3915 results about "Phosphoric Acid Esters" patented technology

A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: wherein[0001]Base is a purine or pyrimidine base;[0002]R1 is OH, H, OR3, N3, CN, halogen, including F, or CF3, lower alkyl, amino, loweralkylamino, di(lower)alkylamino, or alkoxy, and base refers to a purine or pyrimidine base;[0003]R2 is H, phosphate, including monophosphate, diphosphate, triphosphate, or a stabilized phosphate prodrug; acyl, or other pharmaceutically acceptable leaving group which when administered in vivo, is capable of providing a compound wherein R2 is H or phosphate; sulfonate ester including alkyl or arylalkyl sulfonyl including methanesulfonyl, benzyl, wherein the phenyl group is optionally substituted with one or more substituents as described in the definition of aryl given above, a lipid, an amino acid, peptide, or cholesterol; and[0004]R3 is acyl, alkyl, phosphate, or other pharmaceutically acceptable leaving group which when administered in vivo, is capable of being cleaved to the parent compound, or a pharmaceutically acceptable salt thereof.

An anisotropic conductive adhesive contains conductive particles dispersed in a resin composition, wherein the resin composition includes a radical polymerization resin (A), an organic peroxide (B), a thermoplastic elastomer (C) and a phosphoric ester (D). The resin composition can further contain an epoxy silane coupling agent (E) represented by formula (2) or (3). The resin composition is mixed with other components after the radical polymerization resin (A), the thermoplastic elastomer (C), the phosphoric ester (D) and the epoxy silane coupling agent (E) are reacted. It is also possible to preliminarily react only the phosphoric ester (D) and the epoxy silane coupling agent (E) and to react the product of the preliminary reaction with the radical polymerization resin (A) and the thermoplastic elastomer (C), and then to add other components. The anisotropic conductive adhesive of the present invention can be used for electrical joining of electronic or electric parts of electrical apparatus.

A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae:whereinBase is a purine or pyrimidine base;R1 is OH, H, OR3, N3, CN, halogen, including F, or CF3, lower alkyl, amino, loweralkylamino, di(lower)alkylamino, or alkoxy, and base refers to a purine or pyrimidine base;R2 is H, phosphate, including monophosphate, diphosphate, triphosphate, or a stabilized phosphate prodrug; acyl, or other pharmaceutically acceptable leaving group which when administered in vivo, is capable of providing a compound wherein R2 is H or phosphate; sulfonate ester including alkyl or arylalkyl sulfonyl including methanesulfonyl, benzyl, wherein the phenyl group is optionally substituted with one or more substituents as described in the definition of aryl given above, a lipid, an amino acid, peptide, or cholesterol; andR3 is acyl, alkyl, phosphate, or other pharmaceutically acceptable leaving group which when administered in vivo, is capable of being cleaved to the parent compound, or a pharmaceutically acceptable salt thereof.

The present invention relates to catalyst system for propylene hydrogenation and formylation and process of catalytically synthesizing butyl aldehyde. The catalyst system is triaryl phosphine-Rh(I) catalyst system with proper additive, such as bisphosphite ester, in proper amount. Compared with similar available catalyst, the catalyst system has obviously higher catalytic acitivity, higher selectivity, higher stability and raised n-butyl aldehyde / isobutyl aldehyde ratio in the catalytically synthesized product.

An ink composition for ink jet printing is provided which gives a cured object excellent in adhesion to metallic plates, resistance to etchants, and alkali removability and can be stably ejected with an ink jet apparatus. The ink jet composition for etching resists has a viscosity at 25° C. of 3-50 mPa s and includes monomers comprising: either a polymerizable phosphoric ester compound represented by general formula (I); a polyfunctional monomer having two or more ethylenic double-bond groups per molecule and having no phosphoric ester group, the content of the ethylenic double-bond groups being 4×10−3 to 8×10−3 mol / g; and a monofunctional monomer having one ethylenic double-bond group per molecule and having neither phosphoric ester group nor carboxy group.In the formula, X represents C1-3 alkylene, Y represents C2-3 alkylene, and R represents hydrogen or methyl.

The present invention provides a catalyst for polyester production capable of producing a polyester with high catalytic activity and a process for producing a polyester using the catalyst. The catalyst for polyester production comprises a solid titanium compound which is obtained by dehydro-drying a hydrolyzate obtained by hydrolysis of a titanium halide and which has a molar ratio (OH / Ti) of a hydroxyl group (OH) to titanium (Ti) exceeding 0.09 and less than 4. The present invention also provides a method to obtain a polyester having a small increase of the acetaldehyde content during the molding. This method comprises bringing a polyester, which is obtained by the use of a titanium compound catalyst and in which the reaction has been completed, into contact with a phosphoric ester aqueous solution or the like having a concentration of not less than 10 ppm in terms of phosphorus atom. The present invention further provides a polyester having excellent transparency and tint and molded products of the polyester such as a blow molded article, a film, a sheet and a fiber. The polyester is obtained by polycondensing an aromatic dicarboxylic acid or an ester-forming derivative thereof and an aliphatic diol or an ester-forming derivative thereof in the presence of a catalyst for polyester production which comprises a polycondensation catalyst component comprising a solid titanium compound and a co-catalyst component comprising a magnesium compound. This polyester has a titanium content of 1 to 100 ppm, a magnesium content of 1 to 200 ppm and a weight ratio (Mg / Ti) of magnesium to titanium of not less than 0.01.

The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.

A flame-retardant resin composition comprises 10 to 300 parts by weight of a flame retardant (B) and 1 to 200 parts by weight of an inorganic filler (C) (a glass fiber and / or a glass flake), relative to 100 parts by weight of a base resin (A). The flame retardant (B) comprises a polyphenylene oxide-series resin and / or a polyphenylene sulfide-series resin (B1), a phosphoric ester (B2), and a nitrogen-containing cyclic compound (B3) (for example, a polyphosphate of an amino group-containing triazine compound). The inorganic filler (C) has been treated with a surface-treatment agent or sizing agent containing a novolak epoxy resin. Such a resin composition is useful for obtaining a shaped article which has been inhibited from dripping and to which flame retardancy is highly imparted.

A nucleoside compound having activity against hepatitis C virus is disclosed.

The optical filter of the present invention is provided with a near infrared light absorption layer that contains a component composed of copper ions and a phosphoric ester compound expressed by the following Formula (10), in which the phosphorus atom content in the near infrared light absorption layer is 0.4 to 1.3 mol per mole of copper ions, and the copper ion content in the near infrared light absorption layer is 2 to 60 wt %. Thus keeping the phosphorus atom and copper ion content within specific ranges results in good near infrared light absorption and in improved moisture resistance whereby devitrification caused by whitening is suppressed

A method for recovering nickel from an sulfuric acid aqueous solution, for recovering nickel in an effectively utilizable form as a raw material of nickel industry material, by separating efficiently impurity elements of iron, aluminum, manganese and the like, from the sulfuric acid aqueous solution containing nickel and cobalt, and the impurity elements, iron, aluminum, manganese and the like.The method is characterized by comprising the following steps (1) to (5).step (1): to subject the sulfuric acid aqueous solution to oxidation neutralization treatment.step (2): then, to subject the solution to neutralization treatment, and to separate and recover mixed hydroxides containing nickel and cobalt.step (3): to subject the mixed hydroxides to dissolution treatment in a sulfuric acid solution having a concentration of equal to or higher than 50% by mass.step (4): to subject the concentrated solution to solvent extraction treatment, using a phosphate ester-based acidic extraction agent.step (5): by adding a neutralizing agent to the resultant extraction residual liquid, to subject the solution to the neutralization treatment, and to separate and recover nickel hydroxide generated.

A method of synthesizing a polynucleotide which can, for example, be used during fabrication of an array. A second nucleoside is coupled to a first nucleoside through a phosphite linkage, with the second nucleoside having a hydroxyl protecting group that is a non-carbonate protecting group. The product of the foregoing step is exposed to a composition which both oxidizes the formed phosphite to a phosphate and deprotects the protected hydroxyl of the coupled nucleoside. The method has particular application to fabricating an addressable array of polynucleotides on a substrate which carries substrate bound moieties each with a hydroxyl group.

A thermoplastic molding composition having improved flammability rating and mechanical properties is disclosed. The composition contains aromatic polycarbonate having a weight-average molecular weight Mw≧25,000 g / mol., polyalkylene terephthalate, graft (co)polymer characterized in that its grafted phase includes structural units derived from acrylate monomers, an oligomeric organic phosphoric acid ester, and an optional fluorinated polyolefin. In a preferred embodiment the graft (co)polymer is characterized in its core-shell morphology.

A process for preparing phosphoramidate prodrugs or cyclic phosphate prodrugs of nucleoside derivatives, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof.

This invention relates to reduced volatility gelled liquid hydrocarbon treatment fluids and methods of their use and preparation. In one embodiment, this invention provides a method of treating a portion of a subterranean formation comprising: providing a reduced volatility gelled liquid hydrocarbon treatment fluid that comprises a liquid hydrocarbon and a gelling agent that comprises a polyvalent metal salt of a phosphoric acid ester, and treating the portion of the subterranean formation with the reduced volatility gelled liquid hydrocarbon treatment fluid. In another embodiment, this invention provides a gelled liquid hydrocarbon treatment fluid: that comprises a liquid hydrocarbon and a gelling agent that comprises a polyvalent metal salt of a phosphoric acid ester; that has a concentration of less than about 250 mg / liter of trialkyl phosphate esters that have a molecular weight of less than about 350; and that has a diester-to-monoester content molar ratio of at least about 2:1.

The invention provides the nucleoside phosphate compound and the preparation and application, which comprises the nucleoside 3', 5'-cyclic phosphate and the 5'-phosphodiester compound. Wherein, the 3', 5'-cyclic phosphate and the derivatives work as the novel HCV inhibitor and the structural formula is shown in the drawing (I), wherein, X equals to OH and F; R equals to H, NH4, R' 4N, R' 3NH and metals such as Na, K, Ca and Li or the structural formula in the drawing (II), R' equals to linear chain or substituted alkane or cyclane, aromatic hydrocarbon, or substituted aromatic hydrocarbon or heterocyclic aromatic hydrocarbon; the four R' and three R' in the amine are the same or different. The invention has the advantages that the nucleoside phosphate compound is used for treating the HCV or is combined with the Alpha-interferon, ribavirin or other anti-HCV drugs to treat the infection of the hepatic c virus or HCV.

It is an object of the present invention to provide a polylactic acid composition having excellent crystallinity, wet heat stability and melt stability. It is another object of the present invention to provide a molded article which is obtained from the polylactic acid composition and excellent in appearance and color. The present invention is a composition and molded article thereof which comprises a polylactic acid (component A), a carbodiimide compound (component B) and a phosphoric acid ester metal salt (component C).

As a polishing composition which allows high-speed polishing while dishing and erosion are prevented and the flatness of metal film is maintained, there is provided a polishing composition for polishing a metal film provided on a substrate having trenches such that the metal film fills the trenches, so as to provide a planarized surface, wherein the composition comprises water, a phosphate ester having a C≧6 carbon atom alkyl group in its molecule, and an etchant for the metal, and has a pH of 5 to 11.

A flame-retardant resin composition comprises (A) abase resin; (B) a flame retardant comprising (B1) at least one aromatic resin selected from a pblyphenylene oxide-series resin and a polyphenylene sulfide-series resin, (B2) a phosphoric ester, and (B3) a nitrogen-containing cyclic compound; and (C) a styrenic resin having a melt flow rate of not more than 8 g / 10 minutes. The base resin may be a polyester-series resin. The styrenic resin (C) may be a styrenic resin having a melt flow rate of 0.1 g / 10 minutes to not more than 5 g / 10 minutes. The phosphoric ester (B2) may be a condensed phosphoric ester, and the nitrogen-containing cyclic compound (B3) may be a polyphosphate of an amino group-containing triazine compound, a polyphosphoric acid amide, or others. The present invention provides a flame-retardant resin composition which has been flame-retarded without using a halogen-containing flame retardant.

Nonaqueous electrolytic liquids for lithium secondary batteries which have flame retardancy (self-extinguishing characteristics) or incombustibility (no flash point), have a high conductivity, and are electrochemically stable. One of the nonaqueous electrolytic liquids comprises a nonaqueous solvent comprising as an essential ingredient at least one phosphate (a) selected among chain phosphoric esters (a1) and cyclic phosphoric esters (a2). The nonaqueous solvent may further contain a cyclic carboxylic ester (b1) and a cyclic carbonic ester (b2). Another nonaqueous electrolytic liquid comprises the nonaqueous solvent and incorporated therein at least either a vinylene carbonate compound (c1) or a vinylethylene carbonate compound (c2) and one or more compounds selected from the group consisting of cyclic amide compounds (d1), cyclic carbamate compounds (d2), and cyclic hetero-compounds (d3).

The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and / or preventing the onset and / or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia / reperfusion injury and cancer.

A lubricating oil composition is disclosed which comprises a lubricating base oil, (A) at least one type of compound selected from specific phosphoric acid esters and salts thereof or in combination with (B) at least one type of compound selected from specific metal salts of specific phosphoric acid esters, with excellent oxidation stability, base number retention properties, anti-wear properties, extreme pressure properties and anti-corrosion properties and thus can be suitably used, in particular, as a lubricating oil for an internal combustion engine.

Provided are a carbon fiber reinforced composite material which exhibits excellent flame retardance, fast curing properties, heat resistance, and mechanical characteristics. Also provided are an epoxy resin composition suitable for use in producing said carbon fiber reinforced composite material as well as a prepreg and housing for electronic / electrical components. The epoxy resin composition is characterized by comprising: [A] an epoxy resin containing at least 50 mass % of a compound as represented by general formula (I), [B] an organic nitrogen compound based curing agent, [C] a phosphoric acid ester, and [D] a phosphazene compound. In general formula (I), R1, R2, and R3 are either a hydrogen atom or a methyl group, and n is an integer of 1 or higher.

The present invention relates to a flame retardant thermoplastic resin composition that comprises a polycarbonate resin, a rubber modified styrene-grafted copolymer, a styrene-containing copolymer, a (meth)acrylic acid ester copolymer, a phosphoric acid ester as a flame retardant and a fluorinated polyolefin resin, which does not show coalescence of the domain resin that might be caused by the low viscosity at a high temperature, and poor flame retardancy, weld-line strength and mechanical properties such as impact strength, and which has a good balance of physical properties such as impact strength, heat resistance, heat stability, processability and appearance.

The invention provides metal powder constituted from metal particles. Each of the metal particles comprises a base particle having a surface and a metal material constituting at least the surface of the base particle. The base particle is subjected to a surface treatment with a fluorine type phosphoric acid ester. Further, the invention also provides an ultraviolet ray curable ink jet composition to be ejected by using an ink jet method. The ultraviolet ray curable ink jet composition comprises a polymerizable compound and metal powder constituted from metal particles. The metal particles of the metal powder are subjected to a surface treatment with a fluorine type phosphoric acid ester.

The present invention provides a phosphoramidate compound having the structure (I)wherein X comprises a monosaccharide group comprising the structure (II) or (III)or a pharmaceutically acceptable salt, ester or salt of such ester. The present invention also provides processes for the production of (I) and uses thereof.

The invention provides a phosphorus-contained organic silicon resin fire retardant shown as a following formula and a preparation method thereof. The preparation method of the phosphorus-contained organic silicon resin fire retardant comprises the following steps: firstly, adopting polyalcohol and phosphorus oxychloride as raw materials to prepare chlorinated volution phosphoester; then carrying out hydrolytic condensation on amino-containing silane, dialkoxy silane and trialkoxysilane to obtain amino-containing organic silicon resin; finally dissolving the amino-containing organic silicon resin into a methylbenzene solvent, an N,N-dimethyl fomamide solvent or an acetonitrile solvent, and the like, and adding the chlorinated volution phosphoester and an acid-binding agent for synthesis to obtain the phosphorus-containing organic silicon resin fire retardant. The phosphorus-containing organic silicon resin fire retardant can be used as a fire retardant for polyolefin, makrolan, ABS, nylon and PC / ABS, has high efficiency and low toxicity compared with the traditional fire retardant and is an environmental protection type fire retardant for plastics. R1, R2, R3 and R4 are respectively selected from CH3 or C6H5, R5 is selected from CH2 or CH2CH2 or CH2CH2NHCH2CH2, and R6 is selected from the CH3 or C2H5; n is equal to integers of 1 subtracting 50, P is equal to integers of 1 subtracting 50, and q is equal to integers of 1 subtracting 50.

The invention provides a hydrocyanation process for the production of adiponitrile and other dinitriles having six carbon atoms, the process comprising:a) forming a reaction mixture in the presence of at least one Lewis acid, said reaction mixture comprising ethylenically unsaturated nitrites having five carbon atoms, hydrogen cyanide, and a catalyst precursor composition, by continuously feeding ethylenically unsaturated nitrites, hydrogen cyanide, and a catalyst precursor composition;b) controlling X and Z, wherein X is the overall feed molar ratio of 2-pentenenitriles to all unsaturated nitriles and Z is the overall feed molar ratio of hydrogen cyanide to all unsaturated nitrites, by selecting a value for X in the range from about 0.001 to about 0.5, and a value for Z in the range from about 0.5 / 1 to about 0.99 / 1, such that the value of quotient Q, whereinQ=X[(moles3PN+4PNinthefeed)(molesallunsaturatednitrilesinthefeed)]-Zis in the range from about 0.2 to about 10, wherein 3PN is 3-pentenenitriles and 4PN is 4-pentenenitrile; andc) withdrawing a reaction product mixture comprising adiponitrile;wherein the ratio of the concentration of 2-pentenenitriles to the concentration of 3-pentenenitriles in the reaction mixture is from about 0.2 / 1 to about 10 / 1;wherein the catalyst precursor composition comprises a zero-valent nickel and at least one bidentate phosphite ligand; andwherein the bidentate phosphite ligand is selected from a member of the group represented by Formulas I and 11 as described herein.