2120 results about "Edema" patented technology

The present invention provides a system for achieving erythema and / or mild edema in an upper layer of skin, without causing blisters, and without the risk of high fluence levels or critical need for cooling.

A device and method to detect and manage heart failure patient symptoms is provided. Respiration and / or cardiac parameters may be sensed or observed to determine the status of a patient's condition. These symptoms may be classified for appropriate patient disease management. A patient's activity level may be monitored in conjunction with respiration and / or cardiac parameters to provide additional patient status information. These symptoms may be classified for appropriate patient disease management. Pulmonary edema is one condition that may be determined to exist when a respiration parameter is out of range for a given sensed activity level. If edema is determined to be present, the device may be configured to respond to treat the edema.

A device is provided, in direct skin contact, surrounding an injured area for the treatment, reduction of joint inflammation, edema and excitation of neural and muscular stimulation associated with human and mammal tissues. This therapeutic light source includes a multiplicity of light emitting diodes (LED's) found in the ranges of 350 nm to 1000+ nm and fiber optic connections. A neoprene type material or other non-allergenic material is used to set the LED's and fiber optics in layers consisting of contact with the skin to few centimeters from the skin tissue. Distance will vary from contact or near contact with devices to several millimeters of separation. Each LED array is independently controlled allowing for optimal modulation of light frequencies and wavelengths. Technology is integrated allowing for biomedical feedback of tissue temperature and other statistical information. A low voltage, portable power supply, is integrated into the device as well as an analog / digital, input / output connection device. The design will be created for continuous wear, flexibility and comfort.

A self-powered compression device for use in promoting circulation, said device embodying a plurality of inflatable sleeves arranged sequentially for applying compression to a body or limb and which further comprises a pump, a piping system and a bandage or boot to enclose the device in its entirety. A method for using self-generated pressure in promoting circulation in conditions including but not limited to, lymphatic and traumatic edemas, venous disorders, limb ulcers, varicose veins, muscle fatigue, sports medicine, cellulite treatment, diabetic feet, feet massage for recreation or cosmetic enhancements.

A method and apparatus of treating tissue adjacent to a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema employs the circulation of warmed fluid to maintain the temperature of the bodily conduit walls and compresses the tissue to be treated to increase the effectiveness of the irradiated heat. An energy-emitting source containing catheter is inserted in a bodily conduit and is positioned in a region of the tissue to be treated so that the energy-emitting source radiates energy to the tissue to be treated. Fluid warmed to over 30° C. is circulated into and through the catheter to warm walls of the bodily conduit adjacent the catheter. The circulated fluid inflates a balloon to a pressure to compress the tissue to be treated. The combination of warmed fluid over 30° C. being circulated adjacent the bodily conduit to maintain the warmth in its walls and the compression of the tissue to be treated enables a natural stent to be formed that remains after the catheter and compression balloon is removed.

The present invention provides compositions and methods for treating ocular neovascularization, angiogenesis, retinal edema, diabetic retinopathy, and / or retinal ischemia in order to prevent the loss of visual acuity associated with such conditions. More specifically, the present invention provides compositions containing receptor tyrosine kinase (RTK) inhibitors having unique binding profiles and their use in treating ocular disorders.

Methods, apparatus and systems for personal care, such as treatment of a skin or hair treatment surface, are disclosed. In some embodiments, a base device is configured to thermally modify (heat or cool) an applicator on a hand piece that can then be used to cleanse, treat and / or otherwise rejuvenate the treatment surface. The applicator can be formulated with a smooth or abrasive material that can absorb, be coated with or otherwise take up a variety of materials, such as liquids, lotions, gels or creams, which are suitable for application to the treatment surface. The base device may thermally modify the material that is then coupled to the applicator and applied to the treatment surface during treatment. Application of the applicator at the desired temperature to the treatment surface may, for example, stimulate deeper blood circulation, clear pores, diminishes or removes deep and fine wrinkles, accelerate acne clearing, treat blemished skin, decrease edema and erythema of the skin, and / or reduce puritis of various etiologies. The hand piece may comprise one or more secondary treatment elements, such as LEDs for photoactivation, electrodes for delivery of micro-currents or vibrating elements for rubbing or abraiding, in order to achieve additional activation of the treatment surface and / or of the thermally modified material coupled to the applicator, which may enhance or improve treatment.

A therapeutic pad system (200) is disclosed for the treatment of edema, wherein the pressure applied to the user by the pad encourages the proximal flow of lymph. A fluid is provided to one or more bladder-type pads (220) in the pad through an inlet port (218) at a distal end of the pad, and is expelled from the bladder through an outlet port (220) at the proximal end of the bladder, thereby producing a pressure gradient across the pad. The system includes a flexible and compressible liner (250) filled with a number of small foam pieces (258) that is adapted to be wrapped about the therapeutic pad, and a relatively rugged, outer binder (270) that is securable about the liner (250). An advantage of the present system is that it may be applied in a number of different modes and combinations providing many treatment options.

A walking brace for immobilizing and / or protecting the lower leg of a patient comprises a leg portion adapted to fit substantially around the lower leg of a patient and a sole portion that fits beneath the patient's foot. The sole portion is provided with a dual layer of resilient shock absorbing material disposed along its bottom surface. The dual layer comprises an upper layer of a relatively softer material and a lower layer of a relatively more durable material. The dual layer can provide good shock absorbency but can be made thinner to provide a lower profile. In another aspect of the invention, the walking brace is provided with one or more inflatable air cells to provide adjustable therapeutic pressure to the leg and the leg portion of the brace is in the form of a rigid shell provided with a protruding region for receiving the air cell outlet associated with each air cell such that the air cell outlet is directed toward the front of the walking brace for easy access by the user. In yet another aspect of the invention, the rigid shell member of the leg portion is provided with one or more longitudinal slits that allow expansion of the leg portion to accommodate an enlarged lower leg portion of a patient. The expanded leg portion can accommodate users with enlarged lower limbs, such as those suffering from severe edema.

The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and / or multinucleated / giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.

Footgear with an inner sole (66) having a grid of removable resilient elements to permit removal of selected elements (68) to provide relief to ulcerated or injured areas of the foot. An air bladder (64) may underlie sole (66), preferably with additional cushioning material (40) within the air bladder. A walker (12) with a soft support (20) may be provided with the inner sole within the support. Some of the removal resilient elements may have a higher density or height than others. The footgear may include an adhesively-backed resilient pad (212) to provide additional support to a region. The footgear may include means for reducing shear stress on a bottom surface of the foot. An edema patch (240) may be provided for covering an open space (248) left after a user has removed a removable section from the grid. The edema patch applies pressure to the afflicted zone of the foot (250) preventing fluids from building up.

A method and morphologically adaptable apparatus for altering the charge distribution upon living membranes with functional stabilization of the membrane physical electrical integrity further comprising a method for using quadripolar, circular, center charged, energy balanced magnetic device in a four (4) magnet array of alternating polarity in which the magnetic poles are in multiple planes and are separated by a predetermined distance which provide an effective magnetic sphere of influence on all adjacent poles to suppress the firing of action potentials of mammalian sensory neurons. The method and apparatus further provides a static magnetic device for production of a magnetic field for treatment of various disorders that can be focused at the site of pain or edema to deliver a gradient in the magnetic field to prevent or reduce charge flow. Further there is provided a static magnetic device for production of a magnetic field for treatment of disorders wherein the device provides a static magnetic field such that the focused magnetic field gradient is oriented To be perpendicular to the neuron or membrane charge flow providing maximum deflection of the ion or charge flow.

An edema monitoring system includes an implantable medical device (IMD) and a personal edema monitor. The IMD measures an intra-thoracic impedance and transmits intra-thoracic impedance data and other biological data to the personal edema monitor, which generates a user interface based on patient inputs relating to activities and health assessments, the measured intra-thoracic impedance data and the other biological data.

The present invention provides a method of treating edematous retinal disorders. The method comprises administration of a pharmaceutical formulation comprising a hydrolysis-resistant P2Y receptor agonist to stimulate the removal of pathological extraneous fluid from the subretinal and retinal spaces and thereby reduce the accumulation of said fluid associated with retinal detachment and retinal edema. The P2Y receptor agonist can be administered with therapeutic and adjuvant agents commonly used to treat edematous retinal disorders. The pharmaceutical formulation useful in this invention comprises a P2Y receptor agonist with enhanced resistance to extracellular hydrolysis, such as dinucleoside polyphosphate compounds, or hydrolysis-resistant mononucleoside triphosphate salts. The present invention also provides P1-(2′-deoxycytidine 5′-)P4-(uridine 5′-)tetraphosphate, tetra-(alkali metal) salts such as tetrasodium, tetralithium, tetrapotassium, and mixed (tetra-alkali metal) salts. The present further provides a pharmaceutical formulation comprising a P1-(2′-deoxycytidine 5′-)P4-(uridine 5′-)tetraphosphate, tetra-(alkali metal) salt, in a pharmaceutically acceptable carrier.

The invention provides an MRI (Magnetic Resonance Imaging) brain tumor localization and intratumoral segmentation method based on a deep cascaded convolution network, which comprises the steps of building a deep cascaded convolution network segmentation model; performing model training and parameter optimization; and carrying out fast localization and intratumoral segmentation on a multi-modal MRIbrain tumor. According to the MRI brain tumor localization and intratumoral segmentation method provided by the invention based on the deep cascaded convolution network, a deep cascaded hybrid neuralnetwork formed by a full convolution neural network and a classified convolution neural network is constructed, the segmentation process is divided into a complete tumor region localization phase andan intratumoral sub-region localization phase, and hierarchical MRI brain tumor fast and accurate localization and intratumoral sub-region segmentation are realized. Firstly, the complete tumor region is localized from an MRI image by adopting a full convolution network method, and then the complete tumor is further divided into an edema region, a non-enhanced tumor region, an enhanced tumor region and a necrosis region by adopting an image classification method, and accurate localization for the multi-modal MRI brain tumor and fast and accurate segmentation for the intratumoral sub-regions are realized.

Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia / reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as retinopathies or macular degeneration or other vitreoretinal diseases, inflammatory diseases, vascular leakage syndrome, edema, transplant rejection, adult / acute respiratory distress syndrome (ARDS), and the like.

Disclosed is an edema measuring method comprising the steps of: putting at least two pairs of electrodes on different locations selected in the body; making an alternating current to flow in the body via one pair of electrodes; measuring voltage appearing between the other pair of electrodes; calculating impedance on the basis of the supplied alternating current and the measured voltage; and calculating an index value representing the degree of edema on the basis of the impedance. Also, an apparatus using the method is disclosed.

Devices that employ external compression stocking-type garments in the treatment of edema, chronic wounds, deep venous thrombosis prevention or claudication all share a number of significant limitations. These include the frequent need for custom fitting to assure an appropriate fit, vigilant maintenance to assure a continued “good fit,” limited compliance with proper use by patients and difficulty of application. There is a large body of evidence demonstrating that patients often decline to wear the compressive stockings as prescribed or in the form that would be most beneficial because they find these devices to be difficult to put on and take off.Building on the limitations of existing therapies, and distilled lessons learned from the field of prosthetics and wound healing, the present invention employs vacuum-assisted negative pressure to provide compression and help pump fluid from the tissues of affected limbs. The device is embodied in the form of a flexible stocking-like garment that will utilize a pumping mechanism to generate negative pressure around the limb and thus create vacuum compression that will mobilize fluid in a limb and increase venous return to the heart. Through the use of a circumferential wrap, the present invention provides a major advance in both the distribution of vacuum and the securing of the device over the limb.

Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia / reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as retinopathies or macular degeneration or other vitreoretinal diseases , inflammatory diseases, vascular leakage syndrome, edema, transplant rejection, adult / acute respiratory distress syndrome (ARDS), and the like.

A garment is provided that positions and maintains therapeutic materials relative to a selected body part. A first version holds an icepack or optionally a heat emitting material proximate to a body part of a wearer, while minimally restricting the wearer's mobility. As one example, the wearer might be able to continue engaging in a sports activity while treating an edema of a body part with an icepack comprised in the garment. In another version, the garment might position and maintain heat emitting material or device relative to a first body part of a wearer while simultaneously positioning and maintaining a second therapeutic material, e.g., a cold pack, relative to a second body part of the wearer. In another version, the garment might position magnets or objects of psychological or spiritual significance, e.g., an object bearing a religious image or signage, separately, in combination or proximate to a therapeutic material

Systems and methods of monitoring a patient. Exemplary methods include receiving sensor data associated with the patient from a plurality of sensors of a patient monitoring device and determining whether the sensor data satisfies one or more trigger conditions. For each of the trigger conditions satisfied, one or more messages are sent to at least one of the patient monitoring device and an external computing device for display thereby to at least one of the patient, a caregiver, and a support person. Satisfaction of one or more of the trigger conditions may indicate the patient has edema and / or is trending toward decompensation. The sensor data may have been collected from a heart rate sensor, an oximeter, an accelerometer, and / or a sensor configured to detect a distance around a limb of a patient. In some embodiments, the trigger conditions are provided by the patient, caregiver, and / or support person.

A therapeutic pad system (200) is disclosed for the treatment of edema, wherein the pressure applied to the user by the pad encourages the proximal flow of lymph. A fluid is provided to one or more bladder-type pads (220) in the pad through an inlet port (218) at a distal end of the pad, and is expelled from the bladder through an outlet port (220) at the proximal end of the bladder, thereby producing a pressure gradient across the pad. The system includes a flexible and compressible liner (250) filled with a number of small foam pieces (258) that is adapted to be wrapped about the therapeutic pad, and a relatively rugged, outer binder (270) that is securable about the liner (250). An advantage of the present system is that it may be applied in a number of different modes and combinations providing many treatment options.

The invention discloses red date and ginger tea and a preparation method thereof. The red date and ginger tea comprises the following raw materials in parts by weight: 10-12 parts of ginger, 4-6 parts or red dates and 2-4 parts of brown powdered sugar. The preparation method comprises the following steps of: adding water into red dates and ginger, soaking and then decocting for 2h; separating to obtain a decoction liquid a and an insoluble substance a, adding water into the insoluble substance a, decocting for 1h, and separating to obtain a decoction liquid b and an insoluble substance b; merging the decoction liquid a and the decoction liquid b, filtering, and concentrating the filter liquid to obtain an extract; and crushing brown sugar into 100-mesh powder, mixing the crushed brown sugar with the eaxtract, uniformly stirring, granulating into 14-16-mesh powder, and drying to obtain a finished product. The red date and ginger tea has the functions of invigorating blood circulation, dispelling cold, removing moisture, inducing perspiration, disintoxicating, promoting digestion, arresting vomiting, avoiding fish smell, eliminating edema, relaxing the bowels, caring the skin and beautifying the face. The red date and ginger tea can be drunk by adding water and is convenient to carry, and the effective ingredients can be rapidly, effectively and thoroughly extracted.

A body water amount condition judging apparatus which is capable of judging body water amount condition, such as edema or dehydration, in detail exactly is disclosed. In the apparatus, at least two values selected from intra-cellular water resistance, extra-cellular water resistance, combined resistance of the intra-cellular and extra-cellular water resistance, and a ratio of intra-cellular and extra-cellular water are judging parameters for body water amount condition, The apparatus comprises a multi-frequency bioelectric impedance measuring means for measuring bioelectric impedance using AC currents having different frequencies, a calculating means for calculating each value of a judging parameter based on the measured bioelectric impedance value, a body water amount condition judging means for judging body water amount condition based on the calculated each value of the judging parameter, and a display means for displaying the judging result of the body water amount condition so judged.

Frequent monitoring of early-stage burns is necessary for deciding optimal treatment and management. Superficial-partial thickness and deep-partial thickness burns, while visually similar, differ dramatically in terms of clinical treatment and are known to progress in severity over time. The disclosed method uses spatial frequency domain imaging (SFDI) far noninvasively mapping quantitative changes in chromophore and optical properties that may be an indicative of burn wound severity. A controlled protocol of graded burn severity is developed and applied to 17 rats. SFDI data is acquired at multiple near-infrared wavelengths over a course of 3 h. Burn severity is verified using hematoxylin and eosin histology. Changes in water concentration (edema), deoxygenated hemoglobin concentration, and optical scattering (tissue denaturation) are statistically significant measures, which are used to differentiate superficial partial-thickness burns from deep-partial thickness burns.

A method and apparatus (100) of treating tissue adjacent a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema, includes injection of a drug-encapsulated within a heat-sensitive carrier, such as a liposome, within a region of tissue to be treated. The heat produced by the energy-emitting source (110) heats a portion of the tissue surrounding the bodily conduit to a temperature of approximately 43° C. for a time sufficient to destroy the heated portion of the tissue. In addition, the heat produced by the energy-emitting source (110) activates the heat-sensitive carrier to activate the release of the encapsulated drug and the drug targets the tissue to be heated. The focused energy of the energy-emitting source together with the compression acting on the target area can assist in delivering drugs to the target area so that a natural stent has a long term efficacy.