The invention discloses a paste for relieving pain and itching caused by mosquito bite. The paste comprises the following raw materials in parts by weight: 15-20 parts of eupatorium, 2-4 parts of liquorice, 5-8 parts of Chinese herbaceous peony, 0.1-0.5 part of alumen, 2-4 parts of apiary, 8-10 parts of fructus kochiae, 4-8 parts of fructus quisqualis, 1-2 parts of ligusticum wallichii, 2-3 parts of turmeric, 4-6 parts of garlic stem leaves, 1-3 parts of glycerinum, 25-50 parts of deionized water, 0.5-0.8 part of thickening agent and 50-100 parts of solvent. According to the invention, natural raw materials are selected; on the basis of scientific allocation, the required effective constituents are extracted in the manner of microwave extraction, and then effective constituents are subjected to decompression concentration, heating, pressurizing stirring, and the like; the use ratio of the effective constituents is 25% higher than that of the present manner, such as water boiling and filtering; the itching-relieving effect is specially obvious; the required time is short; the drug property is more mild; the paste is stimulation-free to a human body; the pregnant women, infants or low-immunity people all can use the paste; the paste is free from toxic or side effect.