765 results about "Bone mass" patented technology

A sleeve and loop knotless suture anchor assembly for attachment of tissue to bone mass. The assembly includes a hollow anchoring sleeve with a suture loop attached thereto and an anchor device for capturing the loop with a snag element or recess thereon or therein the anchor device. Once the loop is captured, the anchor is inserted securely into the hollow anchoring sleeve which is installed in the bone mass which facilitates a repair of the torn away soft tissue.

A free loop knotless suture anchor assembly for attachment of tissue to bone mass. The assembly includes a continuous suture loop and an anchor means for capturing portions of the loop with a snag means or recess thereon or therein the anchor means. Once the loop is captured, the anchor is inserted securely into a bone mass which facilitates in a repair of the torn away soft tissue.

A one-piece or two-piece knotless suture anchor assembly for the attachment or reattachment or repair of tissue to a bone mass. The assembly allows for an endoscopic or open surgical procedure to take place without the requirement of tying a knot for reattachment of tissue to bone mass. In one embodiment, a spike member is inserted through tissue and then inserted into a dowel-like hollow anchoring sleeve which has been inserted into a bone mass. The spike member is securely fastened or attached to the anchoring sleeve with a ratcheting mechanism thereby pulling or adhering (attaching) the tissue to the bone mass.

A system and method for anterior fixation of the spine utilizes a cylindrical implant engaged in the intradiscal space at the cephalad and caudal ends of the construct. The implants are cylindrical fusion devices (10) filled with bone material to promote bone ingrowth and fusion of the disc space. An attachment member (40) is connected to each of the fusion devices (10) and bone screws (30) having similar attachment members (33) are engaged in the vertebral bodies of the intermediate vertebrae. A spinal rod (50) is connected to each of the attachment members using an eyebolt assembly (53, 54, 55). In a further inventive method, a revision of the construct is achieved by removing the fusion devices. Each fusion device is engaged by an elongated guide member (62) over which a cylindrical trephine (70) is advanced. The trephine (70) has an inner diameter larger than the diameter of the fusion implant and includes cutting teeth (72) for extracting a core (84) of bone material around the fusion implant. The trephine (70) and guide member (62) are removed along with the bone core (84) containing the fusion implant (10). The trephine (70) is also used to extract a bone dowel from a solid bone mass to be inserted into the space left by the removed bone core (84).

A snagging knotless suture anchor assembly for attachment of tissue to bone mass. The anchor assembly includes one or more suture elements attached to the anchor. The one or more suture elements are captured by a snag means or recess located on the anchor means. Once the one or more suture elements are captured, the anchor is inserted securely into the bone mass which facilitates a repair of torn away soft tissue.

An improved suture anchor is formed from body tissue. The body tissue is shaped to a desired configuration for the anchor and defines a passage through the anchor. A suture is inserted into the passage in the body tissue of the anchor. The anchor is then positioned in a patient's body with a suture extending into the passage in the anchor. The anchor may be formed of osseous body tissue, hard compact bone, dense connective body tissue, or other body tissue. The body tissue may be dried so that it absorbs fluid and expands upon being inserted into a patient's body.

Disclosed are compositions and methods for augmenting bone formation by administering isolated human mesenchymal stem cells (hMSCs) with a ceramic material or matrix or by administering hMSCs; fresh, whole marrow; or combinations thereof in a resorbable biopolymer which supports their differentiation into the osteogenic lineage. Contemplated is the delivery of (i) isolated, culture-expanded, human mesenchymal stem cells; (ii) freshly aspirated bone marrow; or (iii) their combination in a carrier material or matrix.

The present invention provides improved methods and systems for diagnosis, prevention, and treatment of a bone related condition such as osteoporosis. The present invention integrates bone mass measurement techniques with various preventive and treatment measures to create a protocol for prevention and treatment of the bone related condition. In one embodiment, a medical practitioner treats bone mass degradation occurring in a patient by measuring a bone characteristic level in at least one of the patient's bones to yield a score, conducting a gait analysis to yield a gait characterization, measuring a bone mass marker concentration in at least one of the patient's body fluids to yield a bone marker level, and prescribing one or more therapies. Optionally, the treatment may include designating a future time to repeat the measurement of a bone characteristic level, the gait analysis, and the measurement of bone marker level.

An artificial knee joint that compresses both osseous impingement and soft tissue impingement from occurring and can endure usage over a long period of time is provided.The artificial knee joint of the present invention comprises a femoral component, a tibial tray and an insert plate fixed onto the top surface of the tibial tray. The femoral component comprises a femoral articular surface and a cam that is provided on the rear end of the femoral articular surface and protrudes from the femoral articular surface, the insert plate comprises a tibial articular surface that makes contact with the femoral articular surface and a cam-receiving slide surface that makes contact with the cam. When the knee is extended, the joint takes a first sliding state in which the femoral articular surface slides against the tibial articular surface. When the knee is bent at an angle in a range from 90 to 160 degrees, the joint shifts from the first sliding state to a second sliding state in which the cam slides on the cam-receiving slide surface. When the knee is bent deeply with a bending angle of 180 degrees, the second sliding state is assumed in which a resection surface of the femoral component and the rear end of the insert plate are offset.

Method and devices are provided for extended and controlled delivery of parathyroid hormone to a patient. The method includes implanting a medical device into the patient, the medical device comprising a substrate, a plurality of reservoirs in the substrate, a release system contained in each of the reservoirs, wherein the release system comprises parathyroid hormone; and controllably releasing a pharmaceutically effective amount of the parathyroid hormone from the reservoirs. The parathyroid hormone can be released intermittently, such as once daily over an extended period (e.g., two months, ten months, or more.). The device can further include reservoirs containing a bone resorption inhibitor or other drug for release. The devices are useful in delivering PTH for the treatment and prevention of bone loss, such as associated with osteoporosis.

A glenoid component is provided to reduce glenoid loosening when implanted in orthopedic joint replacement / reconstruction, such for a shoulder. The glenoid component can include pegs or a keel and articulating surface geometry that uses complex, non-spherical geometry to recreate a level of constraint that is adequate, but not excessive, to thereby mitigate loosening of the glenoid component after implantation. In addition, some embodiments provide that peak stresses both within cement and at an interface of the cement and a supportive component can be reduced. Further, geometry of the pegs can allow stresses to be evenly applied to a cement mantle formed in the supportive component. Finally, the pegs can be configured to desired lengths in order to avoid placement in areas of the supportive component, for example, that have insufficient bone stock.

The present invention relates to antibodies against sclerostin and compositions and methods of use for said antibodies to treat disease related to bone abnormalities such as osteoporosis. An embodiment of the invention herein provides an antibody or a functional protein comprising an antigen-binding portion of said antibody for a target in sclerostin polypeptide, characterized in that the antibody or functional protein specifically binds to sclerostin polypeptide and can increase at least one of bone formation, bone mineral density, bone mineral content, bone mass, bone quality and bone strength in a mammal.

This invention is directed to methods for treating conditions which present with low bone mass in a patient in need thereof using continuous combination therapy with a synergistically effective combination of an EP4 receptor selective agonist or a pharmaceutically acceptable salt thereof, such as 5-(3-{2S-[3R-hydroxy-4-(3-trifluoromethyl-phenyl)-butyl]-5-oxo-pyrrolidin-1-yl}-propyl)-thiophene-2-carboxylic acid or a pharmaceutically acceptable salt thereof; and an estrogen or a pharmaceutically effective salt thereof, The present methods are useful for treating conditions that present with low bone mass including osteoporosis, osteotomy, osteoporotic fracture, childhood idiopathic bone loss, periodontitis and low bone mass and for enhancing bone healing following facial reconstruction, maxillary reconstruction or mandibular reconstruction, inducing vertebral synostosis, enhancing long bone extension, enhancing the healing rate of a bone graft or a long bone fracture or enhancing prosthetic ingrowth in a patient in need thereof.

The present invention discloses agents and methods for inducing osteoblastic cellular differentiation, as well as the use of such agents and method to treat patients to maintain bone mass, enhance bone formation and / or bone repair. Exemplary agents include oxysterols, alone or in combination with particular oxysterols, or other agents known to assist in bone formation. The invention further includes medicaments including oxysterols for the treatment of bone disorders, local injections of oxysterols or cells (206) and implants (202) having agents or cells (203) to facilitate bone repair.

Apparatus and methods for therapeutically treating bone fractures, osteopenia, osteoporosis, or other tissue conditions. A platform supports a body to be treated. An oscillator is positioned within the platform and is configured to impart an oscillating force on the body. A capacitor assembly is positioned adjacent the platform for automatically determining the mass of the body being supported on the platform. Once the mass of the body is determined, an amplitude of the frequency of the oscillating force is adjusted to provide a desired therapeutic treatment to the patient. Also, the capacitor assembly is configured to turn the oscillator on and off as a function of whether or not a body is being supported on the platform.

A prosthesis for facet joints of the spinal column includes a bearing piece and a guide rod. The bearing piece includes a pressure plate that is configured for resting on an articular surface of the vertebra and, on the opposite side, a bearing insert which has an articular surface configured for interacting with an articular surface of an adjacent vertebra. The guide rod is secured on the bearing piece by means of a pivot joint. The bearing forces are transmitted to the vertebra via the pressure plate. In this way, the guide rod can have a narrow configuration, such that a slit excavated in the vertebra for receiving the guide rod can also be made narrow to permit a simple and reliable implantation technique which at the same time is gentle on the bone substance.

The present invention relates to improved diagnostic methods for early detection of a risk for developing an arthritic disorder in humans, and screening assays for therapeutic agents useful in the treatment of arthritic disorders, by comparing the levels of one or more indicators of altered mitochondrial function. Indicators of altered mitochondrial function include enzymes such as mitochondrial enzymes and ATP biosynthesis factors. Other indicators of altered mitochondrial function include mitochondrial mass, mitochondrial number and mitochondrial DNA content, cellular responses to elevated intracellular calcium and to apoptogens, and free radical production. Methods of treating, and of stratifying, human patients as such methods relate to disclosed indicators of altered mitchondrial function are also provided.

The invention encompasses compositions, methods, and kits, for fixing bone and / or repairing connective tissue associated with bone using a fenestrated bone screw. In certain embodiments, the invention encompasses a pedicle screw system including a bio-resorbable or implantable capsule containing cement and methods of use thereof for treating, preventing, and managing disorders in osteoporotic patients. In certain embodiments, the invention encompasses a fenestrated pedicle screw with cement containment skin that is useful in treating subjects in need of spine surgery due to neurologic deficit, deformity, or trauma, which subjects do not have sufficient time for the medical treatment of osteoporosis.

Prostaglandin agonists of formula (I), in which, for example, A is a sulphonyl or acyl group, B is N or CH, M contains a ring and K and Q are linking groups, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits useful for the treatment of bone disorders including osteoporosis.

A method of increasing bone mass throughout the body of a user. The method may include the steps of obtaining a distributor comprising a plurality of electromagnetic coils, obtaining a controller comprising a processor and a memory device, operably connected to one another, the memory device storing code executable by the processor, selecting a source of electrical current, connecting the source to the controller, and positioning a user proximate the distributor. The method may further include controlling, by the controller in accordance with the code, delivery of electrical current sequentially and exclusively to each coil of the plurality of electromagnetic coils to generate a magnetic field extending into the user.

Osteogenesis and osseointegration promotion and maintenance devices for osseous implants include an implant member having a first electrode, an inlaid second electrode positioned on the member so that it is electrically isolated from and substantially flush with the member surface, and an electrical stimulation mechanism preferably located at the member and operative to provide electrical stimulation signals to endosseous tissue surrounding the implant through the first and second electrodes. The first electrode may be the member itself or a second inlaid electrode. The implant is thus electrically functionalized for osteogenesis and osseointgration acceleration. The device is applicable to both non-dental and dental implants. In all embodiments, the use of inlaid electrode(s) enables the general appearance, external surface and mechanical integrity of the implant to be left essentially unchanged.

The invention discloses a biomimetic artificial hip joint with an internal growth function. The joint is composed of an artificial cartilage layer, an interface bonding layer and a porous bracket, wherein the artificial cartilage layer and the porous bracket have elliptic surfaces; the surface wrapping angle of the joint is 60-120 degrees; when the wrapping angle is 80-120 degrees, 3-6 convex columnar bodies, which are uniformly distributed, are designed on the inner surface of a prosthesis along the peripheral direction; a porous coating with biological activity is prepared on the outer surface of a femoral component and materials of the coating have gradient changes from inside to outside; the porous bracket is designed into a porous structure with gradient according to a finite element optimization result, and the pore diameter is 300-800 microns; the porosity is 20%-85%. According to the biomimetic artificial hip joint disclosed by the invention, bone mass and biomechanical characteristics of thigh bones can be kept to the greatest extent; the biomimetic artificial hip joint has good mechanical properties and tribological properties; the growth of bone cells is induced or promoted so as to guarantee effective interface bonding intensity between a prosthesis implantation material and a natural bone, the stability of the planted prosthesis is improved and the service life is prolonged.

A pharmaceutical composition for treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient.An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for treatment and / or prevention of diseases associated with decrease in bone mass.

The invention provides a novel method for down-regulating the biological activity of osteoprotegerin ligand (OPGL, TRANCE) thereby rendering possible the treatment / amelioration of diseases characterized by excessive loss of bone mass, e.g. osteoporosis. Down-regulation is effected by inducing an immune response against OPGL in an individual in need thereof. Immune responses can be raised by classical immunization with immunogenic variants of OPGL or by nucleic acid immunization where the nucleic acids encode the OPGL variant. The invention also pertains to compositions, polypeptides and nucleic acids useful in the invention, as well as to vectors and transformed host cells useful in the preparation thereof.

Described is a new bone healing method and class of bone fixation implants that change shape once implanted so as to minimize non-healing and speed the bone healing process. The bone fixation method involves shape changing implants that continuously hold the bones in apposition so that a gap does not form. Gaps in time allow non-bony tissue to infiltrate and stop healing. Furthermore, the implants actively compress bone to increase bone mass and strength. Bone cell pressure due to compression and electrical current flow due to bone deformation act to stimulate healing. The new implant designs also provide a scaffolding to conduct bone through the implant and across the healing bone interface. The methods and designs are applicable to but not limited to use for bone screws, plates, staples, rods, cylinders and external fixation devices.

The invention discloses an ultrasound bone density measuring and analyzing system. The system comprises an ultrasound parameter measuring apparatus, a communication interface and a human machine interaction device, wherein the ultrasound parameter measuring apparatus comprises transmitting unit consisting of a pulse generator, a high-voltage pulse excitation module and a transmitting probe, an ultrasound receiving unit consisting of a receiving probe, a simulation pretreatment module, a gain adjustable amplifier, a phrase comparator, a high-speed ADC and an asynchronous FIFO, and a central processor, a power supply control module and a structural body. the human machine interaction device controls the ultrasound parameter measuring apparatus through the communication interface to measure the width of a calcaneus of a detected person, the transmission speed of an ultrasound wave in the calcaneus, broadband ultrasonic attenuation to calculate the bone intensity indexes and the bone density, so a medical report can be made according to diagnostic standards of osteoporosis and a special data base can be built for long term use. The system adopts wet or dry coupling and other technologies to improve the precision and accuracy of measure and has the advantages of easy carrying, low cost, no damage caused by radiation and can be use in long term monitoring of bone condition of the detected person.

The present invention discloses agents and methods for inducing osteoblastic cellular differentiation, as well as the use of such agents and methods to treat patients to maintain bone mass, enhance bone formation and / orbone repair. Exemplary agents include oxysterols, alone or in combination with particular oxysterols, or other agents, such as bone morphogenic proteins, known to assist in bone formation. The invention further includes medicaments including oxysterols for the treatment of bone disorders and implants to facilitate bone repair.