541 results about "Joint pain" patented technology

Topical compositions having as the active ingredient a lipid, fatty acid ester, natural wax, sterol, or combinations thereof referred to herein as “lipophilic vehicle” or “LV” and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of an ointment, cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The LV may contain a penetration enhancer, most preferably one with membrane disruptive properties. The formulation may be applied to or impregnated into a gauze, wrap, bandage, cotton-tipped stick, adhesive bandage strip, or other support wrap or medical bandage or wound cover. For example, the compositions may be are incorporated onto or into disposables such as hemorrhoid wipes, sponge, mouth guards, dental trays; needles or catheters; adult diapers; gloves, socks or wrist bands, for ease of application. The composition is applied topically to a site at or adjacent to a painful region. The composition is reapplied as necessary. Pain relief is typically obtained within minutes and lasts for periods of variable duration ranging from minutes to several hours and even, in some cases, days. The composition is variably effective to treat visceral, somatic and neuropathic pain both acute and chronic as well as muscle pain and stiffness and joint pain and stiffness.

A medical device and methods to relieve joint pain and adapted for knee joint repair, replacement and augmentation. The invention discloses joint lubricant, particularly hyaluronate compositions and methods for treatment of osteoarthritis.

The present invention is drawn to solidifying formulations for dermal delivery of a drug for treating musculoskeletal pain, inflammation, joint pain, etc. The formulation can include a drug selected from certain drug classes, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system having one or more volatile solvent, and a non-volatile solvent system having one or more non-volatile solvent, wherein the evaporation of at least some of the volatile solvent converts the formulation on the skin into a solidified layer and the non-volatile solvent system is capable of facilitating the topical delivery of the drug(s) at therapeutically effective rates over a sustained period of time.

Various embodiments provide systems and methods of treating damaged cartilage injuries to joints and connective tissue. Methods and systems useful for permanent relief of pain in joints are also provided herein. Various embodiments provide for combining therapeutic ultrasound energy directed to a joint with a medicant injected into the joint.

This invention describes a topical delivery mechanism that contains a mixture of cetylated fatty esters that act as transdermal carriers of desired therapeutic molecules. The proposed cetyl fatty ester penetrant-complex (Base CFEP-complex) contains specific cetyl fatty esters, polar solvents, a carrier base (gel, cream, lotion, patch or stick gel), antioxidants and the desired pharmaceutical, cosmetic or antigenic response eliciting molecules that are efficaciously delivered by selectively varying component ratios in the complex. The invention proposes the use of transdermal delivery of medications such as those used in treatment of urinary incontinence, testosterone deficiency, arthritic and joint pain and other pains such as pain in the neck, lower back, back, knees, headaches, and other types of inflammatory pains, peripheral neuropathic pain, pain associated with repetitive strain injuries such as myofacial pain, rapid treatment of epileptic seizures, soluble antigens in the immuno-therapeutic treatment of allergies, actives in the treatment of foot cracks and elbow cracks, actives in the treatment of facial and other wrinkles in the form of anti-aging creams and gels and other topically delivered therapies.

The invention relates generally to a formulation which may comprise additional vitamins, minerals, herbs and supplements and methods for using the same for joint pain relief. The formulation may comprise supplements such as glucosamine, hyaluronic acid and methylsulfonylmethane (MSM) and acetaminophen for acute joint pain. The invention also encompasses methods for joint pain relief with the formulation described herein.

Beneficial and synergistic effects for alleviating joint pain and symptoms of osteoarthritis and / or rheumatoid arthritis have been found with krill oil and / or marine oil in combination with other active constituents, including astaxanthin and polymeric hyaluronic acid or sodium hyaluronate (hyaluronan) in an oral dosage form.

Corticosteroid microparticle formulations are provided for use for treating pain, including pain caused by inflammatory diseases such as osteoarthritis or rheumatoid arthritis, and for slowing, arresting or reversing structural damage to tissues caused by an inflammatory disease, for example damage to articular and / or peri-articular tissues caused by osteoarthritis or rheumatoid arthritis. Corticosteroid microparticle formulations are administered locally as a sustained release dosage form (with or without an immediate release component) that results in efficacy accompanied by clinically insignificant or no measurable effect on endogenous cortisol production.

The invention relates to a medicament for easing the pain of a human body and a preparation method thereof, in particular to a medicament composition with the functions of promoting blood circulation and removing blood stasis, resisting inflammation and diminishing swelling and easing pain, and a preparation method thereof. The medicament composition comprises the raw materials as follows: 20-100 parts by mass of Chinese teasel root, 20-110 parts by mass of cape jasmine fruit, 10-100 parts by mass of Baikal skullcap root and 20-100 parts by mass of angelica root. The preparation method of the medicament composition comprises the following steps of: extracting the raw materials of the medicament composition with water or an ethanol solution, filtering, and collecting the filtrate to obtain the medicament composition, wherein the percent of the ethanol in the ethanol solution by volume is more than 0 and less than or equal to 85%, and the mass ratio of the raw materials to the water or the ethanol solution is 1: 5-8. Clinical experiments show that the medicament composition has good curative effect for easing the neck / shoulder pain, the lumbocrural pain, the joint pain and the muscle pain caused by the rheumatism, the osteoproliferation, tumble and sprain, and the like.

This invention describes a topical delivery mechanism that contains a mixture of cetylated fatty esters that act as transdermal carriers of desired therapeutic molecules. The proposed cetyl fatty ester penetrant-complex (Base CFEP-complex) contains specific cetyl fatty esters, polar solvents, a carrier base (gel, cream, lotion, patch or stick gel), antioxidants and the desired pharmaceutical, cosmetic or antigenic response eliciting molecules that are efficaciously delivered by selectively varying component ratios in the complex. The invention proposes the use of transdermal delivery of medications such as those used in treatment of urinary incontinence, testosterone deficiency, arthritic and joint pain and other pains such as pain in the neck, lower back, back, knees, headaches, and other types of inflammatory pains, peripheral neuropathic pain, pain associated with repetitive strain injuries such as myofacial pain, rapid treatment of epileptic seizures, soluble antigens in the immuno-therapeutic treatment of allergies, actives in the treatment of foot cracks and elbow cracks, actives in the treatment of facial and other wrinkles in the form of anti-aging creams and gels and other topically delivered therapies.

A method of treating Sjögren's syndrome in a patient eligible for treatment is provided involving administering an effective amount of an antagonist that binds to a B-cell surface marker to the patient to provide significant improvement over baseline in two or more of dryness, fatigue, and joint pain on a Visual Analogue Scale, and an article of manufacture therefor. Methods and articles are also provided involving treating Sjögren's syndrome in a subject eligible for treatment is provided involving administering an effective amount of an antibody that binds to a B-cell surface marker to the subject to provide an initial exposure and a subsequent exposure to the antibody within certain dosing regimens and an article of manufacture therefor.

The invention describes a non-electrically stimulation system, devices, and methods for non-invasive vibration stimulation procedures for treating, reducing and alleviating symptoms associated with pain, e.g., headache pain, migraine pain, and joint pain, stroke, mood, vascular action, breathing disorders during sleep and waking, limb, head and swallowing movement disorders, and sleep induction. The invention also describes a system, devices, and methods for non-invasive vibration stimulation procedures for retraining breathing.

The present invention provides new formulations of injectable particles (e.g. microspheres) useful for intra-articular (i.a.) injection. The formulations are made of biocompatible polymers that biodegrade to generate NSAIDs, ad are useful for treating inflamed joints, thus providing safe, long-lasting relief of joint pain and swelling. In one embodiment, the present invention provides an injectable particle, comprising a biodegradable polymer comprising an agent selected from the group consisting of an NSAID, a COX-2 inhibitor, an anesthetic and a narcotic analgesic.

The invention comprises a computer-based system and method for enhanced goniometry using consumer grade data capture components coupled with software to monitor, track, and diagnose joint pain, injuries, and disorders. A video capture device is used to capture and display the movements of a patient in real time and stored in a database for review on a time-delayed basis. The patient movements are digitized by the video capture components and analyzed by the computer software program. By observing variations in joint movements and tracking the variations over time, a medical professional can monitor, evaluate, and diagnose a wide variety of joint diseases, injuries, and disorders. The medical professional can also prepare individualized treatment plans and monitor the results as the patient progresses in treatment and therapy. Additionally, the medical professional may use aggregated anonymous joint movement data to determine “best practices” for future patients, based on past results.

The present invention provides pharmaceutically acceptable salts having local anesthetic and anti-inflammatory activities. The preferred pharmaceutically acceptable salt is a diclofenac salt of lidocaine. Diclofenac is a non-steroidal anti-inflammatory drug (“NSAID”). Lidocaine is a local anesthetic. Other NSAID (except the salicylic acid derivatives of NSAID) can be used to replace diclofenac and / or other local anesthetics can be used to replace lidocaine. The pharmaceutically acceptable salts are crystalline compounds, which are distinctively different from either the NSAID alone or the local anesthetic alone, as indicated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), High Performance Liquid Chromatography (HPLC) and Fourier-Transformed Infrared Spectroscopy (FTIR) analyses. These pharmaceutically acceptable salts are suitable for use in topical treatment or parenteral injection to treat patients with localized pain, including muscle pain, joint pain, pain associated with herpes infection, and wound pain (such as surgical wound, burn wound etc.).

Topical compositions having as the active ingredient a lipid, fatty acid ester, natural wax, sterol, or combinations thereof referred to herein as “lipophilic vehicle” or “LV” and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of an ointment, cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The LV may contain a penetration enhancer, most preferably one with membrane disruptive properties. The formulation may be applied to or impregnated into a gauze, wrap, bandage, cotton-tipped stick, adhesive bandage strip, or other support wrap or medical bandage or wound cover. For example, the compositions may be are incorporated onto or into disposables such as hemorrhoid wipes, sponge, mouth guards, dental trays; needles or catheters; adult diapers; gloves, socks or wrist bands, for ease of application. The composition is applied topically to a site at or adjacent to a painful region. The composition is reapplied as necessary. Pain relief is typically obtained within minutes and lasts for periods of variable duration ranging from minutes to several hours and even, in some cases, days. The composition is variably effective to treat visceral, somatic and neuropathic pain both acute and chronic as well as muscle pain and stiffness and joint pain and stiffness.

The invention provides food for caring pet jonit, which is prepared with the following raw materials in parts by weight: 100 parts of lean meat, 1.0-2.0 part(s) of glycerin, 0.5-0.8 part of shrimp shell meal, 0.1-0.5 part of rosemary, 0.1-0.5 part yucca, 0.01-0.05 part of mineral, 0.1-0.5 part of vitamin E, 0.1-0.5 part of vitamin C, 0.1-0.5 part of glucosamine, 0.3-1.0 part of taurine and 0.1-0.5 part of chondroitin sulfate. Due to the addition of the components such as the shrimp shell meal, the chondroitin sulfate, the glucosamine and the like which can protect the joint and eliminate the joint inflammation, the pet food provided by the invention can protect the joint of the pet cat / dog, relieve the joint pain, and ease the joint inflammation.

The invention relates to a quadruple long-acting medicine composition and application thereof to pain treatment, in particular to the quadruple long-acting medicine composition. The medicine composition contains lappaconitine, tetrahydropalmatine, fumaric acid and succinic acid of the treatment and / or effective quantity as active ingredients. Compared with a composition formed by single ingredients or two ingredients or three ingredients, the quadruple long-acting medicine composition has the characteristics of good water solubility, good curative effect, low toxic and side effects and the like. The quadruple long-acting medicine composition can be used for preventing and / or treating diseases relevant to the pain; the pain includes tumor pain, pain of cancer patients after chemotherapy, joint pain, trauma pain, postoperative pain, inflammatory pain, pain caused by drug detoxification or drug addicition and intractable pain due to unknown reasons. The quadruple long-acting medicine composition can also be used for sedation, hypnosis, collaborative anesthesia, antiarrhythmia and the like.

The present invention is a portable hand-held battery-operated therapeutic ultrasonic device that is specifically designed for clinical applications in muscle and joint pain management. The present invention generates stepwise high resolution, high frequency microprocessor-based signal to drive piezo-crystals for applying on the skin of the user. It makes use of a novel electronic driving technology that enables it to generate therapeutically combinations of acoustic intensities from 0 to 2 W / cm2 and with 80-85% efficiency. It is a lightweight device and can be programmed wirelessly by a physician / professional to be used at home by a patient.

Collagen peptide chelated mineral products, pharmaceutical formulations thereof and methods for preparing same are provided. Also provided is a method for generating the optimal size of collagen peptide for optimum mineral chelation as well as optimum biological function for supporting bone health and joint health. Also disclosed are methods of increasing bone density / preventing osteoporosis, of reducing joint pain and / or joint deterioration from osteoarthritis, degenerative joint disease, joint defect, and rheumatoid arthritis.

Handheld flashlight type vibratory therapeutic treatment invention, devices, and methods that can house a small piezoelectric crystal adjacent to a bulb in the emitting chamber portion of a flashlight housing, where the crystal is located next to or between light source, or off-axis to the light emitting beam of the flashlight. The crystal can generate a fixed output of approximately 7 to approximately 8 Hertz while the flashlight body is positioned up to approximately 18 inches over the body part being treated with a light beam from the bulb being aimed at the area to be treated. Treatment effectiveness can occur within approximately 2 minutes of being treated. The flashlight invention can be used for treating a variety of ailments such as inflammations, nerve problems, joint pain, muscle pain, as well as gall bladder type problems.

New topical medicaments are provided. The medicaments comprise menthol and camphor, preferably provided as part of a base gel, supplemented with potassium and a source of oxygen. The most preferred base gel is sold under the name SOMBRA, while the most preferred source of oxygen is a chlorite (e.g., sodium chlorite) and / or spirulina. The medicaments provide high metabolic activities and sustain those activities over prolonged periods of time, thus being useful for treating a large variety of ailments, including diabetic neuropathy, post hepatic neuralgia, scleroderma, psoriasis, strain, spasticity, headaches, neuropathy secondary to drugs, peripheral neuropathy, leg pain, muscle cramps, muscle aches and pains, bruise, sinusitis, sprain, arthritis, joint pain (arthralgia), and edema.

The present invention relates to a medical implant for reducing pain in diseased joints such as synovial joints, in particular ball and socket joints such as the hip joint and the shoulder joint. One embodiment relates to a medical implant for attachment to and at least partly covering the femoral head, said medical implant comprising a dome shaped shell with an orifice, said shell having a height h1, an equatorial shell radius rs and an orifice radius ro wherein the shell radius rs>ro, and h1>rs, and the orifice is defined by a circumferential rounded edge.

The present invention provides methods, reagents and kits for the diagnosis and treatment of spinal-related pain, e.g., radiculopathic pain, facet pain and discogenic pain. Cytokine biomarkers, e.g., IFNγ can be used to diagnose spine-related injury. It is also a finding of the present invention that spinal-related pain can be alleviated by administering therapeutic agents to the site of diagnostic presence of the cytokine biomarker. This invention further provides methods for extraction of samples from the spine, e.g., disc space samples, epidural samples and facet joint samples.

The invention discloses all-natural green fruit and vegetable washing salt with special effect on heavy metal removal. The fruit and vegetable washing salt is prepared from one or more of the following raw materials: sodium chloride, natural alkaloid, a plant-based surfactant, a preservative, deionized water and an efficient heavy metal complexing agent. Heavy metal ions can cause human headache, dizziness, insomnia, forgetfulness, neurological disorders, joint pain, stones, cancer and the like, daily diet is an important way for the heavy metal ions to enter the body, so removal of heavy metals from surfaces of food materials such as fruits and vegetables is beneficial to human health. The provided washing salt has the advantages that the heavy metal ions are removed on the basis of combination of the demulsification action of the salt, the neutralization effect of alkaloidne substances on pesticide and the decontamination effect of the plant-based surfactant by the aid of part of complexing agent, a synergistic effect is realized, and accordingly, pesticide residues on surfaces of fruits and vegetables are effectively removed, and the heavy metal ions are also efficiently removed.

Topical compositions having as the active ingredient a hydrophilic material, such as a polyalkylene oxide homopolymer or copolymer, and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of a cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The composition may contain a penetration enhancer, most preferably one with membrane disruptive properties. In one embodiment, the compositions are incorporated onto or into disposables such as hemorrhoid wipes, gauze, sponge, bandages, and wraps; mouth guards, dental trays; needles or catheters; adult diapers; gloves, socks or wrist bands, for ease of application. The composition is applied topically to a site at or adjacent to a painful region. The composition is reapplied as necessary. Pain relief is typically obtained within minutes and lasts for periods of variable duration ranging from minutes to several hours and even, in some cases, days. The composition is variably effective to treat visceral, somatic and neuropathic pain both acute and chronic as well as muscle pain and stiffness and joint pain and stiffness.

The present invention relates to a method of treating exercise-induced joint pain in arthritis-free mammals by the administration of undenatured Type II collagen.

Collagen peptide chelated mineral products, pharmaceutical formulations thereof and methods for preparing same are provided. Also provided is a method for generating the optimal size of collagen peptide for optimum mineral chelation as well as optimum biological function for supporting bone health and joint health. Also disclosed are methods of increasing bone density / preventing osteoporosis, of reducing joint pain and / or joint deterioration from osteoarthritis, degenerative joint disease, joint defect, and rheumatoid arthritis.

Biomarkers, including isolated fibronectin-aggrecan complexes that correlate with spinal or joint pain and inflammation, and methods for their detection are provided. Also provided are methods for identifying treatment sites in the spine or joint for treatment of pain and inflammation by detecting the presence of, or increased levels of, fibronectin-aggrecan complexes. Methods for treating spinal or joint pain and inflammation are also provided.