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The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

A device and method for spatially resolved photodetection and demodulation of temporally modulated electromagnetic waves makes it possible to measure phase, amplitude and offset of a temporally modulated, spatially coded radiation field. A micro-optical element (41) spatially averages a portion (30) of the scene and equally distributes the averaged intensity on two photo sites (51.1.51.2) close to each other. Adjacent to each of these photo sites (51.1) are two storage areas (54.1, 54.2) into which charge from the photo site can be moved quickly (with a speed of several MHz to several tens or even hundreds of MHz) and accumulated essentially free of noise. This is possible by employing the charge-coupled device (CCD) principle. The device combines a high optical fill factor, insensitivity to offset errors, high sensitivity even with little light, simultaneous data acquisition, small pixel size, and maximum efficiency in use of available signal photons for sinusoidal as well as pulsed radiation signals. The device and method may be used in a time-of-flight (TOF) range imaging system without moving parts, offering 2D or 3D range data.

A UV irradiation apparatus for processing a semiconductor substrate includes: a UV lamp unit; a reaction chamber disposed under the UV lamp unit; a gas ring with nozzles serving as a first electrode between the UV lamp unit and the reaction chamber; a transmission window supported by the gas ring; an RF shield which covers a surface of the transmission window facing the UV lamp unit; a second electrode disposed in the reaction chamber for generating a plasma between the first and second electrodes; and an RF power source for supplying RF power to one of the first or second electrode.

Event planning using social networking enables an efficient implementation of planning an event, as well as minimizing network traffic and optimizing other technological aspects of life. Additional information acquired by sensors and other technology is able to improve the quality of the event planning. Social network information as well as the additional information is able to be used to select aspects of the event such as time, location, and / or many other aspects of the event.

The invention provides a method and apparatus for sealing tissue for applications in such cases where there is a benefit to having an additional sealing capability. In this regard, the preferred embodiment of the invention, in addition to thermal sealing, or alternatively, incorporates a stapling cartridge or similar sealing mechanism into a surgical electrocautery device of the type that is used to seal and dissect long sections of connective tissue that secure organs or segments of organs.

A method of virtualizing memory through shadow page tables that cache translations from multiple guest address spaces in a virtual machine includes a software version of a hardware tagged translation look-aside buffer. Edits to guest page tables are detected by intercepting the creation of guest-writable mappings to guest page tables with translations cached in shadow page tables. The affected cached translations are marked as stale and purged upon an address space switch or an indiscriminate flush of translations by the guest. Thereby, non-stale translations remain cached but stale translations are discarded. The method includes tracking the guest-writable mappings to guest page tables, deferring discovery of such mappings to a guest page table for the first time until a purge of all cached translations when the number of untracked guest page tables exceeds a threshold, and sharing shadow page tables between shadow address spaces and between virtual processors.

The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles comprise steps of extension, ligation, and, preferably, cleavage. In certain embodiments the methods make use of extension probes containing phosphorothiolate linkages and employ agents appropriate to cleave such linkages. In certain embodiments the methods make use of extension probes containing an abasic residue or a damaged base and employ agents appropriate to cleave linkages between a nucleoside and an abasic residue and / or agents appropriate to remove a damaged base from a nucleic acid. The invention provides methods of determining information about a sequence using at least two distinguishably labeled probe families. In certain embodiments the methods acquire less than 2 bits of information from each of a plurality of nucleotides in the template in each cycle. In certain embodiments the sequencing reactions are performed on templates attached to beads, which are immobilized in or on a semi-solid support. The invention further provides sets of labeled extension probes containing phosphorothiolate linkages or trigger residues that are suitable for use in the method. In addition, the invention includes performing multiple sequencing reactions on a single template by removing initializing oligonucleotides and extended strands and performing subsequent reactions using different initializing oligonucleotides. The invention further provides efficient methods for preparing templates, particularly for performing sequencing multiple different templates in parallel. The invention also provides methods for performing ligation and cleavage. The invention also provides new libraries of nucleic acid fragments containing paired tags, and methods of preparing microparticles having multiple different templates (e.g., containing paired tags) attached thereto and of sequencing the templates individually. The invention also provides automated sequencing systems, flow cells, image processing methods, and computer-readable media that store computer-executable instructions (e.g., to perform the image-processing methods) and / or sequence information. In certain embodiments the sequence information is stored in a database.

Field programmable gate arrays (FPGA's) may be structured in accordance with the disclosure to have a register-intensive architecture that provides, for each of plural function-spawning LookUp Tables (e.g. a 4-input, base LUT's) within a logic block, a plurality of in-block accessible registers. A register-feeding multiplexer means may be provided for allowing each of the plural registers to equivalently capture and store a result signal output by the corresponding, base LUT of the plural registers. Registerable, primary and secondary feedthroughs may be provided for each base LUT so that locally-acquired input signals of the LUT may be fed-through to the corresponding, in-block registers for register-recovery purposes without fully consuming (wasting) the lookup resources of the associated, base LUT. A multi-stage, input switch matrix (ISM) may be further provided for acquiring and routing input signals from adjacent, block-interconnect lines (AIL's) and / or block-intra-connect lines (e.g., FB's) to the base LUT's and / or their respective, registerable feedthroughs. Techniques are disclosed for utilizing the many in-block registers and / or the registerable feedthroughs and / or the multi-stage ISM's for efficiently implementing various circuit designs by appropriately configuring such register-intensive FPGA's.

A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family 7 (CE-7) based on the conserved structural features. Further, disinfectant formulations comprising the peracids produced by the processes described herein are provided.

Techniques for arranging operations performable on information in an information processing system are provided. In a system having a plurality of information producers and a plurality of information subscribers, paths are identified over which information traverses, and within which the information is subject to select and / or transform operations. The present invention optimizes the system by reorganizing the sequence of select and transform operations so that transforms follow select operations; and by combining multiple select and transform operations into single select and transform operations, respectively. Using these optimizations, the processing resources of the system can be reorganized, and / or information flow graphs describing the system can be designed, so that the select operations are "pushed" toward the producers, and transform operations are "pushed" toward the subscribers. Efficient content-based routing systems can then be used to implement the select operations.

A new general method for building hybrid processors achieves higher performance in applications by allowing more powerful, tightly-coupled instruction set extensions to be implemented in reconfigurable logic. New instructions set configurations can be discovered and designed by automatic and semi-automatic methods. Improved reconfigurable execution units support deep pipelining, addition of additional registers and register files, compound instructions with many source and destination registers and wide data paths. New interface methods allow lower latency, higher bandwidth connections between hybrid processors and other logic.

A plasma processing apparatus comprising at least a plasma processing chamber for plasma-processing an object; object-holding means for disposing the object in the plasma processing chamber; and plasma-generating means for generating a plasma in the plasma processing chamber. The inner wall of the plasma processing chamber is at least partially covered with an oxide film based on a pre-treating plasma. A plasma processing apparatus and a plasma processing method effectively prevent the spluttering and the etching of the inner wall of the plasma processing chamber while suppressing contamination to the object.

A system and method for paying bills without requiring interaction with the payors disclosed. The system includes a payor control interface, a communications interfacee, a bill generator, and a TCF message generator. The bill generator generates bill records from payor and payee information stored within the system for recurring bills. The bill generator may also generate bill records from the payor and payee information and from bill data messages received from payees. The generated bill records are used by the TCF message generator to generate the EFT messages for transferring funds electronically between payors and payees. Payors may alter the payment amount and date for a bill as well as reverse payment of a bill already paid. Payees are also able to alter recurring bill records or may present bill data so that bill records reflecting variable obligation amounts may be generated.

The lighting device includes: a heat radiating part provided with a cavity that accommodates a part of a plurality of drive circuit components driving a light source module; and a base part provided with a cavity that accommodates another part (e.g., a transistor) of the drive circuit components. Then, the drive circuit components are accommodated in the cavity of the heat radiating part and the cavity of the base part.

A method and apparatus are provided for communicating data across a communication link, in a manner that senses and dynamically adapts to the simultaneous transmission of voice information across the local loop. In accordance with one aspect of the invention, a method is provided for dynamically communicating data over a local loop using a modem comprising the steps of transmitting data in a full-band transmission state, sensing a band-limiting condition, and adjusting the transmission of data from the full-band transmission state to a bandlimited transmission state, in response to the sensing step. In accordance with the method, data may be transmitted by the modem across the local loop at the same time that voice information is communicated via telephone across the same local loop. A significant aspect of the present invention is the dynamic allocation of the data transmission bandwidth, whereby the invention senses a condition indicative of whether voice information is being communicated. If so, then the system shifts and / or narrows the data transmission bandwidth to allow for voice communications without interference from or with the data transmission. However, when no voice information is being communicated, the invention dynamically allocates the data transmission bandwidth to utilize at least a portion, if not all, of the frequency band otherwise used for communicating voice information.

The invention concerns a method for determining whether to grant access of a user equipment (UE) to a radio access network in a present position of the user equipment (UE) within a communications system. The communications system comprises a control node (N1, N2) handling services for the user equipment (UE) and an access node (AN1, AN2) controlling the access network. The method is initiated by receiving a request for service processing for the user equipment (UE) in the control node (N1, N2) with an identification of the user equipment (UE). A subscriber group information is determined for the user equipment (UE) according to the identification of the user equipment and sent to the access node (AN1, AN2). Furthermore, an area access information according to the present location of the user equipment (UE) is determined in the access node (AN1, AN2). The access granting of the user equipment (UE) to the radio access network is performed according to a logical combination of the subscriber group information and the area access information. A communication network, nodes and software programs embodying the invention are also described.

To avoid a fixed assignment of wide-area mobile communication units to components of a container surveillance system for increase of reusability, there is provided a mobile communication device for surveillance of at least one transported unit being carried by a tansporting unit, comprising a short range data communication unit (30) adapted to a short range wireless data exchange with at least one tag attached to the transported unit; a long range data communication unit (32) adapted to a long range wireless data exchange to a transport surveillance system; wherein communication unit the mobile communication unit is fixed to operating equipment of the transported unit or to the transporting unit during surveillance of the transported unit and is detachable from the transported unit or the transporting unit when the transported unit must not be surveyed.

An ultra-low latency optical router with a peta-bit-per-second total aggregate switching bandwidth, that will scale to a total connectivity of 1000 by 1000, and beyond by modular upgrades, that utilizes advanced optical technologies to achieve such high capacity with two to three orders of magnitude less volume and power requirements than the electrical router counter part, that serves as a universal engine to other optical routers being developed by vendors and researchers today, that can function in the context of circuit-switching, flow-switching, burst-switching, and packet-switching, that uses advanced wavelength conversion technology to effectively achieve three methods of contention resolution in the router: deflection in wavelength, deflection in space, and buffering in time, and that interfaces a local network to the Supernet.

A transceiver employing a steerable phased-array antenna includes a modem architecture in which signals from each antenna element in the array are independently processed down to the individual baseband channel level, and digital beamforming is performed at baseband. The data rate reduction from IF to baseband permits parallel signal data from multiple antenna elements to be time multiplexed and serially processed at acceptable data rates at baseband with minimal modem hardware requirements. Both for transmit signal modulation and received signal demodulation, the computation of carrier tracking, automatic gain control (AGC) / power-control, and beamforming are shared by the same processing circuitry for all channels when performed at baseband. The resulting baseband circuitry is only incrementally larger than that required for carrier tracking and AGC alone, yet accomplishes independent beamforming for each antenna element on each user channel.

The method employs interrelated cryptographic processes and protocols to provide reliability to vote casting, ballots recount, and verification of vote or poll results. These cryptographic processes and protocols jointly constitute a cryptographic voting scheme capable of meeting the specific reliability requirements of an electronic voting where voters remotely cast their votes. These reliability requirements include voter authentication and privacy; accurate results, the impossibility of coercion and sale of votes, verifying the final results and, if necessary, the secrecy of intermediate results before completing the vote or poll. The cryptographic voting method minimizes the confidence level to be placed on any of the electronic voting individual party and participants.

A flexible and relatively hardware efficient LDPC encoder is described. The encoder can be implemented with a level of parallelism which is less than the full parallelism of the code structure used to control the encoding process. Each command of a relatively simple microcode used to describe the code structure can be stored and executed multiple times to complete the encoding of a codeword. Different codeword lengths can be supported using the same set of microcode instructions but with the code being implemented a different number of times depending on the lifting factor selected to be used. The LDPC encoder can switch between encoding codewords of different lengths, without the need to change the stored code description information, by simply changing a code lifting factor used to control the encoding processes. When coding codewords shorter than the maximum supported codeword length some block storage locations and / or registers may go unused.

A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family 7 (CE-7) based on the conserved structural features. Further, disinfectant formulations comprising the peracids produced by the processes described herein are provided.

An apparatus and method for providing a virtual graffiti function and a recording medium for the same. The apparatus for providing a virtual graffiti function includes: a touch-screen display for displaying information on its screen, and at the same time receiving user-entry data created by a user touching the screen; and a controller connected to the touch-screen display, which overlaps a graffiti screen image with a main screen image in a virtual graffiti area for providing a portion of the screen with virtual graffiti, classifies the user-entry data created by the user touching the screen into application execution entry data and graffiti entry data according to the touched position and / or method, and processes the classified user-entry data differently from each other. Therefore, the apparatus can effectively implement a graffiti function in a hand-held device limited in size, and can also provide an effective recording medium.