184 results about "Open wounds" patented technology

A hemostatic composition for stopping or decreasing blood flow from an open wound or medical or surgical procedure. Compositions of the invention comprise a mixture of a cationic polymer and a cation exchange material. In one embodiment, the composition comprises a mixture: (1) a high molecular weight copolymer of diallyl dimethyl ammonium chloride (DADMAC) and acrylamide [DADMAC copolymer], and (2) the hydrogen form of a crosslinked, sulfonated polystyrene (hydrogen resin). In an exemplified embodiment, a composition of the invention comprises the mixture of DADMAC copolymer and hydrogen resin provided in a dry powdered form. The compositions of the invention may be applied directly to a wound or treatment site, or they may be incorporated into a wound dressing, such as a bandage. The seal formed at a wound or treatment site treated with the present invention is adhesive and exhibits considerable toughness.

A system and method for the temporary closure of a wound, especially an abdominal wound, to facilitate re-entry, final closure, and long term healing of the wound. An abdominal wound dressing and methods of use are described that enable the application of negative pressure to the wound site in a site healing promoting manner while also limiting the formation of adhesions that would prevent the removal of the dressing. The dressing comprises a layer of porous foam material (36) enclosed by sheets of elastomeric material (38) punctuated by a number of appropriately placed holes (34). Multiple layers of porous foam may also be used. A suction tube connector (16) is provided on an upper surface of a layer of foam (12) for connection to a negative pressure source. At least one layer of foam is enclosed in elastomeric material and is placed in direct contact with the tissue within the open wound. Fluids are drawn by negative pressure through the holes positioned in the elastomeric envelope, and through the foam. If multiple foam layers are employed, the lower layer(s) of foam are of a finer porosity while the upper layer of foam is coarse. An adhesive elastomeric sheet (14) covers the entire wound dressing and seals the edges to the skin surrounding the wound. An appropriate vacuum device is attached to the suction tube connector.

A dressing for an open wound includes a cover layer dimensioned for positioning relative to a wound bed. The cover layer permits an evacuation of the space around the wound bed such that a sub-atmospheric pressure may be established to stimulate healing and facilitate the removal of fluid from the wound. Multiple performance zones in the cover layer allow the wound dressing to remain in position through repeated cycles of evacuation without placing undue strain on the wound bed. An outer peripheral zone may include a high peal-strength adhesive while an intermediate zone may include a shear resistant adhesive. A central zone may be devoid of any coating to maximize moisture transmission through cover layer.

An apparatus for drainage of a wound or surgical site of a human or animal fits anatomically, passes from inside the wound or surgical site percutaneously or covering an open wound surface and extends externally for accumulation of fluids. A plurality of fibers each with an internal end, middle and an external end is elongate with a thickness and a length wherein its thickness is substantially less than its length for flexibility. The fibers form a loose bundle with gathered external ends and with internal ends unrestrained for spreading divergently inside the wound or surgical site. A collector is positioned in fluid communication with the gathered external ends for accumulating bodily fluid guided along and amongst the fibers from the internal ends along the middle and to the external ends during drainage. Vacuum connects to draw fluid from the collector. A method has steps of providing fibers with the internal ends unrestrained, the external ends gathered in a collector to accumulate drained fluid. The method guides bodily fluid along and amongst the fibers from the internal ends along the middle and to the gathered together external ends during drainage. The fibers spread divergently for accumulating bodily fluid inside the wound or surgical site. A method of manufacture of the apparatus has the steps of accumulating a plurality of fibers with internal ends, a middle and external ends in a loose bundle but gathering together in a collector at their external ends while leaving the internal ends unrestrained.

A surgical bandage for treating a wound that allows various fluids or fluid-like substances including cyanoacrylate adhesives to be applied. The surgical bandage has a wound treatment portion for being placed over a wound and a place for a flowable cyanoacrylate adhesive or any other fluid or fluid-like substance to be applied to the underlying wound (laceration, surgical incision or other tissue separation). A source is used to apply the cyanoacrylate or other fluid to the wound treatment portion flowing through at least one opening of the wound treatment portion to the underlying wound and its surrounding area either by direct application or from a non-contact distance. The surgical bandage allows for direct visualization before, during and after its application. The surgical bandage allows for removal of blood or any fluid that may be present in, on or around the wound by blotting or wiping.

A vacuum system for draining an open wound from liquids exuded therefrom, comprising an enclosure sealable to the wound circumference, a vacuum pump including a disposable pump unit detachably attachable to a non-disposable drive unit, and a waste container for collection of drained liquids. The enclosure has an outlet connected by means of a tube to an inlet of the pump unit and the waste container is connected to an outlet of the pump unit, such that when the vacuum pump is operated the drained liquids flow through the vacuum pump. The enclosure has one or more bleeding holes provided therethrough or adjacent to its outlet so that ambient air may enter the tube and flow together with the drained liquids. The enclosure and the waste container are disposable so that the drained liquids contact only disposable elements and may be disposed of together with all disposable elements.

Super-oxidized water based on hypochlorous acid, such as is obtained by the electrochemical treatment of a saline solution, may be used in the treatment of leg ulcers or other open wounds. Preferably, the pH of the super-oxidized water is in a range of 4 to 7, and the water has a redox potential of >950 mV. Medicaments based on the super-oxidized water may be in liquid or gel form. The super-oxidized water is able to control the microbial population within the wound and at the same time permit cell proliferation.

Devices and methods aimed at shortening the time required for healing open wounds are disclosed. The tissues adjacent to wounds are expanded and / or stretched medially by means of an actuator which compressed by vacuum exerts traction on adjacent skin or tissues by means of an adhesively applied circumferent or transverse flange, thus reducing the size of the wound. The degree of vacuum, and traction, may be varied according to demand and applied continuously, cyclically or intermittently. Active treatment of the wound may be accomplished concomitantly by means of a conduit through the said actuator.

An apparatus for drainage of a wound or surgical site of a human or animal fits anatomically, passes from inside the wound or surgical site percutaneously or covering an open wound surface and extends externally for accumulation of fluids. A plurality of fibers each with an internal end, middle and an external end is elongate with a thickness and a length wherein its thickness is substantially less than its length for flexibility. The fibers form a loose bundle with gathered external ends and with internal ends unrestrained for spreading divergently inside the wound or surgical site. A collector is positioned in fluid communication with the gathered external ends for accumulating bodily fluid guided along and amongst the fibers from the internal ends along the middle and to the external ends during drainage. Vacuum connects to draw fluid from the collector. A method has steps of providing fibers with the internal ends unrestrained, the external ends gathered in a collector to accumulate drained fluid. The method guides bodily fluid along and amongst the fibers from the internal ends along the middle and to the gathered together external ends during drainage. The fibers spread divergently for accumulating bodily fluid inside the wound or surgical site. A method of manufacture of the apparatus has the steps of accumulating a plurality of fibers with internal ends, a middle and external ends in a loose bundle but gathering together in a collector at their external ends while leaving the internal ends unrestrained.

Methods and systems are provided for a sub-atmospheric wound-care (SAWS) system for treating an open wound. The SAWS system includes a regulated vacuum source for developing a negative pressure, a flow rate meter configured to measure a flow rate of liquid removed from the wound, a primary pressure regulating sensor located proximate the wound for directly measuring the negative pressure at the wound, a backup pressure regulating sensor located vacuum tube, a porous dressing suitable to be sealed airtight which is positioned within a wound interface chamber, a collection canister configured to collect said liquid removed from the wound, and an adapter configured to use wall suction a primary regulated vacuum source.

A vascular catheter embedded with a radiopaque material providing a distinct, non-physiological pattern that may be easily detected on a radiograph. The radiopaque material may be embedded within the wall of the catheter in an open wound, helical formation. Detection of the catheter by x-ray is increased due to the non-physiological radiograph pattern and due to the increased presence of the radiopaque material. The non-physiological formation increases the radiopacity of the catheter, yet requires less radiopaque material than traditional radiopaque catheters. The non-physiological formation and decreased amount of radiopaque material provides for a more detectible and less rigid catheter that is resistant to kinks and occlusions.

Applicable to humans, animals and fish, a method for injecting thoroughly diffused ambient air or disinfectant into water prior to its delivery into a therapy tank plus an underwater PZT probe transmission of separate stable and transient cavitation signals from which a microcomputer determines, 1) the average number of transducer generated sinoidal equal amplitude alternating compression and rarefaction ultrasonic acoustic pressure waves cycles necessary to create inertial and / or transient cavitation and the required number of rectified sinoidal equal amplitude ultrasonic compression acoustic pressure waves necessary to suppress the inertial / transient cavitation and thereby maintain stable cavitation for cleaning and open-wound therapy treatment for 15-minutes, (or greater) time periods and, 2) the necessary dilution of water and disinfectant and its activation by dual-mode transient cavitation to kill the pathogens shed by the “patient” following “patient” cleaning or wound-therapy treatment.

The invention described herein relates to methods for reducing and / or stopping bleeding or fluid loss from open wound, denuded tissue, or burned skin, comprising the step of applying to the open wound, denuded tissue or burned skin a gel-forming composition comprising at least one of the following compositions: a polyacrylic acid having the structural formula [CH2═CHCO2H]n, where n is between 10,000 and 70,000; a polyacrylic acid and a desiccated water soluble organic or inorganic base; polyacrylic acid and a desiccated poorly soluble basic salt, and a polyvinyl alcohol having the structural formula of [CH2═CHOH]n, where n is between 15,000 and 150,000. When the gel-forming composition is applied to the open wound, denuded tissue, or burned skin, its ions react therein in the presence of water from blood or body fluid therein to form an aqueous gel or mucilage having sufficient viscosity and adhesiveness to cover and adhere to the open wound, denuded tissue, or burned skin so that bleeding or fluid loss is thereby reduced and / or stopped.

A biomaterial for suturing comprising a physiologically compatible support material coated with a cellular population with proliferative and / or differentiation capacity, characteristics which facilitate the regeneration of the sutured tissue. This biomaterial for suturing not only brings together the two edges of an open wound, but also contributes actively to the healing process, thereby accelerating the tissue repair process. Also disclosed are methods for making the biomaterial and methods for using the biomaterials in therapy.

The present invention relates to the use of one or more natural or modified oxygen carriers, devoid of plasma or cellular membrane constituents, for the production of an agent for the external treatment of open wounds, particularly chronic wounds. Hemoglobin or myoglobin of human or animal origin are suitable as oxygen carriers. The oxygen carriers can also preferably be modified. Suitable modifications are cross-linking, reaction with polyalkylene oxides, chemically reactive or chemically non-reactive effectors, or combinations. The agent is applied to the wound area particularly by means of spraying on an aqueous solution containing the oxygen carrier(s). The oxygen carriers can be used in particularly effective manner in the case of chronic wounds resulting from tissue degeneration, particularly diabetic tissue degeneration.

A wound closure device has internal and external components designed to close, shrink or approximate an open wound. The internal component preferably comprises sachets filled with highly absorbent material such as carboxymethylcellulose, disposed at the surface of the wound bed to absorb exudate from the wound. The external components preferable include paddles that adhere to the skin, and form part of, or have a mechanism to couple to an elastic tensioning fabric. The internal component is placed between the open wound and the elastic tensioning fabric, such that expansion of the internal component applies pressure on the wound base. It is contemplated that the two components will work synergistically together to create ‘micro-deformation’ forces that stimulate granulation tissue.

The subject invention pertains to methods and compositions for wound treatment. The methods and compositions provide for promoting and accelerating wound healing; provide for inhibition of microbial infection; provide for a protective scab-like covering on a wound; and / or for arresting the flow of blood or body fluids from an open wound. The methods and compositions can be used to increase granulation and epithelialization in a wound. In one embodiment, a substantially anhydrous compound of a salt ferrate and a cation exchange material is provided. Compositions of the invention can also include silver compounds. In use, compositions of the invention are preferably applied as a dry dressing to an exuding chronic wound site. If the chronic wound site is dry, the wound site may be wetted with a suitable liquid or aqueous media prior to applying the dressing in dry form.

A surgical bandage for treating a wound that allows various fluids or fluid-like substances including cyanoacrylate adhesives to be applied. The surgical bandage has a wound treatment portion for being placed over a wound and a place for a flowable cyanoacrylate adhesive or any other fluid or fluid-like substance to be applied to the underlying would (laceration, surgical incision or other tissue separation). A source is used to apply the cyanoacrylate or other fluid to the wound treatment portion flowing through at least one opening of the wound treatment portion to the underlying wound and its surrounding area either by direct application or from a non-contact distance. The surgical bandage allows for direct visualization before, during, and after its application. The surgical bandage allows for removal of blood or any fluid that may be present in, on, or around the wound by blotting or wiping.

Provided is a wound closure assisting and maintaining apparatus that can be attached to a wide open wound of a patient and can stretch skin around the wound gradually to achieve the wound closure and maintain the wound closure during most critical postoperative period. The apparatus includes: a loop suture being threaded through skin; a tightening member for gathering both ends of the threaded loop suture at one point and for exerting a pressure of wound tightening force evenly on skin; a pulling member for pulling the loop suture in order to tighten the threaded loop suture; a housing member for housing the pulling member and making the loop suture tightened by transformation of a pulling force to a wound tightening force when pulling member pulls the loop suture out of skin; and a locking member for fixing a position of the pulling member to maintain the tightened status.

Super-oxidized water based on hypochlorous acid, such as is obtained by the electrochemical treatment of a saline solution, may be used in the treatment of leg ulcers or other open wounds. Preferably, the pH of the super-oxidized water is in a range of 4 to 7, and the water has a redox potential of >950 mV. Medicaments based on the super-oxidized water may be in liquid or gel form. The super-oxidized water is able to control the microbial population within the wound and at the same time permit cell proliferation.

This present invention relates to methods for treating or attenuating pain in a patient. Specifically, the invention provides a method for attenuating pain in proximity to the site of an open wound or surgical incision comprising instilling a pharmaceutical composition comprising a capsaicinoid into the wound or incision, allowing the pharmaceutical composition to dwell for a predetermined period of time, and aspirating the wound or incision to remove the pharmaceutical composition. The invention also provides a method for attenuating pain in proximity to a joint comprising intra-articularly injecting a pharmaceutical composition comprising a capsaicinoid into the joint, allowing the pharmaceutical composition to dwell for predetermined period of time, and aspirating the joint to remove the pharmaceutical composition. In certain embodiments of the invention, the capsaicinoid is capsaicin.

A biomaterial for suturing comprising a physiologically compatible support material coated with a cellular population with proliferative and / or differentiation capacity, characteristics which facilitate the regeneration of the sutured tissue. This biomaterial for suturing not only brings together the two edges of an open wound, but also contributes actively to the healing process, thereby accelerating the tissue repair process. Also disclosed are methods for making the biomaterial and methods for using the biomaterials in therapy.

The present invention relates to stable compositions comprising α- and β-chitosan and derivatives thereof for controlled absorption and / or coagulation of fluids from a wound or bleeding site. The invention further provides methods for preparing these stable compositions and articles of manufacture comprising these compositions. The stable compositions of the present invention are particularly useful in methods for treatment of open wounds or bleeding sites in a mammal using disposable medical and personal care articles that require controlled absorption, hemostasis, and tensile strength.

The invention provides a collagen gel and a preparation method thereof. The collagen gel comprises collagen and an antibacterial agent, wherein the antibacterial agent is at least one of chitosan and nano silver. The collagen gel also comprises a preservative, a substrate, a dispersing agent, a film-forming agent and water; and 1g of gel comprises 0.5 to 8.0mg of collagen, 0.001 to 15mg of antibacterial agent, 1 to 50mg of preservative, 10 to 50mg of matrix, 50 to 100mg of dispersing agent, 1 to 10mg of film-forming agent, and the balance of water. The method for preparing the collagen gel comprises the following steps of: performing dispersion and dissolution on the substrate by adopting the dispersing agent under ten-thousand grade clean environment; adding the dispersing agent, the substrate, the preservative, the antibacterial agent, and collagen solution into a vacuum emulsified homogenizer one by one; after fully mixing, standing and defoaming, filling the product. The collagen gel is applied to various open wounds and infected wounds, lightens hyperpigmentation, has good effect of accelerating wound healing, and can maintain long-term anti-bacteria function.

Application to humans, animals and fish, a method for injecting thoroughly diffused ambient air or disinfectant into water prior to its delivery into a therapy tank plus an underwater PZT probe transmission of separate stable and transient cavitation signals from which a microcomputer determines, 1) the average number of transducer generated sinoidal equal amplitude alternating compression and rarefaction ultrasonic acoustic pressure waves cycles necessary to create inertial and / or transient cavitation and the required number of rectified sinoidal equal amplitude ultrasonic compression acoustic pressure waves necessary to suppress the inertial / transient cavitation and thereby maintain stable cavitation for cleaning and open-wound therapy treatment for 15-minutes, (or greater) time periods and 2) the necessary dilution of water and disinfectant and its activation by dual-mode transient cavitation to kill the pathogens shed by the “patient” following “patient” treatment.

The invention discloses a non-toxic environment-friendly solvent type double-layer nanofiber skin dressing and a preparation method thereof. The non-toxic environment-friendly solvent type double-layer nanofiber skin dressing comprises a drug-loaded hydrophilic repair natural polymer fiber layer and a waterproof and breathable synthetic polymer fiber layer, and is prepared by adopting a non-toxicenvironment-friendly solvent system through an electrostatic spinning technology layer by layer. The preparation method comprises the steps that a natural polymer and a drug are dissolved in a non-toxic environment-friendly solvent, and a cross-linking agent is added; a synthetic polymer is dissolved in the non-toxic environment-friendly solvent, and a water repellent agent is added; and a naturalpolymer solution and a synthetic polymer solution are placed in an injection syringe, and an electrostatic spinning device is adopted for spinning to prepare a double-layer fiber membrane. The double-layer nanofiber skin dressing prepared through the preparation method does not contain a toxic solvent, and does not generating toxic and side effects on open wounds when serving as the dressing; andthe double-layer nanofiber skin dressing has waterproof and breathable performance, is good in cytocompatibility, can promote wound healing of rats with skin damages, and has the huge application prospects in the field of skin dressings.

A synthesized composition containing zinc ions, calcium ions, rubidium ions and / or potassium ions in a pharmaceutically acceptable carrier, which, when applied to an open wound, effectively modulates the activity of at least MMP-2 and / or MMP-9 in the wound. A method for treatment of wounds is disclosed.