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30 results about "Cerebral hypoxia" patented technology

Cerebral hypoxia is a form of hypoxia (reduced supply of oxygen), specifically involving the brain; when the brain is completely deprived of oxygen, it is called cerebral anoxia. There are four categories of cerebral hypoxia; they are, in order of severity: diffuse cerebral hypoxia (DCH), focal cerebral ischemia, cerebral infarction, and global cerebral ischemia. Prolonged hypoxia induces neuronal cell death via apoptosis, resulting in a hypoxic brain injury.

Multi-Wavelength Spatial Domain Near Infrared Oximeter to Detect Cerebral Hypoxia-Ischemia

Methods and apparatus for measuring cerebral O2 saturation and detecting cerebral hypoxia-ischemia using multi-wavelength near infrared spectroscopy (NIRS). Near-infrared light produced by an emitter is directed through brain tissue. The intensity of the light that passes through the brain tissue is measured using photodiode detectors positioned at distinct distances from the emitter. This process is conducted for at least three wavelengths of near-infrared light. One of the wavelengths used is substantially at an isobestic point for oxy-hemoglobin and deoxy-hemoglobin, but the other two may be any wavelengths within the near-infrared spectrum (700 nm to 900 nm), so long as one of the additional wavelengths is greater than the isobestic point and the other is less than the isobestic point. Tissue oxygenation is calculated using an algorithm derived from the Beer-Lambert law. Cerebral hypoxia-ischemia may be diagnosed using the calculated tissue oxygenation value.
Owner:KURTH CHARLES DEAN

Antagonists of a non-selective cation channel in neural cells

InactiveUS20100092469A1Reduce mortalityReduces stroke sizeBiocideNervous disorderDiseaseNervous system
The present invention is directed to a combination of therapeutic compounds and treatment methods and kits using the combination. In particular, one of the combination affects the NCca-ATP channel of neural tissue, including neurons, glia and blood vessels within the nervous system. Exemplary SUR1 and / or TRPM4 antagonists that inhibit the NCca-ATP channel may be employed in the combination. The combination therapy also employs one or more of a non-selective cation channel blocker and / or an antagonist of VEFG, NOS, MMP, or thrombin. Exemplary indications for the combination therapy includes the prevention, diminution, and / or treatment of injured or diseased neural tissue, including astrocytes, neurons and capillary endothelial cells, that is due to ischemia, tissue trauma, brain swelling and increased tissue pressure, or other forms of brain or spinal cord disease or injury, for example. In other embodiments, there are methods and compositions directed to antagonists of TRPM4, including at least for therapeutic treatment of traumatic brain injury, cerebral ischemia, central nervous system (CNS) damage, peripheral nervous system (PNS) damage, cerebral hypoxia, or edema, for example.
Owner:THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPT OF VETERANS AFFAIRS

Method of reducing brain cell damage or death

A method of reducing the occurrence of brain cell damage or death caused by transient cerebral hypoxia / ischemia condition or a traumatic brain injury (TBI) event. The method typically comprises identifying a subject with a transient cerebral hypoxic and / or ischemic condition, or a TBI, and within 24 hours of onset of the condition, administering to the subject a continuous intravenous infusion dose of methamphetamine in an amount sufficient to reduce the occurrence of brain cell damage or death caused by the condition. Preferably, in addition to the continuous intravenous infusion dose, a bolus dose of methamphetamine is administered to the subject as soon as possible after onset of the condition or occurrence of the TBI event.
Owner:UNIVERSITY OF MONTANA

Method for extracting common macrocarpium fruit total glycoside and application of common macrocarpium fruit total glycoside to preparation of hypoxia tolerant medicines

The invention relates to a method for extracting a common macrocarpium fruit total glycoside and application of the common macrocarpium fruit total glycoside serving as active ingredients to the preparation of hypoxia tolerant medicines. The method comprises the following steps of: boiling, performing enzymolysis for extracting and purifying. The pharmacodynamic test proves that the common macrocarpium fruit total glycoside extracted by the method can improve the cardio-cerebral hypoxia capacity of mice, enhance physical strength, improve antifatigue capacity of organisms, and promote the establishment of hypoxia tolerant acclimatization.
Owner:NORTHWEST UNIV(CN)

Method of reducing brain cell damage, inflammation or death

A method of reducing the occurrence of brain cell damage or death caused by transient cerebral hypoxia, ischemia, brain inflammation or a traumatic brain injury (TBI) event. The method typically comprises identifying a subject with transient cerebral hypoxia, ischemia, brain inflammation or a TBI, and within 24 hours of onset of the condition, administering to the subject a continuous intravenous infusion dose of methamphetamine in an amount sufficient to reduce the occurrence of brain cell damage or death caused by the condition. Preferably, the dose is increased in response to a delay in administration. The invention also relates to a method for modulating cytokine expression within the brain to treat such conditions.
Owner:UNIVERSITY OF MONTANA

2-iminobiotin for use in the treatment of brain cell injury

ActiveUS10525039B2Organic active ingredientsNervous disorderBrain HypoxiaHypoxia ischemia
The present disclosure relates to the use of 2-iminobiotin for treating brain cell injury, in particular in adults. The treatment may be used for the treatment of cerebral hypoxia-ischemia and / or reperfusion injury, including one or more symptoms thereof. Provided are methods of treatment comprising administering a therapeutically effective dose of 2-iminobiotin to an individual in need thereof.
Owner:NEUROPHYXIA

Sunset abelmoschus flower beverage

The invention relates to a beverage, and concretely relates to a health care beverage adopting sunset abelmoschus flower as a raw material. The beverage is prepared by mixing 58-60% of a sunset abelmoschus flower juice with 1-2% of isomaltooligosacharide, 4-5% of fructooligosaccharide, 0.3-0.4% of sorbitol, 0.1-0.2% of citric acid, 0.1-0.2% of malic acid, 0.1-0.3% of xanthan gum, 0.1-0.2% of glucomannan, 0.1-0.2% of sodium chloride, and the balance of water. The beverage has the advantages of easily obtained raw materials, simple process, convenient drinking, suitableness for both young and old, less sugar, moderate sweet and sour taste and no toxic side effects, can be frequently drunk to enhance the human body resistance, improve circulation and resist cerebral ischemia and hypoxia, has a protective effect on cerebral hypoxia injury, and also has inflammation preventing, refreshing, brain strengthening, aging resisting, endocrine regulating, cancer resisting, cancer preventing, blood sugar lowering and blood lipid lowering effects.
Owner:太和县宝丰润中药材种植专业合作社

Method of reducing neuronal cell damage

InactiveCN101516194AImmediate or extended release formulationsBiocideSenses disorderTricyclic antidepressantPharmaceutical care
The present invention is directed to a method of reducing the occurrence of neuronal cell damage, including death, caused by transient cerebral hypoxia and / or ischemia. The method comprises the steps of: diagnosing a subject having a transient cerebral hypoxic and / or ischemic condition; and within 16 hours after onset of the condition, administering to the subject a neuroprotective amount of a pharmaceutical agent. The pharmaceutical agent is preferably selected from the group consisting of: a central nervous system stimulant (CNSS), monoamine neurotransmitter, monoamine oxidase inhibitor (MAOI), tricyclic antidepressant (TCA), or a combination thereof. Preferred agents include amphetamines, methamphetamine, methylphenidate, methylenedioxymethamphetamine, or a combination thereof.
Owner:UNIVERSITY OF MONTANA

Methods for antagonists of a non-selective cation channel in neural cells

The present invention is directed to a combination of therapeutic compounds and treatment methods and kits using the combination. In particular, one of the combination affects the NCCa-ATP channel of neural tissue, including neurons, glia and blood vessels within the nervous system. Exemplary SUR1 and / or TRPM4 antagonists that inhibit the NCCa-ATP channel may be employed in the combination. The combination therapy also employs one or more of a non-selective cation channel blocker and / or an antagonist of VEFG, NOS, MMP, or thrombin. Exemplary indications for the combination therapy includes the prevention, diminution, and / or treatment of injured or diseased neural tissue, including astrocytes, neurons and capillary endothelial cells, that is due to ischemia, tissue trauma, brain swelling and increased tissue pressure, or other forms of brain or spinal cord disease or injury, for example. In other embodiments, there are methods and compositions directed to antagonists of TRPM4, including at least for therapeutic treatment of traumatic brain injury, cerebral ischemia, central nervous system (CNS) damage, peripheral nervous system (PNS) damage, cerebral hypoxia, or edema, for example.
Owner:U S GOVERNMENT REPRESENTED BY THE DEPT OF VETERANS AFFAIRS

Treatment of cerebral hypoxia including stroke, chronic traumatic encephalopathy, and traumatic brain injury

PendingUS20220023350A1Enhance regenerative activityNervous disorderAntibody ingredientsBrain HypoxiaInjury brain
Disclosed are methods, compositions of matter, and means of treatment or prophylaxis using fibroblasts possessing regenerative properties for the treatment of brain injuries including stroke, transient ischemic injuries, chronic traumatic encephalopathy, traumatic brain injury, and tauopathies. Embodiments of the disclosure administer fibroblasts with regenerative properties either systemically, locally, or a combination of the two prior to, concurrent with, or subsequent to a brain injury. In some embodiments of the disclosure fibroblasts or products thereof, are administered intranasally, intrathecally, and / or intravenously.
Owner:FIGENE

Method of reducing brain cell damage, inflammation or death

A method of reducing the occurrence of brain cell damage or death caused by transient cerebral hypoxia, ischemia, brain inflammation or a traumatic brain injury (TBI) event. The method typically comprises identifying a subject with transient cerebral hypoxia, ischemia, brain inflammation or a TBI, and within 24 hours of onset of the condition, administering to the subject a continuous intravenous infusion dose of methamphetamine in an amount sufficient to reduce the occurrence of brain cell damage or death caused by the condition. Preferably, the dose is increased in response to a delay in administration. The invention also relates to a method for modulating cytokine expression within the brain to treat such conditions.
Owner:POULSEN DAVID J +1

Human body brain-invigorating and intelligence-benefiting shampoo and preparation method thereof

The invention discloses human body brain-invigorating and intelligence-benefiting shampoo and a preparation method thereof. A traditional Chinese medicine composition of the shampoo is mainly preparedfrom the following crude drugs: radix angelicae sinensis, rhizoma chuanxiong, fructus psoraleae, semen cuscutae, radix morindae officinalis, fructus alpiniae oxyphyllae, fructus ligustri lucidi, herba epimedii, semen juglandis and fructus lycii. The traditional Chinese medicine composition provided by the invention is used for accelerating brain blood circulation by taking a traditional Chinese medicine method of promoting blood circulation and removing blood stasis, so that the brain circulation amount is increased and cerebral hypoxia is effectively resisted; brain cell energy metabolism and metabolic activity of intra-cerebral neurotransmitters are promoted and the brain-invigorating and intelligence-benefiting effects can be realized after the shampoo is used for a long period.
Owner:伍明权

A kind of traditional Chinese medicine preparation of oxygen-enhancing pill for external use and its preparation and application method

The invention relates to the technical field of Chinese herbal medicines, and in particular relates to a traditional Chinese medicine preparation of an external oxygenation pill, and preparation and using methods thereof. The traditional Chinese medicine preparation comprises the following effective raw materials in parts by weight: 400-600 parts of pine pollen, 100-200 parts of acacia catechu, 50-100 parts of asarum sieboldii, 150-300 parts of siberian cocklour fruit, 100-200 parts of flos magnoliae liliflorae, 100-200 parts of Chinese honeylocust fruit, 80-150 parts of rhizoma nelumbinis, 100-200 parts of angelica dahurica and 100-300 parts of green Chinese onion. A soybean-shaped pill is prepared from the raw materials and is placed in a nostril; the most remarkable effect is achieved in cooperation with a fumigating therapy; after the pill is taken out, the nostril approaches the lower part of a bowl containing boiled fumigating drugs including 4-7 parts of flos magnoliae liliflorae, 15-25 parts of siberian cocklour fruit, 10-18 parts of angelica dahurica, 15-30 parts of lily and 5-15 parts of green Chinese onion, and is fumigated. The traditional Chinese medicine preparation has the advantages that the components are simple; a formula is reasonable; a remarkable treatment effect is achieved; cerebral hypoxia and headache caused by altitude stress and altitude anoxia, nasal obstruction and headache caused by rhinitis, dyspnea and pneumonia caused by cold and the like are mainly treated.
Owner:谭春哲

Cell Beauty Preparations

The invention discloses a cell beauty preparation, and the technical problem to be solved is to treat gynecological diseases and qi and blood caused by chloasma, senile plaque, pigmentation, acne, alopecia, psoriasis, vitiligo, hyperthyroidism, hypothyroidism, frailty, cold and dampness Deficiency, low immune function, cerebral anemia, cerebral hypoxia, fatigue and menopausal syndrome. This product is made of the following raw materials in mass ratio: ants 1-6000, pearl powder 1-3500, motherwort 1-2000, angelica 1-1500, bee pollen 1-2500, medlar 1-3000. Compared with the prior art, the present invention provides necessary and sufficient life substances to human tissue cells by nourishing the kidneys and essence, replenishing qi and nourishing blood, clearing the meridians, ensuring the integrity of the cell structure and the normal progress of metabolism, and making the tissue cells full of youth. Vitality, delaying the aging process of cells, and solving wrinkles, pigmentation, memory loss, and lack of energy caused by the inability of cells to carry out normal life activities.
Owner:深圳市日月神生物科技股份有限公司

Methods of reducing brain cell apoptosis

A method of reducing the occurrence of brain cell damage or death caused by transient cerebral hypoxia / ischemia condition or a traumatic brain injury (TBI) event. The method typically comprises identifying a subject with a transient cerebral hypoxic and / or ischemic condition, or a TBI, and within 24 hours of onset of the condition, administering to the subject a continuous intravenous infusion dose of methamphetamine in an amount sufficient to reduce the occurrence of brain cell damage or death caused by the condition. Preferably, in addition to the continuous intravenous infusion dose, a bolus dose of methamphetamine is administered to the subject as soon as possible after onset of the condition or occurrence of the TBI event.
Owner:UNIVERSITY OF MONTANA

Method for extracting common macrocarpium fruit total glycoside and application of common macrocarpium fruit total glycoside to preparation of hypoxia tolerant medicines

The invention relates to a method for extracting a common macrocarpium fruit total glycoside and application of the common macrocarpium fruit total glycoside serving as active ingredients to the preparation of hypoxia tolerant medicines. The method comprises the following steps of: boiling, performing enzymolysis for extracting and purifying. The pharmacodynamic test proves that the common macrocarpium fruit total glycoside extracted by the method can improve the cardio-cerebral hypoxia capacity of mice, enhance physical strength, improve antifatigue capacity of organisms, and promote the establishment of hypoxia tolerant acclimatization.
Owner:NORTHWEST UNIV

Drinking bottle with aeration device

The invention relates to a drinking water bottle with an oxygen increasing device and relates to a drinking water packaging product. The drinking water bottle with an oxygen increasing device is suitable for the occasion where the existing bottled drinking water is used. The freshness of the known bottled water is obviously reduced, and the freshness of the water is mainly related to the oxygen solubility of the water. In order to overcome the defect that the existing drinking water bottle cannot maintain the taste of water quality, the drinking water bottle with an oxygenation device provided by the present invention can not only hold drinking water, but also improve the oxygen solubility of drinking water before drinking, and improve the safety of bottled water. water quality. For brain hypoxia, excessive exercise, and high temperature weather, drinking oxygen-containing water is beneficial to the body. The drinking water bottle is composed of a water bottle main body, a main bottle cap, an attached bottle cap, an oxygen connecting tube, and an oxygen overflow bag. It consists of a connector, the bottom piece of the oxygen overflow bag, and the top piece of the oxygen overflow bag. (see Attachment).
Owner:浙江龙鹰光电科技有限公司

Application of folium mori total alkaloids in preparation of medicine for preventing and treating cerebral ischemia injury

ActiveCN114796318ASmall doseReduce the amount of peroxidation productsNervous disorderCardiovascular disorderDiseasePharmaceutical drug
The invention relates to novel application of mulberry leaf extract, in particular to application of mulberry leaf total alkaloids in preparation of drugs for preventing and treating cerebral ischemia injury. The mulberry leaf total alkaloid can be used as an effective component to be applied to a medicine for preventing and treating cerebral ischemic stroke, and the new application of mulberry leaves is expanded. A new choice is provided for preventing and treating cerebral ischemic stroke; specifically, the invention relates to application of mulberry leaf total alkaloids in drugs for preventing and treating cerebral ischemic stroke. The invention relates to application of mulberry leaf total alkaloids in medicines for preventing and treating cerebral ischemic diseases. The invention discloses application of mulberry leaf total alkaloids in preparation of drugs for preventing and treating cerebral hypoxia fatigue. The invention relates to application in preparation of medicines for preventing and treating myocardial ischemia diseases.
Owner:CHINA PHARM UNIV

Acupoint stimulating structure

The invention discloses an acupoint stimulating structure. The acupoint stimulating structure comprises a main body and a bottom plate. The technical effect of the acupoint stimulating structure is asfollows: 1, the acupoint stimulating structure has a certain curative effect to cervical and lumbar pain, cerebral numbness, blood current circle, cerebral hypoxia and the like; 2, the acupoint stimulating structure is suitable for a pillow, a back cushion, a seating cushion, a mattress, a chair and the like, and can be used in multiple situations, the interior of a body is provided with a stimulating mechanism, and a spring is used for ejecting a stimulating needle for pressing a human body acupoint, so the acupoint is stimulated; 3, the acupoint stimulating structure can be ascended and descended in a lifting groove by using an adjusting structure, and the strength is adjusted by adjusting a height of the stimulating needle, so the acupoint stimulating structure is suitable for the different crowds; and 4, the acupoint stimulating structure is made of incense wood optimally, and has a nerves-calming function, the acupoint stimulating structure is capable of performing self-massage by using a human body sleeping posture or a sitting posture, a negative effect cannot be brought to a person, and a safety failure problem does not exist in the acupoint stimulating structure.
Owner:资龙

Health improving wine

InactiveCN106177256AEnhance immune functionEnhanced resistance to radiation damageSenses disorderNervous disorderDiseaseAmnesia
The invention discloses health improving wine. The wine has efficacies of liver-kidney nourishing, spleen-stomach strengthening, bone and muscle strengthening, heart-heat clearing, nerve calming, lung moistening, Qi replenishing, marrow and semen generation promoting, intelligence improving, mind refreshing, blood circulation promoting, meridian activating, wind dispelling and dampness removing and is extremely beneficial to conditioning of internal organs. People frequently drink the wine can be improved in physical fitness and body immunity, the wine has an excellent regulation effect on valetudinarianism, intolerance of cold and chronic fatigue syndromes including cerebral hypoxia, physical decline, neurasthenia, tinnitus, insomnia, amnesia, irritability, sharp sexual function decline and the like caused by staying up or high work stress, and the wine further has a great curative effect on whole-body fatigue, limb weakness, whole-body discomfort, activity slowness, myalgia, loss of appetite, greasiness rejecting, lack of hunger sensation, dietary bias, indigestion, abdominal distention, excrement form change, astriction, dryness, stool frequency increase and the like caused by non-internal medicine or psychiatry diseases.
Owner:东莞市青杉信息科技有限公司

Method of reducing neuronal cell damage

InactiveCN103479603AImmediate or extended release formulationsSenses disorderNervous disorderTricyclic antidepressantAmine oxidase inhibitors
The present invention is directed to a method of reducing the occurrence of neuronal cell damage, including death, caused by transient cerebral hypoxia and / or ischemia. The method comprises the steps of: diagnosing a subject having a transient cerebral hypoxic and / or ischemic condition; and within 16 hours after onset of the condition, administering to the subject a neuroprotective amount of a pharmaceutical agent. The pharmaceutical agent is preferably selected from the group consisting of: a central nervous system stimulant (CNSS), monoamine neurotransmitter, monoamine oxidase inhibitor (MAOI), tricyclic antidepressant (TCA), or a combination thereof. Preferred agents include amphetamines, methamphetamine, methylphenidate, methylenedioxymethamphetamine, or a combination thereof.
Owner:UNIVERSITY OF MONTANA

A preparation method of rhodiola highland barley health wine with the function of preventing cerebral hypoxia

The invention discloses a production method of rhodiola and highland barley health wine with the function of preventing cerebral hypoxia, and belongs to the technical field of wine making. The invention utilizes Rhodiola rosea, coriander root and highland barley to co-ferment health-care wine, adopts the method of preliminary enzymolysis and extruding and puffing, not only effectively shortens the process time, but more importantly increases the content of active substances in Rhodiola rosea and coriander root. Utilization rate, combined with the mixed bacteria fermentation process in the subsequent fermentation, further improves the utilization rate of raw materials, and at the same time makes the whole process easy to control and improves the stability of the product. The obtained rhodiola highland barley health wine has the function of preventing brain hypoxia, and at the same time, the dissolution rate of the active ingredients in the rhodiola is high, and the bad flavor of the rhodiola itself is improved.
Owner:西藏藏缘青稞科技有限公司

Traditional Chinese medicine preparation of external oxygenation pill, and preparation and using methods thereof

The invention relates to the technical field of Chinese herbal medicines, and in particular relates to a traditional Chinese medicine preparation of an external oxygenation pill, and preparation and using methods thereof. The traditional Chinese medicine preparation comprises the following effective raw materials in parts by weight: 400-600 parts of pine pollen, 100-200 parts of acacia catechu, 50-100 parts of asarum sieboldii, 150-300 parts of siberian cocklour fruit, 100-200 parts of flos magnoliae liliflorae, 100-200 parts of Chinese honeylocust fruit, 80-150 parts of rhizoma nelumbinis, 100-200 parts of angelica dahurica and 100-300 parts of green Chinese onion. A soybean-shaped pill is prepared from the raw materials and is placed in a nostril; the most remarkable effect is achieved in cooperation with a fumigating therapy; after the pill is taken out, the nostril approaches the lower part of a bowl containing boiled fumigating drugs including 4-7 parts of flos magnoliae liliflorae, 15-25 parts of siberian cocklour fruit, 10-18 parts of angelica dahurica, 15-30 parts of lily and 5-15 parts of green Chinese onion, and is fumigated. The traditional Chinese medicine preparation has the advantages that the components are simple; a formula is reasonable; a remarkable treatment effect is achieved; cerebral hypoxia and headache caused by altitude stress and altitude anoxia, nasal obstruction and headache caused by rhinitis, dyspnea and pneumonia caused by cold and the like are mainly treated.
Owner:谭春哲

Cerebral hypoxia tolerance training device

The invention relates to a cerebral hypoxia tolerance training device comprising a U-shaped protection jacket (1). An adjusting shaft (2) is fixedly connected to the arc surface close to the end surface of the protection jacket (1); the adjusting shaft (2) is in rotation cooperation with a rotating rod (3) having a long strip structure; a flat sleeve (3.1) is arranged at one end of the rotating rod (3); the sleeve (3.1) is provided with a first through hole (3.2); the adjusting shaft (2) is arranged in the first through hole (3.2); and a massage rod (4) is in sliding fit with the long strip part of the rotating rod (3). The cerebral hypoxia tolerance training device is advantageous in that by employing the cerebral hypoxia tolerance training device, a patient can independently complete cerebral hypoxia tolerance training without the help of other people and without the restriction of time and place, the clean and sanitation can be better guaranteed as the patient uses the device independently, and a cotton massage ball makes the patient comfortable.
Owner:YUNNAN SECOND PEOPLES HOSPITAL

Medicine for treating angiocardiopathy and cerebrovascular disease and its preparing method

InactiveCN100536864CGood effectImprove cerebral hypoxia tolerancePowder deliveryLyophilised deliveryDiseaseReperfusion injury
The invention discloses a medicine for treating cardiovascular and cerebrovascular diseases. It is a traditional Chinese medicine injection prepared by extracting and purifying Radix Astragali and Panax notoginseng as raw materials, and adding appropriate amount of medicinal auxiliary materials, including injection, large infusion and freeze-dried powder injection. The invention also discloses a preparation method of the medicine. The medicine of the invention has good stability and long effective period, and can be used for intramuscular injection, intravenous injection or intravenous drip. Pharmacodynamic tests show that the medicine of the present invention has protective effects on cerebral ischemia and myocardial injury in SD rats caused by ischemia-reperfusion. It can significantly improve the ability of mice to withstand cerebral hypoxia, improve neurological symptoms and cerebral edema in rats with cerebral ischemia, and reduce pathological changes; it can obviously inhibit the overflow of LDH and CK during myocardial injury in rats caused by ischemia-reperfusion, and reduce serum LDH, CK activity, narrowing the range of myocardial infarction, for the treatment of cardiovascular and cerebrovascular diseases, rapid onset, definite curative effect, no toxic side effects.
Owner:陈玲玲
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