51 results about "Dermal dressing" patented technology

A skin dressing, particularly a wound dressing, comprises oxidoreductase enzyme and, optionally, peroxidase enzyme, wherein the enzyme(s) are present in hydrated condition, e.g. being present in one or more hydrated hydrogels. The dressing is used by being located on the skin of a human or animal e.g. over a wound. The oxidoreductase enzyme catalyses a reaction that produces hydrogen peroxide from an appropriate substrate, the substrate either being naturally present in body fluids and / or being supplied separately and / or being incorporated into the dressing. The currently preferred oxidoreductase enzyme is glucose oxidase. The catalyses reaction of β-D-glucose substrate to give hydrogen peroxide and gluconic acid. A mixture of oxidoreductase enzyme can undergo reaction (optionally catalysed by the peroxidase enzyme) to produce a variety of species including reactive oxygen intermediates that have antimicrobial properties and that can therefore assist in promoting wound healing.

A skin dressing is adapted, on activation, to release one or more S-nitrosothiols, preferably S-nitroso-L-glutathione. S-nitrosothiols decompose spontaneously to produce nitric oxide, which has beneficial effects on tissues, particularly in wound healing.

A transparent film dressing (1) for protection of skin surrounding a wound, the dressing includes a film layer (2) coated with a skin friendly adhesive (3) on one side, a stiffening layer (4) releasably attached to the film layer on the side thereof opposite to the side coated with adhesive, and a release layer (5) releasably attached to the adhesive coating on the film layer. A protection layer (6) is releasably attached to the release layer (5) on the side thereof opposite to the side attached to the adhesive coating (3), and a hole (9) extends through the stiffening layer (4), the coated film layer (2,3) and the release layer (5) but not through the protection layer, all the layers being transparent. A method of applying such a dressing is also described.

A skin dressing comprises a hydrated hydrogel material including a source of lactate ions and a supply of glucose, optionally also including a source of zinc ions and a source of iodide ions. The dressing has beneficial effects on skin.

Improvements relating to skin dressing A skin dressing adapted, on activation, to generate one or more S-nitrosothiols by reaction between a thiol and a nitrate salt in the dressing, the skin dressing comprising a source of Cu2+, Zn2+ and / or Fe2+ ions for delivery of nitric oxide to a body site is provided.

A skin dressing comprises a hydrated hydrogel material including a source of lactate ions and a supply of glucose, optionally also including a source of zinc ions and a source of iodide ions. The dressing has beneficial effects on skin.

A skin dressing, particularly a wound dressing, comprises oxidoreductase enzyme and, optionally, peroxidase enzyme, wherein the enzyme(s) are present in hydrated condition, e.g. being present in one or more hydrated hydrogels. The dressing is used by being located on the skin of a human or animal e.g. over a wound. The oxidoreductase enzyme catalyses a reaction that produces hydrogen peroxide from an appropriate substrate, the substrate either being naturally present in body fluids and / or being supplied separately and / or being incorporated into the dressing. The currently preferred oxidoreductase enzyme is glucose oxidase. The catalyses reaction of β-D-glucose substrate to give hydrogen peroxide and gluconic acid. A mixture of oxidoreductase enzyme can undergo reaction (optionally catalysed by the peroxidase enzyme) to produce a variety of species including reactive oxygen intermediates that have antimicrobial properties and that can therefore assist in promoting wound healing.

The invention discloses a non-toxic environment-friendly solvent type double-layer nanofiber skin dressing and a preparation method thereof. The non-toxic environment-friendly solvent type double-layer nanofiber skin dressing comprises a drug-loaded hydrophilic repair natural polymer fiber layer and a waterproof and breathable synthetic polymer fiber layer, and is prepared by adopting a non-toxicenvironment-friendly solvent system through an electrostatic spinning technology layer by layer. The preparation method comprises the steps that a natural polymer and a drug are dissolved in a non-toxic environment-friendly solvent, and a cross-linking agent is added; a synthetic polymer is dissolved in the non-toxic environment-friendly solvent, and a water repellent agent is added; and a naturalpolymer solution and a synthetic polymer solution are placed in an injection syringe, and an electrostatic spinning device is adopted for spinning to prepare a double-layer fiber membrane. The double-layer nanofiber skin dressing prepared through the preparation method does not contain a toxic solvent, and does not generating toxic and side effects on open wounds when serving as the dressing; andthe double-layer nanofiber skin dressing has waterproof and breathable performance, is good in cytocompatibility, can promote wound healing of rats with skin damages, and has the huge application prospects in the field of skin dressings.

Occlusive tissue dressings and methods including an elastomeric drape and a liquid component, at least partially cross-linked at least after one of drying and curing, suitable for application at a dressing-to-skin interface in order to create a substantially air-tight seal. The same or a different liquid component may be applied by a user at a tube-to-dressing interface in order to create a similar air-tight seal around the tube, if not occlusively sealed during its manufacture.

Occlusive tissue dressings and methods including an elastomeric drape and a liquid component, at least partially cross-linked at least after one of drying and curing, suitable for application at a dressing-to-skin interface in order to create a substantially air-tight seal. The same or a different liquid component may be applied by a user at a tube-to-dressing interface in order to create a similar air-tight seal around the tube, if not occlusively sealed during its manufacture.

The invention belongs to the technical field of biomedical engineering, in particular relates to the technical field of skin wound dressing preparation, and discloses an antibacterial acellular dermal dressing with vascularization inducing capability and a preparation method thereof. The antibacterial acellular dermal matrix dressing comprises porcine acellular dermal matrix, poly dopamine, vascular endothelial growth factor (VEGF) composition and antibacterial peptide LL37. The antibacterial acellular dermal dressing with the vascularization inducing capability has the advantages of low immunogenicity, good biocompatibility and antibacterial ability, and has obvious wound healing and vascularization promoting effect.

The invention relates to an active oxygen elimination antibacterial and anti-inflammatory hydrogel skin dressing and a preparation method thereof. The skin dressing is prepared by the ring-opening reaction of amino of acetone [bis-(2-amino-ethyl)-dithioalcohol] and 3,3'-dithiobis(propionohydrazide) with epoxy groups of poly (polyethylene glycol methyl ether methacrylate-co-glycidyl methacrylate) to form a main body hydrogel network, and meanwhile, polyvinyl alcohol chain segments are inserted into the hydrogel network to form a semi-interpenetrating network; the freeze-dried hydrogel is swelled in a hyperbranched polylysine solution to realize loading of antibacterial substances, so that the active oxygen eliminating antibacterial and anti-inflammatory hydrogel skin dressing can be obtained. The antibacterial and anti-inflammatory hydrogel skin dressing capable of eliminating active oxygen can be used for repairing skin injury, has broad-spectrum antibacterial and bacteriostatic effects, can achieve the effects of regulating and controlling the inflammation level of a wound part, promoting wound healing and reducing scar generation by eliminating excessive active oxygen at the wound part, and does not generate drug resistance.

A skin dressing is adapted, on activation, to release one or more S-nitrosothiols, preferably S-nitroso-L-glutathione. S-nitrosothiols decompose spontaneously to produce nitric oxide, which has beneficial effects on tissues, particularly in wound healing.

The invention provides a novel 3D bionic skin dressing and a preparation method thereof. The novel 3D bionic skin dressing comprises a hydrophilic layer fibrous membrane and a hydrophobic layer fibrous membrane which are connected with each other, wherein the hydrophilic layer fibrous membrane is loaded with a bioactive substance, the hydrophobic layer fibrous membrane is loaded with an antibacterial substance, the surface of the hydrophilic layer fibrous membrane and the surface of the hydrophobic layer fibrous membrane are each provided with a bionic hair follicle layer, each bionic hair follicle layer comprises hair follicle holes which are symmetrically arranged, the hair follicle holes penetrate through the hydrophilic layer fiber membrane and the hydrophobic layer fiber membrane, andthe hair follicle holes are filled with hydrogel layers. The novel efficient dressing is provided for the treatment of burn wounds, the theoretical and application development of the 3D bionic skin dressing in promoting burn wound treatment is promoted, a new thought and approach are provided, and important academic values and application prospects are achieved.

A skin dressing comprising first and second electrodes, an electrical power supply not electrically connected to either or both of the first and second electrodes, and further comprising a physiologically or antimicrobially active precursor substance, the dressing being operable, when placed on a skin site to be treated, to connect the electrical power supply to both the first and second electrodes, thereby to trigger the electrochemical oxidation or reduction of the precursor substance on one of the electrodes to produce a physiologically or antimicrobially active oxidised or reduced compound which is capable of diffusing towards the skin site for the treatment thereof.

The invention provides a double-bioenzyme modified blending biological material containing gelatin and chitosan and a preparation method and application of the double-bioenzyme modified blending biological material. The blending biological material comprises gelatin and chitosan which are used a blending main body and microbial transglutaminase and tyrosinase which are used as a modifier. The stability of the blending biological material is enhanced, and the mechanical property thereof is improved; furthermore, the material has antimicrobial activity, and has good application prospect and excessively wide application in the fields of biomedical materials and a biomedicine, such as the reduction of infection and inflammatory response, antibiosis, wound protection, a biologically degradable skin dressing, a wound healing agent, artificial skin, and the like; and meanwhile, the material is simple in preparation technology, easy to control, free from side and toxic effects and temperate in preparation condition.

The invention relates to a waterproof, breathable, high-elastic and self-repairing double-layer nanofiber membrane for skin dressing and a preparation method of the nanofiber membrane. The preparationmethod comprises the following steps: firstly, carrying out electrostatic spinning on a precursor spinning solution I consisting of a synthetic polymer solution, an alcohol-soluble hydrophobic agent,an environment-friendly cross-linking agent and a functional drug to prepare a hydrophobic fiber membrane; then carrying out electrostatic spinning on a precursor spinning solution II consisting of anatural polymer solution, a catechol-based molecular solution and anhydrous ferric trichloride powder, and receiving the obtained material on the hydrophobic fiber membrane to prepare a composite fiber membrane; and finally carrying out aftertreatment on the composite fiber membrane to obtain the nanofiber membrane. The water pressure resistance of the prepared double-layer nanofiber membrane is5-50kPa, the air permeability is 5-15kg / m<2> / d, the elastic modulus is 5-15MPa, the tensile strength and elongation at break of a self-repaired fiber membrane are 50-90% of an initial fiber membrane,and the adhesion and comfort of a wound surface can be guaranteed while the healing promoting capability of the dressing is improved.

A male condom skin dressing, a kit, and a method of using it. The skin dressing may include a waterproof, generally conically-shaped shell having a base portion and a tip portion, and securing material circumferentially wrapped around at least the base portion of the shell to aid in releasably securing the shell. The securing material may be flexible adhesive strips or elastic material.

The invention discloses a three-dimensional printing and negative-pressure flushing combining integrated skin dressing and a preparation method thereof. The three-dimensional printing and negative-pressure flushing combining integrated skin dressing comprises a biological semitransparent film, a medical sponge, a three-dimensional screen cloth layer and a biological scaffold layer which are arranged from outside to inside, wherein the biological scaffold layer is made from a bio-active glass / chitosan / silk fibroin composite scaffold material; and the bio-active glass / chitosan / silk fibroin composite scaffold material is prepared from the following raw materials: nano-scale bio-active glass NBG, a silk fibroin concentrated water solution and water-soluble chitosan that a degree of deacetylation DAC is greater than or equal to 85%. The three-dimensional printing and negative-pressure flushing combining integrated skin dressing provided by the invention is cheap in raw materials, simple inpreparation process, capable of easily regulating and controlling structural performances and a degradation rate, easy for standardization of quality and conducive to implementation of large-scale production; the skin dressing can effectively replace partial skin flaps, so as to complete repair of a full-thickness skin defect wound surface with high quality.

The invention discloses a preparation method and application of a skin dressing containing carrageenan / agarose. The skin wound dressing is prepared by blending the carrageenan and the agarose at a mass ratio of (10:90) to (50:50) and then directly drying to obtain a composite film or freeze-drying to obtain a composite scaffold with a three-dimensional porous layered structure; the carrageenan is a purified commercial grade carrageenan. A carrageenan purification method used in the invention solves the problems that the commercial grade carrageenan is insufficient in purity and the difference of the carrageenan between manufacturers is larger, so that a biological material with high stability is able to be prepared. The skin dressing prepared by the invention can provide certain nutrition for tissue healing, protect a surface of a wound resist virus and prevent infection during the tissue healing, and at the same time can regulate part functions of a body immune system in the process and really produce an effect of promoting the healing of surface of the wound.

The invention discloses conductive polypyrrole / traditional Chinese medicine composite hydrogel, a preparation method and application thereof. According to the method, polypyrrole hydrogel is used as amain body structure, and traditional Chinese medicine molecules are used as a doping agent to be doped into a hydrogel network, so that the antibacterial hemostatic skin dressing with the wound healing promoting function is prepared. According to the invention, the preparation method is simple, the cost is low, and the reaction conditions are easy to control; and the obtained composite hydrogel is good in biocompatibility, has a certain antibacterial effect and a certain effect of promoting cell proliferation and adhesion, and is a very good skin dressing material.

A dressing composition for use as a skin dressing comprises an elastomeric-adhesive composition, and a zeolite comprising releasably adsorbed nitric oxide. The zeolite may comprise a transition metal cation such as Co, Fe, Mn, Ni, Cu, Zn, Ag or a mixture thereof as an extra-framework metal cation, preferably Zn. The elastomeric adhesive composition may be a hydrocolloid-adhesive composition comprising, hydrocolloid and elastomer. The dressing composition releases nitric oxide, which may have beneficial effects, when used on wounds or moist skin, with a substantially constant release rate over a long period of time. A dressing including a layer of the dressing composition has a backing layer and may have a release liner removably attached to the skin-contacting surface of the dressing layer.

The invention discloses a medical porous fiber membrane and a preparation method thereof. According to the invention, gelatin, konjac glucomannan and sodium hyaluronate are used as main raw materials,glacial acetic acid is used as a solvent to increase the strength and toughness of the porous membrane by adding nano-hydroxyapatite, and the sodium hyaluronate / gelatin / konjac glucomannan / nano-hydroxyapatite porous fiber membrane can be prepared. The preparation process is short, the method is simple and convenient, and the prepared medical porous fiber membrane has good mechanical properties and good biocompatibility. The physically crosslinked porous fiber membrane material has great application potential in artificial skin, skin dressing, drug loading, cartilage repair, cancellous bone microdefect and the like.

The present invention discloses a puncture skin-free surface skin incision stapler. The puncture skin-free surface skin incision stapler comprises skin dressings, suture hanging brackets, bell mouths, clamping tongues, notches and a suture, the suture hanging brackets are arranged on the skin dressings in a side-by-side manner, the bell mouths are located on the suture hanging brackets, the clamping tongues are located at small openings of the bell mouths, and the notches are located opposite the bell mouths. An external structure is used to clamp the suture, and the puncture skin-free surface skin incision stapler withstands tension of sutured wounds, avoids damages to skin tissues, eliminates stress concentration, avoids scarring during a healing process, and is simple in structure, low in production cost and closer to a traditional suture closure effect.

The invention provides a method for manufacturing a fungus pharmaceutical composition. The method comprises steps of knocking, kneading, extension, organic solvent extraction, high temperature alkali treatment, filtering and decolouring. The method is used for extracting poly(glucosamine) cellulose from fungus cell walls. The poly(glucosamine) cellulose is different poly(glucosamine) cellulose made from a China Taiwan patent, the patent number of which is 442496, and having defects of ultralow yield, rougher cellulose, and yellowy color. The poly(glucosamine) cellulose made through the method relatively shows the advantage of high yield, fine cellulose, and white color. The prepared poly(glucosamine) cellulose can be made into an excipient. Furthermore, it is proved through experiments that the poly(glucosamine) cellulose has excellent adsorption power and moisture maintenance of a tissue fluid, and is quite suitable for being used as a skin dressing, artificial skin, or a mask.

The invention discloses a skin dressing and a preparation method of the skin dressing. The skin dressing takes bacterial cellulose as a base and has a skin contact surface and a conductive surface, wherein the electric conductivity of the skin contact surface is smaller than 10<-5>S / cm and the skin contact surface contains 2Mug / cm<2> to 20Mug / cm<2> of drugs; the conductive surface contains 5mg / cm<2> to 50mg / cm<2> of a conductive material, and the conductive material is one or more of a conductive macromolecular material and a conductive nano material; the skin contact surface is used for being in direct contact with a skin so as to heal a wound of the skin; the conductive surface is used for loading voltage so as to control the releasing speed of the drugs on the skin contact surface, and is also used for simulating a biological endogenous electrical field and indirectly accelerating the healing of the wound. According to the skin dressing disclosed by the invention, the conductive surface is in tight combination with the skin contact surface, so that the endogenous electrical field of the wound of the skin can be simulated very well and the skin dressing is more convenient to use.

The invention relates to a composite propellant system for demoline skin dressings, belonging to the technical field of aerosol preparation, comprising the following raw materials: propellant, latent solvent, dispersant, solubilizer, synergist, sterilization and disinfectant and Emulsifier, no freon propellant, environmentally friendly, healthy and environmentally friendly, and added a self-made synergist, with the characteristics of cationic quaternary ammonium salt type gemini surfactant, containing pyridyl quaternary ammonium salt, with high antibacterial performance, and the synergist contains hydrophilic groups (‑OH, ‑NH 2 , quaternary ammonium salt structure) and lipophilic group (alkyl long chain), showing surface activity and solubilizing effect; adding it to the projectile system can effectively disperse and uniformly adsorb the Demoline skin dressing powder, maintain The state of the system is stable, and it cooperates with the sterilizing and disinfecting agent to play a sterilizing and disinfecting effect, so that the Demoline skin dressing powder can better exert its efficacy.

The invention provides a traditional Chinese medicine ingredient modified multifunctional bacterial cellulose-based skin dressing and a preparation method thereof. The traditional Chinese medicine ingredient modified multifunctional bacterial cellulose-based skin dressing comprises a chitosan quaternary ammonium salt / bacterial cellulose composite membrane and traditional Chinese medicine organic acid grafted on the composite membrane. According to the invention, function modification is performed on bacterial cellulose by utilizing active ingredients of natural traditional Chinese medicines, namely traditional Chinese medicine organic acid and chitosan quaternary ammonium salt, so that the original bacterial cellulose base has the functions of resisting bacteria, resisting inflammation, resisting oxidation, promoting wound healing and the like.

The invention provides a 3D bionic skin dressing and a preparation method thereof, comprising interconnected hydrophilic layer fiber membranes and hydrophobic layer fiber membranes, the hydrophilic layer fiber membranes are loaded with biologically active substances, and the hydrophobic layer fiber membranes are loaded with Antibacterial substance, the surface of the hydrophilic layer fiber membrane and the surface of the hydrophobic layer fiber membrane are provided with a bionic hair follicle layer, the bionic hair follicle layer includes symmetrically arranged hair follicle holes, the hair follicle holes run through the hydrophilic layer fiber membrane, hydrophobic A layer of fibrous membrane, the pores of the hair follicle are filled with a hydrogel layer. The invention provides an efficient dressing for the treatment of burn wounds, promotes the development of the theory and application of 3D bionic skin dressings in the treatment of burn wounds, provides new ideas and approaches, and has important academic value and application prospects.