Disclosed is a method for preparing a
liposome formulation. In the disclosed method, a
lipid fraction is dissolved in an
organic solvent. The solution including a bioactive component and the
lipid fraction, together with a carrier, is put in a reaction vessel, and a
supercritical fluid is introduced thereto, so as to prepare particles coated with the bioactive component-lipid. The
supercritical fluid is discharged by compression to obtain proliposome particles, and then the proliposome particles are hydrated by an
aqueous solution including water so as to form a
liposome solution. Preferably, the formulation may include one or more bioactive components. As required, the
liposome formulation may be further processed by methods such as
particle size reduction, removal of
organic solvent, and freeze-
drying. The preparation method can be easily carried out at a
laboratory scale.; Furthermore, the same method can be employed in liposome formulation preparation in
mass production, or at a
commercial scale.