41606 results about "Macromolecule" patented technology

This invention discloses methods for preparing compositions of cyclodextrin polymers for carrying drugs and other active agents. Methods are also disclosed for preparing cyclodextrin polymer carriers that release drugs under controlled conditions. The invention also discloses methods for preparing compositions of cyclodextrin polymer carriers that are coupled to biorecognition molecules for targeting the delivery of drugs to their site of action. The advantages of the water soluble (or colloidal) cyclodextrin polymer carrier are: (1) Drugs can be used that are designed for efficacy without conjugation requirements. (2) It will allow the use of drugs designed solely for efficacy without regard for solubility. (3) Unmodified drugs can be delivered as macromolecules and released within the cell. (4) Drugs can be targeted by coupling the carrier to biorecognition molecules. (5) Synthesis methods are independent of the drug to facilitate multiple drug therapies.

The invention concerns a dried form of a porous polymer gel material which may be rehydrated and placed under pressure or compression to induce solvation, thereby forming a high concentration gel, in the form of an injectable viscous putty or dough, which may be implantated in the body.

Oligonucleotides and other macromolecules are provided which have increased nuclease resistance, substituent groups for increasing binding affinity to complementary strand, and subsequences of 2′-deoxy-erythro-pentofuranosyl nucleotides that activate RNase H. Such oligonucleotides and macromolecules are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to oligonucleotide therapeutics.

Oligonucleotides and other macromolecules are provided that have increased nuclease resistance, substituent groups for increasing binding affinity to complementary strand, and sub-sequences of 2'-deoxy-erythro-pentofuranosyl nucleotides that activate RNase H enzyme. Such oligonucleotides and macromolecules are useful for diagnostics and other research purposes, for modulating protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to antisense therapeutics.

Macromolecules are provided that have increased nuclease resistance, increasing binding affinity to a complementary strand, and that activate RNase H enzyme. The macromolecules have the structure PNA-DNA-PNA where the DNA portion is composed of subunits of 2'-deoxy-erythro-pento-furanosyl nucleotides and the PNA portions are composed of subunits of peptide nucleic acids. Such macromolecules are useful for diagnostics and other research purposes, for modulating protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to therapeutics.

The object of the present invention is to provide a carbon nanotube composition that does not impair the characteristics of the carbon nanotubes itself, allows the carbon nanotubes to be dispersed or solubilized in a solvent, does not cause separation or aggregation of the carbon nanotubes even during long-term storage, has superior electrical conductivity, film formability and moldability, can be easily coated or covered onto a base material, and the resulting coated film has superior moisture resistance, weather resistance and hardness; a composite having a coated film composed thereof; and, their production methods. In order to achieve this object, the present invention provides a carbon nanotube composition that contains a conducting polymer (a) or heterocyclic compound trimer (i), a solvent (b) and carbon nanotubes (c), and may additionally contain a high molecular weight compound (d), a basic compound (e), a surfactant (f), a silane coupling agent (g) and colloidal silica (h) as necessary; a composite having a coated film composed of the composition; and, their production methods.

The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.

The invention relates to polydimethylsiloxane which is provided with an initiator at the surface, and is the silicon-hydrogen bonding cross-linked polydimethylsiloxane, of which the surface contains 0.01 to 1At percent 2-bromine-2-methyl propioric acid 10-undecene ester. The material is formed by mixing a polymer precursor, a cross-liner and the initiator with olefinic end in the weight ratio of 10: 1: 4-0.01 and placing for 6 to 24 hours. The polydimethylsiloxane with the initiator at the surface which is provided by the invention further modifies a function layer on the surface by triggering the polymerization reaction on the surface, so the polydimethylsiloxane can be applied on biocompatible, organic solvent compatible and thermal sensitive materials. The invention uses the simple and convenient method to realize the universal, permanent, diverse and functional surface modified polydimethylsiloxane.

A droplet deposition-based freeform fabrication method for making a three-dimensional object from a design created on a computer, including (a) providing a support member; (b) operating a droplet dispensing head for dispensing droplets of a material composition in a fluent state at a first temperature onto the support member, the material composition including a reactive prepolymer with a melting point above 23° C. and the first temperature being greater than the prepolymer melting point; (c) operating material treatment devices for causing the material composition to rapidly achieve a rigid state in which the material composition is substantially solidified to build up the 3-D object, the material treatment devices also working to convert the reactive prepolymer to a higher molecular weight thermoplastic resin; and (d) operating control devices for generating control signals in response to coordinates of the object design to control the movement of the dispensing head relative to the support member and for controlling the droplet dispensing of the material composition to construct the 3-D object.

A composition of enzyme, polymer, and crosslinker forms a network of covalently bound macromolecules. The covalently immobilized enzyme preparation has enzymatic activity, and retains stable activity when dried and stored at ambient conditions. Methods for preparing an immobilized enzyme and methods for using the enzyme are disclosed.

The present invention provides for a practical, universal and efficient method to ligate two large macromolecules (e.g., proteins) using the alkyne-azide 1,3-dipolar cycloaddition reaction to produce a conjugated macromolecule, such as a multivalent scFv. The present invention also provides for conjugate macromolecules comprising a plurality of macromolecule components cross-linked through at least one linking group comprising at least one 1,2,3-triazole moiety, wherein at least 50 percent of the macromolecule components in the conjugate macromolecule has only one site available for cross-linking.

The present invention is directed to a process of atom (or group) transfer radical polymerization for the synthesis of novel homopolymer or a block or graft copolymer, optionally containing at least one polar group, with well defined molecular architecture and narrow polydipersity index, in the presence of an initiating system comprising (i) an initiator having a radically transferrable atom or group, (ii) a transition metal compound, and (iii) a ligand, the present invention is also directed to the synthesis of a macromolecule having at least two halogen groups which can be used as a macroinitiator component (i) to subsequently form a block or graft copolymer by an atom or group transfer radical polymerization process; the present invention is also directed to a process of atom or group transfer radical polymerization for the synthesis of a branched or hyperbranched polymer; in addition, the present invention is directed to a process of atom or group transfer radical polymerization for the synthesis of a macroinitiator which can subsequently be used to produce a block or graft copolymer.

A main chain-type or side chain-type polymeric compound having a structure wherein at least one metal complex segment having a plurality ligands is introduced into a main chain or a side chain is provided. In the case where the polymeric compound is the main chain-type polymeric compound, the metal complex segment has at least one ligand constituting a polymer main chain of the polymeric compound and having a carbon atom and oxygen atom bonded to a metal atom. On the other hand, in the case where the polymeric compound is the side chain-type polymeric compound, a polymer main chain thereof has a conjugated structure, preferably a conjugated double bond. A ligand for the polymeric compound includes a chain or cyclic ligand, of which a bidentate ligand having an organic cyclic structure is preferred, and the ligand has at least one carbon atom or oxygen atom and is bonded to a center metal atom, preferably iridium, via the carbon atom or oxygen atom. In a case of forming a luminescence layer by using the polymeric compound as a luminescent material, a resultant organic luminescence device is less liable to cause a concentration extinction and is a high-luminescence efficiency device excellent in stability.

The present invention belongs to the field of inorganic nanometer material technology, in particular, it relates to a method for preparing mesoporous molecular sieve carrier material by using diblockmacromolecular polymer. It is characterized by that under the acid condition it uses polyoxyethylene-polyoxybutylene diblock macromolecular surfactant as template agent and makes hydrothermal synthesis at 100 deg.C to prepare mesoporous silicon oxide material with two-dimensional hexagonal structure with high degree of order and large specific surface area and laminate silicon oxide material withhigh degree of order. These new material can be used as catalyst, catalyst carrier, adsorption film, organic-inorganic composite material, sensor and chromatographic packing, etc.

An intravaginal drug delivery device comprises a device body comprising a hydrophobic carrier material having at least one channel defining at least one opening to the exterior of said device body, said at least one channel being adapted to receive at least one drug-containing insert; at least one drug-containing insert positioned in said at least one channel, said drug-containing insert capable of releasing a pharmaceutically effective amount of at least one drug suitable for intravaginal administration and containing about 1% to about 70% of at least one water-soluble release enhancer, both the drug and the water-soluble release enhancer dispersed in an insert carrier material; wherein said hydrophobic carrier material and said insert carrier material may be the same or different; and wherein said at least one drug-containing insert is exposed on said exterior of said device body when said intravaginal drug delivery device is in use.

The invention relates to compound millimicron fibrous membrane material of cellulose and cellulose matrix which can perform the biological degradation and the biological absorption and a preparation method thereof and an industry and medical purpose, and belongs to the biological macro-molecule non woven fabric material field which can perform the biological degradation and the biological absorption. Electrostatic spinning equipment is used to obtain the fibrous membrane material which can perform the biological degradation and the biological absorption, the weight of the cellulose is taken as basic reference, the component of the material comprises cellulose more than 0 and less than or equal to 100 weight parts, other biomacromolecule more than and equal to 0 and less than 100 weight parts, 0 to 10 weight parts of curative drug or 0 to 50 weight parts of inorganic catalyzer and / or 0 to 50 weight parts of inorganic strengthening agent. The material of the invention has good biological compatibility, biological degradation property and degradation absorptivity, and can be used for haemostasia material, wound cladding material, organization engineering supporting rack material, the transportation and release of medicine, artificial skin and blood vessel, and postoperation anti blocking material, beauty material and catalyzer carrier, filtering membrane and radiation protection material and so on.

The invention relates to a hyaluronan and biodegradable high polymer modified material and a preparation method, in particular to a method for complex crosslinking and grafting of the hyaluronan and a derivative thereof with a biodegradable high polymer with active functional groups through a crosslinking agent. The method comprises the steps of taking the hyaluronan and the biodegradable high polymer as raw materials, conducting complex crosslinking or grafting reaction of a hyaluronan aqueous solution and at least one biodegradable high polymer solution with the presence of the crosslinking agent, and removing a solvent. According to the method, plural gel, an amphiphilic polymer, a graft polymer, a star polymer and a microsphere can be prepared. The method has the advantages that the reaction condition is simple, the utilization ratio of the crosslinking agent is high, the residual quantity of the crosslinking agent is small, and the gel is higher in thermostability and good in biological compatibility. The method is applicable to the fields of cosmetics, tissue filling and repair, biological stents, ophthalmonogy, sustained-release delivery and targeted drug delivery and the like, and has a wider application prospect.

An object of the invention is to provide a method for delivery of macromolecules into biological cells, such as Langerhans cells (22) in the epidermis (20) of a patient, which includes the steps of coating electodes (16) in an electrode assembly (12) with solid phase macromolecules to be delivered, such as a DNA, and / or RNA vaccine or a protein-based vaccine, attaching the electrode assembly (12) having the coated electrodes (16) to an electrode assembly holder (13), providing a waveform generator (15), establishing electrically conductive pathways between the electrodes (16), and the waveform generator (15), locating the electrodes (16) such that the biological cells are situated therebetween, such as by penetrating the needle electrode (16) into the epidermis (20) above the epidermal basal lamina, and providing pulse waveform from the waveform generator (15) to the electrodes (16), such that macromolecule on the electrodes (16) is driven off of the electrodes (16), and delivered into the biological cells, such as the Langerhans cells (22).

A medical instrument coupled to first and second energy means and a computer controller for the controlled volumetric removal of thin tissue layers. The system provides a source for introducing a gas to controllably form and capture transient gas volumes in a microchannel structure at the working surface of the instrument that interfaces with a targeted tissue site. Each of the microchannel features of the working surface carries an electrode element coupled to the electrical source. The energy may be applied to the targeted site in either of two modes of operation, depending in part on voltage and repetition rate of energy delivery. In one mode of energy application, electrical potential is selected to cause an intense electrical arc across the transient ionized gas volumes to cause an energy-tissue interaction characterized by tissue vaporization. In another preferred mode of energy delivery, the system applies selected levels of energy to the targeted site by means of an energetic plasma at the instrument working surface to cause molecular volatilization of surface macromolecules thus resulting in material removal. Both modes of operation limit collateral thermal damage to tissue volumes adjacent to the targeted site. Another preferred embodiment provides and an ultrasound source or other vibrational source coupled to the working end to cause cavitation in fluid about the working end.

The invention provides a method for preparing a complexly shaped biomedical porous titanium molybdenum alloy implant body and belongs to the technical field of biomedical porous metallic material preparation. The method comprises the following steps of: taking a mixture of titanium and molybdenum metallic element powder and organic polymer powder as raw materials, and then preparing the biomedical porous titanium molybdenum alloy implant body by adopting the processes, such as three-dimensional modeling, selective laser-firing rapid forming, thermal de-greasing, vacuum sintering, and the like. The processing steps are simple, the period is short, the use ratio of materials is high, the cost is low, any complexly shaped porous titanium alloy implant body can be conveniently manufactured, and the method has efficiency and economic advantages in individual design and rapid manufacturing of the implant body. A titanium molybdenum alloy material prepared by using the method has the advantages that pore space is uniform, adjustment scopes of porosity, aperture ratio and aperture are wide, elasticity modulus and compression strength are in close proximity to natural bone, and the demand on biomechanical compatibility required by a biomedical material is met.

The present invention provides one kind of water gel containing natural high molecular material and its preparation process. The water gel has cross-linking degree of 70-95 % and water absorption of 500-80000 %, and contains natural high molecular material or its derivative selected from chitin, chitin derivative, chitosan, chitosan derivative, carrageenin, etc. The water gel may have synthetic high molecular material, inorganic filler, cross-linking sensitizer, medicine and other assistant added. It is prepared through radiation cross-linking, with the radiation dosage being 10-40 kGy. The water gel of the present invention has high water absorption, high flexibility, good medicine slow releasing performance, and may be used in wound dressing, etc.

A device for concentrating and / or purifying macromolecules in liquids is disclosed wherein the concentration / purification is accomplished by a membrane separating concentration and filtration chambers, the membrane and chambers being compressively held in fluid-tight relationship by sliding engagement with a sleeve-like housing. A method for assembling such a device is also disclosed.

A high throughput screening and isolation system identifies rare enhancer mixtures from a candidate pool of penetration enhancer combinations. The combinations are screened for high penetration but low irritation potential using a unique data mining method to find new potent and safe chemical penetration enhancer combinations. The members of a library of chemical penetration enhancer combinations are screened with a high throughput device to identify “hot spots”, particular combinations that show higher chemical penetration enhancement compared to neighboring compositions. The irritation potentials of the hot spot combinations are measured to identify combinations that also show low irritation potential. A active component, such as a drug, is then combined with the combination in a formulation which is tested for the ability of the drug to penetrate into or through skin. It is then assessed whether the formulation can deliver the quantity of drug required, and animal tests are conducted to confirm in vivo the ability of the chemical penetration enhancer combinations to facilitate transport of sufficient active molecules across the skin to achieve therapeutic levels of the active molecule in the animal's blood. The invention provides specific unique and rare mixtures of chemical penetration enhancers that enhance skin permeability to hydrophilic macromolecules by more than 50-fold without inducing skin irritation, such as combinations of sodium laurel ether sulfate and 1-phenyl piperazine, and combinations of N-lauryl sarcosine and Span 20 / sorbitan monolaurate.

Methods of analyzing features such as the physical size of macromolecules or biomarkers along large genomic DNA molecules were disclosed as well as the devices for carrying out such high throughput analysis in a massively parallel fashion. Methods of fabricating such devices are also disclosed.

This invention provides a process of removing sulfur oxides, mercury vapor, and fine particulate matters from industrial flue gases that contain such pollutants. The pollutants are removed by modules, which contain microporous adsorbent (i.e., sorbent) material that is held within a polymer matrix. The preferred polymers are fluoropolymers. The composite material that contains the microporous absorbent material held within a polymer matrix removes sulfur oxides by converting them into high concentration sulfuric acids. It also removes mercury vapor by chemically adsorbing the mercury into the matrix. It also removes fine particulate matters by surface filtration. The sulfuric acid that is produced inside the composite material is automatically expelled onto the external surfaces of the composite material and is drained into an acid reservoir together with the fine particulate matters which are washed from the external surfaces of the composite material by the constant dripping of the sulfuric acid along the external surfaces of the composite material.

The invention relates to a composition for killing virus and preventing influenza and a cold prevention plaster prepared by the composition. An aromatic traditional Chinese medicine volatile extract product and fragrant plant essential oil are used as effective components of the plaster; high-molecular colloid, which can be compatible with the effective components and has a stereo network structure, and an excipient are used to wrap the effective components to prepare a microcapsule; the microcapsule is used to coat on a matrix to prepare a tablet; a double faced adhesive tape is used to plaster the tablet at the position close to mouth and nose (such as collar, shoulder, chest and the like) so as to allow the effective components to slowly release at uniform speed. The plaster can be used to kill pathogen and virus in the air and enhance the immunity of upper respiratory tract, has an obvious effect of preventing influenza, and has a certain prevention effect for common cold, hand-foot-mouth disease, varicella, measles, epidemic encephalitis B, epidemic mumps, chronic respiratory tract diseases and the like. The plaster is convenient to use, has fragrant smell and is safe without side-effect.

PCT No. PCT / EP96 / 04234 Sec. 371 Date Mar. 30, 1998 Sec. 102(e) Date Mar. 30, 1998 PCT Filed Sep. 27, 1996 PCT Pub. No. WO97 / 12528 PCT Pub. Date Apr. 10, 1997There is provided a biodegradable filter tow or filter material from renewable raw materials for the use as a tobacco smoke filter element of cigarettes, cigars or pipes as well as a method for preparing it, wherein fibers, films or foams prepared in an extrusion method from biopolymers based on thermoplastic starch or its polymer compositions are processed to the filter tow or filter material according to the present invention. The advantages of this invention reside in the use of mainly renewable raw materials, a fast and complete biodegradability of the natural biopolymer filter material, a pollutant-reducing flavor-increasing filtering effect and an economically favorable preparation method.