The invention discloses a perfect compound feed for groupers, which is a compound feed suitable for the culture of grouper large-size fish seeds. The perfect compound feed is prepared by adopting imported fish meal, fermented soybean meal, alpha-starch, flour, squid meal, krill meal, yeast extracts, fairy shrimps, fish oil, soybean phospholipids, DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid), composite mineral salt, compound vitamins, compound enzyme preparations, compound immunopotentiators, hepatinica and compound microecologic preparations as raw materials. The perfect compound feed disclosed by the invention can promote the digestion and absorption of the groupers, regulate the stability of the intestinal flora of the groupers, enhance the immunity of the groupers and play a lipotropic role by sufficiently considering the digestion and physiology characteristics of the culture period of the groupers and adding various additives to the feed, has the advantages of balanced and complete nutrition without drugs, namely added antibiotics and the like, and no pollution on water bodies and belongs to a high-efficiency environment-friendly nuisanceless feed.