The invention provides a liver oxygen-carrying mechanical perfusion device which comprises a temperature control container as well as a first centrifugal pump, an oxygenator, a filtration and bubble discharge device, a flow controller, a first pressure sensor and a portal vein perfusion tube that are sequentially connected with one another by a pipeline to form a first perfusion circulation system, wherein the portal vein perfusion tube is connected with a portal vein of a liver. The liver oxygen-carrying mechanical perfusion device also comprises a suprahepatic vena cava tube, a second pressure sensor, an elastic water container and a second centrifugal pump that are sequentially connected with one another by a pipeline to form a second perfusion circulation system, wherein the suprahepatic vena cava tube is connected with a suprahepatic vena cava of the liver. The elastic water container and the second centrifugal pump are additionally arranged at a liver outflow tract to simulate physiological conditions; with the fluctuation of the pressure of the suprahepatic vena cava in a cardiac impulse process, the resistance of the liver outflow tract is regulated, so that the liver perfusion is more sufficient. According to the device, a marginal donor liver can be repaired, so that the liver confirms to the transplantation requirements, therefore, the liver donation source is greatly expanded.