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Bracket for joint repair

A joint and porous metal technology, applied in the field of prosthesis, can solve the problems of unsatisfactory force transmission, damaged stent, insufficient strength, etc., and achieve the effects of good buffer function, good force transmission, and good seepage characteristics.

Active Publication Date: 2020-09-29
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Articular cartilage damage can also easily cause joint lesions of subchondral bone, and because cartilage has no nerves, blood vessels, and lymphatic system, its self-repair ability is very limited, and cartilage defects with a diameter > 2 mm can hardly be completely repaired
There are obvious defects in current clinical treatment methods: conservative treatment and joint cleaning surgery can only temporarily relieve pain, but cannot cure it; autologous bone transplantation will cause defects in other parts, and the source is limited, so it is difficult to repair large-area defects; allogeneic osteochondral transplantation susceptible to immune rejection
[0007] Although many studies have been carried out, the structure of the cartilage / subchondral bone joint repair scaffold is still unreasonable, there is no function of each layer of cartilage / subchondral bone or the function is quite different from the natural cartilage / subchondral bone, and the force The transmission is not ideal, the bracket is easy to be damaged, and some of them are not strong enough, and the effect of repair and regeneration is not good

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The bracket for joint repair in this embodiment is composed of a porous polymer material layer 1 and a porous metal material layer 2 from top to bottom. Porous polymer material layer 1 adopts type I collagen, its pore diameter is 3 μ m-10 μ m, porosity is 70%, and thickness is 3 mm, porous metal material layer 2 is porous niobium, wherein porous niobium has two layers, see figure 2 , wherein the porous niobium upper layer 3 (first layer) connected to the porous polymer material layer 1 has a pore diameter of 50 μm-80 μm, a porosity of 37%, and a thickness of 2 mm. The porous niobium lower layer 4 (second layer) has a pore diameter of 100μm-500μm, the porosity is 82%, the thickness is 4mm, and the pores inside and between the layers of porous niobium materials are interconnected. The preparation method of the bracket for joint repair is as follows:

[0038] (1) Prepare the porous niobium upper layer 3 (the first layer) by the foam soaking method.

[0039] (2) Prepare ...

Embodiment 2

[0045] The scaffold for joint repair of this embodiment is similar to that of Embodiment 1, except that the porous metal material layer is a porous nickel-titanium alloy, the pore diameter of the first layer is 70 μm-100 μm, the pore diameter of the second layer is 500 μm-1000 μm, and the porous height is The molecular material layer adopts type II collagen and chitosan, and its volume ratio is 3:2. The preparation method is similar to Example 1.

Embodiment 3

[0047] The scaffold for joint repair in this embodiment is composed of a porous polymer material layer and a porous metal material layer sequentially from top to bottom. The porous polymer material layer uses type II collagen and chitosan (the volume ratio is 3:2) as raw materials, and the thickness is 3.5mm. The porous metal material layer is porous titanium, which is a three-layer gradient porous material, see image 3 , the porous titanium upper layer 5 adjacent to the porous polymer material layer has a pore diameter of 3 μm-10 μm and a thickness of 1 mm, the porous titanium intermediate layer 6 has a pore diameter of 50 μm-70 μm, and the cavity wall material of the pores is the above-mentioned pore diameter of 3 μm- 10μm porous titanium material with a thickness of 2mm, the pore diameter of the porous titanium bottom layer 7 is 100μm-600μm, and its cavity wall material is the above-mentioned porous titanium material with a pore diameter of 3μm-10μm, and a thickness of 4mm...

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Abstract

The invention discloses a scaffold for repairing joints. The scaffold is composed of a porous polymer material layer and a porous metal material layer from top to bottom. The porous metal material layer is a gradient porous metal material layer. The scaffold effectively realizes artificial joint simulation and good force transmission, has excellent mechanical properties and good percolation characteristics, is conducive to colonization, differentiation and proliferation of cartilage and bone cells and is an integrated articular cartilage and subchondral bone repair scaffold.

Description

technical field [0001] The invention relates to a prosthesis, in particular to a bracket for joint repair. Background technique [0002] Due to traffic accidents, natural disasters, diseases and other reasons, human tissues and organs are damaged to varying degrees. The need for repairing defective tissues and organs is increasingly prominent, among which articular cartilage damage is the most common. Articular cartilage damage can also easily cause joint lesions of subchondral bone, and because cartilage has no nerve, blood vessel, and lymphatic system, its self-repair ability is very limited, and cartilage defects with a diameter > 2 mm can hardly be completely repaired. There are obvious defects in current clinical treatment methods: conservative treatment and joint cleaning surgery can only temporarily relieve pain, but cannot cure it; autologous bone transplantation will cause defects in other parts, and the source is limited, so it is difficult to repair large-area...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/20A61L27/22A61L27/24A61L27/18A61L27/04A61L27/06A61L27/56A61L27/52A61L27/50
CPCA61L27/045A61L27/047A61L27/06A61L27/18A61L27/20A61L27/222A61L27/227A61L27/24A61L27/50A61L27/52A61L27/56A61L2430/06A61L2430/24C08L5/08C08L5/12C08L67/04C08L71/02
Inventor 叶雷
Owner CHONGQING RUNZE PHARM CO LTD
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