63results about How to "Improve mitochondrial function" patented technology

The invention is directed to formulations comprised of multiple dietary and endogenously made antioxidants and B-vitamins and the use of these formulations in preventing and treating coronary artery disease.

Compositions and methods comprising bioenergetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures, are described.

The disclosure provides derivatives of both the oxidized form and the reduced form of nicotinamide riboside (NR) and nicotinic acid riboside (NAR). The NR and NAR derivatives have improved stability and bioavailability compared to NR and NAR, and can increase cellular NAD+ levels and improve mitochondrial function. Therefore, the NR and NAR derivatives are useful for treating mitochondrial diseases, mitochondria-related diseases and conditions, and other disorders and conditions.

The invention belongs to the technical field of biological medicine, and relates to a method for improving in-vitro and in-vivo maturation quality of oocytes and application of the method. Melatonin is directly added into an in-vitro maturation culture solution of the oocytes, female animals take in the melatonin, and the melatonin is proved to be capable of relieving quality reduction of the oocytes induced by oxybenzophenone. The application has the advantages that the in-vitro and in-vivo maturation rate of oocytes and the development rate of early embryos are increased, the spindle body morphology and the mitochondrial function are improved, the ROS level in the oocytes is reduced, the GSH level is increased, and the early apoptosis level is inhibited. The invention provides a method for improving the influence of oxybenzophenone on the quality of female animal oocytes, and the method has important significance for diagnosis and treatment of patients with abnormal maturation of oocytes caused by environmental factors clinically and in-vitro production of animal embryos.

The present invention provides modified metformin compounds, particularly mito-metformin compounds, and pharmaceutical compositions thereof. Methods of using the compounds to provide neuroprotection and in the treatment and / or prevention of neurodegenerative diseases are also described.

Methods and compositions relating to isolated mitochondria are disclosed. For example, cells, tissues, or organs can be treated with isolated mitochondria, such as porcine mitochondria, to improve mitochondrial function in the cell, tissue, or organ. The improvements to mitochondrial function include increased oxygen consumption and increased ATP synthesis. Such methods and compositions are useful for cell therapy; organ and tissue transplantation; organ and tissue engineering; and cold storage or shipment of harvested organs, tissues, and cells.

The present invention relates to a composition for preventing or treating mitochondrial diseases caused by immunosuppressants, and immune diseases, containing metformin and, more specifically, to a composition for treating mitochondrial diseases caused by immunosuppressants, containing metformin; a pharmaceutical composition for preventing or treating immune diseases, containing, as active ingredients, metformin and an immunosuppressant, which is a target of rapamycin inhibitor (mTOR inhibitor); and a pharmaceutical composite formulation for preventing or treating immune diseases, containing, as ingredients, metformin and a mammalian target of rapamycin inhibitor, wherein the metformin and mammalian target of rapamycin inhibitor are administered simultaneously or separately, or administered in a predetermined sequence. The composition effectively alleviates mitochondrial dysfunction, occurring as a side effect of conventional immunosuppressants, while having a more improved immunosuppressive therapeutic effect, thereby being usable in prevention and treatment of transplant rejection, autoimmune diseases, inflammatory diseases, and the like, all of which require immunosuppression.

Disclosed in certain embodiments is a pharmaceutical composition comprising a sugar; a Krebs cycle intermediate, precursor of a Krebs cycle intermediate, salt thereof, or combination thereof; and a component selected from the group consisting of an unsaturated lipid, phenylethylamine, a soluble calcium compound, or a combination thereof.

The invention relates to the field of medicines, and particularly relates to an application of notoginsenoside R1. Experiments prove that NTR1 can be used for improving the cognition, learning and memory capabilities of an APP / PS1 transgenic AD mouse, restoring the intracerebral ChAT level of the mouse, reducing the intracerebral malondialdehyde level, and improving the mitochondrial function of the AD mouse by improving the CcO activity. In addition, the NTR1 also can be used for increasing the IDE level so as to promote degradation of A beta and inhibit the accumulation of the A beta. Therefore, the invention further provides the application of the notoginsenoside R1 to preparation of a medicament for treating an alzheimer disease. Moreover, experiments prove that the notoginsenoside R1 causes no influences to cell viability within a concentration range of 0-500 micromoles, so the notoginsenoside R1 is proved to be safe in medication.

The invention discloses an intestinal mitochondrial functional protector for alleviating heat stress in broiler chickens, wherein the intestinal mitochondrial functional protector consists of 5-10 parts by weight of a ginkgo leaf extract, 6-10 parts by weight of chlorogenic acid, 5-10 parts by weight of betaine and 10-25 parts by weight of palygorskite. Compared with addition of the ginkgo leaf extract, chlorogenic acid, betaine and palygorskite separately in a feed, the protector can significantly alleviates heat stress in the broiler chickens, significantly increases the intestinal mitochondrial autophagy level under heat stress in the broiler chickens and improves intestinal mitochondrial functions of heat stress in the broiler chickens. The four components have significant interactionin increasing mitochondrial function of the broiler chickens and mitochondrial autophagy level, and have positive synergistic combined effect. The palygorskite has controlled-release effect on the ginkgo leaf extract, chlorogenic acid and betaine, the ginkgo leaf extract, chlorogenic acid and betaine are allowed to be easily mixed with a feed, a uniform dispersion system is formed and use is convenient. Through the synergistic effect of all the components, the level of mitochondrial autophagy under heat stress in the broiler chickens is significantly improved, and the intestinal mitochondrialfunction injury caused by heat stress is significantly alleviated.

Compositions and methods comprising bioenergetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures, are described.

A skin care composition is useful for augmenting cellular metabolism in skin cells and thereby enhancing the regulation of intracellular signaling. The composition comprises a primer for skin cell mitochondrial function, such as a Krebs cycle intermediate, a precursor of a Krebs cycle intermediate, salts or esters thereof, or combinations thereof. The composition may also include antioxidants for free radical regulation and a pharmaceutically acceptable topical vehicle, such as an emollient base for skin health. A method for stimulating the mitochondrial activity of skin cells comprises administering to the skin of a person in need thereof a composition as described herein.

The present invention relates to pharmaceutical compositions active in preventing, stabilizing and treating Alzheimer's disease and cognitive dysfunctions related thereto.