2491 results about "Carbodiimide" patented technology

The present invention relates to biscarbodiimides, thiourea derivatives, urea derivatives, and cross-linked hyaluronan derivatives having at least one intramolecular disulfide bond, and methods of preparation thereof. The invention also includes thiolated hyaluronan derivatives and salts thereof having at least one pendant thiol group or a modified pendant thiol group, and methods of preparation thereof. An example of a modified pendant thiol group is a sulfhydryl group linked to a small molecule such as a bioactive agent, for example a drug or pharmaceutically active moiety. A hyaluronan derivative having a sulfhydryl group linked to a pharmaceutically active moiety is useful as a sustained or controlled release drug delivery vehicle. Compositions containing the hyaluronan derivatives of the invention can reversibly viscosify in vivo or in vitro, in response to mild changes in condition, and are thus useful in ophthalmic surgery and in tissue engineering.

A composition comprising a collagen protein and demineralized bone matrix is described wherein the composition is chemically cross-linked with a carbodiimide such as N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride (EDC). The crosslinking reaction can be conducted in the presence of N-hydroxysuccinimide (NHS). The collagen can be in a porous matrix or scaffolding. The DBM can be in the form of particles dispersed in the collagen. A method of making the composition is also described wherein a collagen slurry is cast into the desired shape, freeze dried to form a porous scaffolding and infitrated with a solution comprising the cross-linking agent. The composition can be used as an implant for tissue (e.g., soft tissue or bone) engineering.

Non-glutaraldehyde fixation of an organ or a prosthesis for implantation in a mammal is based upon carbodiimide treatment. A solution containing a sterilizing agent, such as EDC, in combination with a coupling enhancer, such as Sulfo-NHS, and a high concentration of a diamine cross linking agent is used. As a result, only minimal surface reduction occurs during fixation, and the resultant products show a dramatic increase in resistance to calcification.

A resin composition in which a polylactic acid resin (A) 95-5 wt %, an aromatic polycarbonate resin (B) 5-95 wt %, and, with respect to 100 wt parts of the total of the (A) and the (B), at least one compatibilizer selected from a polymer compound containing an acrylic resin or styrene resin unit as a graft (C), a polymer compound to which a glycidyl compound or an acid anhydride is grafted or copolymerized (D) and an oxazoline compound, an oxazine compound and a carbodiimide compound (E) are compounded.

The present invention relates to a collagen gel, its production process, a medical material in which it is used or a kit for its production, wherein said collagen gel is obtained by crosslinking collagen with polyanion and carbodiimide.

A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, such as artificial or synthetic cartilage. The network is made by first providing a polyamine or polycarboxylate macromolecule (having a plurality of amine or carboxylic acid groups respectively attached along the length of the molecule), reacting this macromolecule with a hydroxyphenyl compound having a free carboxylic acid group in the case of a polyamine or a free primary amine group in the case of a polycarboxylate, and substituting the hydroxyphenyl compound onto the macromolecule via a carbodiimide-mediated reaction pathway to provide a hydroxyphenyl-substituted macromolecule. This macromolecule is then linked to other such macromolecules via an enzyme catalyzed dimerization reaction between two hydroxyphenyl groups attached respectively to different macromolecules under metabolic conditions of temperature and pH. In a preferred embodiment, the macromolecular network is made up of tyramine-substituted hyaluronan molecules that are linked by dityramine bonds to provide a stable, coherent hydrogel with desired physical properties. A method of preparing such a network is also provided.

The present invention discloses a method of cross-linking amnion to be an improved biomedical material. The present invention adopts the amnion cross-linked by EDC (N-(3-dimethylaminopropyl)-N′-ethyl-carbodiimide HCI) or NHS (N-hydroxysuccinimide), and the cross-linked amnion not only has more resistance to protease, but also binds specific extracellular matrix (ECM) such as heparin by using cross-linked functional group. Further, by using the affinity of the ECM with specific growth factors, the amnion can be an efficient carrier for specific growth factor. Hence, some specific diseases may be treated.

The invention relates to a preparation method of a polyurethane prepolymer, which comprises: mixing polyisocyanate and an organic polyol compound for reaction, wherein the molar ratio of the -NCO in the polyisocyanate and the -OH in the organic polyol compound is (4-15):1; the polyisocyanate is two or more of polymethylene polyphenyl isocyanate (PAPI), methylene diphenyl diisocyanate (MDI) and carbodiimide modified MDI 5412; and the organic polyol compound comprises one or more of polyether glycol with functionality of 2 to 4 and number-average molecular weight of 300 to 5,000, polyester polyol and polyether-polyester polyol. The invention also relates to the polyurethane prepolymer and a polyurethane grouting material. The polyurethane grouting material is a single-component grouting material, has little toxicity to the environment and construction personnel and can well improve foaming rate and anti-contraction performance; during packaging, the need of independent packaging of a catalyst is obviated, so the packaging cost is lowered; and the material is more convenient to use and transport and has a more wide application range and a bright prospect.

A thermosetting water-borne coating composition which, when used as a water-borne coating, have both sufficient curability and sufficient storage stability and provides coating films excellent in water resistance, a method of forming a coating film using the same and a method of forming a multilayer coating film using the same are provided.The coating composition comprises a polycarbodiimide compound modified for hydrophilicity and a carboxyl-containing aqueous resin composition,wherein the polycarbodiimide compound has a structure such that a carbodiimide unit and a polyol unit occur alternately via a urethane bond and repeatedly anda hydrophilic unit occurs at both molecular termini and is bound to a carbodiimide unit via a urethane bond.

A method for preparing diphenol compounds, which method includes the steps of coupling a hydroxyphenyl carboxylic acid with a L-tyrosine ester in a water-miscible organic reaction solvent containing a carbodiimide capable of forming a water-solvent urea by-product, thereby forming a diphenol reaction product; and combining the reaction mixture with an amount of water effective to precipitate the diphenol as a water-immiscible organic phase, so that a water-immiscible organic phase is formed containing the diphenol reaction product. New diphenol monomers and polymers polymerized therefrom are also disclosed.

Disclosed are a macrocyclic carbodiimide (MC-CDI) and a process for synthesizing the same through condensation of a molecule with multiple-isocyanate terminal functional groups under high dilution in the presence of a phospholene catalyst such as phospholene or arsenic catalyst. Also disclosed are MC-CDI derivatives, such as MC-urea (MC-U), MC-acylurea (MC-ACU), acid functionalized MC-ACU, and anhydride functionalized MC-ACU, processes for synthesizing the same, and the applications of such derivatives as hydrolysis stabilizers in organic polymeric materials, such as polyurethane (PU) and polyesters, as well as the applications in the syntheses of the amide- and imide-modified polyurethane by ring-opening reaction of the MC-ACU.

It is an object of the present invention to provide a polylactic acid composition having excellent crystallinity, wet heat stability and melt stability. It is another object of the present invention to provide a molded article which is obtained from the polylactic acid composition and excellent in appearance and color. The present invention is a composition and molded article thereof which comprises a polylactic acid (component A), a carbodiimide compound (component B) and a phosphoric acid ester metal salt (component C).

The present invention provides a working fluid composition for a refrigerator machine comprising a base oil comprising an ether-based compound, a carbodiimide compound, and an unsaturated fluorinated hydrocarbon refrigerant. The present invention also provides a refrigerating machine oil comprising a base oil containing an ether-based compound and a carbodiimide compound, the refrigerating machine oil being used together with an unsaturated fluorinated hydrocarbon refrigerant.

The invention discloses a quantitative detecting method for various metabolic components in a biological sample, and a metabolic chip used for the quantitative detecting method. The quantitative detecting method is characterized in that the biological sample is subjected to derivatization treatment, and the biological sample subjected to derivatization is detected through liquid chromatography andmass spectrometry combination; and during derivatization treatment, 3-nitrophenylhydrazine serves as a derivatization reagent, and 1-(3-dimethylaminopropyl)-3-ethly carbodiimide serves as a derivatization reaction catalyst. According to the quantitative detecting method, high-sensitivity detection can be achieved, and a plurality of level-crossing metabolic components can be covered during detection, and the quantitative detecting method is simple, fast and suitable for being applied to clinical and scientific research testing. The metabolic chip comprises a chip carrier microtitration plateand related reagents, and thus the multiple level-crossing metabolites such as amino acid, phenols, phenyl or benzyl derivatives, indole, organic acid, fatty acid, sugar and bile acid in the biological samples can be subjected to quantitative detection on the same microtitration plate.

A compressible substrate coated at least in part with a waterborne coating composition comprising at least one base neutralized active hydrogen containing film-forming resin and a water dispersible carbodiimide crosslinker capable of reacting with the film-forming resin to form a crosslinked film is disclosed. An article of manufacture having at least two different flexible substrates coated at least in part with such a coating is also disclosed.

A medical device, the medical device formed at least in part from a melt blend of at least one polymer comprising hydrolysable groups and a carbodiimide.

The invention relates to a process for reducing the monomeric aziridine content in a polyaziridine forming reaction mixture by adding to the polyaziridine forming reaction mixture an excess of a carbodiimide scavenger wherein the excess is based on the equivalent ratio of scavenger to monomeric aziridine, and to a product obtained by this process and to a coating composition containing the product obtained by the process.

The invention relates to transparent, biaxially oriented and heat-set films having one or more layers and compris, as main constituent, at least one crystallizable thermoplastic, in particular a polyester, and also comprise at least one hydrolysis stabilizer. The hydrolysis stabilizer is preferably a phenolic compound, an oxazoline, and / or a monomeric or polymeric carbodiimide, where appropriate combined with an organic phosphite. It is preferably added in the form of a masterbatch. The film exhibits low longitudinal and transverse shrinkage. On exposure to moisture and heat it shows practically no embrittlement and retains its ultimate tensile strength. The additional functionality is preferably that the film has been made UV-resistant, or flame-retardant, or on one side or on both sides has been coated, or is sealable, and / or has been corona- or flame-treated. The film is generally produced by extrusion or coextrusion, the hydrolysis stabilizer being added in the form of a predried or precrystallized masterbatch.

The invention relates to a microporous polyether urethane elastomer composite material and a preparation method thereof. The composite material is formed by the prepolymerization reaction of a polyhydric alcohol component A and a prepolymer component B, wherein the polyhydric alcohol component A comprises the following raw materials in the formula: 20 to 90 parts of polyoxytrimethyl-ene polyhydric alcohol, 5 to 50 parts of polyether polyol II, 5 to 50 parts of polymer polyether polyol, 2 to 30 parts of chain extender, 0.5 to 2 parts of nanometer graphene, 0.2 to 4 parts of foaming agent, 0.2 to 2 parts of foam homogenizing agent and 0.2 to 4 parts of catalyst; and the prepolymer component B comprises the following raw materials in the formula: 30 to 60 parts of diisocyanate, 4 to 20 parts of polyisocyanate modified by carbodiimide and 20 to 60 parts of polyoxytrimethyl-ene polyhydric alcohol. The polyether polyol II is formed by one or two of polyoxytrimethyl-ene epoxyethane copolyether polyol or / and polyethylene tetrahydrofuran polyol. The composite material provided by the invention is excellent in comprehensive mechanical property, antibacterial property and definite flame resistance.

The invention provides a monocomponent moisture cure urethanes adhesive. The adhesive comprises the following compositions in portion by weight: 100 portions of isocyanate terminated polyurethane prepolymer, 0.025 to 0.25 portion of composite catalyst, 0.001 to 0.3 portion of stabilizer, 0.5 to 2 portions of coupling agent, 0.05 to 0.30 portion of antioxidant and 0 to 25 portions of diluting agent which react and are mixed, wherein the isocyanate terminated polyurethane prepolymer is prepared by reactions of polyisocyanates which is mixed by carbodiimide modified methyl diphenylene diisocyanate or 4,4'-methyl diphenylene diisocyanate and polyaryl polymethylene isocyanate, and polyester polyol with number average molecular weight of Mn of between 400 and 2,500 or polyether polyol with number average molecular weight of Mn of between 400 and 4,000 and a chain extender. The adhesive has higher curing speed and longer applicable time, can be bonded with an aluminum alloy with shearing strength more than or equal to 8MPa after curing at room temperature, has plump fluff and good hand feeling in electrostatic flocking products with abrasion resistance of a spinning machine roller reaching over 10,000 times.

Polycarbodiimides, processes for their preparation, water-borne coating compositions and the use of the water-borne coating compositions to coat flexible substrates such as leather, artificial leather, textile fabrics, fibers and non-wovens that are used in the manufacture of athletic footwear are disclosed.

The invention provides a method of modifying a phosphomonoester moiety of a target compound. The method can include the steps of (a) providing a target compound having an electrophilic moiety and a phosphomonoester moiety; (b) contacting the target compound with a first carbodiimide compound under conditions for preferential addition of the first carbodiimide compound to the electrophilic moiety over the phosphomonoester moiety, thereby forming an electrophile-protected target compound; and (c) contacting the electrophile-protected target compound with a second carbodiimide compound and a nucleophilic compound under conditions for addition of the nucleophilic compound to the phosphomonoester.

The invention relates to cationic water-based polyurethane / acrylic ester composite emulsion and the preparation process, belonging to the chemical product and preparation technology field. Raw materials comprise diisocyanate mixture, polyhydric alcohol, organotin catalyst, chain extender, thinner, neutralizing agent and initiating agent. The preparation process comprises adding polyhydric alcohol into a reactor to dehydrate in vacuum, adding into diisocyanate mixture and organotin catalyst, conducting prepolymerization reaction to synthesize prepolymer with isocyanate-termi-nated, coldly adding thinner to dilute and to condense and reflow, adding chain extender to obtain mixture through chain extending reaction, cooling down, adding neutralizing agent to finish salt-forming reaction, regulating pH value, adding deionized water to conduct dispersed emulsification to obtain cationic water-based polyurethane elusion, and heating up and adding initiating agent to initiate free radical polymerization reaction to prepare composite elusion. The cationic water-based polyurethane / acrylic ester composite emulsion is synthesized through adopting non solvent process with low pollution and environment-friendly, increases solvent resistance, water resistance and tensile strength of glue film through introducing micro-cross-linked structure, increases hydrolytic stability of the glue film through introducing carbodiimide structure, and increases elongation at break and elasticity property through of glue film through introducing 2, 4-MDI.

Provided is a film made of a composition obtained by mixing a compound at least having a ring structure containing one carbodiimide group, the first nitrogen and second nitrogen thereof being linked together through a linking group, with a polymer compound having an acidic group. A film which has improved hydrolysis resistance and from which no free isocyanate compounds are produced can be provided.

A molded article excellent in dynamic characteristics and water degradation resistance can be obtained by using a fiber-reinforced polypropylene resin composition including a carbodiimide-modified polyolefin (a), a polypropylene resin (b) and reinforcing fibers (c), wherein the content of the carbodiimide group contained in a resin component in the fiber-reinforced polypropylene resin composition is 0.0005 to 140 mmol based on 100 g of a matrix resin component, and the reinforcing fibers (c) are sizing-treated with a polyfunctional compound (s); and a molding material using the fiber-reinforced polypropylene resin composition.

A precursor for the construction of chelated metal conjugates which demonstrate improved assay performance and utility in minimizing non-specific binding while maintaining specificity for target molecules is disclosed. The precursor has tridentate functionality towards multivalent ions such as iron and nickel and contains a diacetyl glycine group covalently linked via an amide to a molecule such as a proteinaceous molecule providing a primary amide group for amide bond formation. The precursor is preferably prepared in monomeric form by reacting nitrilotriacetic acid or a salt thereof in an aqueous medium at an alkaline pH of at least 8 with a proteinaceous molecule containing a primary amine group in the presence of a carbodiimide. The proteinaceous molecule may be bovine serum albumin or an enzyme such as alkaline phosphatase or horseradish peroxidase.

The invention discloses a thermoplastic polyurethane elastomer which is hydrolysis resistant and the preparation thereof and particularly discloses a thermoplastic polyurethane elastomer which uses organic vulcabond comprising carbodiimide modification as a hydrolysis resisting accessory ingredient. The thermoplastic polyurethane elastomer not only is provided with good hydrolysis resistant performance, but also has good compatibility and low cost without the need to add auxiliary production equipment, therefore the production cost is reduced to a large extent.

The invention relates to a carbodiimide compound or mixture of carbodiimide compounds derived from a carbodiimidization reaction of at least one oligomer having at least one isocyanate group and comprising at least two repeating units deriving from one or more ethylenically unsaturated monomers.

The invention relates to a chitosan modified alginate hydrogel three-dimensional porous bracket with specific in-vitro degradability and a preparation method thereof. The method comprises the following steps: dissolving sodium alga acid serving as a raw material in phosphate buffer solution; performing amidation reaction of a carboxyl group in the sodium alga acid and an amino group in a cross-linking agent cystamine or dimethyl cystinate under the activation of water-soluble carbodiimide to form a chemically crosslinked hydrogel; performing freeze drying on the hydrogel to obtain a porous bracket material of the hydrogel; and performing surface modification on the porous bracket by using chitosan. In solution of a reducing agent such as cysteine with an appropriate concentration, a disulfide bond in a hydrogel cross-bridge is degraded through a disulfide bond-sulfydryl conversion reaction, so the porous bracket is decomposed and dissolved and disappears. Therefore, the porous bracket can be used as an in-vitro cell culture template material. The hydrogel porous bracket researched by the invention has the characteristics of simple preparation, rich raw material source, low cost and availability. Various physiochemical performances, mechanical strength, degradation rate and surface properties of the bracket material are controllable within a large range.