous contact of the touch sensitive screen. The user traces an input pattern for word by starting at or near the first letter in a decided word and then tracing through or near each letter in sequence. The present invention then generates a list of possible words associated with the entered part and presents it to user for selection.

In some arrangements, product packaging is digitally watermarked over most of its extent to facilitate high-throughput item identification at retail checkouts. Imagery captured by conventional or plenoptic cameras can be processed (e.g., by GPUs) to derive several different perspective-transformed views—further minimizing the need to manually reposition items for identification. Crinkles and other deformations in product packaging can be optically sensed, allowing such surfaces to be virtually flattened to aid identification. Piles of items can be 3D-modelled and virtually segmented into geometric primitives to aid identification, and to discover locations of obscured items. Other data (e.g., including data from sensors in aisles, shelves and carts, and gaze tracking for clues about visual saliency) can be used in assessing identification hypotheses about an item. A great variety of other features and arrangements are also detailed.

A flow-based intrusion detection system for detecting intrusions in computer communication networks. Data packets representing communications between hosts in a computer-to-computer communication network are processed and assigned to various client / server flows. Statistics are collected for each flow. Then, the flow statistics are analyzed to determine if the flow appears to be legitimate traffic or possible suspicious activity. A concern index value is assigned to each flow that appears suspicious. By assigning a value to each flow that appears suspicious and adding that value to the total concern index of the responsible host, it is possible to identify hosts that are engaged in intrusion activity. When the concern index value of a host exceeds a preset alarm value, an alert is issued and appropriate action can be taken.

Systems, methods, apparatus and devices for performing improved gynecologic and urologic procedures are disclosed. The system and devices provide simplified use and reduced risk of adverse events. Patient benefit is achieved through improved outcomes, reduced pain, especially peri-procedural pain, and reduced recovery times. The various embodiments enable procedures to be performed outside the hospital setting, such as in a doctor's office or clinic.

An Internet-based server with speech support for enhanced interactivity is disclosed. This server hosts a server-side speech recognition engine and additional linguistic and database functions that cooperate to provide enhanced interactivity for clients so that their browsing experience is more satisfying, efficient and productive. This human-like interactivity which allows the user to ask queries about topics that range from customer delivery, product descriptions, payment details, is facilitated by the allowing the user to articulate the his or her questions directly in his or her natural language. The answer typically provided in real-time, can also be interfaced and integrated with existing telephone, e-mail and other mixed media services to provide a single point of interactivity for the user when browsing at a web-site.

A method for forming and the structure of a vertical channel of a field effect transistor, a field effect transistor and CMOS circuitry are described incorporating a drain, body and source region on a sidewall of a vertical single crystal semiconductor structure wherein a hetero-junction is formed between the source and body of the transistor, wherein the source region and channel are independently lattice strained with respect the body region and wherein the drain region contains a carbon doped region to prevent the diffusion of dopants (i.e., B and P) into the body. The invention reduces the problem of short channel effects such as drain induced barrier lowering and the leakage current from the source to drain regions via the hetero-junction and while independently permitting lattice strain in the channel region for increased mobility via choice of the semiconductor materials. The problem of scalability of the gate length below 100 nm is overcome by the heterojunction between the source and body regions.

Medical procedure trays and related methods are provided to accommodate joining a first non-sterile medical device with a second sterile medical device and maintaining required sterilization of the second sterile medical device to perform an associated medical procedure. One example of such medical procedures includes biopsy of a bone and / or associated bone marrow using a non-sterile powered drive and a sterile biopsy needle or biopsy needle set. Medical procedure trays and related methods may also be provided for use during aspiration of bone marrow and / or stem cell transplant procedures. Each medical procedure tray may include a containment bag or sterile sleeve. A coupler assembly, one or more sharps protectors, a biopsy sample ejector and / or associated ejector funnel may also be included. Some medical procedure trays may allow engaging a non-sterile powered driver with one end of a coupler assembly and sealing the non-sterile powered driver in a sterile sleeve or containment bag without compromising sterility of other components in the medical procedure tray.

Methods are provided for treating germanium surfaces in preparation for subsequent deposition, particularly gate dielectric deposition by atomic layer deposition (ALD). Prior to depositing, the germanium surface is treated with plasma products or thermally reacted with vapor reactants. Examples of surface treatments leave oxygen bridges, nitrogen bridges, —OH, —NH and / or —NH2 terminations that more readily adsorb ALD reactants. The surface treatments avoid deep penetration of the reactants into the germanium bulk but improve nucleation.

A real-time system incorporating speech recognition and linguistic processing for recognizing a spoken query by a user and distributed between client and server, is disclosed. The system accepts user's queries in the form of speech at the client where minimal processing extracts a sufficient number of acoustic speech vectors representing the utterance. These vectors are sent via a communications channel to the server where additional acoustic vectors are derived. Using Hidden Markov Models (HMMs), and appropriate grammars and dictionaries conditioned by the selections made by the user, the speech representing the user's query is fully decoded into text (or some other suitable form) at the server. This text corresponding to the user's query is then simultaneously sent to a natural language engine and a database processor where optimized SQL statements are constructed for a full-text search from a database for a recordset of several stored questions that best matches the user's query. Further processing in the natural language engine narrows the search to a single stored question. The answer corresponding to this single stored question is next retrieved from the file path and sent to the client in compressed form. At the client, the answer to the user's query is articulated to the user using a text-to-speech engine in his or her native natural language. The system requires no training and can operate in several natural languages.

An impact tool includes: a motor; a trigger; a controller configured to control driving power supplied to the motor using a semiconductor switching element according to an operation of the trigger; a striking mechanism configured to drive a tip tool continuously or intermittently by rotation force of the motor, the striking mechanism including a hammer and an anvil. The controller drives the semiconductor switching element at a high duty ratio when the trigger is manipulated. The motor is driven so that the duty ratio is lowered before a first striking of the hammer on the anvil is performed and the first striking is performed at a low duty ratio lower than the high duty ratio.