8999results about How to "Overcome limitations" patented technology

An improved pulse oximeter provides for simultaneous, noninvasive oxygen status and photoplethysmograph measurements at both single and multiple sites. In particular, this multiple-site, multiple-parameter pulse oximeter, or “stereo pulse oximeter” simultaneously measures both arterial and venous oxygen saturation at any specific site and generates a corresponding plethysmograph waveform. A corresponding computation of arterial minus venous oxygen saturation is particularly advantageous for oxygen therapy management. An active pulse-inducing mechanism having a scattering-limited drive generates a consistent pulsatile venous signal utilized for the venous blood measurements. The stereo pulse oximeter also measures arterial oxygen saturation and plethysmograph shape parameters across multiple sites. A corresponding calculation of delta arterial saturation and comparison of plethysmograph shape parameters between multiple sites is particularly advantageous for the detection and management of persistent pulmonary hypertension in neonates (PPHN), a patent ductus arteriosis (PDA), and aortic coarctation.

This invention is directed to a medical device with a handle and a catheter. The handle can include a body having a proximal end and a distal end, an actuator moveably coupled to the body, and a handle control member coupled to the actuator, wherein the actuator can be configured to move relative to the body to move the handle control member. The catheter can include a shaft having a proximal end and a distal end, wherein the proximal end of the shaft and the distal end of the body can be configured for releasable coupling. The catheter can also include a steering section located along the shaft and a catheter control member coupled to the steering section. A securing member may move relative to at least one of the handle and the catheter to releasably couple the handle control member to the catheter control member.

An apparatus for ablating tissue, the apparatus having first and second opposing jaws operative to compress tissue to be allayed therebetween, the first jaw having a first ablation surface directing ablative energy into the tissue and the second jaw having a second ablation surface reflecting incident ablative energy into the tissue. The ablative energy may be ultrasonic, microwave, cryoablation, radio-frequency, photodynamic, laser, and cautery energy. The instrument may also have a pointed tip for piercing tissue, allowing the instrument to clamp the tissue wall of a hollow organ before ablation. Alternately, the instrument may clamp two or more tissue layers of a hollow organ without piercing prior to clamping an ablation.

The invention describes rolled electroactive polymer devices. The invention also describes employment of these devices in a wide array of applications and methods for their fabrication. A rolled electroactive polymer device converts between electrical and mechanical energy; and includes a rolled electroactive polymer and at least two electrodes to provide the mechanical / electrical energy conversion. Prestrain is typically applied to the polymer. In one embodiment, a rolled electroactive polymer device employs a mechanism, such as a spring, that provides a force to prestrain the polymer. Since prestrain improves mechanical / electrical energy conversion for many electroactive polymers, the mechanism thus improves performance of the rolled electroactive polymer device.

Systems, apparatus and methods are described that provide abstractions, tools and delivery systems useful in the publication, sharing, viewing, communication, transmission and reception of information on telephone networks. The invention also provides systems, apparatus and methods for conducting transactions on telephone networks. The systems, methods and apparatus can be optimized for use in mobile devices and may be addressed using existing telephone numbers. The abstraction typically maintains a built-in location capability. A plurality of tools are provided including a language for rendering information on telephone devices, and a protocol for enabling communications between telephone devices. In some embodiments, personal and business telephone numbers can be associated with addressable useful information about that telephone number. In many embodiments, the invention enables the calling of a telephone number to initiate voice communication in a manner identical to accessing published information associated with the target telephone number or user.

A suture lock utilizes a first engaging element and a second engaging element to define a non-through bore capture zone. Each of the engaging elements possesses a surface including at least one mating element that corresponds to a mating element on a surface of the opposing engaging element. When engaged across suture segments, the mating elements apply a frictional holding force to the suture segments. The frictional holding force secures the suture along the length of the suture in the capture zone between the mating elements.

A system for monitoring medical conditions including pressure ulcers, pressure-induced ischemia and related medical conditions comprises at least one sensor adapted to detect one or more patient characteristic including at least position, orientation, temperature, acceleration, moisture, resistance, stress, heart rate, respiration rate, and blood oxygenation, a host for processing the data received from the sensors together with historical patient data to develop an assessment of patient condition and suggested course of treatment. In some embodiments, the system can further include a support surface having one or more sensors incorporated therein either in addition to sensors affixed to the patient or as an alternative thereof. The support surface is, in some embodiments, capable of responding to commands from the host for assisting in implementing a course of action for patient treatment. The sensor can include bi-axial or tri-axial accelerometers, as well as resistive, inductive, capactive, magnetic and other sensing devices, depending on whether the sensor is located on the patient or the support surface, and for what purpose.

The present invention relates to improved ophthalmic diagnostic measurement or treatment methods or devices, that make use of a combination of a high speed eye tracking device, measuring fast translation or saccadic motion of the eye, and an eye position measurement device, determining multiple dimensions of eye position or other components of eye, relative to an ophthalmic diagnostic or treatment instrument.

Self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme, resulting in a microsphere-based analytic chemistry system. Individual microsphere sensors are disposed in microwells at a distal end of a fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle to form an optical fiber bundle sensor. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.

A system and a method for detecting malicious content associated with an electronic message are described. An electronic message, such as an e-mail, a chat request, a torrent file or a text message is initially received. The electronic message can then be compared to known viruses using pattern or signature matching techniques. The electronic message is then transmitted to a virtual machine which executes the electronic message in an environment simulating the destination computing system of the electronic message. The virtual machine monitors execution of the electronic message to identify one or more malicious actions and classifies the electronic message accordingly. For example, message component execution is monitored for attempts to access system files, attempts to access user information, attempts to transmit system configuration data or attempts to transmit user information.

A system and method for preventing propagation of malicious content associated with an electronic message are disclosed. An electronic message and content associated with the electronic message is simulated in a virtual machine which emulates the destination computing device of the electronic message. A virtual firewall receives one or more commands as the electronic message or content associated with an electronic message is executed. Initially, the virtual firewall establishes a network connection and determines the type of action associated with the commands. If the type of action comprises a connection maintenance or configuration command, the network connection is maintained. If the type of action comprises a data transmission command, the network connection is terminated. This allows the virtual machine to simulate performance of a networked computer by transmitting a subset of the data through a network connection.

Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.

The present invention presents techniques for the linking of physical blocks of a non-volatile memory into composite logical structures or “metablocks”. After determining an initial linking of good physical blocks into metablocks, a record of the linking is maintained in the non-volatile memory where it can be readily accessed when needed. In one set of embodiments, the initially linking is deterministically formed according to an algorithm and can be optimized according to the pattern of any bad blocks in the memory. As additional bad blocks arise, the linking is updated using by replacing the bad blocks in a linking with good blocks, preferably in the same sub-array of the memory as the block that they are replacing.

A user borne portable personal digital assistant, a brain activity sensing system, a surround sensing system, and correlation system are provided for video logging and memory enhancement. Signatures simultaneously input from the brain system and surround system representing the environment around the user at a given time and place are correlated into a historical relational database. Real-time query means for identifying correlations between the historical database and current internal and external signatures as the user moves through space and time are provided. Body integrated sensor, processing, and display devices are provided to accomplish statistically valid neural representations within the brain correlated to externally originated geo-spatial information and sensory representations surrounding the user. Methods and systems are disclosed for using the resultant data from the data logging system as input into a simulation, stimulation, search engine, social network, telecommunication, or emulation system within a biological, mechanical, and bio-mechanical system.

In accordance with the principles of the present invention, an audio-conference bridging system and method are provided. The present invention discards the traditional notion of a single mixing function for a conference. Instead, the novel, flexible design of the present invention provides a separate mixing function for each participant in the conference. This new architecture is described generally herein as “EdgePoint mixing.” EdgePoint mixing overcomes limitations of traditional conferencing systems by providing each participant control over his / her conference experience. EdgePoint mixing also allows, when desired, the simulation of a “real-life” conference by permitting each participant to receive a distinctly mixed audio signal from the conference depending on the speaker's “position” within a virtual conference world. The present invention also preferably accommodates participants of different qualities of service. Each participant, thus, is able to enjoy the highest-level conferencing experience that his / her own connection and equipment will permit.

Methods and apparatus for a gate-length biasing methodology for optimizing integrated digital circuits are described. The gate-length biasing methodology replaces a nominal gate-length of a transistor with a biased gate-length, where the biased gate-length includes a bias length that is small compared to the nominal gate-length. In an exemplary embodiment, the bias length is less than 10% of the nominal gate-length.

A system and method for interactive video advertising comprising advertising overlays that are displayed on a video screen to prompt user interaction. User interaction causes additional advertising content to be made available in a user interface that may be accessed immediately or at a later time point. Advertising content that populates the user interface is chosen based on marketing and behavioral data and parameters. The user interface allows users to access advertising material, send advertising materials to other users and networks such as social networks, social media, telephone networks, wireless telephone networks, cellular telephone networks, computer networks, cable television networks, satellite television networks, video game system networks, the internet, individuals, or combinations thereof. The types of data and advertising materials that may be shared are videos, pictures, photographs, text messages, sweepstakes, contests, emails, telephone calls, popularity indicators, and combinations thereof.

In a consumer information system, a method of comparing products and services including providing product specific information, providing merchant specific information on the specified product, providing merchant specific business information, providing product specific information collected by third parties, providing merchant specific information collected by third parties, applying weighting factors to the information provided, producing an aggregate value for each merchant based on the weighting factors as applied to the information provided, and producing a ranking of the merchants offering the specified product based on the aggregate value for each merchant. The system provides for consumers to select a set of standardized weighting factors or to modify the standardized weighting factors or to create their own weighting factors. The system provides detailed information to consumers on the breakdown of factors influencing the rating.

Disclosed are novel synthetically-modified B. thuringiensis chimeric crystal proteins having improved insecticidal activity against coleopteran, dipteran and lepidopteran insects. Also disclosed are the nucleic acid segments encoding these novel peptides. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and transformation of suitable host cells. Transformed host cells and tansgenic plants expressing the modified endotoxin are also aspects of the invention.

Disclosed are novel synthetically-modified B. thuringiensis chimeric crystal proteins having improved insecticidal activity against coleopteran, dipteran and lepidopteran insects. Also disclosed are the nucleic acid segments encoding these novel peptides. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and transformation of suitable host cells. Transformed host cells and transgenic plants expressing the modified endotoxin are also aspects of the invention.

A system and method for wirelessly transmitting signals via antenna phased array. In order to decrease the distance between individual antennae in the array, the antennae are submersed in a high dielectric material in addition to being arranged at right angles to one another, both features precluding one or more antennae from coupling. Furthermore, wires are covered in high dielectric material in order to refract RF signals around them, allowing antennae towards the center of the array to successfully transmit signals past other layers.

An apparatus and method for combining the functionality of multiple airborne traffic surveillance systems that operate in the L-band frequency range. The apparatus and method combine the functionality of both a Traffic Alert Collision Avoidance System (TCAS) and a Mode-Select (Mode-S) transponder in an integrated L-band traffic surveillance apparatus having a single processor that is embodied in a single Line Replaceable Unit.

Provided are an adaptive drive supporting apparatus and method that provide a personalized telematics user interface capable of supporting safe driving and convenient use. The adaptive drive supporting apparatus includes: a statistics database unit which stores and manages information on an average degree of attention required when a driving operation, a state of a car, or an external environment changes, information on degrees of attention required for manipulations of interfaces of the car, and a similarity between the functions of the interfaces; a personal characteristic setting unit which sets an individual degree of attention for each driver based on the average degree of attention according to a change in at least one of the driving operation, the state of the car, and the external environment; and an interface providing unit which determines whether or not a sum of the individual degree of attention and the degree of attention required when each driver manipulates a requested interface is larger than a predetermined threshold degree of attention required for safe driving.

CBR control strategies provide constant or relatively constant bitrate output with variable quality. The control strategies include various techniques and tools, which can be used in combination or independently. For example, an audio encoder uses a trellis in two-pass or delayed-decision CBR encoding. The trellis nodes are states derived by quantizing buffer fullness values. The transitions between nodes of a previous stage and nodes of a current stage depend on encoding a current chunk of audio at different quality levels. When pruning the trellis, the encoder uses a cost function that considers smoothness in quality as well as quality in absolute terms. The encoder may store compressed data at different quality levels, then output the compressed data after simplification of the trellis to a suitable point. If the two-pass or delayed-decision CBR encoding fails, the encoder uses one-pass CBR encoding for the sequence or part of the sequence.

A multi-dimensional audio processor receives as an input either a single channel signal or a two channel signal from an audio signal source; for example a musical instrument or an audio mixer. The processor is programmable to divide the input among at least 3 output channels in a user-defined manner. The processor is also user programmable to provide a variety of effect and mixing functions for the output channel signals.

An apparatus and method for combining the functionality of multiple airborne traffic surveillance systems that operate in the L-band frequency range. The apparatus and method combine the functionality of both a Traffic Alert Collision Avoidance System (TCAS) and a Mode-Select (Mode-S) transponder in an integrated L-band traffic surveillance apparatus having a single processor that is embodied in a single Line Replaceable Unit.

A wireless Mobile Executive Assistant (MEA) in the form of a PDA / Phone having multiple, independently oriented screens configured to provide data, video independently or in combined fashion. Formed in the opposing first and second edges adjacent to a body having main display screen formed thereon are first and second slots, respectively, the first and second slots formed to receive first and second, slidingly engaging ancillary display screens. Each of the first and second display screens provide independent video or data information from the MEA, or video or other data transmission via the MEA, and can accordingly be used to conference simultaneously with three independent parties on three separate screens. The first and second screens each slidingly engage from a stored position fully with their respective first and second slots, wherein the screens are not discernable to the observer, and the MEA has the appearance of an ordinary cellular-type phone; alternatively, the first and second screens may emanate so that the phone has a first screen emanating from one side, and a second screen emanating generally from the opposite side of the unit, with the main screen situated therebetween. In addition to independent transmissions, all three screens can be deployed to form a single wide screen transmission.

A method for forming an active pillar of a vertical channel transistor includes forming a hard mask pattern on a substrate, etching vertically the substrate using the hard mask pattern as an etch barrier to form an active pillar, and etching horizontally to remove by-product remaining on the exposed substrate, the hard mask pattern and the active pillar and at the same time to reduce line width of the hard mask pattern and the active pillar, wherein a unit cycle in which the vertical etching and the horizontal etching are each performed subsequently once, respectively, is performed repeatedly at least two times or more. According to the present invention, an active pillar having vertical profiles on its sidewalls and having height and line width (or diameter) required in a highly integrated vertical channel transistor can be provided.

Mechanisms and techniques provide the system that allows a server computer system to capture the complete state of the browser process performing on a client computer system in a remote manner. In the server computer system, which may be a collaboration adapter computer system operating a dynamic content adapter, the invention provides a system and method, such as a servlet process, for initiating a collaboration adapter session with a client computer system. The system receives a content object from the client computer system and storing document content information such as HTML and frameset content, URL information, cookie information and the like contained within the content object for shared access by participants to the collaboration adapter session. The system also generates a collaboration adapter session identification information for the collaboration adapter session based on document location information contained within the content object. The system then returns the collaboration adapter session identification information to the client computer system such that the client computer system can participate in the collaboration adapter session.

Methods and uses for molecular tags are disclosed. Molecular tags may be attached to nucleic acid molecules. The attachment of the nucleic acid molecules prior to PCR amplification and sequencing improves the accuracy of genetic analysis and detection of genetic variations and diversity. Molecular tags may also be used for detection of drug-resistant variants. Methods for using molecular tags for determining and correcting PCR errors and / or sequencing error are also disclosed.