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171 results about "S-Adenosyl methionine" patented technology

S-Adenosyl methionine is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although these anabolic reactions occur throughout the body, most SAM-e is produced and consumed in the liver. More than 40 methyl transfers from SAM-e are known, to various substrates such as nucleic acids, proteins, lipids and secondary metabolites. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase (EC 2.5.1.6). SAM was first discovered by Giulio Cantoni in 1952.

Biofuel and chemical production by recombinant microorganisms via fermentation of proteinacious biomass

Provided herein are metabolically modified microorganisms characterized by having an increased keto-acid flux when compared with the wild-type organism and comprising at least one polynucleotide encoding an enzyme, and causing the production of a greater quantity of a chemical product when compared with the wild-type organism. The recombinant microorganisms are useful for producing a large number of chemical compositions from various nitrogen containing biomass compositions and other carbon sources. More specifically, provided herein are methods of producing alcohols, acetaldehyde, acetate, isobutyraldehyde, isobutyric acid, n- butyraldehyde, n-butyric acid, 2-methyl-l-butyraldehyde, 2-methyl-l -butyric acid, 3- methyl-l-butyraldehyde, 3 -methyl- 1 -butyric acid, ammonia, ammonium, amino acids, 2,3-butanediol, 1,4-butanediol, 2-methyl-l, 4-butanediol, 2-methyl- 1,4-butanediamine, isobutene, itaconate, acetoin, acetone, isobutene, 1,5-diaminopentane, L-lactic acid, D- lactic acid, shikimic acid, mevalonate, polyhydroxybutyrate (PHB), isoprenoids, fatty acids, homoalanine, 4-aminobutyric acid (GABA), succinic acid, malic acid, citric acid, adipic acid, p-hydroxy-cinnamic acid, tetrahydrofuran, 3-methyl-tetrahydrofuran, gamma-butyrolactone, pyrrolidinone, n-methylpyrrolidone, aspartic acid, lysine, cadeverine, 2-ketoadipic acid, and/or S-adenosyl-methionine (SAM), from a suitable nitrogen rich biomass.
Owner:RGT UNIV OF CALIFORNIA

Method for preparing S-adenomethionine

The invention discloses a method of preparing S-adenosyl methionine, according to the method, by using polyhydroxyl organic reagent to keep the activity of enzyme, by taking adenosine triphosphate precursor, L-methionine and phosphate ions as a substrate and taking glucose and / or Maltose as an energy supplier, and by adding the combination of metal ions, the producing strain with permeability can be used for producing S-adenosyl methionine in the way of whole-cell biocatalysis. The invention can use the combination of metal ions to regulate the metabolism flow to improve energy self-coupling efficiency; and organic reagent is added to keep the activities of thalli and enzyme. The strain with permeability is used for producing S-adenosyl methionine, thereby shortening the synthesis time and accumulating outcomes outside cells, so that the cost of the following separation can be reduced, and the operational steps also can be simplified.
Owner:NANJING UNIV OF TECH

Preparation method and applications of S-adenosylmethionine molecular imprinting sensor

The invention discloses a preparation method and applications of an S-adenosylmethionine molecular imprinting sensor. The preparation method is characterized by comprising the following steps: firstly modifying a glass-carbon electrode by using nanogold and carbon nano-tubes; successfully researching an imprinting electrochemical sensor with the specific selectivity on the surface of the glass-carbon electrode modified by using the nanogold and the carbon nano-tubes by combining a sol-gel imprinting technology, a layer-by-layer self-assembly method and an electric polymerization method. The S-adenosylmethionine molecular imprinting sensor prepared by adopting the method disclosed by the invention is greatly improved in response, shows the relatively high affinity and selectivity on S-adenosylmethionine forms a sensor which can specifically identify template molecules by being connected with an electrochemical work station and has the advantages of low cost, high sensitivity, good specificity, fastness in detection and repeatability in use.
Owner:UNIV OF JINAN

Compositions and methods for use of eflornithine and derivatives and analogs thereof to treat cancers, including gliomas

Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a higher grade. Compositions and methods can include eflornithine or a derivative or analog of eflornithine, together with other agents such as conventional anti-neoplastic agents for treatment of glioma, inhibitors of polyamine transport, polyamine analogs, or S-adenosylmethionine decarboxylase inhibitors.
Owner:ORBUS THERAPEUTICS INC
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