Lipid composition for improving brain function

A technology of brain function and lipid composition, applied in drug combination, application, food science, etc., can solve problems such as reducing meal intake and gastrointestinal discomfort

Active Publication Date: 2010-06-16
NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is generally known that high doses of MCTs may cause gastrointestinal distress
In addition, MCT administration leads to feelings of satiety, which may reduce subsequent meal size

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Fluids for Prodromal Patients

[0050] The liquid contained 3g protein (casein / whey 80 / 20), 7g lipid (MCT / brassica / phospholipid / marine oil weight ratio 50 / 30 / 6 / 14) and 8g digestible carbohydrates (60 / 10 / 30 maltodextrin 19 / fructose / lactose ratio) with:

[0051] UMP 500mg [other nucleotides <10mg]; Choline 300mg;

[0052]Vitamin B6 1.1 mg; vitamin B12 2.3 μg; folic acid 300 μg; other trace elements, minerals and vitamins used as supplements in the prior art;

[0053] Galacto-oligosaccharides 0.6g; pea fiber 0.6g

[0054] An osmolality of 490 mOsm / kg water was obtained.

[0055] The drink was administered to a patient with prodromal dementia in an amount of 125ml / day for one week in order to see the effect on brain function, especially on better social skills, more mobility and fitness and better cognitive function, and more Good alertness and ability to concentrate.

Embodiment 2

[0057] Stick once or twice daily for patients with Alzheimer's disease.

[0058] Each 25 g dry mass of said stick contains:

[0059] 10.5g Lipids: (40MCT; Milkfat 25, Fish Oil 15, Brassica 15, Chocolate 5)

[0060] 3g protein (milk protein)

[0061] 9g carbohydrates (glucose syrup)

[0062] 1g premix which provides 100ug of folic acid, 2ug of vitamin B12 and 1mg of vitamin B6 with 200mg of UMP

[0063] 1.5g Fiber (GOS 10, Hydrolyzed Guar Gum 40, Soy Fiber 50)

Embodiment 3

[0065] Fluids for patients with cognitive decline.

[0066] Patients should consume at least 200ml of the product per day, each 100ml of the product contains:

[0067] Energy 600kcal

[0068] Protein 3.1g milk protein

[0069] Lipid 14.6g; 7g C6:0+C8:0; 0.2g α-linolenic acid; 0.6g eicosapentaenoic acid and

[0070] 0.9g docosahexaenoic acid, 5.9g other fatty acids

[0071] Carbohydrates 0.6g

[0072] UMP 500mg

[0073] Fiber: 1.5g 1:1 blend of beet fiber and hydrolyzed pectin

[0074] Vitamin A 253IU; Vitamin D 2.2IU; Vitamin C 9mg; Vitamin K 6μg; Thiamine 0.14mg; Riboflavin 0.15mg; Niacin 1.5mg; Vitamin B6 1.1mg; Folic Acid 100μg; ; Pantothenic acid 0.6mg; Inositol 4mg; Na 4.3mg; K 4.1mg; Cl 4.3mg; Ca 86mg; P 100mg; Mg 22mg; Zn 1.2mg; Fe 1.5mg; Mo 6μg; Se 4.4μg; Cr 3μg

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PUM

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Abstract

The invention pertains to the use of a lipid fraction for the support of brain function. The lipid fraction comprises the medium-chain fatty acids at least 4 g hexanoic acid and / or at least 5 g octanoic acid, at least 1 g eicosapentaenoic acid, and in addition more than 0.4 g alpha - linolenic acid per 100 g fatty acids of the lipid fraction.

Description

technical field [0001] The present invention relates to lipid mixtures containing selected fatty acids and their use in the preparation of nutritional or pharmaceutical products for the improvement of mammals, especially the elderly. Background technique [0002] The nervous system, especially the brain, plays an important role in the life of mammals. Functions such as cognitive, emotional, social, sensory, motor, and regulatory are primarily determined by the brain. In Western societies, more and more diseases, disorders and problems related to brain function are being recognized. For example, there is an increase in young people suffering from brain injuries due to intoxication such as alcohol abuse or drug abuse, traumatic brain injuries such as traumatic brain injuries (TBI) caused by sports accidents, work accidents, vehicle accidents, etc., or due to systemic malnutrition. Furthermore, during aging, several deleterious changes occur in the nervous system, especially ...

Claims

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Application Information

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IPC IPC(8): A23L1/29A23L1/30A61K31/00A23L33/00
CPCA23V2002/00A61K31/202A61K31/19A61K31/201A23L1/3008A23L1/296A23L1/3006A23L2/52A23L33/40A23L33/115A23L33/12A61P25/00A61P25/28A61P5/50A61P3/10A61K2300/00A23V2250/187A23V2250/1868A23V2250/1874A23V2250/1882A23V2250/28A23V2250/54246A23V2250/704A23V2250/7056A23V2250/70A23V2250/156
Inventor R·J·J·哈格曼E·M·范德比克M·格罗南迪克P·J·G·H·坎普伊斯
Owner NUTRICIA
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