A generally rectangular shaped universal pickup cradle (50, 154 or 156 ) for an electric musical stringed instrument (20 or 150) allows a plurality of different pickups (50, 154, 156) to be interchangeably inserted into the stringed musical instrument. In addition, there are one or more receptacle cavities (36, 38, 40, 152) in the stringed musical instrument (20, 150) so that any of the universal pickup cradles (50, 154, 156) may be placed within any of the receptacle cavities. The universal pickup cradles (50, 154, 156), in combination with a separate electronics module (177, 200), provide a flexible and upgradeable system for an electric stringed instrument.