46 results about "Vascular obstruction" patented technology

Method and device for treating vascular obstruction using ultrasonic energy in combination with cryogenic energy and/or an expandable member is disclosed. Ultrasound energy is delivered from a specially designed ultrasound transducer that is inserted in a blood vessel. Ultrasound energy can be delivered in conjunction with cryogenic energy. Ultrasound energy can also be delivered in conjunction with an expandable member such as expandable tubing, a hinged transducer, or a balloon. Ultrasound energy can also be delivered in conjunction with both cryogenic energy and an expandable member. The use of ultrasound energy in combination with cryogenic energy and/or an expandable member can treat a vascular obstruction.

An emergency system for treatment of a patient (20) experiencing an acute vascular obstruction, employing a non-invasive vibrator (10), optimally in conjunction with drugs, for disrupting and lysing thromboses, relieving spasm (if associated), and thereby restoring blood perfusion. Vibrator (10) is operable in the sonic to infrasonic range, with a source output of up to 15 mm. For acute myocardial infarction cases, a pair of contacts (12), are advantageously placed to bridge the sternum at the fourth intercostal space. Vibration is initiated at 50 Hz (or any frequency, preferably within the 20-120 Hz range), and is ideally adjusted to a maximal amplitude (or force) deemed tolerable and safe to the patient (20), preferably with the administration of thrombolytic agents or other form of drug therapy. A synergistic effect is achieved between vibration and drugs to facilitate the disruption of thromboses, relieve spasm, and restore blood perfusion. In a variation, ultrasonic imaging may be used to direct vibration therapy.

A therapeutic device and method for use thereof for treatment of blood flow disorders is disclosed. In one embodiment, a first line emergency response system for treatment of acute thrombotic and/or vasospastic vascular obstructions via the noninvasive application of low frequency vibration with at least one, and preferably a plurality of randomly administered vibratory waveform characteristics (herein after “Randomic Vibration”) is detailed. The disclosed apparatus and methods are based on the intuition that transcutaneously imparted low frequency randomic vibration can provide enhanced clot disruption and mixing of clot disruptive agents to acutely thrombosed vessels, due to the addition of mechanical chaos via non-regular, multi-vectored convection currents. In a preferred embodiment, the disclosed apparatus and methods preferably utilize randomic vibration as an adjunct to systemically administered drug therapy, most preferably intravenously administered thrombolytic drug therapy.

What is disclosed is a system and method for determining an arterial pulse transit time of a subject of interest in a remote sensing environment. A video imaging system is used to capture a time varying source images of a proximal and distal region of a subject intended to be analyzed for arterial pulse transit time. A time series signal for each of the proximal and distal regions is extracted from the source images and a phase of each of the extracted time series signals is computed. A difference is then computed between these phases. This phase difference is a monotonic function of frequencies in the signals. From the monotonic function, an arterial pulse transit time of the subject is extracted. The subject's arterial pulse transit time is then communicated to a computer system. The computer system determines blood pressure, blood vessel blockage, blood flow velocity, or a peripheral neuropathy.

A telescoping catheter is provided such as for distal neurovascular aspiration or access. The catheter includes an elongate, flexible tubular body, having a proximal section with at least one lumen and a distal section which is axially movably positioned within the lumen. A control is provided for advancing the distal section from a first, proximally retracted position within the proximal section to a second extended position, extending distally beyond the proximal section. The distal end of at least one of the proximal and distal sections may be provided with at least one active feature, such as at least one movable jaw or rotatable agitator, to assist in the capture of vascular obstruction. The jaw may be operable in response to application of pulsatile negative pressure through the catheter.

A pharmaceutical composition for treating one of a cardiovascular disease and a pulmonary artery disease, comprising one of a first compound having a Formula I and a second compound having a Formula II.

A non-invasive hand-held treatment imaging probe for treatment of acute blood flow disturbances and states of low blood perfusion. The treatment imaging probe is operable to emit high intensity therapeutic mechanical acoustic waves while under ultrasonic imaging guidance. The probe has a substantially rigid application surface, sized to enable seating within a rib space of a patient (i.e. for cardiac applications), comprising the combination of an engagement face of an ultrasonic imaging transducer and an application end of a high powered therapeutic actuator operable in about the 1-500 kHz (and preferably 1-150 kHz) range. Treatment imaging probe can be used as an adjunct to thrombolytic therapy in the treatment of acute thrombotic vascular obstructions, such as in acute myocardial infarction, or alternatively to enhance localized delivery of angiogenic agents or other useful medications to targeted vascular regions.

A device and method for opening blood vessel blockages, such as chronic total occlusions, is disclosed. The device has drilling unit and a stationary unit having a plurality of curved alignment structures along its outer edge for bracing against the inner surface of a blood vessel wall. A torque-transmitting member (drive shaft) is disposed within the stationary unit and extends into the rotating drilling unit. The curved alignment structures along the outer surface of the device help to centrally align the device within the blood vessel, thereby preventing the device from deflecting and puncturing blood vessel walls. The drilling unit that has a plurality of loops on its distal tip, located at the distal region of the drilling unit. These loops break apart occlusions as the device advances and rotates through the blood vessel.

A system and method for determining a patient's degree of cardiac vascular blockage or, equivalently, a patient's risk of cardiac ischemia, based on the time interval between the onset of exercise activity and the onset of an episode of cardiac ischemia. In one embodiment, an implantable cardiac device may obtain an EGM and possibly other measures of patient physiologic activity. These measures are used to determine when the patient has initiated exercise activity. Analysis of the EGM then detects an elevated or depressed ST segment, which typically indicates an episode of cardiac ischemia. The time interval between the onset of exercise and the onset of ischemia is a metric reflecting the patient's degree of vascular blockage or, equivalently, the patient's risk of ischemia. Other metrics may be derived, such as a substantially workload-level invariant measure determined as the product of the exercise workload level and the ischemia onset time interval.

A methods of placing large bore aspiration catheters is disclosed. The method of removing a vascular obstruction includes the steps of transvascularly advancing a distal end of an aspiration catheter into proximity with an obstruction, activating a low flow, detection mode of aspiration through the catheter, and thereafter activating a momentary control to activate a high flow, aspiration mode of operation and draw obstructive material into the distal end of the access catheter.

A device and method for opening blood vessel blockages, such as chronic total occlusions, is disclosed. The device has a main body and motor unit. The main body has an inner tubular member disposed inside an outer tubular member. The inner tubular member is reinforced with hydrophilic polymer coated wires, which are drawn out into two pairs of loops at the distal end of the device. The motor unit also has an inner tubular member disposed within an outer tubular member. The motor unit is used to create torque to rotate the main body having the pairs of loops. When torque transmitted to main body, the device spins. As the device is advanced through a blood vessel, the rotating loops penetrate and break down the occlusion, and recanalizes the blood vessel. Then device is then exchanged over a guidewire and further therapeutic interventions can be performed to improve blood flow.

Methods and systems are provided for assessing the presence of functionally significant stenosis in one or more coronary arteries, further known as a severity of vessel obstruction. The methods and systems can implement a prediction phase that comprises segmenting at least a portion of a contrast enhanced volume image data set into data segments corresponding to wall regions of the target organ, and analyzing the data segments to extract features that are indicative of an amount of perfusion experiences by wall regions of the target organ. The methods and systems can obtain a feature-perfusion classification (FPC) model derived from a training set of perfused organs, classify the data segments based on the features extracted and based on the FPC model, and provide, as an output, a prediction indicative of a severity of vessel obstruction based on the classification of the features.

Sensor devices and methods of operating for use with catheter-based treatments of microcardial microvascular obstruction by infusion of fluids having protective agents into vasculature are provided herein. Such catheter devices can include a first lumen configured for advancement over a guidewire and for passage of fluid having protective agents after removal of the guidewire and a second lumen for inflation of an angioplasty balloon and can further include a temperature and/or pressure sensor mounted on the catheter body. Such catheter devices can further include use of a distal occlusive membrane between the angioplasty balloon and distal end to facilitate infusion into microvasculature. The occlusive membrane can be deployed by relative movement of concentric channels, thereby reducing the need for additional lumen while optimizing the size of the catheter device and lumens.

The present invention relates to the method(s) of synthesis of and the therapeutic and cosmetic applications of biologically active peptides for improving the appearance of skin, for hastening wound healing and for treating and/or preventing the progression of various conditions, injuries and diseases, including but not limited to viral hepatitis B and C, herpes zoster ganglioneuritis, diabetic peripheral polyneuropathy, nephrotic syndrome, juvenile rheumatoid arthritis, rheumatoid arthritis, psoriatic arthritis, bronchial asthma, respiratory infection, breast cancer, epilepsy, psoriasis, atherosclerosis and other forms of vascular obstructions, myocardial infarction, HIV and SARS infection, brain cell malfunction due to ischemia and trauma, pathologic consequences of ischemia-reperfusion, rejection reaction following organ transplantation, chemical and drug intoxication including but not limited to anesthetic, alcohol and morphine, cancer, type 1 diabetes mellitus, multiple sclerosis, septic shock (Gram negative sepsis), Parkinson's disease, type 2 diabetes mellitus, Alzheimer's disease, amyotrophic lateral sclerosis, hyperthyroidism, Guillain-Barre syndrome, systematic lupus erythematosus, parasitic infections, especially leishmaniasis, and other collagen diseases, and diseases in which apoptosis occurs.

The invention provides a cardiac coronary venous vascular exclusion device, and relates to the field of medical devices. The exclusion device includes a first catheter and a first sacculus. A proximalconnection part of the first catheter is connected to a filling mechanism; the first sacculus has an accommodation space therein; the first sacculus is communicated with the distal end of the first catheter; and the filling mechanism makes the first sacculus to be in a filling state through the first catheter. The device is placed in the vein to push the blood in the vein back into the cardiac muscle, thus avoiding myocardial ischemia caused by the inability of continuously supplying blood to the cardiac muscle due to arterial microvascular obstruction. By pushing the blood back to the cardiac muscle from the vein, the myocardial blood supply is guaranteed, and myocardial damage caused by no reflow is avoided.

The invention discloses a catheter assembly capable of removing vascular obstruction plaques. The catheter assembly comprises a balloon catheter; the balloon catheter comprises an inner catheter and an expandable balloon arranged on the inner catheter; the catheter assembly further comprises a first catheter, a second catheter and a filter screen sleeve; the balloon catheter is sleeved with the first catheter in a relative sliding mode; the first catheter is sleeved with the second catheter in a relative sliding mode; the peripheral wall of the filter screen sleeve is in a net shape; a first sleeve is sleeved with the filter screen sleeve in a relative sliding mode; the front end part of the filter screen sleeve is fixedly connected to the front part of the first catheter; and the rear endpart of the filter screen sleeve is fixedly connected to the front part of the second catheter. After the obstructive calcified plaques in the blood vessel are removed, the catheter assembly can be used for removing the broken calcified plaques from the blood vessel, so that the risk caused by the fact that the calcified plaques are still left in the blood vessel and flow along with blood is avoided. The catheter assembly is simple in structure and convenient to operate.