260 results about "Organ damage" patented technology

This invention relates to active protective garments which are inconspicuously worn by an individual and which activate upon certain conditions being met. Activation causes inflation of regions of the active protective garment to provide padding and impact cushioning for the wearer. The invention is an active protective garment such as pair of shorts or pants, a jacket, a vest, underwear, and the like. The garments comprise multiple layers of material that constrain pockets or regions that are inflatable by a source of compressed gas or foam. The garments also comprise sensors to detect ballistic parameters such as acceleration, distance, relative acceleration, and rotation. The sensor information is used to determine whether activation is required. Detection and activation are accomplished in a very short time period in order to offer maximal protection for the individual wearing the garment. The system comprises a computer or logic controller that monitors the sensor data in real time and coordinates the information from all sensors. The system calculates velocity, distance, and rotational velocity. A rule-based system is used to detect a complex fall in progress and discriminate said fall in progress from the events of every day life. The pockets or inflatable regions of the garment protect the individual against falls and other impacts that may cause bone fracture or organ damage.

An optical method and apparatus is utilized to quantify ischemic tissue and / or organ injury. Such a method and apparatus is non-invasive, non-traumatic, portable, and can make measurements in a matter of seconds. Moreover, such a method and apparatus can be realized through optical fiber probes, making it possible to take measurements of target organs deep within a patient's body. Such a technology provides a means of detecting and quantifying tissue injury in its early stages, before it is clinically apparent and before irreversible damage has occurred.

The present invention identifies biomarkers that are diagnostic of nerve cell injury, organ injury, and / or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.

Modified annexin proteins, including a homodimer of human annexin V, are provided. Methods for their use, such as to prevent thrombosis without increasing hemorrhage, enhancing the survivability of platelets during storage or transfusion and to attenuate ischemia-reperfusion injury (IPI), are also provided. The modified annexins bind phosphatidylserine (PS) on cell surfaces, thereby preventing the assembly of the prothromkinase complex. The modified annexin decreases the binding of leukocytes and platelets during post-ischemic reperfusion, thereby restoring microvascular blood flow and decreasing organ damage. In addition, the modified annexin prevents lipid loss from platelets during storage.

The presently disclosed subject matter provides methods of isolating populations of stem cells that from bone marrow, peripheral blood, and / or other sources. Also provided are methods of using the stem cells for treating tissue and / or organ damage in a subject.