Product
Patsnap Eureka
For R&D, Patsnap Eureka makes reading and utilizing patents & technical documents easy.
Patsnap Eureka AIR
Designed for self-driven R&D workflows. Generate viable solutions, solve complex R&D challenges, empower your innovation with AI.
Patsnap Eureka Materials
Designed for material experts only. Revolutionize your material R&D, from search, analyze, to developing new materials.
Feature
TechResearch
Generate reliable direction feasibility study reports for your R&D in just a few steps.
TechSeek
Discover and master advanced knowledge NOW. Basics, ideas, possibilities, all at once.
TechMind
As an expert in R&D Theories, TechMind can generates customized viable solutions instantly.
TechRisk
Analyze your overall solution with one click, know your potential R&D risks in advance.
TechMonitor
Get weekly tech updates, stay abreast of the latest tech innovations and key insights.
Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
199 results about "Collagen gel" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Processes for the preparation of novel collagen-based supports for tissue engineering, and biomaterials obtained
A composite product is disclosed as a collagen support comprising at least one porous collagen layer covered on at least one side with an essentially compact collagen membrane consisting either of a collagen film prepared by drying a collagen gel, preferably in air or a gaseous fluid, or of a very highly compressed collagen sponge. At least one of the two layers, i.e. the porous layer and the essentially compact membrane, may comprise normal, genetically modified or malignant living cells originating particularly from young or elderly subjects. This composite product is used as a collagen support for the manufacture of artificial skin intended especially for performing in vitro tests on the efficacy of potentially active substances or for reconstructing damaged areas of skin in vivo.
Owner:BASF BEAUTY CARE SOLUTIONS FRANCE SAS
Collagen gel
InactiveUS6335007B1High bonding strengthEliminate riskPowder deliveryConnective tissue peptidesChemistryCollagen gel
The present invention relates to a collagen gel, its production process, a medical material in which it is used or a kit for its production, wherein said collagen gel is obtained by crosslinking collagen with polyanion and carbodiimide.
Owner:SHIMIZU YASUHIKO +1
Method of preparing a collagen sponge, a device for extracting a part of a collagen foam, and an elongated collagen sponge
InactiveUS7098315B2Improve featuresHigh densitySurgical adhesivesPeptide/protein ingredientsAprotininFibrin glue
A method of preparing a collagen sponge comprises mixing air into a collagen gel, so as to obtain a collagen foam which is dried. From the dried product thereby obtained, collagen sponge is obtained by isolating parts of sponge with a chamber diameter of more than 0.75 mm and less than 4 mm, or parts with an average chamber diagonal dimension of 3 mm. The collagen sponge may be used as a material for sealing wounds, possibly with a coating comprising a fibrin glue, such as a combination of fibrinogen, thrombin and aprotinin. A device for extracting a part of a collagen foam and for degenerating another part of the collagen foam to a collagen gel is disclosed. An elongated collagen sponge having a through-going hole or bore and a flexible wall may be used for re-establishing walls in a mammalian gastrointestinal funnel or trachea system.
Owner:TOPAZ INVESTMENT AS
Collagen gel and process of producing the same
InactiveUS20060177492A1Improve stabilityHigh strengthPowder deliveryPeptide/protein ingredientsCross-linkFiber
The present invention relates to a process of producing a collagen gel comprising collagen fibers cross-linked with each other by a cross-linking agent on the way of fibrosis of collagen, and a collagen gel comprising the cross-linked collagen fibers obtained by the process. The collagen gel comprising cross-linked collagen fibers of the present invention has high strength and thermal stability and can be widely used as cell carriers and medical materials.
Owner:IHARA
Dialdehyde carboxymethyl cellulose-collagen frozen gel and preparation method thereof
InactiveCN101845226AHigh reactivityImprove mechanical propertiesSurgeryProsthesisBiologic scaffoldPorosity
The invention provides dialdehyde carboxymethyl cellulose-collagen frozen gel and a preparation method thereof. The method comprises the following steps of: first uniformly mixing 1 to 3 mass percent of the aqueous solution of collagen and 0.01 to 1 mass percent of the aqueous solution of dialdehyde carboxymethyl cellulose; then injecting the mixed solution into a mold and storing the mixed solution in a low-temperature reactor at the temperature of -40 to 0 DEG C for 1 to 7 days; and finally, taking the obtained product out and slowly unfreezing the obtained product to obtain the dialdehyde carboxymethyl cellulose-collagen frozen gel. The dialdehyde carboxymethyl cellulose-collagen freezing gel prepared by the method is improved in mechanical property, thermal stability and enzymatic degradation resistance at the same time of maintaining the biological activity of collagen gel per se, has the advantages of porosity, hydrophilicity, water absorbing and preserving property, good market application prospect and the like, and is widely used in biomedical fields, such as biologic scaffolds, cell culture, drug delivery, tissue engineering, wound and burning treatment and the like.
Owner:SICHUAN UNIV
Collagen base freezing gel suitable for biological medical material and preparation thereof
ActiveCN101234216APromote degradationGood tissue compatibilitySurgeryAbsorbent padsCross-linkPorosity
The invention provides a collagen matrix freezing gel used for biomedical materials and a preparation method thereof. The collagen matrix freezing gel is the collagen extracted from skins or tendons of healthy domestic animals using the enzyme method with the molecular weight of 280 to 320kDa and a well maintained triple helical structure; the collagen reacts for 1 to 7 days in the condition of low temperature of 0 to minus 50 DEG C in a die after through cross linked and modified reaction with hydroformylation polysaccharide, then extrudes the die and is defrosted, thus forming the collagen matrix freezing gel. The preparation of the collagen matrix freezing gel of the invention in particular relates to the extraction of the collagen, the preparation of the hydroformylation polysaccharide and the synthesis of hydroformylation polysaccharide-collagen matrix freezing gel. The hydroformylation polysaccharide-collagen matrix freezing gel prepared by the invention improves the mechanical property, thermal stability and anti-enzyme degradation, etc., of pure collagen gels, and the freezing gel has the advantages of porosity, plasticity, hydrophilic property and non-toxicity, and can be used as biomedical materials such as bio-scaffold, cell cultivation, drug controlled release and biological dressings.
Owner:北京益而康生物工程有限公司
3D printed mask and manufacturing technology thereof
InactiveCN104940113AKeep the active ingredients intactSimple methodCosmetic preparationsAdditive manufacturing apparatusManufacturing technology3d printer
The invention provides a manufacturing technology of a 3D printed mask. The technology includes the following steps that under sterile vacuum conditions, according to human facial profiles, collagen gel and mask essence are sequentially stacked and printed through a 3D printer to obtain the 3D printed mask. The mask is manufactured through the 3D printing technology, the mask can be obtained by sequentially stacking and printing the collagen gel and the mask essence, the method is simple, and consumed time is short. Besides, the high-temperature process is not needed during printing, and effective components of the mask essence can be completely stored. Besides, a porous mask support is formed through the collagen gel in the vacuum condition, and the mask essence can be adsorbed to the largest extent. The obtained 3D printed mask is specialized according to individuation of the human facial profiles, and can completely fit with pores on human face skin.
Owner:GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
Support with crosslinked marine collagen for tissue engineering and manufacture of biomaterials
InactiveUS20050208478A1Simple and inexpensive mannerBroaden their knowledgeMicrobiological testing/measurementBiological material analysisCollagen spongeTissue engineering
The invention relates to a method of in vitro testing of the efficacy of a potentially active substance comprising monitoring the effect of said potentially active substance on an artificial skin, comprising a composite product forming a collagen support comprising at least one porous collagen layer covered on at least one side with a collagen membrane component selected from the group consisting of a collagen membrane prepared by compression of a collagen sponge at a pressure of at least about 50 bar and of a collagen membrane comprising a collagen film prepared by drying a collagen gel separately from the porous collagen layer, thereby providing a reliable method for finding new potentially active substances.
Owner:COLETICA
Method for protecting and restoring skin using selective MMP inhibitors
InactiveUS20020119107A1Type of reductionEliminate the effects ofCosmetic preparationsToilet preparationsUltravioletSolar ultraviolet radiation
The invention is based on selective inhibition of the enzyme (MMP-1), which causes the dermal matrix damage in humans, while sparing the enzyme(s) (MMP-9 and perhaps MMP-2) which not only do not cause the damage (based on extrapolation from our in vitro collagen gel system to real skin) but actually "clear away" the damage produced by MMP-1 to restore normal function to the skin. Matrix metalloproteinase-1 (MMP-1; fibroblast collagenase) is induced by UV radiation from the sun and is naturally elevated in old age. Human fibroblasts exposed to the degradation products of MMP-1 contract collagen, but when this debris is removed from their environment, the fibroblasts behave normally. Inhibiting MMP-1 but sparing enzymes that remove the debris improves human skin after onslaught from solar UV radiation, old age, and acne.
Owner:RGT UNIV OF MICHIGAN
Support with collage base for tissue engineering and manufacture of biomaterials
InactiveUS20040002055A1Reduce sensitivityHigh mechanical strengthPowder deliveryEpidermal cells/skin cellsBone tissue engineeringCollagen sponge
The invention relates to a method of in vitro testing of the efficacy of a potentially active substance comprising monitoring the effect of said potentially active substance on an artificial skin, comprising a composite product forming a collagen support comprising at least one porous collagen layer covered on at least one side with a collagen membrane component selected from the group consisting of a collagen membrane prepared by compression of a collagen sponge at a pressure of at least about 50 bar and of a collagen membrane comprising a collagen film prepared by drying a collagen gel separately from the porous collagen layer, thereby providing a reliable method for finding new potentially active substances.
Owner:BASF BEAUTY CARE SOLUTIONS FRANCE SAS
Methods for making and delivering rho-antagonist tissue adhesive formulations to the injured mammalian central and peripheral nervous systems and uses thereof
InactiveUS7141428B2Avoid crackingReduce deliveryOrganic active ingredientsPowder deliveryNervous systemFibrin glue
The present invention provides methods for making, delivering and using formulations that combine a therapeutically active agent(s) (such as for example a Rho antagonist(s)) and a flowable carrier component capable of forming a therapeutically acceptable matrix in vivo (such as for example tissue adhesives), to injured nerves to promote repair and regeneration and regrowth of injured (mammalian) neuronal cells, e.g. for facilitating axon growth at a desired lesion site. Preferred active agents are known Rho antagonists such as for example C3, chimeric C3 proteins, etc. or substances selected from among known trans-4-amino(alkyl)-1-pyridylcarbamoylcyclohexane compounds or Rho kinase inhibitors. The system for example may deliver an antagonist(s) in a tissue adhesive such as, for example, a fibrin glue or a collagen gel to create a delivery matrix in situ. A kit and methods of stimulating neuronal regeneration are also included.
Owner:BIOAXONE BIOSCI +1
High-strength collagen gel and preparation method thereof
ActiveCN104231288AHigh mechanical strengthIncrease the degree of cross-linkingMacromolecular non-active ingredientsProsthesisCross-linkThree Dimensional Size
The invention relates to high-strength collagen gel. The collagen gel is characterized in that the high-strength collagen gel undergoes three-dimensional size shrinkage by immersing radiation cross-linked low-density collagen hydrogel in water or an aqueous solution for a period of time and maintaining a certain temperature; the compression modulus is increased by 2-5 times that of the low-density collagen hydrogel after self-shrinkage by solution immersion; and the high-strength collagen gel has a three-dimensional structure or high porosity, and the pore diameter is distributed in a gradient manner. The invention further relates to a method for preparing the high-strength collagen gel.
Owner:北京同威典石技术有限公司
Collagen gel and preparation method thereof
ActiveCN101829320AHigh puritySingle ingredientCosmetic preparationsOrganic active ingredientsDissolutionAntibacterial agent
The invention provides a collagen gel and a preparation method thereof. The collagen gel comprises collagen and an antibacterial agent, wherein the antibacterial agent is at least one of chitosan and nano silver. The collagen gel also comprises a preservative, a substrate, a dispersing agent, a film-forming agent and water; and 1g of gel comprises 0.5 to 8.0mg of collagen, 0.001 to 15mg of antibacterial agent, 1 to 50mg of preservative, 10 to 50mg of matrix, 50 to 100mg of dispersing agent, 1 to 10mg of film-forming agent, and the balance of water. The method for preparing the collagen gel comprises the following steps of: performing dispersion and dissolution on the substrate by adopting the dispersing agent under ten-thousand grade clean environment; adding the dispersing agent, the substrate, the preservative, the antibacterial agent, and collagen solution into a vacuum emulsified homogenizer one by one; after fully mixing, standing and defoaming, filling the product. The collagen gel is applied to various open wounds and infected wounds, lightens hyperpigmentation, has good effect of accelerating wound healing, and can maintain long-term anti-bacteria function.
Owner:GUANGZHOU TRAUER BIOTECH
Preparation method of bionic mineralized collagen scaffold
The invention provides a preparation method of a bionic mineralized collagen scaffold. The preparation method comprises the following steps: 1), preparing a bionic mineralized liquid: adjusting the pHvalue of carboxymethyl chitosan-amorphous calcium phosphate (or amorphous strontium phosphate or amorphous strontium carbonate) nanocomposite liquid to be lower than an isoelectric point of CMC; 2),preparing the bionic mineralized collagen scaffold: mixing the bionic mineralized liquid and acid-dissolved type-I collagen, then putting into a dialysis bag, sealing, then putting into a PBS buffer liquid, self-assembling and mineralizing for 2-5 days, then adding an alkaline CMC / ACP (ASP or ASC) liquid into the dialysis bag, and changing the PBS buffer liquid; 1-3 days later, putting the dialysis bag into deionized water for dialyzing for 10-72h, changing the deionized water for several times, centrifuging the liquid in the bag to obtain collagen gel, and performing freeze drying to obtain the bionic mineralized collagen scaffold. By the preparation method, collagen self-assembly and mineralization are cooperatively performed, intra-collagen fiber mineralization is achieved at relativelyhigh efficiency, and osteogenic ability-promoting strontium is integrated into the collagen scaffold, so that the preparation method has a wide clinical application prospect.
Owner:博纳格科技(天津)有限公司
Recombinant human collagen gel and preparation method thereof
InactiveCN105169374AMoisturizing, isolatingImprove atrophyOrganic active ingredientsPeptide/protein ingredientsGlycerolButanediol
The invention relates to the technical field of medical gels, and in particular relates to a recombinant human collagen gel and a preparation method thereof. The recombinant human collagen gel consists of the following raw materials in percentage by weight: 1-3% of small-molecule collagen, 1.5-2.5% of glycerol, 1-2% of chitosan quaternary ammonium salt, 0.5-1.5% of sodium hyaluronate, 0.5-1.5% of epsilon-polylysine, 0.3-0.7% of borneol, 0.3-0.7% of poloxamer, 0.3-0.7% of coenzyme Q10, 0.3-0.7% of butanediol and the balance of purified water. The recombinant human collagen gel provided by the invention has effects of moisture retention and isolation, can improve vaginal atrophy, increase vaginal elasticity and relieve dyspareunia, and also can improve the wettability and the dry state of a vagina, relieve dry and coarse stabbing pain symptoms of cunnus, and ease itching, calor, skin mucous membrane fissure and diffuse superficial bleeding caused by vaginal dryness.
Owner:DONGGUAN DAQING MEDICAL DEVICES CO LTD +2
Tooth mineralization liquid and tooth mineralization method
ActiveCN110693724AEasy to handleImprove permeabilityImpression capsMedical preparationsCollagenanCollagen sponge
The invention discloses a tooth mineralization liquid and a tooth mineralization method. The tooth mineralization liquid is used for mineralizing collagen and teeth and comprises two separate parts, namely a reagent A with a compound of non-collagenous protein analog and calcium salts, and a reagent B with phosphates. The preparation of the tooth mineralization liquid requires adjusting pH of thereagents A and B to 5-12. The tooth mineralization method via the tooth mineralization liquid includes smearing the reagent A to the tooth surface, allowing to the smeared reagent A to stand, smearingthe reagent B to the tooth surface, and allowing the smeared reagent B to stand, wherein smearing can be carried out many times as required to arrive at tooth mineralization. In addition, the tooth mineralization liquid also allows the collagen to be biomineralized in the same way; mineralization includes taking single-layer recombinant collagen fibers, collagen gel and collagen sponge, soaking or suspending in the reagent A, taking out, suck-drying with filter paper, and soaking or suspending in the reagent B to arrive at biomineralization, wherein the mineralization can also be performed many times.
Owner:ZHEJIANG UNIV
Preparation method of collagen sponge
ActiveCN102416195AGood biocompatibilityImprove tissue repair abilityAbsorbent padsFermentationCross-linkTissue repair
The invention discloses a preparation method of collagen sponge. The method comprises the following steps: carrying out enzymolysis on cattle heel tendon in protease aqueous solution at pH value of 1.0-5.0; centrifuging the enzymolysis liquid, collecting supernatant, and salting out collagen with saturated salt solution; dialyzing salted-out collagen; cross-linking the dialyzed collagen in a cross-linking agent aqueous solution; and freeze-drying cross-linked collagen gel, cross-linking the collagen in a cross-linking agent aqueous solution and freeze-drying to obtain the collagen sponge. The collagen sponge obtained by the preparation method of the collagen sponge disclosed by the invention has certain elastic and tensile toughness after being immersed in water, and has good biocompatibility and tissue repairing performance, and high protein content and is controllable in degradation.
Owner:北京益而康生物工程有限公司
Removable edible label based on collagen for labelling food products
Removable edible label based on collagen for labelling food products, the label being free of any adhesive layer, being able to stick to the food product throughout the slaughter process until packaging and being able to be removed intact from the food product whenever desired, said label has a swelling rate in water between 120% and 450% and a pH value between 5,5 and 10,0. The present invention relates to removable edible labels based on collagen for labelling food products, to edible films based on collagen, to a process for preparing an edible film based on collagen from a collagen gel and to a process for preparing removable edible labels based on collagen from edible films.
Owner:NATURIN GMBH & CO
Method for preparing high-strength collagen tissue repair material product
InactiveCN101564552AIncrease crosslink densityHigh strengthCatheterProsthesisTissue repairVolumetric Mass Density
The invention relates to a method for preparing a high-strength collagen tissue repair material product. The method obtains the final collagen product through the treatment steps of salting out, centrifugation, dehydration, crosslinking and drying of a collagen solution. Because the treatment method adopts the mode of improving the solid content of collagen in collagen gel and the crosslinking density in the collagen gel, the mechanical property of the final product is greatly improved. Simultaneously, because the adopted method does not influence the biological property of the collagen, the final collagen product still maintains good biological activity. The collagen product can be used for the repair treatment of articular cartilage, meniscus and skin, the construction of artificial blood vessels and nerve conduits, and the like.
Owner:SOUTH CHINA UNIV OF TECH
Method for modifying freshwater fish skin collagen by adjusting alkalinity acidity
InactiveCN1629191AHigh strengthNo change in structureConnective tissue peptidesPeptide preparation methodsHazardous substanceFresh water organism
The invention provides a method for modifying freshwater fish skin collagen by adjusting alkalinity acidity, wherein acids or alkali are employed for adjusting the pH of fresh water fish skin collagen aqueous solution to the isoelectric point of collagen, the acids can be hydrochloric acid, acetic acid or citric acid, the concentration being 0.5-1 mol / L, the alkali can be sodium hydroxide, sodium carbonate or potassium hydroxide, the concentration being 0.5-1 mol / L. The method can increase the gelatin strength of the fresh water fish skin collagen by one times, and high safety can be achieved.
Owner:OCEAN UNIV OF CHINA
Collagen gel artificial skin substitute
An artificial collagen gel skin is prepared from ox tendon collagen dispersing liquid 80 portions, DMEM culture liquid 10, glutamine solution 1, dicarbonate solution 6 and fetal calf serum 12 through proportionally mixing, adding human embryo skin fibroblast suspension, and external culture.
Owner:INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
Chitosan collagen gel and application thereof
InactiveCN102108211AKeep a humid environmentPromote healingAbsorbent padsBandagesChronic woundWater soluble
The invention relates to a chitosan collagen gel and an application thereof, and the gel comprises 1-15% of chitosan, 1-20% of collagen, 0.1-1% of gel matrix and water, wherein the chitosan is water-soluble chitosan with the molecular weight of 1500 Daltons-0.4 million Daltons, the molecular weight of the collagen is 5000 Daltons-3 million Daltons; and the gel matrix is selected from one or two of carbomer, polyethylene type and cellulose derivatives. The chitosan collagen gel is applied in hemostasis of acute and chronic wounds, absorption of seepage, autolytic debridement, protection of exposed nerve endings and pain relief, and can be simultaneously used for keeping moist environment of the wounds, accelerating the healing of the wounds and inhibiting scar formation.
Owner:沈阳圣兴生物科技有限公司
Collagen gel containing nanogold, and prepetition method and application thereof
ActiveCN104739657AAvoid sex changeThe degree of anti-oxidation is controllableCosmetic preparationsToilet preparationsProtein CCollagen gel
The invention discloses a collagen gel containing nanogold, and a preparation method and an application thereof. The gel is prepared by the method of reducing a gold precursor by collagen. Firstly, reducing groups in collage react with the gold precursor to generate nanogold, then the generated nanogold further crosses link a three-screw structure of collagen in situ, to form compact gel. The property stability of the collagen is even, the particle size of contained nanogold is controllable, the preparation process is simple and convenient, chemical cross linking agent is not required, and so the collagen gel has a wide application prospect in the fields of daily cosmetic antioxidant masks and the like.
Owner:INST OF PROCESS ENG CHINESE ACAD OF SCI
Aquatic collagen fish bean curd and preparation method thereof
The invention relates to an aquatic collagen fish bean curd and a preparation method thereof. The fish bean curd is composed of the following raw materials by mass: 65-90% of aquatic collagen glue peptone, 2.5% of soybean isolate protein, 0.1-0.5% of a protein cross-linking agent, 0.5-2% of egg white protein, 1-5% of vegetable protein, 0-10% of starch, 1-8% of pork fat, 0.1-2% of thermal reversible colloid, 0.1-1% of thermal irreversible glue, and 2-10% of a seasoning. The preparation method of the fish bean curd comprises: preparing the raw materials into a collagen gel peptone shape, then adding soybean isolate protein to perform pulping and adding the protein cross-linking agent to conduct chopping, then adding auxiliary materials and the seasoning, mixing the materials evenly and carrying out rough processing shaping, finally conducting deep processing to obtain a finished product and then carrying out vacuum packaging, sterilizing, cooling, encasement and warehousing. The fish bean curd provided by the invention has the characteristics of high protein content, rich nutrition and convenient eating, and solves the technical barrier that traditional collagen products have poor heat resistance. The preparation method of the fish bean curd provided by the invention has the advantages of simple and convenient operation and high efficiency, and is suitable for popularization and application.
Owner:厦门美拉德食品科技有限公司
Covered micro gel fiber
ActiveUS8785195B2High mechanical strengthEasy to preparePeptide/protein ingredientsConjugated cellulose/protein artificial filamentsHigh intensityUltimate tensile strength
Owner:THE UNIV OF TOKYO
Nerve regeneration promoters containing semaphorin inhibitor as the active ingredient
InactiveUS20070015820A1Promotes neurite outgrowthInhibitory activityBiocideSenses disorderGrowth cone collapseDepressant
To provide a semaphorin inhibitor; a peripheral or central nerve regeneration promoter which contains said semaphorin inhibitor as an active ingredient; and a preventive or remedy for a neuropathic disease and a neurodegenerative disease containing said nerve regeneration promoter, or the like. A low-molecular weight compound, which acts at a concentration of 10 μg / ml or below to inhibit the growth cone collapse activity of semaphorin such as semaphorin 3A, semaphorin 6C or the like and / or the nerve outgrowth inhibitory activity of semaphorin in a collagen gel and which does not substantially affect cell proliferation, is obtained from the culture of strain SPF-3059 belonging to the genus Penicillium. The low-molecular weight compound with the semaphorin inhibitory activity thus obtained exhibits the in vivo nerve-regeneration promoting action.
Owner:SUMITOMO DAINIPPON PHARMA CO LTD
Method for improving tensile strength of collagen fiber material
ActiveCN104213238AHigh tensile strengthConsistent alignmentMonocomponent protein artificial filamentCross-linkWater baths
The invention discloses a method for improving the tensile strength of a collagen fiber material. The method comprises the following steps: 1) dissolving natural collagen with acetic acid solution and dialyzing a phosphate buffer solution to obtain a collagen solution with collagen concentration of 1-20mg / mL and pH value of 6.0-9.0; 2) transferring the collagen solution into centrifugal tubes in a centrifuge with a horizontal rotor, and centrifuging for 5 to 120 minutes; 3) placing the centrifugal tubes vertically in a water bath or an incubator, standing for 2-48 h to get collagen gel; 4) placing the collagen gel in a 0.5%-10% aqueous solution of glutaraldehyde for cross-linking for 1-24 h, and then repeatedly rinsing with distilled water; and 5) naturally drying for 12 to 36 h, and drying in a blast drying box for 12-36 h to obtain the collagen fiber material. The collagen fiber prepared by the method of the invention has collagen fibers in consistent arrangement direction, and the tensile strength of the material can be improved significantly.
Owner:GUANGZHOU TRAUER BIOTECH
A tooth mineralization solution and its mineralization method
ActiveCN110693724BEasy to handleImprove permeabilityImpression capsMedical preparationsCollagenanCollagen sponge
Owner:ZHEJIANG UNIV
Micro cell hollow fiber reactor
The micro hollow fiber cell reactor consists of silica gel tube of permeable silica gel material, permeable silica gel stopper and hollow fiber filament. Cell is embedded inside the hollow fiber filament with collagen gel, and the micro hollow fiber cell reactor has oxygen transferring and mass transferring capacity suitable for cell to survive and maintains the medicine metabolizing and other functions of cell. The micro hollow fiber cell reactor combines the advantages of miniature orifice plate and 3D bionic artificial liver reactor, maintains the bioactivity of animal cell. It may be used as in vitro mold of liver cell for the research of medicine metabolism and pharmacological and toxicological research and may be used in the lab research of cell culturing condition and cell product. It may be also used as the carrier for the research of animal cell culturing condition and lays the foundation for industrial production.
Owner:ZHEJIANG UNIV
Medical collagen gel and preparation method thereof
InactiveCN104306324ANo toxicityNon-immunogenicPeptide/protein ingredientsAntipyreticCuticleCervicitis
The invention relates to a medical collagen gel and a preparation method thereof. The gel contains 1-3% by weight of collagen, 2.5-5% by weight of polyvinyl pyrrolidone, 0.5-3% by weight of a water-soluble polymer and 89-96% by weight of sterile water for injection. The medical collagen gel prepared by the method provided by the invention has good curative effects in treatment of female lower genital tract inflammation, cervicitis, cervical erosion, burns, scalds, bedsore infections, other wound infections and the like. In the aspect of treatment of gynecological inflammation, the gel has a good anti-inflammatory effect and moisturizing property and can regulate the pH value in a human body and maintain balance of an internal environment; and in the treatment aspect of repairing wounds, the gel can effectively reduce inflammation, reduce wound secretions, can be closely combined with newborn wounds to naturally form films to temporarily replace skin epidermis, prolongs the replacement time, reduces the suffering of the wounds, promotes the healing of the wounds and reduces scarring.
Owner:无锡贝迪生物工程股份有限公司
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Patsnap Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com