The invention provides a locker system and a method adopting the locker system for goods storage and pickup. The locker system comprises a locker, an electronic coded lock, a control system, a system power supply, a high-definition monitoring system, a sensing system, a communication module and a user communication terminal, wherein the electronic coded lock is arranged on the locker; the control system controls the electronic coded lock; the high-definition monitoring system, the sensing system and the communication module are connected with the control system; and the user communication terminal is connected with the communication module through a communication network. During goods storage and pickup, a delivery man and a consignee can acquire use and pickup passwords of the locker through the user communication terminal, and storage and pickup operation can be finished according to prompts of the control system. In the process of goods storage and pickup, when the sensing system senses that a person is close to the locker for a certain distance, the sensing system informs the control system of starting the high-definition monitoring system to record a video, the video recording is finished after the person leaves for certain time, and the video file is stored, so that the safety and convenience of the delivery man and the consignee can be improved during goods storage and pickup.