298 results about "Burn wound" patented technology

A bandage of the type used on acute wounds, minor wounds, burn wounds and irritations, includes a first layer for covering the wound site and an area around the wound site, with the first layer including a top surface and bottom surface; a second layer over the first layer bottom surface, for absorbing exudates from the wound site; the second layer including a poly(ethyleneoxide)-based compound and a chitosan-based compound. A third layer is situated over the second layer, the third layer being of a perforated film, and wherein, at least one antimicrobial agent is associated with the bandage in a position where the antimicrobial agent will come in contact with the wound site, and which is transferable from the bandage to the wound site, upon contact with the wound site.

The invention produces polyethylene alcohol hydrogel dressing containing medicine and chitosan with 60Co gamma-radial or high energy electron beam radial cross linking. Additional, adds in some humectant, plasticizer, medicine, the solvent is the secondary distilled water, physiological saline or phosphate neutral buffer liquid. The product can release medicine slowly and has natural amylose chitosan with biology sterilization activity, it has active sterilization function, at the same time, it has high water quantity, and good water reserving performance, the mechanical intensity is moderate, and the light penetration and air penetration are excellent. It can accord the demands for curing each kind of wound. It can used as the permanent dressing for light skin injuries, and it also can be applied to the temporally close of severe skin organization wound or burn wound.

A method of noncontact imaging for performing qualitative and quantitative analysis of wounds includes the step of performing structured illumination of surface and subsurface tissue by both diffuse optical tomography and rapid, wide-field quantitative mapping of tissue optical properties within a single measurement platform. Structured illumination of a skin flap is performed to monitor a burn wound, a diabetic ulcer, a decubitis ulcer, a peripheral vascular disease, a skin graft, and / or tissue response to photomodulation. Quantitative imaging of optical properties is performed of superficial (0-5 mm depth) tissues in vivo. The step of quantitative imaging of optical properties of superficial (0-5 mm depth) tissues in vivo comprises pixel-by-pixel demodulating and diffusion-model fitting or model-based analysis of spatial frequency data to extract the local absorption and reduced scattering optical coefficients.

The composite spongy biological dressing contains chitosan, collagen and calcium alginate with weigh tmixing ratio o f 0.5-8:0.5-8:0.1-8. Its preparation method includes the following steps: selecting chitosan and collagen type I, adding calcium alginate, compounding and cross-linking, using buffer solution to make neutralization, emulsifying, prefreezing and one-step freeze-drying so as to obtain the invented dressing with good biological compatibility and strong adhesion property. Said invented dressing possesses active function of promoting wound healing and hemostatic action, can be combined with anti-bacterial medicine to obtain gene engineeirng dressing for curing wound surface infection, also can be combined with active growth factor or active cell to form gene engineering dressingfor curing intractable ulcer and burn wound surface.

The present invention relates to therapeutic nanoemulsion compositions and to methods of utilizing the same. In particular, nanoemulsion compositions are described herein that find use in the treatment and / or prevention of infection (e.g., respiratory infection (e.g., associated with cystic fibrosis)), in burn wound management, and in immunogenic compositions (e.g., comprising a Burkholderia antigen) that generate an effective immune response (e.g., against a bacterial species of the genus Burkholderia) in a subject administered the immunogenic composition. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.

Disclosed are keratin preparations for use in medical applications. Methods of treating wounds are provided, wherein keratin preparations are applied to the wound in a treatment effective amount. Methods of treating burn wounds are also provided. Surgical or paramedic aids are provided, comprising a substrate with keratin preparations provided thereon. Kits comprising keratin derivatives packaged in sterile form are also provided.

The present invention relates to a process for the preparation of a novel chemically modified fibrin-fibrillar protein (FFP) composite sheet for medical application and the FFP composite prepared thereby. The FFP sheet finds potential use as a dressing aid in the treatment of various external wounds of different nature, which include cut wounds, burn wounds and even ulcers in animals and human beings.

This invention relates to formulations for the prevention of infection and / or abnormal conditions of mucosae and / or skin caused by any pathogen and / or any disease, and more particularly for the prevention of sexually transmitted infections specially HIV and HSV. This invention also relates to formulations for the treatment of infection and / or abnormal conditions of skin and / or mucosae and more particularly for the treatment of herpetic lesions. The formulations could be used as a prophylactic agent to prevent accidental infection of health care workers. The formulations could be used for the healing and / or treatment of burn wounds and prevention of further infection. This invention also relates to the development of a unique vaginal / ano-rectal applicator for the uniform delivery of any topical formulations to treat and / or prevent any infection and / or abnormal conditions of mucosa cavity caused by any pathogen and / or disease.

The invention is a class of medical bandages that are effective for use in the treatment of various types of tissue burns, such as burns due to heat, chemicals, or sun exposure. The inventive bandages are comprised of a thin metal substrate in combination with a heat-sink. The inventive bandages incorporate a metal substrate (such as aluminum) having a burn-facing side for direct contact with the burn to draw heat away from the burn by conduction, and a heat-sink facing side opposite the burn-facing side for contact with a hydrogel to draw heat away from the metal layer by conduction. The thin aluminum layer and associated hydrogel heat-sink ensures flexibility and effective heat-transfer characteristics to rapidly cool a burn wound.

The invention discloses application of ozonized oil to preparation of raw materials of medical health-care products and belongs to the field of medical health care. In particular, the ozonized oil is applied to preparation of toothpaste for preventing and treating saprodontia and oral diseases, preparation of cosmetics for preventing all the skin infectious diseases, preparation of medical dressing for externally applying to surgical wounds and skin diseases and preparation of ointment applied to burnt wound surfaces and traumatic wound surfaces. The ozonized oil has unmatched effect on daily sterilization compared with any other bactericide and does not have toxicity and medicament tolerance.

The present invention provides pharmaceutically acceptable salts having local anesthetic and anti-inflammatory activities. The preferred pharmaceutically acceptable salt is a diclofenac salt of lidocaine. Diclofenac is a non-steroidal anti-inflammatory drug (“NSAID”). Lidocaine is a local anesthetic. Other NSAID (except the salicylic acid derivatives of NSAID) can be used to replace diclofenac and / or other local anesthetics can be used to replace lidocaine. The pharmaceutically acceptable salts are crystalline compounds, which are distinctively different from either the NSAID alone or the local anesthetic alone, as indicated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), High Performance Liquid Chromatography (HPLC) and Fourier-Transformed Infrared Spectroscopy (FTIR) analyses. These pharmaceutically acceptable salts are suitable for use in topical treatment or parenteral injection to treat patients with localized pain, including muscle pain, joint pain, pain associated with herpes infection, and wound pain (such as surgical wound, burn wound etc.).

The invention relates to a cell-free compound artificial skin and a preparation method thereof. The compound skin of the invention is provided with a double layer structure of a dermis layer and an epidermis layer; the dermis layer is a loose porous structure made of extracellular matrix; gel-shaped epidermis-like materials are coated on the upper surface of the dermis layer to solidify, thus forming the epidermis layer, and the epidermis layer is inserted into a void structure of the surface of the dermis layer; compared with the existing skin substitutes, the skin of the invention has the functions of promoting the regeneration of wound skin, enhancing the elasticity, flexibility and mechanical wear resistance of the skin after the wound is healed, reducing the scar proliferation, controlling the contracture, improving the success rate of skin implantation and improving the healing quality; the skin of the invention has a sustained release function and can make individual-based treatment for different diseases by releasing different drugs and being directly applied to the treatment of skin defects caused by inflammations, ulcers, burn wounds and iatrogenic causes; the epidermis layer and the dermis layer are embedded together organically with a tight structure; the shapes, sizes and the thicknesses of the skin can be prepared according to specific requirements. The skin of the invention has wide sources of preparation materials, simple production process, short production period, long period of product storage and convenient transportation.

The present invention relates to therapeutic nanoemulsion compositions and to methods of utilizing the same. In particular, nanoemulsion compositions are described herein that find use in the treatment and / or prevention of infection (e.g., respiratory infection (e.g., associated with cystic fibrosis)), in burn wound management, and in immunogenic compositions (e.g., comprising a Burkholderia antigen) that generate an effective immune response (e.g., against a bacterial species of the genus Burkholderia) in a subject administered the immunogenic composition. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.

The invention discloses the preparation and clinical application of a fat-derived stromal cell composite graft material rich in cytokines. The preparation method is through 1) the acquisition and purification of fat granules; 2) the acquisition of nano-fat stromal cells; 3) the biological characteristics and multi-directional differentiation identification of nano-fat-derived stem cells (NFSCs); 4) fibrin glue rich in cytokines The preparation of transplant materials in four steps is used for the clinical repair and correction of sunken deformities of the face, chest and other body surface soft tissues. The invention is based on the new technology of stromal vascular components to promote trauma or wound repair, reduce scar hyperplasia, promote tissue regeneration repair and organ reconstruction, shorten the recovery time of patients, improve the quality of rehabilitation, and achieve good curative effect. It is a clinically assisted autologous fat Tissue transplantation provides experimental basis and theoretical support for the repair of soft tissue or organ defects, burn wounds, refractory wounds, and breast reconstruction after breast cancer surgery.

The invention discloses a hydrogel skin wound dressing capable of resisting bacteria and promoting healing and a preparation method of the hydrogel skin wound dressing. The dressing comprises the following components: 10-15% of water-soluble macromolecular compounds, 0.1-5% of Chinese herbal medicine extracts, 0.1-1% of natural moisturizing and healing promoting materials, and the balance of water, wherein the natural moisturizing and healing promoting materials are selected from at least one kind of micromolecule collagen peptides, low-molecular weight hyaluronic acid and micromolecule natural silk peptides. According to the hydrogel skin wound dressing disclosed by the invention, Chinese herbal medicines which have the functions of resisting bacteria, diminishing inflammation, promotingtissue regeneration and removing necrotic tissues and the natural moisturizing and healing promoting materials are compounded and are in combined use to have a synergistic effect, so that the compatibility of the Chinese herbal medicines and the natural moisturizing and healing promoting materials with a hydrogel basal body is improved; the hydrogel skin wound dressing is slowly released and deeply infiltrates into skin, so that absorption of medicines and nutrient contents is promoted, and the healing of wounds is accelerated; besides, the hydrogel dressing disclosed by the invention has favorable bacterium resistance, high water absorption, favorable transparency and favorable healing promoting effects; the product is pure, and the technology is simple and convenient; the hydrogel skin wound dressing is especially suitable for wound healing of the skin, and can effectively promote healing of a II degree burn wound.

The invention belongs to the field of medicinal preparations and a novel medical technology and relates to an in situ gel preparation loaded with Kangfuxin and its preparation method and use. The in situ gel preparation loaded with Kangfuxin has temperature sensibility. The in situ gel preparation loaded with Kangfuxin is characterized in that Kangfuxin as a raw material and polymers are dissolved in a buffer solution or purified water according to a ratio. Because of polymer reverse-phase gel properties, the in situ gel preparation loaded with Kangfuxin is in a liquid state and can freely flow at a room temperature (of 20 DEG C) under storage conditions, and when the in situ gel preparation loaded with Kangfuxin is spread on a wound, under the action of a body temperature, the in situ gel preparation loaded with Kangfuxin forms fast semi-solid gel. The in situ gel preparation loaded with Kangfuxin is convenient for patient use, improves patient compliance, can effectively store drugs and can slowly release drugs so that drug action time is prolonged and drug efficacy is improved. Through oral administration, the in situ gel preparation loaded with Kangfuxin can be used for treating blood stasis, stomachache, gastrorrhagia, gastric ulcer and duodenal ulcer and assistantly treating Yin deficiency and pulmonary tuberculosis, and phthisis. Through external administration, the in situ gel preparation loaded with Kangfuxin can be used for treatment and anti-adhesion of metal-inflicted wounds, trauma wounds, ulcer wounds, fistula wounds, burn wounds, scald wounds, bedsore wounds and surgical wounds.

The invention discloses an application of a self-assembled short-peptide RADA16-1 for preparation of medicine for curing burn wound. Model of rat burned skin is established by using temperature adjusting mode electrical scald instrument and flame. Hydrogel formed by self-assembled short-peptide RADA16-1 and typic medicines for curing burn wound as dressing such as chitosan, collagen, polylactic acid perform therapeutic experiment. The results show that the self-assembled short-peptide RADA16-1 can control the extension of burn wound and edema, promote the ordered rearrangement of collagen of burn wound, burn wound healing, regenerating and repairing the skin and the appendage of skin tissue. Compared with the chitosan, collagen, polylactic acid, the said medicine has better curative effect.

Reactive oxygen species associated with a wound are modulated through treatment of the wound with a solution of metal ions selected from the group consisting of potassium ions, zinc ions, calcium ions and rubidium ions, at a pH of between about 5 and about 7. Preferably, citric acid is employed to adjust the pH of the solution. Application of the extract to a wound exhibiting superoxide anions has been found to be effective in the treatment of these wounds through the reduction of the level of superoxide anions. Moreover, treatment of partial thickness excision wounds as well as contact burn wounds with the present composition has been found to improve epithelialization of these wounds. In addition to the antioxidant activity of the present invention, treatment of the wound employing the present composition produces inhibitory effects on ROS production by human PMNs and on human complement activation, and therefore, is further beneficial in chronic wound management.

The invention discloses an external used medicine and process for preparation, which comprises the components as following, raw rheubarb, coptis chinesis, honeysuckle, polygonum ciliinerve, raw gardenburnet, phellodendron bark, radix notoginseng, polygonum cuspidate, astragalus, lithospermum, safflower, myrrh, olibamum, margarita, camphol, zine oxide, and sesame oil, and is processed in steps. The invention sinks gauze dressing in the form of oil solution, and then is stuck on wound, thereby reducing the water evaporation of wound, preventing wound infection, and avoiding wound incrustation,and the effusion of wound can easily mix with the finish oil gauze, which is beneficial for wound drainage, and largely relieves sufferings of burn patients. The invention is an externally used medicine for treating burn wound, which has short course of treatment, fast effect, strong safety, excellent repair virtue for wound, few scars after curing, and no side effect.

The present invention relates to a composition for skin regeneration, using a culture medium or a secretion in the culture of an embryonic stem cell-derived endothelial progenitor cell, and to the use thereof. As the present invention uses the secretion in the culture as a medicine and not the embryonic stem cell-derived endothelial progenitor cell itself, the risk of teratoma formation is prevented, and angiogenic activity is promoted to achieve improved effectiveness in healing wounds and burn wounds. The composition of the present invention, when used as a material in cosmetics, increases collagen synthesis and thus prevents skin aging. Particularly, the composition of the present invention in which the secretion in the culture is concentrated into a high concentration provides superior wound-healing effects as compared to a conventional human growth hormone (hGH).

Preparation and application of an antibacterial modified exosome burn wound healing-promoting biological dressing are disclosed. A raw dressing is a novel artificially modified exosome prepared by taking cell-derived exosome as a carrier of an antibacterial agent and combining with a broad-spectrum antibacterial agent; and the modified exosome is loaded into an asymmetric chitosan porous moisturizing dressing. The weight ratio of chitosan to water-absorbing molecules to the exosome to the antibacterial agent in the dressing is (40-60): (20-40): (5-20): (1-10). The dressing has a broad-spectrumantibacterial effect, a blood vessel repair promoting effect, a nerve repair promoting effect and a wound healing promoting effect. Meanwhile, the dressing has moisture retention, air permeability, barrier property, high strength and easy disclosure, and is a novel antibacterial compound dressing with a broad-spectrum antibacterial effect. The dressing is prepared through freeze-drying, has advantages of simple preparation process, low cost, outstanding treatment effect and good safety, and has remarkable medical value and industrialization potential.

The invention relates to a preparation method of artificial skin, in particular to a preparation method of artificial skin with hair follicles and the skin made by the method, belonging to biomedical field. The preparation method comprises the following steps: (1) preparing the epithelial cells of the hair follicle; (2) culturing the dermal papilla cells; (3) culturing the artificial skin with hair follicles. The preparation method of artificial skin has the advantages that: (1) the invention originally prepares artificial skin with hair follicles on skin support by hair follicle cells, and reduces the antigenicity greatly compared with the artificial skin made by animal cells; (2) the artificial skin comprises hair follicles, and enable to do physiological functions of skin; (3) the artificial skin is not easy to shrink but easy to absorb; (4) the artificial skin can be used as wound-cover material for large area burn wounded person in clinic and accelerates the wound to heal naturally; (5) the invention resolves the trouble of skin source for large area burn; (6) the preparation method is reasonable in design, convenient in operation and easy in scale production.

The invention discloses an amino acid-based antibacterial hydrogel containing nano-silver, and a preparation method and a use thereof. The antibacterial hydrogel containing nano-silver is formed through co-assembling amino acid and silver nitrate. The amino acid hydrogel has the advantages of flexible and adjustable mechanical performances, uniform nano-silver distribution, broad-spectrum continuous antibacterial performance, stable and uniform gel, good biocompatibility, biodegradability, and simplicity in preparation, and is expected to play a great role in the fields of biological nano-materials, aseptic treatment, wound dressings and burn wound care.

Various methods are provided, including re-epithelization and wound healing with reduced fibrosis, particularly for the re-epithelization of mucous membrane tissues, most particularly for the treatment and prevention of gum disease and for periodontal regeneration, each of which uses administration of a composition containing one or more rhamnolipids as an active ingredient. The figure provides a graphical representation of the effects of topical BAC-3 on the rate of burn wound closure.

The invention belongs to the medical material technical field, in particular to a calcium alginate-chitosan composite membrane medical dressing and a preparation method thereof; the preparation method comprises the following steps: mixing and stirring calcium alginate solution and chitosan acetic acid water solution containing glycerol fully, preparing films, and drying the films to obtain the dried calcium alginate-chitosan composite membrane medical dressing of the invention. The composite membrane medical dressing prepared by the method has excellent functions of hemostasis and antibiosis, wounds healing and has good mechanical strength and flexibility without toxic and side effect. The medical dressing can be used as biomedical material for clinical care, thus promoting the hemostasis of wounds, reducing the probability of wound infection and promoting the healing of wounds. Skin disinfectant or water soluble antibacterial drug can be used as admixture in the composite medical dressing prepared by the invention to improve the antibacterial and disinfect ability thereof, thus being applicable to the therapy of various surfaces of trauma or burn wounds.

The invention discloses a limb wound nursing device, and relates to the technical field of nursing medical equipment. The limb wound nursing device comprises a base board, an inflation supporting pad mechanism mounted on the base board, a drug delivery nursing mechanism mounted over the inflation supporting pad mechanism. The inflation supporting pad mechanism comprises an inflation supporting pad body, and an inflation air bag in communication with the inflation support pad body. The intermediate portion of the inflation supporting pad body is provided with a liquid waste tank sunk to the bottom. The front side wall and the rear side wall of the inflation supporting pad body are provided with concave arc limb grooves in corresponding positions. The drug delivery nursing mechanism comprises four support rods, a transparent support board and a drug applying block. The four support rods respectively penetrate corresponding four corners of the inflation supporting pad body and are fixedly connected to the base board. The intermediate portion of the transparent board is provided with a guide window. The drug applying block penetrates the guide window and cooperates with the inner wall of the guide window in a sliding mode, and the lower portion of the drug applying block is provided with drug applying cotton. The limb wound nursing device can be used for cleaning and applying drug on a burn wound in a perpendicular mode, the drug changing efficiency can be raised for nurses, and the wound can quickly coalesce.

The invention relates to a preparation method of an acellular matrix biological material. The method comprises the following steps: obtaining tissues; carrying out acellular treatment; carrying out bactericidal treatment; harvesting an acellular matrix material; obtaining adipose tissues; dissociating adipose-derived stem cells; harvesting the adipose-derived stem cells; planting the adipose-derived stem cells; and harvesting the acellular matrix biological material. The invention further provides an application of the acellular matrix biological material. The acellular matrix biological material can be applied to regeneration and repairing of damaged tissues, covering and repairing of burn wounds, repairing of bladders and urethra substitution.

The invention belongs to a traditional Chinese preparation, in particular to a traditional Chinese medicine recipe for restoring deep burnt wound, promoting tissue regeneration and inhibiting scar hyperplasia. A traditional Chinese compound preparation for deep burnt wound restoration and tissue and skin regeneration promotion is characterized by comprising the following ingredients in parts by weight: 0.1 to 100 parts of bletilla, 0.1 to 10 parts of camphor and 0.1 to 5 parts of borneol. The traditional Chinese compound preparation can be used for treating residual burn wound surfaces, chilblain, bedsore, deep skin scratch, lower limb ulcer and chemoradiotherapy skin tissue injury, the restoration is fast, and the effect is obvious.