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108 results about "Vasoconstriction" patented technology
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Vasoconstriction is the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels, in particular the large arteries and small arterioles. The process is the opposite of vasodilation, the widening of blood vessels. The process is particularly important in staunching hemorrhage and acute blood loss. When blood vessels constrict, the flow of blood is restricted or decreased, thus retaining body heat or increasing vascular resistance. This makes the skin turn paler because less blood reaches the surface, reducing the radiation of heat. On a larger level, vasoconstriction is one mechanism by which the body regulates and maintains mean arterial pressure.
Compositions, formulations and kit with anti-sense oligonucleotide and anti-inflammatory steroid and/or obiquinone for treatment of respiratory and lung disesase
InactiveUS20070021360A1Decreased airwayOrganic active ingredientsBiocideDiseaseAntiendomysial antibodies
A pharmaceutical composition and formulations comprise preventative, prophylactic or therapeutic amounts of an oligo(s) anti-sense to a specific gene(s) or its corresponding mRNA(s), and a glucocorticoid and / or non-glucocorticoid steroid or a ubiquinone or their salts. The agents, composition and formulations are used for treatment of ailments associated with impaired respiration, bronchoconstriction, lung allergy(ies) or inflammation, and abnormal levels of adenosine, adenosine receptors, sensitivity to adenosine, lung surfactant and ubiquinone, such as pulmonary fibrosis, vasoconstriction, inflammation, allergies, allergic rhinitis, asthma, impeded respiration, lung pain, cystic fibrosis, bronchoconstriction, COPD, RDS, ARDS, cancer, and others. The present treatment is effectively administered by itself for conditions without known therapies, as a substitute for therapies exhibiting undesirable side effects, or in combination with other treatments, e.g. before, during and after other respiratory system therapies, radiation, chemotherapy, antibody therapy and surgery, among others. Each of the agents of this invention may be administered directly into the respiratory system so that they gain direct access to the lungs, or by other effective routes of administration. A kit comprises a delivery device, the agents and instructions for its use.
Owner:EPIGENESIS PHARMA LLC
Systems, Methods, and/or Apparatuses for Non-Invasive Monitoring of Respiratory Parameters in Sleep Disordered Breathing
ActiveUS20100016694A1Eliminate side effectsIncrease pressureRespiratorsOperating means/releasing devices for valvesPulse oximetersSleep disordered breathing
In certain example embodiments, an air delivery system includes a controllable flow generator operable to generate a supply of pressurized breathable gas to be provided to a patient for treatment and a pulse oximeter. In certain example embodiments, the pulse oximeter is configured to determine, for example, a measure of patient effort during a treatment period and provide a patient effort signal for input to control operation of the flow generator. Oximeter plethysmogram data may be used, for example, to determine estimated breath phase; sleep structure information; autonomic improvement in response to therapy; information relating to relative breathing effort, breathing frequency, and / or breathing phase; vasoconstrictive response, etc. Such data may be useful in diagnostic systems.
Owner:RESMED LTD
Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof
ActiveUS7989593B1Increase oxygenationHigh sensitivityPeptide/protein ingredientsMammal material medical ingredientsArteriolar VasoconstrictionWhite blood cell
A high temperature-stable and highly purified cross-linked (optionally ≧70% β-β linked) tetrameric hemoglobin with high efficiency of oxygen delivery suitable for use in mammals without causing renal injury and vasoconstriction is provided. The dimeric form of hemoglobin is degenerated and purification processes are performed on red blood cells from whole blood. Controlled hypotonic lysis in an instant cytolysis apparatus prevents lysis of white blood cells. Nucleic acids from white blood cells and phospholipids impurities are not detected. Blocking of reactive sulfhydryl groups by a sulfhydryl reagent is performed in an oxygenated environment. Flowthrough column chromatography removes different plasma protein impurities. N-acetyl cysteine is added to the cross-linked tetrameric hemoglobin to maintain a low level of met-hemoglobin. The stabilized hemoglobin is preserved in an infusion bag with aluminum overwrap to prevent formation of inactive met-hemoglobin from oxygen intrusion. The product finds use in tissue oxygenation and cancer treatment.
Owner:BILLION KING INT
Bronchiopulmonary occulsion devices and lung volume reduction methods
InactiveUS20030164168A1Non-invasive and comparatively inexpensiveEfficient and inexpensiveRespiratorsBronchoscopesResorption AtelectasisBronchial tube
Lung volume reduction is performed by the placement of a device (2) into a branch of the airway (34) to prevent air from entering that portion of lung. This will result in adsorption atelectasis of the distal portion of lung. The physiological response in this portion of lung is hypoxic vaso-constriction. The net effect is for a portion of lung to be functionally removed, i.e. a selected portion of lung is removed from both the circulation and ventilation. The build up of secretions is accommodated by using a valve (5, 15, 29) in the obstructive device, the valve opening upon coughing etc.
Owner:PULMONX
Systems, methods, and/or apparatuses for non-invasive monitoring of respiratory parameters in sleep disordered breathing
ActiveUS8646447B2Increase pressureEliminate side effectsRespiratorsOperating means/releasing devices for valvesPulse oximetersSleep disordered breathing
In certain example embodiments, an air delivery system includes a controllable flow generator operable to generate a supply of pressurized breathable gas to be provided to a patient for treatment and a pulse oximeter. In certain example embodiments, the pulse oximeter is configured to determine, for example, a measure of patient effort during a treatment period and provide a patient effort signal for input to control operation of the flow generator. Oximeter plethysmogram data may be used, for example, to determine estimated breath phase; sleep structure information; autonomic improvement in response to therapy; information relating to relative breathing effort, breathing frequency, and / or breathing phase; vasoconstrictive response, etc. Such data may be useful in diagnostic systems.
Owner:RESMED LTD
Blood pumping system
The human heart is assisted in moving blood through blood vessels by alternately applying and relieving pressure about a blood vessel with a vessel constrictor. The blood flow is restricted to one direction along the blood vessel by restrictors. The application of pressure to the blood vessel may be timed with the heart beat.
Owner:ALDERMAN ROBERT J
Stent
The present invention provides a stent which is flexible in the axial direction prior to the expansion of the stent, which shows no contraction in the axial length of the stent during expansion of the stent, which has an extremely large resistance to forces exerted by contracting blood vessels after expansion, which can cause uniform expansion of the struts of the stent, and in which there is no problem of the end portions of the stent warping to a greater diameter than the central portion of the stent at the time of expansion, furthermore a stent in which the size of the basic cells that constitute the stent is reduced so that bulging of endothelial cells of vascular tissues into the inside of the stent is suppressed, furthermore a stent which allows Y stenting into branched blood vessels while maintaining a high radial force and superior scaffold properties.
Owner:KANEKA CORP
Methods and devices for catheter-based intracoronary myocardial delivery of cellular, genetic or biological materials
Methods and systems infuse therapeutic materials into a vascular vessel by means of a catheter based infusion system. In especially preferred forms, the infusate (which comprises a therapeutic material) is infused through a distal end of the catheter and into the vascular vessel by delivering the infusate to the catheter at a substantially constant flow rate while simultaneously imparting a pressure amplitude and frequency to the infusate in dependence upon a sensed pressure condition within the vessel. Preferably, and the pressure amplitude imparted to the constant flow rate of infusate is about twice the vessel systolic pressure. The present invention is therefore especially well suited for the catheter-based infusion of relatively large particles, such as cellular, genetic, viral, polymeric or proteinaceous materials, intravascularly in dependence upon the pressure and flow characteristics of the infusate.
Owner:DUKE UNIV
System and Method for Determining Arterial Compliance and Stiffness
A system and method for calculating the arterial compliance, stiffness, and arterial flow and resistance indices for any artery in issue of a subject having a blood pressure monitoring device configured to calculate systolic and diastolic blood pressure readings for an artery of the subject, a blood flow velocity monitoring device configured to calculate the velocity of blood flowing within the artery of the subject at a peak point of a systolic phase of contraction of the subject's heart muscle, peak-systolic velocity, and the velocity of blood flowing within the artery of the subject at an end point of a diastolic phase of the subject's heart muscle, end-diastolic velocity, and a central processing unit comprising a computer readable program embodied within the central processing unit configured to calculate the arterial compliance, stiffness, and arterial flow and resistance indices as a function of the area of the artery under initial systolic and end diastolic pressure, the area of the artery generating arterial elastic recoil pressure for continuous flow during the systolic and diastolic phases, peak-systolic and end-diastolic arterial flow velocities, and systolic and diastolic blood pressure.
Owner:KURI YAMIL
System and method for detecting symptoms of hypoglycemia
An improved system and method for detecting a hypoglycemic event of a diabetic individual is provided. The system of the invention includes at least three sensors for monitoring the respective physiological parameter selected from the following list: heart rate, motorial activity, respiring rate, vasoconstriction, temperature of the skin and galvanic resistance of the skin of the user. The system automatically alerts the user and / or a member of medical care personnel in a case that at least three different symptoms of a hypoglycemic event, each of which associated with a respective physiological parameter, simultaneously occur. According to the method of the present invention basal levels and basal rates of changes of the respective physiological parameters are generated and repeatedly updated. These basal levels and / or rates provides for detecting changes that go beyond predefined limits for determining a symptom of a hypoglycemic event which is associated with the respective physiological parameter.
Owner:GILI MEDICAL
Intrauterine compression hemostasis method and device
InactiveCN102525590AChange in timeReduce resection rateSurgeryTherapeutic coolingArteriolar VasoconstrictionIce water
The invention discloses an intrauterine compression hemostasis method which comprises the following steps of: putting an elastic hemostasis bag in uterus, and filling low-temperature medium into the elastic hemostasis bag, wherein after the volume of the elastic hemostasis bag is expanded, the compression hemostasis is realized through the pressure of the elastic hemostasis bag on the inner wall of the uterus, and the vasoconstriction of the uterus is promoted by the low-temperature medium. A device realizing the method comprises the elastic hemostasis bag and a connection pipe, wherein the elastic hemostasis bag is provided with only one open end; the open end is in sealed connection with one end of the connection pipe; and a valve is arranged at one end of the connection pipe. The shape of the expanded elastic hemostasis bag is similar to that of the uterine cavity, and pressure in the uterine cavity is uniform; and when the pressure exceeds the systolic arterial pressure, a hemostasis effect is generated for sure. By monitoring the pressure, the autonomous uterine contraction can be discovered in time; and a temperature measuring device displays the change of water temperature, and the ice water can be replaced in time so as to avoid weakening of the hemostasis effect. According to the invention, the operation is simple, the monitoring is visual, the bleeding is minimized to a greatest extent, and the life safety of the patient is guaranteed.
Owner:SHANGHAI TENTH PEOPLES HOSPITAL
Wearable health monitoring device
ActiveUS20200129122A1AngiographyMeasuring/recording heart/pulse rateBlood pressure monitorsIntensive care medicine
A wearable health monitoring includes a monitoring main-body, a wearable component and a biometric monitoring module. The wearable component is connected with the monitoring main-body. The biometric monitoring module is disposed within the monitoring main-body and includes a photoelectric sensor, a pressure sensor and an air-pressure-based blood pressure meter. The air-pressure-based blood pressure meter is embedded and positioned in the embedding slot portion of the embedding seat, and includes a gas-collecting actuator and an elastic air-bag. The gas-collecting actuator transports a gas to the elastic air-bag, and the elastic air-bag is inflated and elastically protrudes to attach to a skin tissue of a wearing user. The pressure sensor measures vasoconstriction pulsation under the skin tissue. A detection signal is generated and converted into health data information, which is outputted to the photoelectric sensor for calibrating a calculation of detection thereof to output precise health data information.
Owner:MICROJET TECH
External-application compound hemostatic analgesia anti-inflammation medicine
InactiveCN1709507AGood hemostasisPlay a hemostatic effectPharmaceutical active ingredientsExternal applicationCurative effect
The present invention discloses a compound hemostatic analgesic anti-inflammatory medicine for external application. It is made up by using (by weight portion) 0.05-5 portions of hemostatic, 0.005-0.02 portion of vasoconstrictor, 0.5-3.0 portions of narcotic and 0.1-5 portions of antimicrobial medicine. At the same time it can be made into various preparations for external application, including spray and powder for external application.
Owner:肖春
Modulators of the g protein-coupled mas receptor and the treatment of disorders related thereto
The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salts, solvates, and hydrates thereof that are useful in methods of treatment and alleviation of diseases and disorders of the heart, brain, kidney, immune, and reproductive system resulting from ischemia, or reperfusion subsequent to ischemia, and any downstream complication(s) related thereto. The present invention further relates to methods of treatment and alleviation of diseases and disorders of the vasculature resulting from vasoconstriction or hypertension and any downstream complication(s) resulting from elevated blood pressure and / or reduced tissue perfusion.
Owner:ARENA PHARMA
Vasoconstriction compositions and methods of use
PendingUS20180360825A1Reducing eye rednessHigh whitenessOrganic active ingredientsSenses disorderArteriolar VasoconstrictionAdrenergic
The invention generally relates to compositions for inducing vasoconstriction. The compositions comprise highly selective alpha-2 adrenergic receptor agonists, at low concentrations, such as below 0.05% weight by volume. The compositions preferably comprise brimonidine. The compositions preferably have pH from about 4.0 to about 7.5.
Owner:EYE THERAPIES
TTG for Body Cooling and Driver Alertness
InactiveUS20130304328A1Dashboard fitting arrangementsDigital data processing detailsDriver/operatorEngineering
A system for keeping a driver alert by employing a thermal grill that includes warm and cool regions. The disclosed system includes an alert module that configures the thermal grill to a heat sink configuration and a heat source configuration. The thermal grill in the heat sink configuration extracts heat from the driver's body, lowers the driver's temperature, and keeps the driver alert. The thermal grill in the heat source configuration raises the driver's temperature and avoids vasoconstriction. The alert module also monitors at least one of the driver's biomarkers like blood flow in the driver's fingers. The alert module monitors the driver's biomarkers to determine when to reconfigure the thermal grill to a configuration other than the heat sink configuration. For example, if the monitored biomarkers indicate that the driver is in a vasoconstricted state, the alert module can reconfigure the thermal grill.
Owner:HONDA MOTOR CO LTD
Application of farrerol, derivative thereof and pharmaceutically-acceptable salts of farrerol and derivative to medicine for treating heart cerebrovascular disease caused by vasoconstriction
InactiveCN102389416ATreat cardiovascular and cerebrovascular diseasesLow toxicityOrganic active ingredientsCardiovascular disorderSide effectVascular ring
The invention discloses new medicinal application of derivatives of flavanone compound farrerol, a pharmaceutically-acceptable salt of the flavanone compound farrerol and farrerol and the pharmaceutically-acceptable salts of the derivatives, particularly application to preparation of a medicine for treating heart cerebrovascular disease caused by vasoconstriction. Through the experiment of an isolated rat aortic vascular ring, the derivatives and the pharmaceutically-acceptable salts thereof have obvious vasodilation effects and simultaneously have the characteristics of low toxicity, small side effect and the like, can be industrially synthesized, are low in price, and can be matched with the pharmaceutically-acceptable medicinal auxiliary materials for use to be prepared into common preparations such as injection, tablets, pills or capsules and the like which can be clinically used for preventing and controlling heart cerebrovascular disease caused by vasoconstriction, so that new methods and means are provided for clinical treatment of heart cerebrovascular disease.
Owner:SHANXI MEDICAL UNIV
Endothelin receptor antagonists
This invention relates to novel endothelin receptor antagonists, derivatives, acceptable acid addition salts thereof. The invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by compounds that block the endothelin signaling pathway that leads to vasoconstriction and in particular those diseases or conditions beneficially treated by endothelin receptor antagonists.
Owner:SUN PHARMA IND INC
Wearable health monitoring device
PendingCN111110215ADiagnostic signal processingEvaluation of blood vesselsSphygmomanometerEmergency medicine
The present invention discloses a wearable health monitoring device. The wearable health monitoring device comprises a monitoring body, a wearable piece and a biological characteristic monitoring module; the wearable piece is connected to outside of the monitoring body; and the biological characteristic monitoring module is arranged in the monitoring body and comprises a photoelectric sensor, a pressure sensor and an air pressure sphygmomanometer, the air pressure sphygmomanometer is positioned in an embedding groove part of an embedding base body and comprises an air collection actuator and an elastic air bag, the air collection actuator supplies air to the elastic air bag, the elastic air bag is inflated to conduct elastic displacement to protrude out of the monitoring body and to be attached to skin tissues of users, the pressure sensor is also used to conduct blood vessel contraction pulsation quantity measurement under the skin tissues to generate detection signals and convert thedetection signals into health data information to be output, and the health data information provides monitoring correcting calculation of the photoelectric sensor to adjust and output the accurate health data information.
Owner:MICROJET TECH
Method of Testing a Patient for Hypertension and Related Method of Treatment and Test Kit
InactiveUS20110044963A1Facilitate simultaneous testingAnalysis using chemical indicatorsPeptide/protein ingredientsAngiotensinogen mrnaMarinobufagenin
Owner:PUSCHETT JULES B
Agent for prophylaxis and treatment of angiostenosis
InactiveUS20060122214A1Good treatment effectPrevent proliferationBiocideOrganic chemistryOrgan transplantationInsertion stent
An agent for the prophylaxis and treatment of vascular constriction is provided, which contains a compound having a Rho kinase inhibitory activity. In particular, a compound having a Rho kinase inhibitory activity, for example, (+)-trans-4-(1-aminoethyl)-1-(4-pyridylcarbamoyl)cyclohexane, suppresses regenerative intima proliferation after disorder of blood vessel and has various other actions. Therefore, it is useful as an agent for the prophylaxis and treatment of vascular constriction, specifically, an agent for the prophylaxis and treatment of vascular constriction induced by disorder of vascular wall, such as vascular restenosis that occurs after an operation of percutaneus transluminal coronary angioplasty, vascular restenosis that occurs after an operation of percutaneus transluminal angioplasty, vascular constriction that occurs after vascular reconstruction, such as DCA, operation of intravascular indwelling of stent and the like, and vascular constriction that occurs after organ transplantation.
Owner:KAI HISASHI +1
Polyanhydrides with therapeutically useful degradation products
InactiveUS20070213500A1Promote degradationEasy to processCosmetic preparationsPowder deliveryTissue reconstructionPolyanhydrides
An aromatic polyanhydride comprising a repeating unit having the structure is disclosed, wherein Ar and R are selected so that the aromatic polyanhydride hydrolyzes to form a therapeutic salicylate, another non-steroidal anti-inflammatory, an antifibrotic aminobenzoate, or a vasoconstricting phenylethanolamine. Implantable medical devices, such as scaffolding implants for tissue reconstruction, drug delivery systems prepared from the aromatic polyanhydrides, as well as therapeutic dosage forms and treatment methods are also disclosed.
Owner:XENOGENICS
Transfusion anti-leakage device for patient nursing and use method thereof
InactiveCN109771745APrevent leakageAvoid extravasationRoller massageIntravenous devicesCircular discHeater Rod
The invention discloses an infusion anti-leakage device for patient nursing, which comprises a first box body, wherein four corners of the bottom end of the first box body are respectively clamped with suckers; a right side screw of an inner cavity of the first box body is connected with a small speed reduction motor; the small speed reduction motor is connected with a singlechip microcomputer circuit; the output end of the small speed reduction motor is welded with a disc; the inner cavity of the disc is clamped with a plurality of heating rods from top to bottom; the circumference of the upper surface of the disc is provided with a plurality of second through holes; the circumference of the top end of the disc is welded with one end of a cylindrical rod by taking the second through holesas circle centers; the other end of the cylindrical rod extend into a circle groove formed in the upper surface of the disc; the top end of the cylindrical rod is clamped with a massage ball. According to the invention, the fingers of a patient can be fixed, and the palm can be massaged and relaxed; and meanwhile, during infusion, the heating rods are used for heating to promote the massager to generate heat to keep the palm warm, so that the phenomenon of extravasation caused by blood vessel contraction is avoided.
Owner:王萍
Novel hemostatic patch and uses thereof
InactiveUS20160151532A1Control and arrestControl and arrest bleedingBiocideOrganic active ingredientsArteriolar VasoconstrictionDense Core Vesicles
Disclosed herein is a novel hemostatic patch that may be used to control and / or arrest bleeding in patients. The patch offers an effective but also minimally invasive way to control and / or arrest bleeding in a patient. The patch comprises a mucoadhesive and a compound that causes vasoconstriction. In a preferred aspect, the patch comprises chitosan and Neuropeptide Y. Also disclosed are methods of using the novel hemostatic patch.
Owner:RUBIN LEO +1
Application of chromane compound HEF-04 in relaxing blood vessel smooth muscle
InactiveCN101618041AReduce tensionOrganic active ingredientsUrinary disorderVascular endotheliumPotassium
The invention relates to the technical field of medicine and provides an application of chromane compound HEF-04 in relaxing blood vessel smooth muscle. In animal in vitro experiment, HEF-04 can relax rabbit in vitro blood vessel smooth muscle shrunk by barium chloride and potassium chloride; the vasodilation effect of chromane compound HEF-04 is not inhibited by the incubation of methylene blue, on the contrary, the blood vessel dose-effect curve shifts left due to higher level of potassium in spasm-induced agent; EC50 value has significant difference before and after the incubation. Documents report that the existence of NO and PGI2 can weaken the generation of EDHF; after NO and PGI2 are inhibited, the effect of endothelium-dependent vascular relaxation caused by EDHF is more prominent, showing that the vascular relaxation effect of HEF-04 is possibly related to the increase of EDHF releasing or caused by the interactions of vascular endothelium relaxing factors.
Owner:SHENYANG PHARMA UNIVERSITY
Contactless blood pressure monitoring of a patient
Contactless blood pressure monitoring, includes: illuminating a blood vessel of a patient with infrared (‘IR’) light; receiving, by an IR camera through a polarizing filter, IR light reflected by the patient; capturing at a time based on a heartrate of the patient, a first IR image of the blood vessel of the patient when the blood vessel is distended; determining, from the first image, a maximum diameter of the blood vessel; capturing at a time based on the heartrate of the patient, a second IR image of the blood vessel of the patient when the blood vessel is contracted; determining, from the second IR image, a minimum diameter of the blood vessel; and calculating blood pressure of the patient in dependence upon the maximum and minimum diameters of the blood vessel.
Owner:IBM CORP
Kumquat essential oil and preparation method and application thereof
ActiveCN112107628ADefinite curative effectLower systolic blood pressureUrinary disorderCardiovascular disorderBiotechnologyRenal Hypertensions
The invention discloses kumquat essential oil and a preparation method and application thereof. The kumquat essential oil is a pure natural substance extracted from kumquat fruits. The kumquat essential oil is obtained through dry steaming extraction, main active ingredients and content in the kumquat essential oil are measured by utilizing GC-MS, and then a hypertension animal model test is established, so that the kumquat essential oil and the active ingredients thereof are proved to be capable of obviously reducing vasoconstriction pressure and regulating vasodilatation factors such as angiotensin II and the like and also capable of relieving target organ damage caused by hypertension; and a cell test proves that the kumquat essential oil is capable of regulating the angiotensin II to induce HUVEC cell viability. Therefore, the kumquat essential oil has good prevention and treatment effects on renal hypertension.
Owner:JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Medical wound covering employing electrical stimulation to control blood flow
ActiveUS10646710B2Eliminating （orNeed for manyElectrotherapySurgical drapesElectrical stimulationsBlood vessel
Owner:FEINSTEIN PATENTS
Method for producing no/n2 gaseous mixtures intended for the medical field
The invention relates to a method for producing an NO / N2 gaseous mixture, comprising the steps of effecting a purification of impure gaseous nitrogen containing impurities at least of the O2 type by putting the impure nitrogen in contact with a catalyst and then with a molecular sieve; mixing the pure nitrogen obtained with nitric oxide (NO), and obtaining a mixture formed from NO and pure nitrogen containing an NO content of less than 20% by volume and a proportion of impurities of the O2 type of less than 5 ppmv and of the H2O type of less than 40 ppmv. The NO / nitrogen mixture may undergo supplementary dilutions with pure nitrogen. Such NO / nitrogen mixtures can be used for treating, by inhalation, pulmonary vasoconstrictions in adults or children, in particular in new-born babies suffering from primitive pulmonary hypertension or in patients undergoing heart surgery.
Owner:AIR LIQUIDE SANTE
Traditional Chinese medicine capsule for treating hypertension
InactiveCN102512504AAdjust supply and demand balanceImprove microcirculationCapsule deliveryCardiovascular disorderSide effectRHODIOLA ROSEA ROOT
Owner:黄炎忠
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