Exemplary embodiments of the present disclosure relate generally to methods, computer-accessible medium and systems for assembling
haplotype and / or
genotype sequences of at least one
genome, which can be based upon, e.g., consistent layouts of short sequence reads and long-range
genome related data. For example, a
processing arrangement can be configured to perform a procedure including, e.g., obtaining randomly located short sequence reads, using at least one
score function in combination with constraints based on, e.g., the long range data, generating a
layout of randomly located short sequence reads such that the
layout is globally optimal with respect to the
score function, obtained through searching coupled with
score and constraint dependent
pruning to determine the globally optimal
layout substantially satisfying the constraints, generating a whole and / or a part of a
genome wide
haplotype sequence and / or
genotype sequence, and converting a globally optimal layout into one or more
consensus sequences.