1897results about How to "Extended duration" patented technology

A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir including the effective agent, an impermeable tube which encloses portions of the reservoir, and a permeable member at an end of the tube.

This invention concerns in general treatment of diseases and pathological conditions with anti-VEGF antibodies. More specifically, the invention concerns the treatment of human patients susceptible to or diagnosed with cancer using an anti-VEGF antibody, preferably in combination with one or more additional anti-tumor therapeutic agents.

The invention provides a drug-oligomer conjugate having the following general formula:wherein D is a therapeutic drug moiety; H and H' are each a hydrophilic moiety, independently selected from the group consisting of straight or branched PEG polymers having from 2 to 130 PEG subunits, and sugars; L is a lipophilic moiety selected from the group consisting of alkyl groups having 2-26 carbon atoms, cholesterol, adamantane and fatty acids; o is a number from 1 to the maximum number of covalent bonding sites on H; m+n+p together have a value of at least one and not exceeding the total number of covalent bonding sites on D for the -H', -L and -H-L substituents; the H-L bond(s) are hydrolyzable and the D-L' bond(s), when present, are hydrolyzable; the conjugate being further characterized by one of the following: (i) m is 0 and p is at least 1; (ii) n is 0 and p is at least 1; (iii) m and n are each 0 and p is at least 1; (iv) p is 0 and m and n are each at least 1. The therapeutic drug moiety is preferably a therapeutic protein or peptide, preferably insulin or a functional equivalent thereof.

A remote device in accordance with the present invention includes an adaptive power receiver that receives wireless power from the wireless power supply by induction. The adaptive power receiver may be switched among two or more modes of operation, including, for example, a high-Q mode and a low-Q mode. By controlling the switching between modes, the amount of energy received by the adaptive receiver may be controlled. This control is a form of adaptive resonance control or Q control.

A system and method for eye gaze tracking in human or animal subjects without calibration of cameras, specific measurements of eye geometries or the tracking of a cursor image on a screen by the subject through a known trajectory. The preferred embodiment includes one uncalibrated camera for acquiring video images of the subject's eye(s) and optionally having an on-axis illuminator, and a surface, object, or visual scene with embedded off-axis illuminator markers. The off-axis markers are reflected on the corneal surface of the subject's eyes as glints. The glints indicate the distance between the point of gaze in the surface, object, or visual scene and the corresponding marker on the surface, object, or visual scene. The marker that causes a glint to appear in the center of the subject's pupil is determined to be located on the line of regard of the subject's eye, and to intersect with the point of gaze. Point of gaze on the surface, object, or visual scene is calculated as follows. First, by determining which marker glints, as provided by the corneal reflections of the markers, are closest to the center of the pupil in either or both of the subject's eyes. This subset of glints forms a region of interest (ROI). Second, by determining the gaze vector (relative angular or Cartesian distance to the pupil center) for each of the glints in the ROI. Third, by relating each glint in the ROI to the location or identification (ID) of a corresponding marker on the surface, object, or visual scene observed by the eyes. Fourth, by interpolating the known locations of each these markers on the surface, object, or visual scene, according to the relative angular distance of their corresponding glints to the pupil center.

Higher overall etch rate and throughput for atomic layer removal (ALR) is achieved. The reaction is a self-limiting process, thus limiting the total amount of material that may be etched per cycle. By pumping down the process station between reacting operations, the reaction is partially “reset.” A higher overall etch rate is achieved by a multiple exposure with pump down ALR process.

Devices and methods for altering gaseous flow within a lung to improve the expiration cycle of an individual, particularly individuals having chronic obstructive pulmonary disease. The methods and devices create channels in lung tissue and maintain the patency of these surgically created channels in tissue. Maintaining the patency of the channels allows air to pass directly out of the lung tissue which facilitates the exchange of oxygen ultimately into the blood and / or decompresses hyper-inflated lungs.

Devices and methods for altering gaseous flow within a lung to improve the expiration cycle of an individual, particularly individuals having chronic obstructive pulmonary disease. The methods and devices create channels in lung tissue and maintain the patency of these surgically created channels in tissue. Maintaining the patency of the channels allows air to pass directly out of the lung tissue which facilitates the exchange of oxygen ultimately into the blood and / or decompresses hyper-inflated lungs.

The method and preprocessor enhances the intelligibility of narrowband speech without essentially lengthening the overall time duration of the signal. Both spectral enhancements and variable-rate time-scaling procedures are implemented to improve the salience of initial consonants, particularly the perceptually important formant transitions. Emphasis is transferred from the dominating vowel to the preceding consonant through adaptation of the phoneme timing structure. In a further embodiment, the technique is applied as a preprocessor to a speech coder.

A self-powered medical device, for example a pacemaker uses the variations of blood pressure inside the heart or a major artery to create a mechanical resonance in an electromagnetic or piezoelectric generator. The resonance extends the time power is generated during the cardiac cycle. The pressure variations compress a bellows carrying the resonant generator. The inside of the bellows may be evacuated to a partial or full vacuum, and a spring restores the bellows to the desired equilibrium point, acting against the blood pressure. The current pulses are stored in a capacitor. Eliminating the battery allows dramatic miniaturization of the medical device to the point it can be implanted at the point of desired stimulation via a catheter.

A method for determining location of a mobile terminal includes repetitively switching power-on and power-off to a GPS receiver circuit which determines location of the mobile terminal using GPS signals. The power-on to power-off duty cycle of the GPS receiver circuit is regulated in response to distance that the mobile terminal has moved from a previously determined location. The power-on to power-off duty cycle can be regulated in response to identifying GPS isolation, in response to an acceleration-determined distance from previous GPS-determine location, an acceleration-determined velocity of the mobile terminal, availability of position assistance information from a cellular system, presence / absence of signals from a WLAN / Bluetooth device, and / or detection of a new cellular base station ID.

Methods and systems are provided for routing callers to agents in a call-center routing environment. An exemplary method includes identifying caller data for a caller in a queue of callers, and jumping or moving the caller to a different position within the queue based on the caller data. The caller data may include one or both of demographic data and psychographic data. The caller can be jumped forward or backward in the queue relative to at least one other caller. Jumping the caller may further be based on comparing the caller data with agent data via a pattern matching algorithm and / or computer model for predicting a caller-agent pair outcome. Additionally, if a caller is held beyond a hold threshold (e.g., a time, “cost” function, or the like) the caller may be routed to the next available agent.

Methods and systems are provided for routing callers to agents in a call-center routing environment. An exemplary method includes routing a caller from a pool of callers based on at least one caller data associated with the caller, where a pool of callers includes, e.g., a set of callers that are not chronologically ordered and routed based on a chronological order or hold time of the callers. The caller may be routed from the pool of callers to an agent, placed in another pool of callers, or placed in a queue of callers. The caller data may include demographic or psychographic data. The caller may be routed from the pool of callers based on comparing the caller data with agent data associated with an agent via a pattern matching algorithm and / or computer model for predicting a caller-agent pair outcome. Additionally, if a caller is held beyond a hold threshold (e.g., a time, “cost” function, or the like) the caller may be routed to the next available agent.

Methods and systems are provided for routing callers to agents in a call-center routing environment. An exemplary method includes identifying caller data for a caller of a plurality of callers in a queue, and routing the caller from the queue out of queue order. For example, a caller that is not at the top of the queue may be routed from the queue based on the identified caller data, out of order with respect to the queue order. The caller may be routed to another queue of callers, a pool of callers, or an agent based on the identified caller data, where the caller data may include one or both of demographic and psychographic data. The caller may be routed from the queue based on comparing the caller data with agent data associated with an agent via a pattern matching algorithm and / or computer model for predicting a caller-agent pair outcome. Additionally, if a caller is held beyond a hold threshold (e.g., a time, “cost” function, or the like) the caller may be routed to the next available agent.

Methods and systems are provided for routing callers to agents in a call-center routing environment. An exemplary method includes identifying caller data for at least one caller in a queue of callers, and skipping a caller at the front of the queue of callers for another caller based on the identified caller data. The caller data may include one or both of demographic data and psychographic data. Skipping the caller may be further based on comparing caller data with agent data associated with an agent via a pattern matching algorithm such as a correlation algorithm. In one example, if the caller at the front of the queue has been skipped a predetermined number of times the caller at the front is the next routed (and cannot be skipped again).

A method for detecting an attack in a computer network includes monitoring communication traffic transmitted over connections on the network that are associated with a stateful application protocol so as to detect respective states of the connections, and analyzing a distribution of the states so as to detect the attack.

Devices and methods for altering gaseous flow within a lung to improve the expiration cycle of an individual, particularly individuals having chronic obstructive pulmonary disease. The methods and devices create channels in lung tissue and maintain the patency of these surgically created channels in tissue. Maintaining the patency of the channels allows air to pass directly out of the lung tissue which facilitates the exchange of oxygen ultimately into the blood and / or decompresses hyper-inflated lungs.

A communication device, for connecting one or more electrical appliances to a remote service centre, comprises a control unit (AMC), means (PLG) for connecting the device (HG) to an alternating voltage electric mains network (Vac) and means (SK) for supplying the alternating mains voltage (Vac) to a power supply line of an electric appliance. The device (HG) further comprises first communication means (CSA), prearranged for receiving information possibly generated by the electric appliance and transmitted through the power supply line thereof, second communication means (ZB), prearranged for establishing a connection with a local area network (HN1) and third communication means (GGM), prearranged for establishing a connection with a further communication network, different from the local network (HN1), to which the remote service centre is connected. The control unit (AMC) is prearranged for acquiring by means of the first communication means (CSA), first information possibly generated by the electric appliance and transmitted through the power supply line thereof and / or second information regarding electric energy consumptions associated to the operation of is the electric appliance, acquiring, by means of the second communication means (ZB), third information possibly available on the local network (HN1), and transmitting to the remote centre (RMC), by means of the third communication means (GGM), at least one of the first, second and third information.

The present invention provides a fluorescent material comprising a light-storing first phosphor that at least partially converts energy emitted by an excitation source to a first emission spectrum that is different from the energy, and a second phosphor that at least partially converts the first emission spectrum to a second emission spectrum that is different from the first emission spectrum; a lamp equipped with such a fluorescent material; a light-emitting device that produces a whitish afterglow, comprising such a fluorescent material for converting the emission by an LED chip; and a display unit comprising a display equipped with a plurality of such light-emitting devices.

Methods and systems are provided for routing callers to agents in a call-center routing environment. An exemplary method includes pooling incoming callers, and causing a caller from the pool of callers to be routed. The caller may be routed from the pool of callers to an agent, placed in another pool of callers, or placed in a queue of callers. The caller data may include demographic or psychographic data. The caller may be routed from the pool of callers based on comparing the caller data with agent data associated with an agent via a pattern matching algorithm and / or computer model for predicting a caller-agent pair outcome. Additionally, if a caller is held beyond a hold threshold (e.g., a time, “cost” function, or the like) the caller may be routed to the next available agent.

An implantable cardiac stimulation system and method having continuous capture management capabilities are provided. Continuous capture management is realized by continuously monitoring for secondary effects of loss of capture, thereby effectively providing continuous capture management in any heart chamber without encountering the limitations normally associated with evoked response sensing. A pacing threshold search is triggered upon detecting a secondary indicator of loss of capture. Secondary indicators of loss of capture may be lead-related changes, changes related to the occurrence of atrial sensed events, changes related related to the occurrence of ventricular sensed or paced events, and / or changes related to a monitored physiological condition.

Compositions, systems and methods of sequencing are disclosed, where the compositions and systems include polymerase enzymes that have been genetically modified to more efficiently incorporate nucleotides including labels having a detectable properties that are released during incorporation, to augment a rate of labeled nucleotide incorporation, to augment a rate of pyrophosphate release, or to augment two or more of these properties and rates. Also disclosed are terminally labeled and dual labeled nucleotides, and click-chemistry based methods of synthesizing the same.

A method of analysing tachometer and vibration response data from an apparatus having one or more rotary components is provided. The method comprises the steps of: providing vibration response data and corresponding tachometer data from the apparatus for a period over which a rotary component of the apparatus varies in rotational speed, the tachometer data being for that component; repeatedly performing at intervals throughout the period the sub-steps of: determining a forcing frequency of the component from the tachometer data and a corresponding vibration response frequency of the apparatus from the vibration response data, comparing the forcing and vibration response frequencies to determine the relative phase difference between the frequencies, and determining the corresponding amplitude of the vibration response from the vibration response data; and plotting the relative phase differences and vibration amplitudes on a polar diagram. The plot trajectory is characteristic of the behavior of the apparatus over the period.

Methods and systems are provided for routing callers to agents in a call-center routing environment. An exemplary method includes identifying caller data for a caller in a queue of callers, and jumping or moving the caller to a different position within the queue based on the caller data. The caller data may include one or both of demographic data and psychographic data. The caller can be jumped forward or backward in the queue relative to at least one other caller. Jumping the caller may further be based on comparing the caller data with agent data via a pattern matching algorithm and / or computer model for predicting a caller-agent pair outcome. Additionally, if a caller is held beyond a hold threshold (e.g., a time, “cost” function, or the like) the caller may be routed to the next available agent.

A method of analysing tachometer and vibration response data from an apparatus having one or more rotary components is provided. The method comprises the steps of: providing vibration response data and corresponding tachometer data from the apparatus for a period over which a rotary component of the apparatus varies in rotational speed, the tachometer data being for that component; repeatedly performing at intervals throughout the period the sub-steps of: determining a forcing frequency of the component from the tachometer data and a corresponding vibration response frequency of the apparatus from the vibration response data, comparing the forcing and vibration response frequencies to determine the relative phase difference between the frequencies, and determining the corresponding amplitude of the vibration response from the vibration response data; and plotting the relative phase differences and vibration amplitudes on a polar diagram. The plot trajectory is characteristic of the behaviour of the apparatus over the period.

A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a C12 / Cmax ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours.

An intragastric balloon and method of adding and / or removing fluid therefrom are disclosed. The intragastric balloon includes a shell, a grasping tab, and a self-sealing portion. A gastroscopic instrument which includes a grasping tool is inserted into the stomach of a patient and used to grasp the grasping tab located on the surface of the shell. Using the grasping tool, the intragastric balloon is securely fastened to the gastroscopic instrument. A filling instrument, such as a needle, is advanced through the self-sealing portion of the shell for the filling or deflating of the intragastric balloon. After inflation or deflation is complete, the filling instrument is then withdrawn from the balloon and the gastroscopic instrument withdrawn from the stomach.

Described herein are therapeutic targets expressed in cancer stem cells and methods for treating and diagnosing cancer by targeting such cells with antibodies, compounds, nucleic acid, or other therapeutic agent. In one embodiment described herein, therapeutic agents for the treatment of cancer are provided based on the identification of cancer stem cell targets. The present invention also includes therapeutic targets for cancer therapy and cancer stem cell-targeted therapy. The invention includes the treatment of cancer by the administration of compounds or agents that target cancer stem cells.