72 results about "Transplant Procedure" patented technology

Medical procedure trays and related methods are provided to accommodate joining a first non-sterile medical device with a second sterile medical device and maintaining required sterilization of the second sterile medical device to perform an associated medical procedure. One example of such medical procedures includes biopsy of a bone and / or associated bone marrow using a non-sterile powered drive and a sterile biopsy needle or biopsy needle set. Medical procedure trays and related methods may also be provided for use during aspiration of bone marrow and / or stem cell transplant procedures. Each medical procedure tray may include a containment bag or sterile sleeve. A coupler assembly, one or more sharps protectors, a biopsy sample ejector and / or associated ejector funnel may also be included. Some medical procedure trays may allow engaging a non-sterile powered driver with one end of a coupler assembly and sealing the non-sterile powered driver in a sterile sleeve or containment bag without compromising sterility of other components in the medical procedure tray.

Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer.

Apparatus and methods are provided to remove biopsy specimens from a bone and / or associated bone marrow using a powered drive and an intraosseous (IO) needle set. The powered driver may rotate the IO needle set at an optimum speed to obtain a biopsy sample of bone and / or bone marrow. Apparatus and methods may also be provided for aspiration of bone marrow and / or stem cell transplant procedures. The apparatus may include a powered driver, a coupler assembly, a containment bag or sterile sleeve and various IO needles and IO needle sets with associated hubs and / or hub assemblies. Each IO needle set may include a cannula or catheter and an associated trocar stylet with respective tips operable to penetrate a bone and / or bone marrow with minimum trauma to a patient. Each hub assembly may be used to releasably dispose a respective stylet within an associated generally hollow cannula. Some coupler assemblies and / or hub assemblies may also be used with manual drivers.

Apparatus and methods are provided to remove biopsy specimens from a bone and / or associated bone marrow using a powered drive and an intraosseous (IO) needle set. The powered driver may rotate the IO needle set at an optimum speed to obtain a biopsy sample of bone and / or bone marrow. Apparatus and methods may also be provided for aspiration of bone marrow and / or stem cell transplant procedures. The apparatus may include a powered driver, a coupler assembly, a containment bag or sterile sleeve and various IO needles and IO needle sets with associated hubs and / or hub assemblies. Each IO needle set may include a cannula or catheter and an associated trocar stylet with respective tips operable to penetrate a bone and / or bone marrow with minimum trauma to a patient. Each hub assembly may be used to releasably dispose a respective stylet within an associated generally hollow cannula. Some coupler assemblies and / or hub assemblies may also be used with manual drivers.

Various devices and methods may be provided to aspirate bone marrow from an associated bone using a powered drive and an aspiration needle or aspiration needle set. Such aspiration devices and methods may also be used in association with stem cell transplant procedures. The aspiration devices may include a coupler assembly, a containment bag or sterile sleeve, an ejector and / or an ejector funnel. An aspiration needle set may include a cannula and trocar with respective tips having optimum configurations, dimensions and / or orientations relative to each other to optimize penetration of a bone and / or bone marrow with minimum trauma to a patient. Exterior portions of some cannulas may include markings to indicate depth of penetration into associated bone marrow. Some cannulas may include one or more side ports for use during aspiration of bone marrow.

A method of conditioning a soft tissue region or site of a patient prior to, during or after a fat grafting procedure, or any combination of these, has the steps of: activating an ultrasonic or acoustic shock wave generator or source to emit ultrasonic or acoustic shock waves; subjecting the soft tissue region or site to ultrasonic or acoustic shock waves stimulating the said soft tissue; wherein the emitted waves are focused or unfocused low energy acoustic shock waves or ultrasonic waves and wherein the soft tissue region or site underlies the patient's skin. The soft tissue region or site is one of a buttock, a breast or a scalp. The method of conditioning a soft tissue region or site further has the step of: treating the soft tissue region or site after conditioning and implanting or injecting viable fat cells in a fat grafting procedure.

Medical procedure trays and related methods are provided to accommodate joining a first non-sterile medical device with a second sterile medical device and maintaining required sterilization of the second sterile medical device to perform an associated medical procedure. One example of such medical procedures includes biopsy of a bone and / or associated bone marrow using a non-sterile powered drive and a sterile biopsy needle or biopsy needle set. Medical procedure trays and related methods may also be provided for use during aspiration of bone marrow and / or stem cell transplant procedures. Each medical procedure tray may include a containment bag or sterile sleeve. A coupler assembly, one or more sharps protectors, a biopsy sample ejector and / or associated ejector funnel may also be included. Some medical procedure trays may allow engaging a non-sterile powered driver with one end of a coupler assembly and sealing the non-sterile powered driver in a sterile sleeve or containment bag without compromising sterility of other components in the medical procedure tray.

The invention provides compositions and methods useful for the depletion of CD117+ cells and for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others. Described herein are antibodies, antigen-binding fragments, and conjugates thereof that can be applied to effect the treatment of these conditions, for instance, by depleting a population of CD117+ cells in a patient, such as a human. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting a population of CD117+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure.

The invention provides compositions and methods useful for the depletion of CD117+ cells and for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others. Described herein are antibodies, antigen-binding fragments, ligands, and conjugates thereof that can be applied to effect the treatment of these conditions, for instance, by depleting a population of CD117+ cells in a patient, such as a human. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting a population of CD117+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure.

The invention discloses an environment-friendly, high-yield and high-quality planting method for flos chrysanthemi. The environment-friendly, high-yield and high-quality planting method includes steps of cultivating seedlings; preparing lands; transplanting the seedlings; managing and controlling water and fertilizers; carrying out top dressing; preventing insects and diseases; carrying out pruning; picking the flos chrysanthemi. The environment-friendly, high-yield and high-quality planting method has the advantages that the death rate of the flos chrysanthemi can be effectively reduced in transplanting procedures, the virus carrying volumes of the seedlings can be reduced to a great extent, and accordingly the quality of the seedlings can be guaranteed; the water and the fertilizers are managed and controlled in planting procedures, top dressing is carried out in the planting procedures, accordingly, flos chrysanthemi plants are neat and robust, and the flos chrysanthemi in flowering periods has healthful flower colors and strong fragrance; large quantities of biological organic fertilizers and plant type sterilization insecticide pesticides are used in planting periods, accordingly, the environment-friendly, high-yield and high-quality planting method is little in environmental pollution, and the flos chrysanthemi is free of pesticide residues; the flos chrysanthemi cultivated by the aid of the environment-friendly, high-yield and high-quality planting method is high in yield and quality, and accordingly the environment-friendly, high-yield and high-quality planting method is applicable to standard large-area flos chrysanthemi cultivation and production and has a high practical value and an excellent application prospect.

A bone graft substitute for use in orthopedic bone grafting procedures comprising a radiolucent bone graft substitute combined with a temporary radiopaque agent. Methods of making and using the composition are also disclosed. Bone graft substitutes have become an effective means of regenerating bone in orthopedic procedures where bone loss results from surgically created defects or traumatic injury to the bone. Bone graft substitutes include mineral-based materials such as hydroxyapatite, calcium phosphates, and calcium phosphosilicates as well as allograft-derived materials and xenograft-derived materials such as collagen-based matrices and demineralized bone matrices.

The invention relates to an endothelized artificial matrix comprising a fibrin gel, which is a superproducer of proantiogenic factors. The inventive matrix comprises a fibrin gel containing embedded endothelial cells which have been transfected in vitro with at least one adenoviral vector containing the sequence encoding at least one proangiogenic factor, which is inserted such that it can be overexpressed in said endothelial cells. The insertion of the aforementioned matrix between a flap and the receptor site thereof during a transplant procedure improves the survival rates of said flap, since the endothelized matrix can induce angiogenesis both in the flap and in the receptor site and, in this way, improve the vascularization of the transplanted area.

The present invention relates to a composition for preserving cells, tissues and organs, comprising as an active ingredient indole and indazole compounds of formula (1), or a pharmaceutically acceptable salt or isomer thereof, which are effective for preventing injury of organs, isolated cell systems or tissues caused by cold storage, transplant operation or post-transplantation reperfusion; a preservation method; and a preparation method of the composition.

The invention provides compositions and methods useful for the depletion of CD117+ cells and for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others. Described herein are antibodies, antigen-binding fragments, and conjugates thereof that can be applied to effect the treatment of these conditions, for instance, by depleting a population of CD117+ cells in a patient, such as a human. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting a population of CD117+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure.