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Resetting biological pathways for defending against and repairing deterioration from human aging

A repair system, selected technology, applied to plant/algae/fungus/moss components, antipyretics, drug combinations, etc.

Pending Publication Date: 2018-07-17
乔尔胡伊赞加
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0109] In general, age-related DNA hypomethylation is the main event leading to increased gene expression, but with age, hypermethylation is common in some promoter regions of DNA, leading to promoter repression

Method used

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  • Resetting biological pathways for defending against and repairing deterioration from human aging

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Embodiment

[0593] The following examples are set forth below to demonstrate methods, compositions and results in accordance with the disclosed subject matter. These examples are not intended to be inclusive of all aspects of the subject matter disclosed herein, but rather to demonstrate representative methods, compositions and results. These examples are not intended to exclude equivalents and modifications of the present invention, as will be clear to those skilled in the art.

[0594] A 61 year old Caucasian male weighing 88 kg was treated at the beginning of treatment with the regimens of class 1, class 2 and class 3 molecules indicated below.

[0595] Nicotinamide mononucleotide (NMN) (MW=334.22)

[0596] Betaine (Trimethylglycine) (MW=117.14)

[0597] h 2 o 2 (MW=34.01)

[0598] NaSH (MW=56.06)

[0599] Solutions of each compound were prepared for administration to subjects by mixing a set of gram quantities with 500 mL of water.

[0600] A typical final concentration of NMN ...

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Abstract

Compositions for addressing one or more of the effects of aging are described. The compositions comprise a first component comprising repair system activator(s) such as nicotinamide adenine dinucleotide (NAD+), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), nicotinic acid adenine mononucleotide (NaMN), nicotinic acid adenine dinucleotide (NaAD), nicotinic acid riboside (NAR), 1-methylnicotinamide (MNM), cyclic adenosine monophosphate (cAMP) and combinations thereof; a second component comprising methyl donor(s), such as S-5'-adenosyl-L-methionine (SAM), methionine, betaine, choline, folate, vitamin B12, or combinations thereof; and a third component comprising antioxidant defense activators, such as H2O2, N2S, NaSH, Na2S, and several others, including combinations thereof.Methods of administering the disclosed compositions or separate formulations of repair system activator, methyl donors, and antioxidant defense activators are also disclosed.

Description

field of invention [0001] The disclosed subject matter generally relates to compositions for preventing and repairing the effects of aging. Background of the invention [0002] Early human ancestors didn't have enough energy to do everything they could benefit from. Constraints in energy utilization during early human evolution resulted in biological trade-offs governing energy use, which limited energy use for defense and repair of cellular damage in the body. Cellular damage has been proposed as a cause of biological aging in humans (Olson C 1987, Holliday R 2004, Kirkwood T 2005, Gavrilov L 2001). Human biological aging has been proposed to be the cause of the human "disease of aging" (Cutler R 2006). [0003] The feedback loop is part of the energy trade-off control [0004] Feedback loops in biochemical synthetic pathways switch off energy expenditure in non-use regions to increase the efficiency of energy use by the total organism. The use of energy and nutrients i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P39/00A23L33/13A23L33/175A61K36/48
CPCA23L33/13A23L33/175A61K31/045A61K31/198A61K31/205A61K31/714A61K33/40A61K36/258A23V2002/00A61P37/04A61P29/00A61K31/706A61K33/04A61K2300/00A23V2200/302A61K9/0019A61K9/0095A61K9/20A61P39/00A61K31/7084A61K9/00A61K33/00A61K36/48A61P43/00
Inventor 乔尔·胡伊赞加
Owner 乔尔胡伊赞加
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