1314 results about "Silanization" patented technology

Methods for preparing a biochip are provided herein wherein the biomolecular probe to be used with the biochip is alternatively bound to a hydrogel prepolymer prior to or simultaneously with polymerization of the prepolymer. In particularly preferred embodiments, a polyurethane-based hydrogel prepolymer is derivatized with an organic solvent soluble biomolecule, such as a peptide nucleic acid probe in aprotic, organic solvent. Following derivatization of the prepolymer, an aqueous solution, for example sodium bicarbonate, preferably buffered to a pH of about 7.2 to about 9.5, is added to the derivatized prepolymer solution to initiate polymerization of the hydrogel. Alternatively, a water soluble biomolecule, such as DNA or other oligonucleotide, is prepared in an aqueous solution and added to the polyurethane-based hydrogel prepolymer such that derivatization and polymerization occur, essentially, simultaneously. While the hydrogel is polymerizing, it is microspotted onto a solid substrate, preferably a silanated glass substrate, to which the hydrogel microdroplet becomes covalently bound. Most preferably the hydrogel microdroplets are at least about 30 mum thick, for example about 50 mum to about 100 mum thick. The resulting biochips are particularly useful for gene discovery, gene characterization, functional gene analysis and related studies.

Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian body are provided. Additionally, the biocompatible metallic medical devices can also be provided with anti-thrombogenic, lubricious coatings that release sustained, therapeutic amounts of nitric oxide. Moreover, the silanized metallic devices are surprisingly durable when exposed to harsh chemical methods often needed to bind nitric oxide-releasing functional groups to nucleophile residues. Furthermore, methods are provided for producing stable, silanized, sustained nitric oxide-releasing metallic medical devices.

The invention relates to a process for the transition metal-catalyzed addition of SiH-containing poly-siloxanes onto olefinic compounds, wherein the catalyst used is a combination of at least two compounds of platinum metals, and also to a corresponding catalyst system.

An improved, user-friendly silane / silica sol copolymer hardcoating composition for protecting optical plastic and other substrates (including wood, metals, glass, plastics and most coated articles) from scratching is able to be manufactured at lower costs and to provide much-improved ease of use in transportation, storage, dipbath (or other coating tank) stability, and blush resistance in ordinary cleanroom atmospheres. The silane / silica sol copolymer is formed as a direct reaction product of an acidic silica sol and monomethyltrialkoxysilane, preferably substantially monomethyltriethoxysilane, in ratios of 30:70 to 70:30, most preferably about 40:60. A tail solvent aids blush resistance, reduces internal stress and permits adhesion to unprimed polycarbonate. Optionally, colloidal silica sol dissolved in water-miscible solvent may be reacted in a second stage with acidic aqueous colloidal silica sol earlier silanized with monomethyltrialkoxysilane.

Oligonucleotides and other biomolecules are immobilized in high density on solid substrates through covalent forces using either a permanent thioether bond, or a chemoselectively reversible disulfide bond to a surface thiol. Substrates which have hydroxyl groups on their surfaces can be first silanized with a trichlorosilane containing 2-20 carbon atoms in its hydrocarbon backbone, terminating in a protected thiol group. The oligonucleotides or other biomolecules are first connected to a tether consisting of a hydrocarbon or polyether chain of 2-20 units in length which terminates in a thiol group. This thiol may be further modified with a halobenzylic-bifunctional water soluble reagent which allows the conjugate to be immobilized onto the surface thiol group by a permanent thioether bond. Alternatively, the oligonucleotide-tether-thiol group can be converted to a pyridyldisulfide functionality which attaches to the surface thiol by a chemoselectively reversible disulfide bond. The permanently bound oligonucleotides are immobilized in high density compared to other types of thiol functionalized silane surface and to the avidin-biotin method.

The invention aims at providing A light-shielding paste which contains a thermoplastic resin and an inorganic member as essential components; A light-shielding paste which contains a thermosetting resin and an inorganic member as essential components; A curable composition which contains, as essential components, (A) an organic compound comprising an organic main chain containing at least two carbon-carbon double bonds reactive with a SiH group in each molecule, (B) a silicon compound having at least two SiH groups in each molecule, (C) a hydrosilylation catalyst, (D) a silane coupling agent and / or an epoxy group-containing compound, (E) a silanol condensation catalyst, and (F) an inorganic member; The above curable composition which further contains (G) silica; The above curable composition which shows such a flow leveling property that when the composition is allowed to stand on a glass substrate inclined at an angle of 80 degrees at 100° C. for 1 hour, the flow-out distance is not longer than 2 cm; A light-shielding paste which comprises the above curable composition; or, A method of forming a light-shielding resin layer on a LED package having an aperture comprising a bottom and sidewalls and formed of a molding resin by a monolithic process with the respective ends of an external positive electrode and an external negative electrode being exposed at a predetermined distance on the aperture bottom which method comprises (1) applying a light-shielding paste to a substrate; (2) bringing the LED package aperture into close contact therewith; and (3) heating the LED package with the aperture facing upward; and thereby the light-shielding paste is allowed to spread along the package sidewalls alone. The curable composition of the invention is excellent in light-shielding ability and is highly resistant to light and, therefore, can be used as a light-shielding paste. Further, the curable composition of the invention is low in fluidity and, therefore, light-emitting diodes with the curing product formed on the LED package sidewalls alone can be obtained by using that curable composition. Furthermore, according to the method of light-shielding resin layer formation according to the invention, it is possible to efficiently apply a light-shielding paste to the LED package sidewalls alone for light-shielding resin layer formation, whereby the productivity is markedly improved.

The invention provides a method for preparing p-xylene through methanol / dimethyl ether conversion. The method adopts a zeolite catalyst modified with metal and silanization to directly prepare high-selectivity p-xylene through methanol / dimethyl ether conversion. The selectivity of p-xylene in aromatic products of methanol / dimethyl ether conversion is more than 80 percent by weight. The selectivity of p-xylene in xylene isomers is more than 99 percent by weight.

A continuous method for performing a hydrosilylation reaction comprising effecting a hydrosilylation reaction between a liquid organosilicon compound (A) having in each molecule at least one silicon-bonded hydrogen atom and a liquid organosilicon compound (B) having in each molecule at least one aliphatic unsaturated bond in the presence of a platinum catalyst (C) continuously in a tubular reactor equipped with a stirring and plug-flow maintaining apparatus located within the reactor.

The invention discloses a method for preparing a multi-level porous titanium-silicon molecular sieve, which comprises the following steps: (1) After mixing the silicon source, the structure-directing agent, the titanium source and water uniformly in a certain proportion, directly adding a silylating agent or first After pre-crystallization, a silylating agent is added to obtain a reaction mixture containing a silylating agent; (2) the reaction mixture containing a silylating agent is crystallized under certain conditions in a pressure-resistant airtight container, and then recovered to obtain a crystallized product; (3) the recovered crystallized product is roasted and then treated with alkali to obtain an alkaline mixture; (4) the alkaline mixture is hydrothermally treated in a pressure-resistant airtight container, and the product is recovered. The hierarchically porous titanium-silicon molecular sieve obtained by the technical scheme has the advantages of high crystallinity, high macromolecular reactivity and selectivity, and adjustable pore structure.

The invention relates to a method for modifying a TS-1 titanium-silicon molecular sieve catalyst, which mainly solves the problems that a silanization reagent is easy to hydrolyze to cover the active center of the catalyst and has large consumption, difficult recovery and environmental pollution when being used for processing the TS-1 molecular sieve catalyst in a dipping mode in the prior art. The method better solves the problem by adopting the technical scheme that a TS-1 titanium-silicon molecular sieve catalyst matrix reacts for 0.5-10 hours by leading into the silanization reagent at 50-300 DEG C in a nitrogen atmosphere, and then a modified TS-1 titanium-silicon molecular sieve catalyst is obtained, wherein the silanization reagent is selected from organosilane, organic silylamine, organic silicyl amide or organic silazane, and the dosage of the silanization reagent is 2-20 percent of the weight of the catalyst matrix. The method can be applied to the industrial production of epoxy chloropropane.

The invention relates to a preparation method of a protein magnetic imprinting nano sphere, in particular to a preparation method of a protein magnetic imprinting nano sphere which takes one of hemoglobin, muramidase or serum protein as template molecules; the preparation method includes the following steps: synthesizing magnetic nano particles which are Fe3O4 nano particles covered with silicon dioxide on the surfaces; carrying out silanization to the amino-groups on the surface of the magnetic sphere; using glutaric dialdehyde to connect protein; using silylation agent to fix the space structure of template protein; alkaline eluting the protein on the surface of the magnetic sphere to form imprinting sites. The hemoglobin, muramidase or serum protein magnetic nano imprinting polymer sphere prepared by the invention combines the precise and specific identification property of molecular imprinting and the quick separation property of the magnetic nano sphere under the action of an external magnetic field, integrates the advantages of molecular imprinting and the magnetic nano sphere, avoids complex centrifugation operation, plays vital roles in the separation of cells, protein and nucleic acid, the detection of biomolecules, tumor diagnosis and medicine targeting therapy and has promising application prospect in the field of isolation analysis.

This invention discloses a method for synthesizing organic-inorganic bentonite composite. The method comprises: utilizing bentonite as the main material, performing inorganic modification through cation-exchange reaction by using hydroxyl aluminum aqueous solution, torrefying to obtain hydroxyl-containing aluminum-pillared bentonite with high porosity and high specific surface area, and reacting between the hydroxyls and silylation agent to graft silane groups onto aluminum-pillared bentonite and obtain organic-inorganic bentonite composite. The organic-inorganic bentonite composite has both the advantages of inorganic pillared bentonite such as high porosity and high specific surface area, and those of organic bentonite such as high organic carbon content and high hydrophobicity thus can be used to treat organic waste gases and wastewater with a good effect by surface adsorption as well as distribution.

The invention belongs to the technical field of nano materials and biomedicine, in particular to multifunctional core-shell structure fluorescent coding magnetic microspheres and a preparation method thereof. On the basis of ferroferric oxide nanoparticles synthesized by a hydrothermal process, pre-prepared coupled product of fluoresceins and amino propyl trimethoxysilane and ethyl orthosilicate are subjected to cohydrolysis in ammonia water to form a multifunctional fluorescent magnetic nano composite material with fluorescent and magnetic properties and high biological stability and biological adaptability. By regulating the mixing ratio of fluoresceins, namely fluorescein isothiocyanate (FITC) and rhodamine B isothiocyanate (RBITC), various fluorescent coding magnetic microspheres can be prepared, and the particle size of obtained material can be regulated according to the different ratios of the added ethyl orthosilicate to the ferroferric oxide. In addition, the obtained multifunctional composite nano material is subjected to amino silanization modification, so the biological application range of the novel fluorescent coding magnetic microspheres is further expanded and the novel fluorescent coding magnetic microspheres have bright application prospect in fields of biomedicine technology, medicine development, suspension chip and the like.

The invention discloses a preparation method of a flexible surface enhanced Raman substrate. The method comprises the steps of preparing a flexible substrate of a micro-nano structure with a regular appearance, sequentially carrying out surface hydrophilic treatment and silanization treatment on the flexible substrate, then depositing gold-silver nano particles on the surface of the flexible substrate, wherein sufficient gold-silver nano particles can be deposited, and the gold-silver nano particles are uniformly distributed. The prepared flexible surface enhanced Raman substrate is high in detection sensitivity, good in signal consistency and convenient to use; the preparation method is simple in process and easy to operate.

The present invention relates to compositions comprising the components A, a polymer obtainable by the reaction in the sense of a hydrosilylation of a siloxane having SiH functions and vinyl functions with a further unsaturated compound, and D, metal atoms or ions, not equal to silicon, a process for the preparation of these compositions, and the use of the compositions for producing antifoams or as antifoams of liquids, and also for suppressing or reducing the foam formation of foaming liquids, and also for foam destabilization.

The invention provides a preparation method and equipment of a gradient wetted surface for achieving self-driving of liquid drops. The method comprises steps as follows: titanium dioxide particles are subjected to silanization treatment to obtain a super-hydrophobic coating; the coating coats a substrate in a spinning manner to obtain a super-hydrophobic surface; regioselective photolysis is carried out by deep ultraviolet light UV under the assist of a mask plate designed with a gradient light transmission area, and a gradient pattern designed on the mask plate can be copied on the surface of the super-hydrophobic coating; and an exposed area is transformed into super-hydrophilicity from super-hydrophobicity to obtain the gradient wetted surface. The equipment comprises the substrate and a hydrophilic-hydrophobic layer coating the surface of the substrate, wherein the hydrophilic-hydrophobic layer is divided into a plurality of areas. The preparation method and the equipment have the beneficial effects that customizing of the wetting gradient can be achieved by combining the gradient wetted surface prepared by hydrophilic-hydrophobic patterning; a microfluid can be self-driven on the surface in a directional manner; external auxiliary equipment is not needed; miniaturization and portability of a microfluidic system are easier to achieve; the preparation method is free of a strict requirement on a production environment and a substrate material; and the production cost is low.

The invention belongs to the technical field of sample pretreatment in analytical chemistry and relates to a preparation method and use of a molecular imprinting-absorbing extraction stirring rod. The preparation process of the method comprises the following steps: sintering one end of a capillary glass tube serving as a substrate of the stirring rod, and subjecting to the sintered capillary glass tube to acid and alkali treatment and surface modification by a silylating agent respectively; performing the self-assembly of template molecules and bifunctional monomers in a polymer solvent, adding a crosslinker and an initiator in the solution, plugging the modified capillary glass tube into the solution; drawing the capillary glass tube out; repeatedly coating the capillary glass tube to a required thickness, and aging the coating; cutting a proper length of coated capillary glass tube, putting the length of coated capillary glass tube in a magnetic core, and sintering the capillary glass tube for end sealing; and eluting the template molecules. The molecular imprinting-absorbing extraction stirring rod prepared by the invention can selectively separate and enrich a trace amount of template molecules and analogues at the same time and is suitable for selectively separating, enriching and analyzing a trace amount of template molecules and analogues in complex samples in terms of organism, food and environment.

A method for synthesizing silicon compounds that contain a substituent bonded to silicon through a Si-C bond comprising a platinum-catalyzed hydrosilylation reaction between SiH-substituted silicon compounds and unsaturated group-functional organic compounds or unsaturated group-functional organosilicon compounds and exhibits a high catalyst activity and stability and affords a high positional selectivity in the hydrosilylation reaction product.

The invention relates to a catalyst for preparing propylene with a high selectivity using methanol or dimethyl ether and a preparation method, in particular to a fluidized bed catalyst for preparing propylene with a high selectivity using methanol or dimethyl ether which fits the manufacturing production and a preparation method thereof. The invention carries out a modification handling for the active component of ZSM-5 molecular sieve catalyst by means of stabilizing the molecular sieve structure with the lanthanon, changing the surface acidity with the alkaline matter, and adorning the porecanal with on-line silanization and other means, and prepares a fluidized bed catalyst for preparing propylene with a high selectivity after the sponging drying; the component of the catalyst is in the light of the weight percentage as follows, the rare-earth 0.1 to 8%, the alkalinity modifying agent 0.5 to 30%, the caking agent 20 to 80%, the silanization silicon 0.05 to 10%, the rest is ZSM-5 molecular sieve.

The invention belongs to the field of high-molecular material modified technology, and discloses a wood-plastic composite material and a preparation method thereof. The wood-plastic composite material is prepared by the following components of, by weight, 40-75 parts of a plastic substrate, 20-50 parts of wood powder and 5-10 parts of auxiliary agents. The preparation method of the wood-plastic composite material comprises the following steps of (1) mixing 20-50 parts of the wood powder, 40-75 parts of the plastic substrate and 5-10 parts of the auxiliary agents which are treated by silanization adequately, for 10-60 min; (2) extruding and granulating the uniform mixture obtained from the step (1) by using a double screw extruder, forming by introducing the obtained materials into an injection machine or flat-panel vulcanizing machine, or forming by introducing the uniform mixture obtained from the step (1) into the flat-panel vulcanizing machine. An inorganic layer is formed on the surface of the wood powder, thereby facilitating improving the interface bonding property between the inorganic layer and the plastic matrix, increasing heat resistant temperature of the wood powder and allowing the wood powder not to be decomposed in a processing process.

The invention discloses a method for preparing a hierarchically porous titanium-silicon molecular sieve, which comprises the following steps: (1) uniformly mixing a silicon source, a structure-directing agent, a titanium source and water in a certain proportion, and then adding a silylating agent and a surfactant Or first precrystallize at 30-90° C. for 0.5-48 hours and then add silylating agent and surfactant to obtain a mixture containing silylating agent and surfactant; (2) the mixture obtained in step (1) in Crystallize at a temperature of 110-230° C. and autogenous pressure for 1-240 hours in a pressure-resistant airtight container to obtain a crystallized product; (3) recover the crystallized product obtained in step (2). According to the technical scheme, the hierarchical porous titanium-silicon molecular sieve with large mesopore volume, adjustable pore structure and good macromolecular reaction performance can be prepared.

A method of producing a polyoxyalkylene polymer having at least one crosslinkable silyl group and at least one hydroxyl group in each molecule which comprisestreating a polyoxyalkylene polymer having at least one unsaturated group and at least one alcoholic hydroxyl group in each molecule and an impurity double metal cyanide complex as mixed therein with a metal-coordinating compound and adding a compound having a hydrogen-silicon bond and a crosslinkable silyl group in each molecule and a hydrosilylation catalyst to thereby carry out the hydrosilylation reaction.

The invention relates to aqueous silanized polymer emulsion and the preparation method and the application thereof. The emulsion of the invention contains a silanized polymer, a hydrolysable silanized compound, water, non-essential emulsifier and non-essential nano-silicon dioxide. By adopting the preparation method of the invention, stable aqueous silanized polymer emulsion can be prepared, the prepared aqueous silanized polymer emulsion has the solid content of smaller than or equal to 85 weight percent, especially, prepared polyorganosiloxane emulsion has the solid content of smaller than or equal to 75 weight percent, and the particle diameter of smaller than 3 micrometers, and can be laid stably at the room temperature. An elastomer can be formed through cross linking after water in the emulsion is volatilized. During the operation, the emulsion can be directly diluted through the water, and can be used for preparing coating, adhesive, sealant, printing ink, release agent, skin food, cleansing agent and so on.

The present invention has its object to provide an effective method of accelerating a hydrosilylation reaction.This invention is related to a hydrosilylation reaction method which comprises carrying out the hydrosilylation reaction between a silicon compound (A) represented by the following general formula (1) and an alkenyl group-containing compound (B) in the presence of a Group VIII metal-containing catalyst (C) and a sulfur compound (D);

The invention relates to a preparation method of rare-earth luminescent nanometer particles based on pyridine dicarboxylic acid. The rare-earth luminescent nanometer particle comprises SiO2 coating luminescent rare-earth composition; the rare-earth composition is produced by ligand pyridine dicarboxylic acid combined with rare-earth ions; and SiO2 nanometer particles with active functional group on the surface are formed by the polymerization reaction of the rare-earth composition in the microemulsion and the silanization. The prepared rare-earth luminescent nanometer particle has high luminous intensity and good water solubility, and can be used for a variety of time-resolved fluorescence analysis and imaging. Compared with the homogeneous rare-earth nanometer particle preparation method, the preparation method has the advantages of low preparation cost and simple method, and can be widely applied.

A curable organopolysiloxane composition comprising at least the following components: (A) a linear diorganopolysiloxane with a mass average molecular weight of at least 3,000, (B) a branched organopolysiloxane, (C) an organopolysiloxane having, on average, at least two silicon-bonded aryl groups and, on average, at least two silicon-bonded hydrogen atoms in one molecule, and (D) a hydrosilylation reaction catalyst; has excellent curability and, when cured, forms a flexible cured product of high refractive index, optical transmissivity, excellent adherence to various substrates, high hardness and slight surface tack.

The invention discloses a preparation method of cefprozil, which comprises: 7-amin cethalosporanic acid (7-ACA) reacts with triphenyl phosphine to get 7- trimethylsilyl amino-3-triphenyl phosphate methylene-4-cethalosporanic acid trimethylsilyl ester through silanization protection and iodination reagent replacing under the condition of catalyst existing; WITTIG reaction is made for the product and acetaldehyde to get 7-trimethylsilyl amino -3-(propenyl-1-alkenyl)-4-cethalosporanic acidtrimethylsilyl ester; then the compound reacts with D-para hydroxybenzene glycine dane potassium salt to geta compound (6R, 7R)-7-[(2R)-2- ethoxycarbonyl-1-methyl - ethylene amino (4-trimethylsilyl oxyphenyl) acetamido group(amide)]-8-oxo-3- (1- propenyl)-5-thio-1- heterobicycle [4.2.0] octylene-2-ene-2-carboxylic acid trimethylsilyl ester; hydrolytic treatment is then used to get the cefprozil. The invent adopts the method of one pot and can participate in next reaction without separating intermediateproducts. The preparation method of cefprozil has the advantages of low cost, convenient operation and high overall yield, adapting to demands of industrial production.

The invention relates to a magnetic / functionalized SiO2 composite microsphere immobilized enzyme and a preparation method thereof, wherein, magnetic microspheres are cores, functionalized SiO2 is the shell, and the type and the content of functionalized groups, the particle size of the core in composite microsphere and the thickness of functionalized SiO2 can all be adjusted. The preparation method comprises the following steps: first synthesizing superparamagnetic microspheres, then treating the microspheres with hydrochloric acid, dispersing the microspheres in an ethanol / water alkaline system evenly by ultrasound, using tetraethoxysilane and silylating agent for further condensation and coating to obtain magnetic / functionalized SiO2 composite microspheres and performing absorbent immobilized and covalent immobilization to biological enzyme. The immobilized enzyme has fast magnetic responsiveness and good operational stability. The method has simple process and low cost and is applicable to industrialized production.

Disclosed herein is a process for the hydrosilylation of a composition containing a silyl hydride and a compound containing at least one unsaturated group, the process comprising contacting a non-previous metal based complex as a catalyst precursor with an activator being a reducing agent shortly before, simultaneously or after contacting the complex with the composition, to cause the silyl hydride to react with the compound containing at least one unsaturated group to produce a hydrosilylation product.

The invention provides a magnetic mesoporous silica gel material extracting agent used for enriching and / or separating trace organic pollutants in an environment water sample, and a preparation method thereof. A core of the extracting agent provided by the invention is a silicon gel microsphere (i.e. magnetic silicon gel microsphere) wrapped with a plurality of Fe3O4 magnetic nano particles, and a shell of the extracting agent is a mesoporous silicon gel shell layer with inner and outer surfaces modified by C18 silanization. The extracting agent integrates huge special surface area, excellent extracting capacity and ultrahigh extracting volume of a mesoporous material, magnetic separating capacity of a magnetic material, strong extracting capacity of C18 groups and special volume exclusion function of a vertical channel of the mesoporous material. In addition, the extracting agent provided by the invention has the advantages of high extracting efficiency, low preparation cost and simple preparation method, and is very suitable for preprocessing samples of the trace organic pollutants in a bulk-mass water sample.