109 results about "Tissue trauma" patented technology

The present invention relates to the use of a gene transfer product to reduce hyperplastic connective tissue growth after tissue trauma or implantation of a medical device. The present invention also relates to a medical device with improved biological properties for an at least partial contact with blood, bodily fluids and/or tissues when introduced in a mammalian body, which device comprises a core and a nucleic acid, encoding a product capable of leading to production of extracellular superoxide dismutase present in a biologically compatible medium. Said nucleic acid encodes a translation or transcription product, which is capable of inhibiting hyperplastic connective tissue growth and promoting endothelialisation in vivo at least partially on a synthetic surface of said core. The present invention also relates to a method of producing a medical device according to the invention.

A flexible medical intubation instrument provided for placement into an animal or human patient comprises a catheter with at least a pair of longitudinally extending lumens or channels including a sensor and/or actuator channel and a working channel. In the sensor/actuator channel is provided a fixed or slideably removable sensor cable having a sensor for sensing a characteristic or condition including any of the following: a visual sensor for optical viewing, a chemical sensor, a pH sensor, a pressure sensor, an infection sensor, an audio sensor, or a temperature sensor. The sensors are coupled by the sensor/actuator cable through light transmission, electric current, or radio transmission to a viewing instrument or other output device such as a meter or video screen for displaying the condition that is sensed within the body of the patient while the flexibility of the composite structure comprising the catheter and cable enable the entire instrument to flex laterally as it moves through curved passages or around obstructions during insertion or removal. While making observations through the sensor channel, the working channel simultaneously functions as a drain or an irrigation duct, a feeding tube, or to provide a passage for the insertion of one or a succession of surgical devices such that the catheter serves as a protective artificial tract or liner as surgical devices are inserted and removed through it in succession so as to minimize tissue trauma, infection, and pain experienced by the patient. The instrument can be used in urology, as well as a visually directed nasogastric tube, as a visually directed external gastrostomy tube, or as a visually directed internal gastric tube or percutaneous endoscopic gastrostomy tube and in other applications.

Tissue dressing assemblies are formed from hydrophilic polymer sponge structures. The tissue dressing assemblies can be used, e.g., (i) stanch, seal, or stabilize a site of tissue injury, tissue trauma, or tissue access; or (ii) form an anti-microbial barrier; or (iii) form an antiviral patch; or (iv) intervene in a bleeding disorder; or (v) release a therapeutic agent; or (vi) treat a mucosal surface; or (vii) combinations thereof. The tissue dressing structures are made compliant, e.g., by (i) micro-fracturing of a substantial portion of the sponge structure by mechanical manipulation prior to use, or (ii) a surface relief pattern formed on a substantial portion of the sponge structure prior to use, or (iii) a pattern of fluid inlet channels formed in a substantial portion of the sponge structure prior to use, or (iv) the impregnation of a sheet material within the sponge structure.

A flexible medical intubation instrument provided for placement into an animal or human patient comprises a catheter with at least one longitudinally extending lumen or channel. A fixed or slideably removable sensor cable is at least partially contained within the channel, having a sensor for sensing a characteristic or condition. While enabling observations through the sensor channel, the working channel may simultaneously function as a drain or an irrigation duct, a feeding tube, or to provide a passage for the insertion of one or a succession of surgical devices such that the catheter serves as a protective artificial tract or liner as surgical devices are inserted and removed through it in succession so as to minimize tissue trauma.

This invention relates to a periodontal instrument and curettage method for separating and removing calculus and diseased granulation tissue from the tooth surface and periodontal cavity in deep pockets greater than 10 mm. The invention is comprised of a straight shaft, a distal portion in parallel orientation with and terminating in a spoon-shaped blade with a rounded tip and continuous sharp edge. The approximate 90 degree angle orientation between the distal and proximal shank portions, rounded blade tip, and parallel alignment of the blade face relative to the distal shank portion enhance maneuverability, accessibility, and efficiency and minimize tissue trauma during periodontal curettage.

The present invention is directed to a combination of therapeutic compounds and treatment methods and kits using the combination. In particular, one of the combination affects the NCca-ATP channel of neural tissue, including neurons, glia and blood vessels within the nervous system. Exemplary SUR1 and/or TRPM4 antagonists that inhibit the NCca-ATP channel may be employed in the combination. The combination therapy also employs one or more of a non-selective cation channel blocker and/or an antagonist of VEFG, NOS, MMP, or thrombin. Exemplary indications for the combination therapy includes the prevention, diminution, and/or treatment of injured or diseased neural tissue, including astrocytes, neurons and capillary endothelial cells, that is due to ischemia, tissue trauma, brain swelling and increased tissue pressure, or other forms of brain or spinal cord disease or injury, for example. In other embodiments, there are methods and compositions directed to antagonists of TRPM4, including at least for therapeutic treatment of traumatic brain injury, cerebral ischemia, central nervous system (CNS) damage, peripheral nervous system (PNS) damage, cerebral hypoxia, or edema, for example.

A method comprises the steps of inserting a microneedle or micropuncture device into a body cavity to achieve a micropuncture into the cavity while reducing tissue trauma at a puncture site. A stepped or tapered guidewire having a reduced diameter distal portion is telescopically disposed through the inner diameter of the microneedle or Micropuncture device. A proximal portion of the guidewire has a diameter larger than the inner diameter of the microneedle or Micropuncture device and extends to a proximal end of the guidewire. The proximal portion is adapted for guiding a larger diameter instrument into and through the vascular system. The microneedle or micropuncture device is withdrawn from the micropuncture while leaving the distal portion of the guidewire extending through the micropuncture. The microneedle or micropuncture device is removed from the guidewire without removing the microneedle or Micropuncture device over the proximal end of the guidewire. As a result, tissue trauma at the puncture site is substantially reduced.

A medical retrieval basket used for entrapping and extracting objects such as urinary and biliary calculi from the body comprising a handle assembly, a flexible shaft, and a basket. The basket comprises a plurality of outwardly disposed shape memory wires and is bulbous in shape at its distal end. Located at the intersection point of the wires at the distal end of the basket is a hub that restricts the degree of relative movement between the wires. This hub also serves to increase contact points with the object to be retrieved and to stabilize the orientation of the basket wires. The substantially tipless configuration of the distal end of the basket permits the basket to retrieve objects from difficult to reach locations and reduces tissue trauma caused by the basket tip. The basket wires have varying cross sectional shapes and sizes in different sections of the basket to optimize the performance to the needs of each section within the basket. The flexible shaft contains a drive wire that exhibits different flexibilities within the same strand of material by varied cross sectional shapes or diameters. This permits the distal section of the shaft to be more flexible, which reduces the possibility of the device shaft limiting the deflection of a flexible endoscope.