41 results about "Cartilage bone" patented technology

Repairs of cartilage defects or of cartilage / bone defects in human or animal joints with the help of devices including a bone part (1), a cartilage layer (2) and a subchondral bone plate (4) or an imitation of such a plate in the transition region between the cartilage layer (2) and the bone part (1). After implantation, the bone part (4) is resorbed and is replaced by reparative tissue only after being essentially totally resorbed. In a critical phase of the healing process, a mechanically inferior cyst is located in the place of the implanted bone part (1). In order to prevent the cartilage layer (2) from sinking into the cyst space during this critical phase of the healing process the device has a top part (11). and a bottom part (12), wherein the top part (11) consists essentially of the cartilage layer (2) and the subchondral bone plate (4) and the bottom part (12) corresponds essentially to the bone part (1) and wherein the top part (11) parallel to the subchondral bone plate (4) has a larger diameter than the bottom part (12). After implantation in a suitable opening or bore (20), the cartilage layer (2) and the subchondral bone plate (4) are supported not only on the bone part (1) but also on native bone tissue having a loading capacity not changing during the healing process. Therefore, the implanted cartilage layer cannot sink during the healing process.

The invention discloses a material combining porous ultrahigh molecular weight polyethylene and bionic cartilage and a manufacturing technology and belongs to biotic implanting materials and manufacturing technologies. The material comprises a dichromic acid oxidation solution, a biotic cartilage material, a grafting solution and a hard-face substrate. The dichromic acid oxidation solution comprises 20% of potassium dichromate and 80% of concentrated sulfuric acid. The biotic cartilage material comprises 15% of polyvinyl alcohol, 82% of deionized water and 3% of nano-hydroxyapatite. The grafting solution comprises 7% of polyvinyl alcohol, 1.5% of concentrated sulfuric acid and 91.5% of deionized water. The hard-face substrate comprises the ultrahigh molecular weight polyethylene and NaC1 powder. The purity of the polyvinyl alcohol is larger than or equal to 99%, the potassium dichromate is of an analytically pure level, the concentrated sulfuric acid is of a mass fraction 98% grade, and the matter is in mass percent. The material combining the porous ultrahigh molecular weight polyethylene and the bionic cartilage and the manufacturing technology have the advantages that on the basis of a human body natural articular bone-cartilage-bone pair matching manner, an artificial joint of the cartilage is manufactured in a bionic mode, the function of the cartilage is replaced to some extent, abrasion and loosening are not prone to happening, the interface lubricity is good, the biological activity is sufficient and the function of replacing the cartilage is truly achieved.

The invention discloses a cartilage-bone-bone marrow composite tissue structure and method based on 3D printing of living cells. The biological information of bone tissue is collected, input into a computer for bionic modeling, and the preparation is suitable for cartilage, osteogenesis, mesenchymal stem, and blood vessels. Bio-ink for cells such as endothelium; prepare hard materials for printing dense bone areas; prepare various casting agents; inoculate living cells in corresponding bio-inks at a certain density; load various types of printing inks separately 3D printing is carried out after setting the printing parameters in the printer silo, and the printed bone tissue is cultured in a tissue engineering bionic incubator. After a certain period of time, the cast is removed at different times by temperature control, enzyme control or light control. The artificial blood vessels are grafted outside the cartilage-bone-bone marrow composite tissue, and cultured in a tissue engineering bionic incubator with continuous cycle perfusion to realize the pre-maturation of the printed tissue. It realizes the long-term survival and biological function of 3D printed bone tissue.

Shown and described is an insulin-mimetic as an inductive agent for cartilage and / or bone repair is disclosed. Sodium tungstate (Na2WO4) was utilized as an inductive factor to enhance human mesenchymal stem cell (MSC) chondrogenesis. The chondrogenic differentiation of MSCs was enhanced in the presence of low concentrations of Na2WO4 as compared to control, without Na2WO4. Also disclosed is a composite scaffold capable of supporting cell and tissue growth. The composite scaffold could include zinc oxide and polycaprolactone.

The present invention provides an osteochondral microfluidic chip culture device and an osteochondral microfluidic chip analysis device containing the same; the osteochondral microfluidic chip culture device includes an osteochondral culture layer and communicates with the osteochondral culture layer The nutrient solution channel and the cell metabolic fluid channel connected with the osteochondral culture layer. The osteochondral microfluidic chip culture equipment provided by the present invention realizes the construction of the three-layer structure of cartilage, bone and calcified layer and the subsequent culture process, fully embodies the characteristics of bionics, can simulate the real osteochondral growth environment, and can simultaneously realize bone and cartilage regeneration and subsequent analysis.