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405 results about "Natural bone" patented technology

Radiolucent bone graft

An improved bone graft is provided for human implantation, bone graft includes a substrate block of high strength biocompatible material having a selected size and shape to fit the anatomical space, and a controlled porosity analogous to natural bone. The substrate block may be coated with a bio-active surface coating material such as hydroxyapatite or a calcium phosphate to promote bone ingrowth and enhanced bone fusion. Upon implantation, the bone graft provides a spacer element having a desired combination of mechanical strength together with osteoconductivity and osteoinductivity to promote bone ingrowth and fusion, as well as radiolucency for facilitated post-operative monitoring. The bone graft may additionally carry one or more natural or synthetic therapeutic agents for further promoting bone ingrowth and fusion.
Owner:AMEDICA A DELAWARE

Method for preparing complexly shaped biomedical porous titanium molybdenum alloy implant body

The invention provides a method for preparing a complexly shaped biomedical porous titanium molybdenum alloy implant body and belongs to the technical field of biomedical porous metallic material preparation. The method comprises the following steps of: taking a mixture of titanium and molybdenum metallic element powder and organic polymer powder as raw materials, and then preparing the biomedical porous titanium molybdenum alloy implant body by adopting the processes, such as three-dimensional modeling, selective laser-firing rapid forming, thermal de-greasing, vacuum sintering, and the like. The processing steps are simple, the period is short, the use ratio of materials is high, the cost is low, any complexly shaped porous titanium alloy implant body can be conveniently manufactured, and the method has efficiency and economic advantages in individual design and rapid manufacturing of the implant body. A titanium molybdenum alloy material prepared by using the method has the advantages that pore space is uniform, adjustment scopes of porosity, aperture ratio and aperture are wide, elasticity modulus and compression strength are in close proximity to natural bone, and the demand on biomechanical compatibility required by a biomedical material is met.
Owner:UNIV OF SCI & TECH BEIJING

Modeling micro-scaffold-based implants for bone tissue engineering

A new conceptual biomedical method is presented for designing scaffold-based bone implants and using these implants in treating deteriorated bones. These implants have micro-architectural bone structures that are capable of mimicking the stochastic micro-structure as in natural bone bio-mineral structures. Moreover, they can be adapted as specific tailor-made compatible bone-repair mediator implants to be used as effective substitutes for natural damaged bone fracture structures.
Owner:TECHNION RES & DEV FOUND LTD

Porous calcium phosphate bone material

Porous calcium phosphate implant compositions that approximate the chemical composition of natural bone mineral are provided. In addition to calcium phosphate, the compositions include an effervescent agent to promote the formation of interconnected pores and a cohesiveness agent to maintain the shape and hardness of the hardened composition. When introduced at an implant site, the calcium phosphate compositions are remodeled into bone. Methods for using the calcium phosphate compositions, e.g., to repair or replace bone, are also provided.
Owner:ETEX

Osteoconductive integrated spinal cage and method of making same

The spinal cage comprises a structural component having sufficient strength to withstand the compressive loading between vertebral bodies. The structural component is integrated with an osteoconductive component to facilitate bone growth between the vertebral bodies. The structural component may comprise any of PEEK, PEKK, or other structural material. The osteoconductive component may comprise any of allograft, natural bone, tricalcium phosphate, hydroxyapatite or a blend of calcium carbonate, calcium lactate and other calcium salts. A method for making the spinal cage involves molding polymers around an osteoconductive component, heat staking, and may further include ultrasonically welding, snap fit or mechanically assembling and / or adhesively bonding components.
Owner:SPINAL ELEMENTS INC

Self-hardening calcium phosphate materials with high resistance to fracture, controlled strength histories and tailored macropore formation rates

InactiveUS6955716B2Strong and tough self-hardeningHigh strengthPhosphatesOther chemical processesFiberHigh resistance
A bone replacement material and therapy comprises the combination of calcium phosphate compounds and two or more soluble fillers in the form of fibers, mesh or other materials which have the dual functions of reinforcing an in vivo implant while dissolving at a programmed rate to form macropores capable of receiving natural bone ingrowth.
Owner:ADA FOUND

Bone cement composite containing particles in a non-uniform spatial distribution and devices for implementation

One embodiment of the invention comprises a differential composite in which bone cement everywhere or substantially everywhere contains at least some non-zero volume fraction of particles, and in which the local volume fraction of particles may vary from place to place in the composite in a controlled manner. The variation may be by identifiable region or may be in the form of a gradient of the local volume fraction of particles. In at least some places, the local volume fraction of particles may be such that the particles act as crack arrestors. Close to the interface with natural bone, the local volume fraction of particles may be greater. In at least some places adjoining natural bone, the local volume fraction of particles may be such as to allow bone ingrowth into appropriate region(s) of the composite, resulting in improved interfacial shear strength. Methods and apparatuses for producing and delivering the composite are also disclosed, which may include use of an introducer and an expandable basket-type device.
Owner:OSSEON THERAPEUTICS

Osteoconductive spinal fixation system

An improved spinal fixation system is provided for human implantation, including a set of screws with interconnecting rods for implantation into the pedicle and between two adjacent vertebrae or a plate with screws for fixating two adjacent vertebrae. The screws, rods, and plates include a substrate portion of high strength biocompatible material and a controlled porosity analogous to natural bone. The substrate portion may be coated with a bio-active surface coating material such as hydroxyapatite or a calcium phosphate to promote bone ingrowth and enhanced bone fusion. Upon implantation, the fixation system provides a desired combination of mechanical strength together with osteoconductivity and bio-activity to promote bone ingrowth and fusion, as well as radiolucency for facilitated post-operative monitoring. The fixation system may additionally carry one or more natural or synthetic therapeutic agents for further promoting bone ingrowth and fusion.
Owner:AMEDICA A DELAWARE

Ultrasound guided automated wireless distraction osteogenesis

A bone distraction device applies guided incremental forces to opposing bone segments for the purpose of generating native bone in an osteotomy site (distraction osteogenesis). The bone distraction device automatically adjusts the rate of the distraction utilizing feedback received from the ultrasound transducer and other sensors, using an adaptive decision algorithm(s). A wireless transmitter allows for remote guidance, feedback and monitoring.
Owner:JUNDT JONATHON +1

Osteoinductive bone material

Osteogenic bone implant compositions that approximate the chemical composition of natural bone are provided. The organic component of these implant compositions is osteoinductive despite the presence of the inorganic component and, further, is present in an amount sufficient to maximize the regenerative capabilities of the implant without compromising its formability and mechanical strength. The composition may be an osteoinductive powder, including demineralized bone matrix (DBM) particles, a calcium phosphate powder, and, optionally, a biocompatible cohesiveness agent. The powder may be combined with a physiologically-acceptable fluid to produce a formable, osteoinductive paste that self-hardens to form a poorly crystalline apatitic (PCA) calcium phosphate having significant compressive strength. The bone implant materials retain their cohesiveness when introduced at an implant site and are remodeled into bone in vivo. Methods for using these implant materials to repair damaged bone and a method of assaying the content of DBM particles, by weight, in a bone implant material are also provided.
Owner:ETEX

Process for producing an artificial bone model and an artificial bone model produced by the process

A process for producing an artificial bone model in accordance with the selective laser sintering process which comprises extending a powder material for sintering comprising 30 to 90 parts by weight of powder of a synthetic resin and 10 to 70% by weight of an inorganic filler to form a thin layer and irradiating a portion of the thin layer having the shape formed based on tomograpic information of a natural bone with laser light so that the irradiated portion of the thin layer is sintered. The extension of the powder material for sintering to form the thin layer and the irradiation of the thin layer with laser light for sintering are conducted repeatedly. The artificial bone model can three-dimensionally reproduce steric shapes of natural bones such as bones in the human body precisely and accurately and exhibits the property for cutting closely similar to that of natural bones. The artificial bone model can be used for educational training or for studying a plan for curing before a surgical operation.
Owner:ONO +1

Bone growth promoting implant

A stem-like bone implant includes longitudinal structural members and tension cables that provide curvature control and support, and rigidity against bending and buckling. The longitudinal structural members and tension cables may become an integral part of a composite regenerated bone having a substantially increased strength over natural bone. The flexibility of the implant is controlled by specifically varying the structural geometry of certain portions of the implant, and by adjusting the tension in the tension cables before, during and after the implantation operation to thereby adjust the stiffness of the implant. The tension cables may be adjusted to produce asymmetric or non-uniform levels of tension in the longitudinal structural members.
Owner:ACTIVE IMPLANTS LLC +1

Customized implants for bone replacement

The present invention relates to customized implants for bone replacement that are prepared from poly(ether ketone ketone) or PEKK, and to a computer-based imaging and rapid prototyping (RP)-based manufacturing method for the design and manufacture of these customized implants. The PEKK customized implants made using rapid prototyping demonstrate biomechanical properties similar (if not identical) to that of natural bone even when prepared without the use of processing aids such as carbon black and aluminum powder.
Owner:OXFORD PERFORMANCE MATERIALS

Machinable preformed calcium phosphate bone substitute material implants

The present invention provides machinable calcium phosphate bone substitute material implants having mechanical properties comparable to those of natural bone. The implants include intimately mixed solid precursor materials that react under physiological conditions to form poorly-crystalline hydroxyapatite and eventually are remodeled into bone in vivo. The implants can include a biocompatible polymer to increase density and strength and control resorbability.
Owner:ETEX

Pore network model (PNM)-based bionic bone scaffold designing method

The invention relates to a pore network model (PNM)-based bionic bone scaffold constructing method. The method comprises the following steps of: acquiring a cross section image of microscopic three-dimensional micropore structural information and three-dimensional space position density information of a human bone by a micro computed tomography (Micro-CT) technology; performing threshold value processing to acquire binarized image data; extracting a spongy bone part, and measuring by using Mimics software to acquire porosity, penetration rate, aperture and the like; programming PNM bone scaffold parameters according to a PNM principle by using the acquired bone overall dimension data and internal size data; acquiring a generating program of the bone scaffold by using a programming tool C++ and OPENGRIP language programming; generating a three-dimensional model of the PNM bionic bone scaffold by using a Unigraphics (UG) secondary development platform; and finally leading the PNM bionic bone scaffold into the Mimics software to verify the parameters, such as the aperture, the penetration rate and the like of the PNM bionic bone scaffold. The bone scaffold well imitates a natural bone, and has high performance similar to that of the natural bone; and a good porous structure and the high penetration rate are favorable for differentiation and flowing of bone derived cells.
Owner:上海蓝衍生物科技有限公司

Nano-calcium phosphates/collagen based bone substitute materials

The present invention relates to a nano-calcium phosphates / collagen composite that mimics the natural bone, both in composition and microstructure, as well as porous bone substitute and tissue engineering scaffolds made by a complex of said composite and poly(lactic acid)(PLA) or poly(lactic acid-co-glycolic acid)(PLGA). The invention also relates to the use of said scaffold in treating bone defect and bone fracture.
Owner:TSINGHUA UNIV

Porous biomaterial-filler composite and method for making the same

A porous biomaterial-filler composite comprising a biomaterial, such as collagen, interspersed with a calcium phosphate-type filler material. The porosity of the composite is similar to that of natural bone and can feature a pore size ranging from a few nanometres to greater than 100 microns. Scaffolds prepared from the biomaterial-filler composite are suitable for resorbable bone substitute materials.
Owner:YING JACKIE Y +4

Transplantable particulate bone composition having high osteoinductive capacity and methods for making and using same

A particulate bone of defined sizes which has a unique property of direct bone osteoinduction without going through endochondral ossification stage is disclosed. The bone is not subjected to chemical extraction or decalcification. This allows for the retention of all physiologically active components of native bone. The invention hinges on the newly discovered ability of bone particles of defined sizes to exert osteoinduction by a pathway superior to and distinct from demineralized bone matrix and similar preparations.
Owner:VIVEX BIOLOGICS GRP INC

Biomimetic artificial hip joint with internal growth function

The invention discloses a biomimetic artificial hip joint with an internal growth function. The joint is composed of an artificial cartilage layer, an interface bonding layer and a porous bracket, wherein the artificial cartilage layer and the porous bracket have elliptic surfaces; the surface wrapping angle of the joint is 60-120 degrees; when the wrapping angle is 80-120 degrees, 3-6 convex columnar bodies, which are uniformly distributed, are designed on the inner surface of a prosthesis along the peripheral direction; a porous coating with biological activity is prepared on the outer surface of a femoral component and materials of the coating have gradient changes from inside to outside; the porous bracket is designed into a porous structure with gradient according to a finite element optimization result, and the pore diameter is 300-800 microns; the porosity is 20%-85%. According to the biomimetic artificial hip joint disclosed by the invention, bone mass and biomechanical characteristics of thigh bones can be kept to the greatest extent; the biomimetic artificial hip joint has good mechanical properties and tribological properties; the growth of bone cells is induced or promoted so as to guarantee effective interface bonding intensity between a prosthesis implantation material and a natural bone, the stability of the planted prosthesis is improved and the service life is prolonged.
Owner:XI AN JIAOTONG UNIV

Self-hardening calcium phosphate materials with high resistance to fracture, controlled strength histories and tailored macropore formation rates

InactiveUS20050081750A1Encourage bone ingrowthHighly integratedImpression capsPhosphatesHigh resistanceFiber
A bone replacement material and therapy comprises the combination of calcium phosphate compounds and two or more soluble fillers in the form of fibers, mesh or other materials which have the dual functions of reinforcing an in vivo implant while dissolving at a programmed rate to form macropores capable of receiving natural bone ingrowth.
Owner:ADA FOUND

A bioactive porous titanium alloy human cervical intervertebral fusion device and its preparation method

The invention provides a porous titanium alloy human cervical interbody fusion cage with bioactivity and a preparation method thereof. The method comprises the following steps: firstly, inputting model data into electron beam melting equipment according to a design requirement to prepare a porous titanium alloy human cervical interbody fusion cage; secondly, preparing gelatin microspheres; and immersing gelatin microsphere dry powder in an rhBMP-2 solution for gelatin coating modification, preparing a gelatin solution A in double distilled water, immersing the porous titanium alloy human cervical interbody fusion cage in the gelatin solution A, mixing the rhBMP-2 gelatin microspheres and absolute ethanol to obtain suspension B, and immersing the gelatin-coating-modified porous titanium alloy human cervical interbody fusion cage in the suspension B to prepare the porous titanium alloy human cervical interbody fusion cage internally containing an rhBMP-2 sustained-release system. The cervical interbody fusion cage prepared with the method has modulus of elasticity close to that of natural bone tissues, and the porous structure and the bioactivity factor sustained-release system inside the cervical interbody fusion cage can induce growth of new bone tissues, so that the binding problem of bone-material interfaces is solved. Therefore, the cervical interbody fusion cage has bettermechanical compatibility and bone integration capability than those of a compact material.
Owner:维度(西安)生物医疗科技有限公司

High-strength collagen base artificial bone repair material

The invention provides a high-strength collagen base artificial bone repair material which can be used for repairing the bone defect of bearing parts of a human body. The high-strength collagen base artificial bone repair material has chemical composition and structure formed by self-assembly of nanometer calcium phosphate and collagen molecules, so that the high-strength collagen base artificial bone repair material has a biomimetic mineralization structure similar to the natural bone tissue of the human body. In terms of mechanical properties, the material has the mechanical strength similar to that of the cortical bone of the human body and can be used for repairing the bone defect of the bearing parts of the human body. The invention also provides a preparation method of the high-strength collagen base artificial bone repair material.
Owner:BEIJING ALLGENS MEDICAL SCI & TECH

Method of manufacture, installation, and system for an alveolar ridge augmentation graft

A bone graft that is made at least partially of synthetic material or demineralized bone matrix and is manufactured in suitable shape and / or dimensions to augment an alveolar ridge. The bone graft may be such as to augment both a portion of the crest of the alveolar ridge and a portion of at least one side of the alveolar ridge. The graft may include at least one hole for the intended position of an implant base, and / or at least one hole for attachment hardware. The graft may be manufactured to standard dimensions or it may be manufactured to patient-unique dimensions which may be determined radiographically prior to surgery and prior to manufacturing of the bone graft. The bone graft may be able to be carved for dimensional adjustment during surgery. The bone graft may have composition and / or local geometry which varies from one place to another, and may have a particular composition and / or local geometry at places intended to adjoin natural bone.
Owner:THERICS

Preparation method for chitosan-based porous scaffolds with biological activity

The present invention discloses a preparation method for a chitosan-based porous scaffold with biological activity. According to the present invention, chitosan and inorganic micro / nanoparticles with biological activities are adopted as raw materials to prepare into slurry; a water-soluble aldehyde polysaccharide polymer is adopted as a cross-linking agent; a Schiff base cross-linking process and a freeze drying method are adopted to prepare a class of chitosan-based composite porous scaffold materials with biological activities, wherein porosities, pore sizes, mechanical properties, degradation performances, and bone conductions / bone inductions and the like can be regulated through the formula and the process conditions. According to the present invention, the porous scaffold provided by the present invention does not adopt harmful chemical cross-linking agents, and can not cause adverse effects to cells; with the cross-linked porous structure and a plurality of hydrophilic groups such as amino, carboxyl, hydroxyl and the like, the porous scaffold has high chemical stability in an aqueous phase with a wide pH range (pH range of 5-9), and has outstanding advantages of softness, high elasticity, swelling ratio of 30 times, and the like; the porous scaffold has advantages of imitation of natural bone extracellular microenvironment in aspects of the porous structure, the chemical composition, the surface chemistry and the like.
Owner:XI AN JIAOTONG UNIV

Three-dimensional printing technology based method for forming medical porous pure titanium implant

The invention relates to a three-dimensional printing technology based method for forming a medical porous pure titanium implant, comprising the following steps of: (1) mixing pure titanium powder with water-soluble binding materials, and grinding; (2) conveying the pure titanium powder to a platform, and inputting a designed titanium implant CAD file into matching software of three-dimensional printing equipment to direct the three-dimensional printing equipment to work; spraying binders to the titanium powder to form a two-dimensional plane by a printing head, , descending a work table to process a next layer after finishing processing one layer, and piling layer by layer for forming till a processed article is sprayed and formed completely; after the processed article is formed, standing the processed article, sweeping unbounded powder to obtain an initially forming article, and then sintering so as to obtain the medical porous pure titanium implant. The method is simple, has low cost and is suitable for industrialized production; the obtained medical porous pure titanium implant has high matching degree with a natural bone and can be better combined with a bone tissue due to a formed porous structure.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Hydroxyapatite-Binding Peptides for Bone Growth and Inhibition

ActiveUS20080279908A1Inhibiting mineral growthPhosphatesPeptide/protein ingredientsCell-Extracellular MatrixApatite
Hydroxyapatite (HA)-binding peptides are selected using combinatorial phage library display. Pseudo-repetitive consensus amino acid sequences possessing periodic hydroxyl side chains in every two or three amino acid sequences are obtained. These sequences resemble the (Gly-Pro-Hyp)x repeat of human type I collagen, a major component of extracellular matrices of natural bone. A consistent presence of basic amino acid residues is also observed. The peptides are synthesized by the solid-phase synthetic method and then used for template-driven HA-mineralization. Microscopy reveal that the peptides template the growth of polycrystalline HA crystals ˜40 nm in size.
Owner:RGT UNIV OF CALIFORNIA
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