136 results about "Nicotinamide riboside" patented technology

The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.

A synthetic process is provided for the preparation of phosphorylated analogs of nicotinamide riboside (“NR”) having the formula (I), or salts thereof, and reduced or modified derivatives thereof, having the formula (II), wherein X−, Y1, Y2, Z1, Z2, n, R1, R2, R3, R4, R5, R6, and R7 are as defined herein. The present disclosure also relates to the preparation of phosphorylated analogs of nicotinic acid riboside (“NAR”) having the formula (I), or salts thereof, and reduced or modified derivatives thereof, having the formula (II). Generally solvent-free conditions are employed using appropriate mechano-chemical techniques as described.

The present disclosure provides nicotinate / nicotinamide riboside compounds or derivatives of formula (I):wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, and synthetic processes for the preparation thereof.

The disclosure relates to a novel method, expression vectors, and host cells for producing nicotinamide riboside by regulating the pathways that lead to the production of nicotinamide riboside.

Compositions, methods, and kits useful for treating hyperlipidemic conditions are provided herein. Such compositions can contain synergizing amounts of nicotinic acid, nicotinamide riboside and / or nicotinic acid metabolites in combination with leucine and / or a leucine metabolite, with or without resveratrol.

The invention provides a method of preventing or treating hearing loss in a mammal in need thereof. The method involves administering to the mammal an agent that increases intracellular NAD+ in the mammal. The invention also provides a method of determining if a compound acts as a neuroprotective agent.

The invention relates to methods of preparing nicotinamide riboside and derivatives thereof. In an aspect, the invention relates to a method of preparing a compound of formula (I), wherein n is 0 or 1; m is 0 or 1; Y is O or S; R1 is selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted primary or secondary amino, and substituted or unsubstituted azido; R2-R5, which may be the same or different, are each independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkynyl, and substituted or unsubstituted aryl; and X− is an anion, selected from an anion of a substituted or unsubstituted carboxylic acid, a halide, a substituted or unsubstituted sulfonate, a substituted or unsubstituted phosphate, a substituted or unsubstituted sulfate, a substituted or unsubstituted carbonate, and a substituted or unsubstituted carbamate.

Derivatives of nicotinic acid riboside (NAR), nicotinamide riboside (NR), and reduced NAR and NR, including 1-(2', 3', 5'-triacetyl-beta-D-ribofuranosyl)-1,4-dihydronicotinic acid (4a), and compositions containing the same and / or reduced derivative forms of nicotinamide riboside including 1-(2',3',5'-triacetyl-beta-D-ribofuranosyl)-1,4-nicotinamide (2), are provided for use in the care of treatment of skin and skin conditions. In some embodiments, the invention relates to pharmaceutical compositions and cosmetic compositions containing one or more NR, NAR, NRH, or NARH derivatives, or prodrugsor salts thereof. In further embodiments, the invention relates to methods of using one or more NR, NAR, NRH, or NARH derivatives, or prodrugs, solvates, or salts thereof, to promote the increase ofintracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival and overall cell and tissue health.

The invention discloses a uridine phosphatase mutant and a preparation method thereof. The amino acid sequence of the mutant is SEQ ID NO: 3, ribose-1-phosphoric acid can be effectively catalyzed to react with nicotinamide to generate nicotinamide ribose; the nicotinamide ribose can form a three-enzyme system together with purine nucleoside phosphorylase and nicotinamide ribose kinase to jointly catalyze a reaction of raw materials guanosine, phosphate, nicotinamide and ATP to synthesize the beta-nicotinamide mononucleotide by a one-pot method, and the product has good industrial development and application prospects.

The invention belongs to the technical field of biological enzyme engineering and particularly relates to a nicotinamide ribokinase mutant as well as an encoding gene and application thereof. Comparedwith wild nicotinamide ribokinase with the amino acid sequence shown as SEQ ID NO: 2, the amino acid sequence of the nicotinamide ribokinase mutant is subjected to single mutation, pairwise joint mutation, three joint mutations or any one of four joint mutations at the 9th site, the 102nd site, the 52nd site and the 146th site of the amino acid sequence shown as SEQ ID NO: 2. The nicotinamide ribokinase mutant provided by the invention can be used for synthesizing and preparing beta nicotinamide mononucleotide. Compared with a wild type enzyme, the nicotinamide ribokinase mutant constructed by the invention has the advantages that the enzyme activity is improved by 3.86-4.53 times, the reaction time is shortened, the use amount of the enzyme can be remarkably reduced, the fermentation capacity and the cost are reduced, the NMN yield is improved, and the nicotinamide ribokinase mutant has a wide prospect of large-scale industrial application.