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527 results about "Target organ" patented technology
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Target organ. 1 an organ intended to receive a therapeutic dose of irradiation, such as the kidney when high-energy x-rays or gamma rays are beamed to the renal area for the treatment of a tumor.
Method and kit for imaging and treating organs and tissues
InactiveUS6331175B1High resolutionStrong specificityElectrotherapyNanomedicineMammalHypoplastic genitalia
Provided are methods and compositions for detecting and treating normal, hypoplastic, ectopic or remnant tissue, organ or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus and by a route providing access to above-mentioned tissue or organ, with an composition comprising antibody / fragment which specifically binds to targeted organ, tissue or cell. The antibody / fragment may be administered alone, or labeled or conjugated with an imaging, therapeutic, cytoprotective or activating agent.
Owner:IMMUNOMEDICS INC
Methods and apparatus for 3D route planning through hollow organs
Methods and apparatus assist in planning routes through hollow, branching organs in patients to optimize subsequent endoscopic procedures. Information is provided about the organ and a follow-on endoscopic procedure associated with the organ. The most appropriate navigable route or routes to a target region of interest (ROI) within the organ are then identified given anatomical, endoscopic-device, or procedure-specific constraints derived from the information provided. The method may include the step of modifying the viewing direction at each site along a route to give physically meaningful navigation directions or to reflect the requirements of a follow-on live endoscopic procedure. An existing route may further be extended, if necessary, to an ROI beyond the organ. The information provided may include anatomical constraints that define locations or organs to avoid; anatomical constraints that confine the route within specific geometric locations; or a metric for selecting the most appropriate route. For example, the metric may define the closest route to the ROI such that the route satisfies all applicable anatomical, device, and procedural constraints.
Owner:PENN STATE RES FOUND
Catheter for introduction of medications to the tissues of a heart or other organ
ActiveUS20070005018A1Shorten the lengthOvercome disadvantagesMulti-lumen catheterInfusion syringesOrgan wallTreatment delivery
This invention overcomes the disadvantages of the prior art by providing a positionable, direct-injection catheters that can access a specific region of the heart or other organ. The catheter is provided with one or two needle shafts, which may be located within respective sheaths that extend axially along the interior of the lumen of a main catheter shaft. Each needle shaft carries, at a distal end thereof a penetrable element or “needle” that is normally retracted within the distal tip of the main shaft during travel to the target organ, but is subsequently deployed by action of a handle-mounted trigger mechanism to extend the needles into the organ's wall. Each extended needle is curved to relative to the shaft's axis to enter the organ wall in a flattened trajectory that both reduces the chance of puncture through the wall and anchors the needles into the wall during injection (for reduced chance of pullout under pressure). A plurality of apertures which provide for more complete agent delivery rapidly, while maintaining a low delivery velocity to effect treatment delivery in as short a period of time as possible without the problems caused by high velocity delivery. The needles are typically arranged to exit the tip at contralateral orientations relative to each other
Owner:TKEBUCHAVA TENGIZ
Treatment of pulmonary disorders with aerosolized medicaments such as vancomycin
InactiveUS20100282247A1Reduce in quantityReduce the amount requiredAntibacterial agentsAntimycoticsDiseaseGlycopeptide
A method of administering an aerosolized anti-infective, such as a glycopeptide, to the respiratory system of a patient. A ratio of an amount of the glycopeptide, such as vancomycin, delivered to the pulmonary system of the patient in a 24 hour period to a minimum inhibitory amount for the target organ for the same period is about 2 or more. A system to introduce aerosolized medicament to a patient may include a humidifier coupled to an inspiratory limb of a ventilator circuit wye, where the humidifier supplies heated and humidified air to the patient, and an endotracheal tube having a proximal end coupled to a distal end of the ventilator circuit wye. The system may also include a nebulizer coupled to the endotracheal tube, where the nebulizer generates the aerosolized medicament.
Owner:NEKTAR THERAPEUTICS INC
Self-stabilizing encapsulated imaging system
Wireless capsule endoscope technology has been used to image portions of the gastrointestinal (GI) tract, particularly the small bowel. However in other GI organs, especially those having larger-lumens, the capsule may become destabilized and tumble, precluding meaningful interpretation of the acquired images. The present invention describes a method and apparatus for permitting capsule imaging of organs having larger-lumens without tumbling, and includes an outer shell surrounding the capsule that targets the colon, as an example. Once the colon has been reached, the shell breaks or dissolves, and allows expansion of expandable materials attached to each end of the capsule, thereby stabilizing the capsule in the targeted organ, while permitting it to be moved by peristalsis and / or other means for locating the capsule. Imagers and light emitting diodes (LEDs) are activated during the expansion process, and enable overlapping of images. The capsule is moved through the colon, taking images at chosen frame rates with data being wirelessly transmitted by means of an RF transmitter, and is eventually expelled from the body.
Owner:UTI LLP
Catheter for introduction of medications to the tissues of a heart or other organ
ActiveUS7691086B2Shorten the lengthMinimizing abrasionMulti-lumen catheterInfusion syringesOrgan wallTreatment delivery
This invention overcomes the disadvantages of the prior art by providing a positionable, direct-injection catheters that can access a specific region of the heart or other organ. The catheter is provided with one or two needle shafts, which may be located within respective sheaths that extend axially along the interior of the lumen of a main catheter shaft. Each needle shaft carries, at a distal end thereof a penetrable element or “needle” that is normally retracted within the distal tip of the main shaft during travel to the target organ, but is subsequently deployed by action of a handle-mounted trigger mechanism to extend the needles into the organ's wall. Each extended needle is curved to relative to the shaft's axis to enter the organ wall in a flattened trajectory that both reduces the chance of puncture through the wall and anchors the needles into the wall during injection (for reduced chance of pullout under pressure). A plurality of apertures which provide for more complete agent delivery rapidly, while maintaining a low delivery velocity to effect treatment delivery in as short a period of time as possible without the problems caused by high velocity delivery. The needles are typically arranged to exit the tip at contralateral orientations relative to each other.
Owner:TKEBUCHAVA TENGIZ
Wall motion analyzer
InactiveUS20050228276A1Used to determineOrgan movement/changes detectionCatheterCardiac wallReference image
A system and method for real-time quantitative analysis of heart wall motion is provided. A Doppler imaging system is used to monitor the movement of a heart, or other organ. A B-mode reference image of the target organ is made and then a region-of-interest is defined through the use of a gate. Then pulsed wave spectral tissue Doppler data of the region-of-interest is formed and used to determine the velocity of a region of the target organ. The system may be used for determining appropriate biventricular pacemaker settings for patients suffering from heart disease.
Owner:TERATECH CORP
Carriers targettable to organ
A carrier for delivering a foreign substance to a target organ which comprises a graft copolymer in which hyaluronic acid is grafted on a polymer composing main chain, wherein the main chain has a part capable of binding to the foreign substance electrostatically, and contains one or more monomer unit having side chain with amino or imino group capable of coupling to hyarulonic acid, which is useful for delivering a foreign substance to a target organ, especially liver.
Owner:HISAMITSU PHARM CO INC +1
Gene or drug delivery system
The present invention includes compositions and methods for delivering one or more active agents in vivo by contacting a target organ or tissue with a microbubble encapsulated active agent comprising a neutrally charged lipid microbubble loaded with cationic liposomes comprising one or more active agents and selectively releasing the active agents at the target by exposing the microbubble at the target with ultrasound, wherein the active agents remain protected in the microbubble until selectively release at the target.
Owner:BAYLOR RES INST +1
Method for computer-aided detection of three-dimensional lesions
ActiveUS7379572B2Maximize sensitivityReducing false positiveUltrasonic/sonic/infrasonic diagnosticsImage enhancementVoxelLesion
A method, system, and computer program product for identifying at least one three-dimensionally extended lesion within a volumetric region encompassing an inner surface, an outer surface, and intervening tissue of a target organ. The method includes: (1) generating a set of voxels representing a total scanned volume from a set of cross-sectional images of the target organ; (2) performing segmentation to extract a set of voxels representing the volumetric region from the set of voxels representing the total scanned volume; (3) detecting a set of candidate lesions based on geometric feature values of each voxel in the set of voxels representing the volumetric region; and (4) selecting the at least one three-dimensionally extended lesion from the set of candidate lesions based on at least one of volumetric, morphologic, and texture feature values of each lesion in the set of candidate lesions.
Owner:UNIVERSITY OF CHICAGO
Double-layered balloon catheter
A dual-layer bag catheter is composed of two ball layers and three cavities. Its internal bag layer is used for expanding blood vessel. Its external bag layer made of unique millipore film is used for delivering the therapeutic genes or medicine to the wall of blood vessel or target organ.
Owner:SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
Methods and apparatus for optimal remote ischemic preconditioning (ORIP) for preventing ischemia-reperfusion injuries to organs
ActiveUS20110238107A1Preventing ischemia-reperfusion injuryMinimize consequencesEvaluation of blood vesselsSensorsReperfusion injuryPercutaneous angioplasty
Ischemia-reperfusion injury commonly results from any surgical procedure requiring stopping of blood supply to an organ followed by reperfusion such as in heart bypass, angioplasty or organ transplant. The invention discloses a method to harness the innate power of repetitive transient ischemia in protecting organs against imminent ischemia-reperfusion, or any patho-physiological insults. This method of optimal remote ischemic preconditioning (ORIP) comprises of utilizing a pair of programmable pneumatic cuffs that inflate / deflate alternately occluding blood circulation to each of the limbs for pre-defined time intervals. The apparatus delivers maximal ORIP dose in shortest possible time either as an EMS procedure during patient transportation to hospital, as elective pre-surgery treatment, or in critical care for preventing multiple-organ-dysfunction-syndrome. ORIP can be self-administered and remotely monitored by clinician especially in chronic patients for homeostasis of malfunctioning target organs. ORIP may also be deployed as adjunct in angioplasty, gene / stem cell heart repair therapies.
Owner:NEOCARDIUM
Method and System for Assessing Vessel Obstruction Based on Machine Learning
ActiveUS20190318476A1Medical simulationDetails involving processing stepsVascular obstructionData set
Methods and systems are described for assessing a vessel obstruction. The methods and systems obtain a volumetric image dataset for a target organ that includes a vessel of interest, extract an axial trajectory extending along of a vessel of interest (VOI) within the volumetric image dataset, and create a three-dimensional (3D) multi-planer reformatted (MPR) image based on the volumetric image dataset and the axial trajectory of the VOI. The methods and systems also extract a VOI parameter from the MPR utilizing a machine learning-based vessel obstruction assessment (VOA) model. Methods and systems are also described for implementing a prediction phase to perform at least one of i) detecting plaque type, ii) classifying anatomical severity of vessel blockage, and / or iii) classifying a hemodynamic severity of vessel obstructions within an unseen portion of the volumetric image data set.
Owner:PIE MEDICAL IMAGING
Systems and methods for segmenting object of interest from medical image
A system for segmenting a target organ tumor from an image includes a background model builder, a foreground model builder and a tumor region locator. The background model builder uses an intensity distribution estimate of voxels in an organ region in an image to build a background model. The foreground model builder uses an intensity distribution estimate of voxels in a target organ tumor to build a first foreground model. The tumor region locator uses the background model and the first foreground model to segment the target organ tumor to obtain a first segmentation result.
Owner:SIEMENS MEDICAL SOLUTIONS USA INC
Spinal neuromodulation and associated systems and methods
Methods for treating a patient using therapeutic spinal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to methods including modulating nerves of one or more targeted organs proximate one or more dorsal root ganglia, stellate ganglia, vertebral ganglia, or cervical ganglia of the nerves using an intravascularly-positioned therapeutic element. One or more measurable physiological parameters corresponding to at least one condition associated with sympathetic activity in the targeted organs and / or central sympathetic activity in the patient can thereby be reduced.
Owner:MEDTRONIC ARDIAN LUXEMBOURG SARL
Method and system for simultaneous scene parsing and model fusion for endoscopic and laparoscopic navigation
InactiveUS20180174311A1Facilitate acquisitionImage enhancementImage analysisPERITONEOSCOPEPre operative
A method and system for scene parsing and model fusion in laparoscopic and endoscopic 2D / 2.5D image data is disclosed. A current frame of an intra-operative image stream including a 2D image channel and a 2.5D depth channel is received. A 3D pre-operative model of a target organ segmented in pre-operative 3D medical image data is fused to the current frame of the intra-operative image stream. Semantic label information is propagated from the pre-operative 3D medical image data to each of a plurality of pixels in the current frame of the intra-operative image stream based on the fused pre-operative 3D model of the target organ, resulting in a rendered label map for the current frame of the intra-operative image stream. A semantic classifier is trained based on the rendered label map for the current frame of the intra-operative image stream.
Owner:SIEMENS AG
Use of endo-lysosomal system and secreted vesicles (exosome-like) in treatments and diagnostics based on small RNA and experimental study of small RNA
InactiveUS20110177054A1Increase reduce activityGood effectOrganic active ingredientsBiocideRegulatory rnaLipid formation
The present invention relates to a method for determining the delivery rates and / or efficiency of a siRNA, miRNA or related molecule to target organs or cells, a kit and the use of proteins or lipids involved in the formation of the endolysosomal system for modulating the activity and / or the cell-to-cell transfer of RNA, small RNA, for example miRNA, siRNA and piRNA, mRNA or non-coding RNA.It finds many applications in particular in methods for identifying the target(s) of miRNA or siRNA therapeutics, in methods for determining the efficiency of a treatment with siRNA and / or miRNA therapeutics, in methods for determining the efficiency of a treatment with siRNA and / or miRNA therapeutics, and in methods for genotyping and / or characterizing the condition of a person, a tumor or a fetus.
Owner:CENT NAT DE LA RECHERCHE SCI
Medical image organ recognition method and segmentation method
ActiveCN105389813AAvoid multiple upsamplingAvoid downsamplingImage enhancementImage analysisPattern recognitionTarget organ
The invention discloses a medical image organ recognition method. The method comprises steps: a to-be-processed medical image is acquired, the medical image is segmented into a plurality of two-dimensional images in X-axis, Y-axis and Z-axis directions respectively, and a detection window is set according to the size of a target organ; the detection window is used to carry out traversing detection on the two-dimensional images respectively according to a set detection step length, and detection results in the X-axis, Y-axis and Z-axis directions are acquired; and result fusion is carried out on the detection results, pixel points which are detected to be positive in the X-axis, Y-axis and Z-axis directions are kept, and a target organ boundary is determined. The medical image organ recognition method of the invention can quickly and accurately recognize the target organ area, the target organ boundary is determined and the adaptive ability is strong. In addition, the invention also provides a medical image organ segmentation method.
Owner:SHANGHAI UNITED IMAGING HEALTHCARE
System and method for bladder detection using harmonic imaging
ActiveUS20090264757A1Improve Segmentation AccuracyEasy to divideUltrasonic/sonic/infrasonic diagnosticsWave based measurement systemsTransceiverHarmonic analysis
Systems, methods, and ultrasound transceivers equipped and configured to execute harmonic analysis and extract harmonic information related to a targeted organ of a subject are described. The methods utilize neural network algorithms to establish improved segmentation accuracy of the targeted organ or structures within a region-of-interest. The neural network algorithms, refined for detection of the bladder and to ascertain the presence or absence of a uterus, is optimally applied to better segment and thus confer the capability to optimize measurement of bladder geometry, area, and volumes.
Owner:VERATHON
Target positioner
A target positioner including a radiation source disposed in a source housing, the radiation source adapted to emit a radiation beam, a target holder adapted to be attached to and generally immobilize a target organ, the target holder being rotatingly attached to a bearing assembly, a patient support table for supporting a patient thereon, a rotator for turning the patient support table about a rotation axis, and a source arm fixedly attached at one portion thereof to the source housing and at another portion thereof to the bearing assembly, such that when the target holder is attached to a target organ and the rotator turns the patient support table about the rotation axis, the target holder constrains the target organ from translating with respect to the radiation source and the source housing, and wherein the target holder permits the target organ to rotate by means of the bearing assembly relative to the source housing while experiencing slight translations with respect to the patient support table, so that the radiation beam emanating from the radiation source impinges upon the target organ at a plurality of angles irrespective of the misalignments between the radiation beam and the patient support table and between the patient support table and the target organ.
Owner:EIN GAL MOSHE
Drug carriers
Compositions that can include a cationic polymeric carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell.
Owner:NITTO DENKO CORP
Dry powder formulations of antihistamine for nasal administration
InactiveUS7833550B2Reduce morbidityNot impart bitter tastePowder deliverySenses disorderNasal cavityAzelastine
Owner:MANNKIND CORP
Medicament comprising HGF gene
The present invention relates to a medicament comprising a HGF gene. The medicament of the present invention may be topically applied to the target organs so that the effects can be selectively exhibited, resulting in minimizing the side effects of HGF.
Owner:ANGES MG INC
Dry powder formulations of antihistamine for nasal administration
InactiveUS7833549B2Reduce morbidityNot impart bitter tasteBiocidePowder deliveryNasal cavityAzelastine
Owner:MANNKIND CORP
Drug carriers
Compositions that can include a cationic polymeric carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell.
Owner:NITTO DENKO CORP
Radiation therapy treatment plan improvement through use of knowledge base
A radiation therapy dose distribution method starts with selecting a treatment type. Then an organ at risk (OAR) distance to target map is determined. The OAR distance to target map comprises distances to a target organ for portions of an OAR. The OAR distances are determined from at least one segmented patient organ image. A cohort average dose distance to target histogram is selected. A dose value to the portions of the OAR are assigned to form a first 3D dose distribution map. The dose values are from the selected cohort average dose distance to target histogram. A second 3D dose distribution map is determined based on a field arrangement determined by the treatment type and the first 3D dose distribution map. A dose distance to target histogram is calculated using the second 3D dose distribution map and the distance to target map.
Owner:VARIAN MEDICAL SYSTEMS
Systems, devices, and methods for organ retroperfusion along with regional mild hypothermia
ActiveUS20130331762A1Reduce the temperatureBalloon catheterOther blood circulation devicesDiseaseVein
Systems, devices, and methods for organ retroperfusion along with regional mild hypothermia. In at least one embodiment of a method of organ perfusion of the present disclosure, the method comprises the steps of positioning at least part of a first catheter having a cannula within an artery of a patient, the first catheter configured to permit arterial blood to flow therethrough and further configured to permit a portion of the arterial blood to flow through the cannula, positioning at least part of a second catheter within a vein of the patient at or near a target organ, the second catheter configured to receive some or all of the portion of the arterial blood, connecting the cannula of the first catheter to a portion of the second catheter so that some or all of the portion of the arterial blood flowing through the cannula is provided into the vein to treat a condition or disease of the target organ, and reducing and / or regulating a temperature of blood flowing through the cannula using a regional hypothermia system operably coupled to the cannula.
Owner:CVDEVICES
Cultivation method of scutellaria
InactiveCN102349412AImprove qualityGuaranteed qualitySeed and root treatmentSoil-working equipmentsDiseaseSoil treatment
The invention discloses a cultivation method of scutellaria. The method comprises land selection, soil treatment, seed treatment, timely sowing, field management, disease and insect pest prevention and control and picking. According to the scutellaria cultivation method, by selecting an appropriate planting plot and completing soil and seed treatment, a foundation for ensuring high yield and good quality is laid, and the purposes of preserving soil moisture, preventing water evaporation, blocking the sun, controlling drought, preserving heat, preventing freezing, preventing soil hardening, stifling and isolating disease and pest sources and improving the germination rate and the survival rate are fulfilled. By appropriate sowing time, timely field management and timely disease and insect pest prevention and control, the growth of target organ roots of the scutellaria is furthest promoted, the harm of diseases and insect pests is prevented, and the yield of unit area is improved; and by the reasonable picking method, the quality of the scutellaria is ensured, and the economic benefit is high.
Owner:屯留县民康中药材开发有限公司
Methods for targeted deliver of genetic material to the liver
InactiveUS20080025952A1Increase pressureProlong residenceBiocideOrganic active ingredientsGenetic MaterialsGene Therapy Agent
The present invention provides methods for enhanced delivery of various therapeutic agents, such as gene therapy agents, to the vasculature of a target organ in a mammalian subject. The methods for targeted gene therapy in the mammalian liver as a whole, or in a single hepatic lobe, are disclosed. The disclosed methods rely on minimally invasive catheter-based procedures wherein a target organ is isolated and treated locally with a gene therapy agent. The methods offer more efficient and localized transfection of tissue and are well-suited for gene therapy in human subjects.
Owner:SCHEULE RONALD K +1
Drug carriers
InactiveUS20100028416A1Growth inhibitionHydroxy compound active ingredientsGenetic material ingredientsCancer cellMedicine
Compositions that can include a carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell.
Owner:NITTO DENKO CORP
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