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Method for improving executive function

A technology that performs functions and uses, and is applied in the directions of preparations, applications, and pharmaceutical formulations for in vivo experiments.

Inactive Publication Date: 2014-09-03
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While the ADAS-cog is a powerful and authoritative tool in assessing trends in studies (especially) of patients with moderate AD (MMSE below 20), other tests exist, such as the The neuropsychological battery (NTB) that focuses on assessing executive functions (such as planning, strategy, and working memory) is used, which may be more sensitive in mild AD

Method used

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  • Method for improving executive function
  • Method for improving executive function
  • Method for improving executive function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0158] The composition of the pack contains per 125ml:

[0159] Energy 125kcal; protein 3.9g; carbohydrate 16.5g; fat 4.9g.

[0160] Fat includes 1.5g of DHA+EPA, and 106mg of phospholipid (soybean lecithin); 400mg of choline; 625mg of UMP (uridine monophosphate); 40mg of vitamin E α-TE; 80mg of vitamin C; 60μg of selenium; .

[0161]Minerals and trace elements: sodium 125mg; potassium 187.5mg; chloride ions 156.3mg; calcium 100mg; phosphorus 87.5mg; magnesium 25mg; iron 2mg; zinc 1.5mg; copper 225μg; manganese 0.41mg; molybdenum 12.5μg; Iodine 16.3 μg. Vitamins: vitamin A200μg-RE; vitamin D30.9μg; vitamin K6.6μg; thiamin (B1) 0.19mg; riboflavin (B2) 0.2mg; niacin (B3) 2.25mg-NE; pantothenic acid (B5) 0.66mg ; Biotin 5 μg.

Embodiment 2

[0163] clinical research

[0164] A proof-of-concept study in drug-naive patients with mild AD (MMSE20-26) showed that the composition of the invention (see Table 1, comprising DHA, EPA, UMP, choline, phospholipids, vitamins B6, B9, B12, vitamins C and E, selenium) were safe and improved subjects' delayed memory function. Source: Scheltens et al., "Efficacy of a medical food in mild Alzheimer's disease: A randomized controlled trial" Alzheimer's & Dementia6 (2010), 1-10.

[0165] Table 1. Nutritional Compositions Used in Clinical Trials

[0166]

[0167] *125ml, daily dose.

[0168] The present study was designed to determine the effect of the composition on memory in drug-naïve patients with mild AD, as well as through a longer intervention period of 24 weeks and by using the Neuropsychological Battery (NTB) The survey was extended by z-scores of all memory regions. The secondary objective was to study the safety and tolerability of the intervention and to assess th...

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Abstract

The invention relates to a composition comprising: (i) one or more of uridine and cytidine, or salts, phosphates, acyl derivatives or esters thereof; and (ii) a lipid fraction comprising at least one of docosahexaenoic acid (22:6; DHA), eicosapentaenoic acid (20:5; EPA) and docosapentaenoic acid (22:5; DPA), or esters thereof, for use in the improvement of executive function of a subject in need thereof, in particular an Alzheimer's or dementia patient.

Description

technical field [0001] The present invention belongs to the field of medical nutrition, and more particularly relates to a nutritional supplement for improving executive function (such as information processing speed, cognitive and thinking flexibility, concentration, reading, etc.), especially in patients with Alzheimer's disease or dementia. (scanning) and cognitive set shifting (cognitive set shifting) combination. Background technique [0002] Over the past decade, uridine, choline and omega-3 fatty acids such as DHA have attracted attention as active ingredients for the treatment of cognitive impairment and age-associated memory impairment (AAMI), see e.g. WO2007 / 089703( Massachusetts Institute of Technology) and WO2009 / 002165 (N.V. Nutricia). These compounds are rate-limiting precursors for membrane phospholipid synthesis. Based on the above applications, it is believed that cognitive or memory function can be improved by improving membrane phospholipid synthesis. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7072A61K45/00A61P25/00A61K31/202
CPCA61K31/675A61K31/519A61K31/14A61K31/375A61K45/06A61K31/202A61K31/683A61K31/355A23L1/3012A23L1/3008A61K31/4415A23L1/296A61K33/04A61K31/7072A61K31/7068A61K31/685A61K31/714A23L33/40A23L33/12A23L33/13A61P25/00A61K2300/00A61K31/23A61K31/522A61K31/688A61K2121/00
Inventor M·格罗南迪克A·邦格尔斯
Owner NV NUTRICIA
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