465results about How to "Improve translation" patented technology

The system described herein enables clinicians and researchers to use aggregated genetic and phenotypic data from clinical trials and medical records to make the safest, most effective treatment decisions for each patient. This involves (i) the creation of a standardized ontology for genetic, phenotypic, clinical, pharmacokinetic, pharmacodynamic and other data sets, (ii) the creation of a translation engine to integrate heterogeneous data sets into a database using the standardized ontology, and (iii) the development of statistical methods to perform data validation and outcome prediction with the integrated data. The system is designed to interface with patient electronic medical records (EMRs) in hospitals and laboratories to extract a particular patient's relevant data. The system may also be used in the context of generating phenotypic predictions and enhanced medical laboratory reports for treating clinicians. The system may also be used in the context of leveraging the huge amount of data created in medical and pharmaceutical clinical trials. The ontology and validation rules are designed to be flexible so as to accommodate a disparate set of clients. The system is also designed to be flexible so that it can change to accommodate scientific progress and remain optimally configured.

A method and system of customizing voice translation of a text to speech includes digitally recording speech samples of a known speaker, correlating each of the speech samples with a standardized audio representation, and organizing the recorded speech samples and correlated audio representations into a collection. The collection of speech samples correlated with audio representations is saved as a single voice file and stored in a device capable of translating the text to speech. The voice file is applied to a translation of text to speech so that the translated speech is customized according to the applied voice file.

A translation memory adapted to sentence-based translation includes a first retrieval dictionary of a first language having a first dictionary TRIE structure and a first index TRIE structure, and a second retrieval dictionary of a second language having a second dictionary TRIE structure and a second index TRIE structure. The first and second dictionary TRIE structures respectively store sub character strings on respective paths from roots to multiple nodes thereof. The first and second index TRIE structure respectively store index information to specify the sub character strings stored in the first and second dictionary TRIE structures. The index information stored in the first retrieval dictionary includes identification information that identifies the index information to specify the sub character strings in the second retrieval dictionary that are translations of those in the first retrieval dictionary.

A forceps includes a housing including a shaft. The shaft includes an end effector assembly having a pair of curved jaw members. The jaw members include an electrically conductive surface and a curved blade channel having opposing sidewalls. A cutting blade is configured for translation within the blade channel. Proximal portions of a first sidewall include incident angles of less than five degrees that engage the cutting blade and direct the blade towards a specific point of contact on the opposing sidewall of the curved blade channel.

A system and method is disclosed for formal verification of software programs that advantageously translates the software, which can have bounded recursion, into a Boolean representation comprised of basic blocks and which applies SAT-based model checking to the Boolean representation.

An assembly for securing an electrode lead within a burr hole formed in a patient's skull. The assembly is provided for reliably, easily, and reversibly securing an implanted electrode lead such that the active portion of the lead which is inside the brain tissue within the skull is not subject to unwanted translations when the external portion of the lead is manipulated. The securing assembly has two separate components. The first is a bone port which seats within a preformed burr hole in the skull. The bone port is a cylindrical shaped short tube which includes a means for gripping the skull on the external periphery of the cylinder. The central axial hole of the port is designed to receive the second lead-locking portion of the assembly. The external surface of the lead-locking portion and the interior surface of the central axial hole of the port include an easily engageable coupling means, for example a bayonet locking mechanism. The lead-locking portion has a central electrode passage through which the electrode lead may slide freely in an unlocked disposition. The upper section of the lead-locking portion includes a sliding member which may be selectively manipulated between a closed and open position. The sliding member has a lateral edge which, when the member is moved into the closed position, partially occludes the electrode passage such that an electrode is secured by friction in the passage, thus preventing movement of the active implanted portion of the electrode within the skull. The external portion of the electrode, however, can be manipulated freely.

Disclosed and claimed are vectors having enhanced expression and methods for making and using them. Enhancement of expression is from substantially co-temporal expression of at least one first nucleic acid molecule and at least one second nucleic acid molecule. The second nucleic acid molecule encodes a transcription factor or a translation factor or a transcription factor and a translation factor. The contemporaneous expression can be from operably linking the first and second nucleic molecules to a single promoter, or from operably linking the first nucleic acid molecule to a first promoter and the second nucleic molecule to a second promoter wherein the first and second promoters function substantially contemporaneously. Thus, the first and second nucleic acid molecules can be at the same locus in the vector, or at different loci. The second nucleic acid molecule can encode: one transcription factor or more than one transcription factor; or one translation factor or more than one translation factor; or at least one transcription factor and at least one translation factor. The transcription factor can be from vaccinia H4L, D6, A7, G8R, A1L, A2L, H5R, or combinations thereof. The translation factor can be from a K3L open reading frame, an E3L open reading frame, a VAI RNA, an EBER RNA, a sigma 3 open reading frame, a TRBP open reading frame, or combinations thereof. The vector can be a poxvirus such as an attenuated poxvirus, e.g., NYVAC, or ALVAC.

Traction planets and traction rings can be operationally coupled to a planetary gearset to provide a continuously variable transmission (CVT). The CVT can be used in a bicycle. In one embodiment, the CVT is mounted on the frame of the bicycle at a location forward of the rear wheel hub of the bicycle. In one embodiment, the CVT is mounted on and supported by members of the bicycle frame such that the CVT is coaxial with the crankshaft of the bicycle. The crankshaft is configured to drive elements of the planetary gearset, which are configured to operationally drive the traction rings and the traction planets. Inventive component and subassemblies for such a CVT are disclosed. A shifting mechanism includes a plurality of pivot arms arranged to pivot about the centers of the traction planets as a shift pin hub moves axially.

The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.

The synthesis of capped / tagged RNA, methods of use and kits providing same are contemplated. Tagged RNA permits isolation of RNA transcripts in vitro. The ability to isolate and purify capped RNA results in improved transcription and translation and provides a tool for identifying RNA-protein interactions. Such capped RNA finds use in therapeutic applications, diagnosis and prognosis and in the treatment of cancers and HIV.

Novel cap analogs which are easily synthesized, resulting in high levels of capping efficiency and transcription and improved translation efficiencies are provided. Such caps are methylated at the N7 position of one or both guanosines of the dinucleotide cap as well as at the 3′ position on the ribose ring. Substituent groups on the ribose ring also result in the cap being incorporated in the forward orientation. Also provided are methods useful for preparing capped analogs and using mRNA species containing such analogs are also contemplated herein, as well as kits containing the novel cap analogs.

Embodiments of the invention relate to computerized systems and methods for automatically translating text between natural languages. Text for translation may be broken into segments, which may themselves be templates including placeholders. If an exact match for a segment is found in a translation database, the segment may be matched with its translation from the database. Otherwise, alternate source language text, corresponding to the segment, for which an exact translation is available, may be identified and presented to the user for selection. Text selected by the user may replace the original segment and be matched with its translation.Translation of a segment may be influenced by other translated segments. Additionally, translations may be modified as the user interactively enters and edits text.

A JIT binary translator translates code at a function level of the source code rather than at an opcode level. The JIT binary translator of the invention grabs an entire x86 function out of the source stream, rather than an instruction, translates the whole function into an equivalent function of the target processor, and executes that function all at once before returning to the source stream, thereby reducing context switching. Also, since the JIT binary translator sees the entire source code function context at once the software emulator may optimize the code translation. For example, the JIT binary translator might decide to translate a sequence of x86 instructions into an efficient PPC equivalent sequence. Many such optimizations result in a tighter emulated binary.

A probe used in deep brain stimulation includes a cannula comprising an elongated housing defining an internal aperture and having a base portion with a notch, the housing having a longitudinal axis, and an electrode configured to be inserted through the aperture of the cannula. The electrode and notch are configured such that the electrode will contact the notch when inserted in the cannula and be directed out of the cannula at a non-zero angle relative to the longitudinal axis of the housing.

A computer implemented method of translating source material in a source natural language into a target natural language includes receiving a first data input which is a first part of a sub-segment of a translation of the source material from the source natural language into the target natural language, identifying a selectable target text sub-segment in the target natural language associated with the received first data input, and outputting the selectable target text sub-segment. The selectable target text sub-segment is extracted from a corpus of previously translated text segment pairs, each text segment pair having a source text segment in the source natural language and a corresponding translated text segment in the target natural language.

A forceps includes a housing including a shaft. The shaft includes an end effector assembly having a pair of curved jaw members. The jaw members include an electrically conductive surface and a curved blade channel having opposing sidewalls. A cutting blade is configured for translation within the blade channel. Proximal portions of a first sidewall include incident angles of less than five degrees that engage the cutting blade and direct the blade towards a specific point of contact on the opposing sidewall of the curved blade channel.

Methods are disclosed for performing proper word alignment that satisfy constraints of coverage and transitive closure. Initially, a translation matrix which defines word association measures between source and target words of a corpus of bilingual translations of source and target sentences is computed. Subsequently, in a first method, the association measures in the translation matrix are factorized and orthogonalized to produce cepts for the source and target words, which resulting matrix factors may then be, optionally, multiplied to produce an alignment matrix. In a second method, the association measures in the translation matrix are thresholded, and then closed by transitivity, to produce an alignment matrix, which may then be, optionally, factorized to produce cepts. The resulting cepts or alignment matrices may then be used by any number of natural language applications for identifying words that are properly aligned.

A network element that is capable facilitating the routing and accounting of messages between a plurality of network elements that do not share a common signaling application protocol nor a common transport protocol suite. In one embodiment of the present invention, a Multi-Protocol Gateway (MPG) is adapted to receive a signaling message and subsequently translate both the signaling and transport protocol suite prior to message routing. The MPG node is also configured to create and maintain usage and measurements data that may subsequently be used to produce billing records.

Novel cap analogs which are easily synthesized, resulting in high levels of capping efficiency and transcription and improved translation efficiencies are provided. Such caps are methylated at the N7 position of one or both guanosines of the dinucleotide cap as well as at the 3′ position on the ribose ring. Substituent groups on the ribose ring also result in the cap being incorporated in the forward orientation. Also provided are methods useful for preparing capped analogs and using mRNA species containing such analogs are also contemplated herein, as well as kits containing the novel cap analogs.

A forceps includes an end effector assembly having first and second jaw members. Each jaw member includes a proximal flange having an inwardly-facing surface. The proximal flanges are coupled to one another for moving the jaw members relative to one another between a first position and a second position for grasping tissue therebetween. The inwardly-facing surfaces of the proximal flanges are disposed in abutting relation relative to one another. A knife is configured to move along a knife path defined along an outwardly-facing surface of one of the proximal flanges. The knife is movable between a retracted position and an extended position, wherein the knife extends between the jaw members to cut tissue grasped therebetween.

A method and apparatus to align and edit chunks of text and translation. Language learners compare segments of text and translation. Both text and translation are segmented into word groups or “chunks” and related to each other. The related chunks are aligned to facilitate their comparison. For a reader, unfamiliar chunks can be related to more familiar chunks. Constant alignment of text and translation chunks occurs in many variable outputs, including bifocal formats and directly editable alignments. Thus, human edits and improvements input into the system can inform improving machine chunk translation. Both text and translation are editable within one single document, manageable in a wide variety of text editing environments, including common Textarea Input fields. Resulting chunk translations are easily printed on paper and / or displayed electronically. Language learners using the system may include humans and machines. Productions of aligned texts are customized for individual language learners.

A surgical retrieval apparatus includes a housing having an elongated sleeve extending therefrom that, together, cooperate to define a lumen extending therethrough. A shaft having an end effector assembly disposed at a distal end thereof is selectively translatable between a first position, wherein the end effector assembly is disposed within the sleeve, and a second position, wherein the end effector assembly extends distally from the sleeve. A specimen retrieval bag is releasably coupled to the end effector assembly and is deployable to an extended position upon movement of the end effector assembly from the first to the second position.

A method and an apparatus for facilitating the translation of computer programs from a source natural language into one or more target natural languages are provided. According to the present invention, development of a source computer program may proceed in parallel with translation of the source computer program into one or more target languages. According to the present invention, status records are updated from time to time, so that a complete and accurate translation of the source program into the target language or languages is obtained.

The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.

The present invention relates to a system and method of translating stored data. In particular the present invention facilitates multilingual interaction with a data store by providing a translation component between data stored in one language and users that prefer to interact in one or more different languages. Queries or commands can be executed on a database and results presented in any one of a plurality of languages selected by a user. Furthermore, a mechanism is also provided to allow users to enter queries in their preferred language rather than the language of the underlying system.

A system and method is disclosed for formal verification of software programs that advantageously translates the software, which can have bounded recursion, into a Boolean representation comprised of basic blocks and which applies SAT-based model checking to the Boolean representation.

Disclosed is a two-component device for closing a laceration or incision. The device includes a first component comprising a first adhesive-backed anchoring member and one or more first connecting members extending from one edge thereof in a first direction. Also included is a second component comprising a second adhesive-backed anchoring member and one or more second connecting members extending from one edge thereof in a second direction generally opposite to the first direction. Means for attaching the one or more first connecting members to the second anchoring member and means for attaching the one or more second connecting members to the first anchoring member is also provided. The attachment of the connecting members to the anchoring members forms attached and bridging portions of the one or more connecting members, the attached portions being attached to an anchoring member, and the bridging portions spanning the over-laceration area between the first and second anchoring members. The first and second components disclosed are transparent, so that visual inspection of the laceration can be achieved subsequent to application of the device. Methods of use are also disclosed.

A method of improving translation knowledge includes the steps of preparing a set of translation knowledge, preparing a bilingual corpus of a source language and a target language, machine-translating sentences of the source language in the bilingual corpus to the target language using a set of translation knowledge, evaluating translation quality of the resulting translations in accordance with a prescribed evaluation standard, calculating degree of contribution to translation quality of a part of the translation knowledge, and removing the corresponding part of the translation knowledge when the calculated degree of contribution of the part is negative.